Category: 1375325-77-1

Otsuka, Shinya published the artcileSynthesis of 4-aryl- and 4-acyl-1,3-dithiole-2-thiones via deprotonative zincation of 1,3-dithiole-2-thione, COA of Formula: C51H42ClNOP2Pd, the publication is Heteroatom Chemistry (2018), 29(3), n/a, database is CAplus.

Deprotonative zincation of 1,3-dithiole-2-thione at the 4-position was developed. Addition of lithium diisopropylamide to a THF solution of 1,3-dithiole-2-thione containing ZnI₂ and LiI generated the corresponding organozinc species. After this zincation, various aryl and acyl groups were installed at the 4-position by Pd-catalyzed cross-coupling reaction with aryl iodides and Cu-catalyzed acylation with acyl chlorides, resp.

Heteroatom Chemistry published new progress about 1375325-77-1. 1375325-77-1 belongs to chlorides-buliding-blocks, auxiliary class Palladium, name is Chloro[(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2-amino-1,1-biphenyl)]palladium(ii), and the molecular formula is C51H42ClNOP2Pd, COA of Formula: C51H42ClNOP2Pd.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Feng, Guang-Jing published the artcileImproved Synthesis of 1-Glycosyl Thioacetates and Its Application in the Synthesis of Thioglucoside Gliflozin Analogues, Related Products of chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2021), 2021(21), 2940-2949, database is CAplus.

An improved method to synthesize 1-glycosyl thioacetates was developed, where per-O-acetylated glycoses were allowed to directly react with potassium thioacetate (KSAc) in the presence of BF₃ · Et₂O in Et acetate under mild conditions. This method not only overcomes the disadvantage of the traditional one-step method, which is that the odorous and toxic thioacetic acid has to be used, but also overcomes the disadvantage of the traditional two-step method, which is that the unstable intermediate, glycosyl halide, has to be synthesized from the per-O-acetylated glycose in advance. Based on this, the per-O-acetylated glucosyl disulfide and the per-O-acetylated glucosyl 1-thiol were efficiently synthesized in high yields (91% and 90% resp.) starting from per-O-acetylated glycoses in two-step without the need to isolate intermediate products. Through metal-catalyzed cross-coupling of per-O-acetylated glucosyl 1-thiol with aryl-iodide under very mild conditions, two thioglucoside gliflozin analogs were efficiently synthesized in high yields for the first time. These two thioglucoside gliflozin analogs I and II were further confirmed to be stable to hydrolysis of β-glucosidase.

European Journal of Organic Chemistry published new progress about 1375325-77-1. 1375325-77-1 belongs to chlorides-buliding-blocks, auxiliary class Palladium, name is Chloro[(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2-amino-1,1-biphenyl)]palladium(ii), and the molecular formula is C51H42ClNOP2Pd, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Yuhua published the artcileMechanistic insights into the palladium-catalyzed hydroaminocarbonylation of alkenes, SDS of cas: 1375325-77-1, the publication is New Journal of Chemistry (2021), 45(17), 7516-7522, database is CAplus.

DFT calculations have been conducted on Pd-catalyzed regioselective hydroaminocarbonylation of alkenes. The favored path I consists of styrene insertion, CO insertion, and nucleophilic attack, which is the rate determining step. In the PPh₃-assisted system, the conjugation between the benzylic units and the acyl group stabilizes the branched transition state in the nucleophilic attack leading to the branched selectivity. On the other hand, in the xantphos-assisted system, the steric repulsion between the substrate and the ligand leads to a higher barrier for the branched transition state; therefore, linear selectivity is favored which is in line with the exptl. observation. The anal. of the electronic and steric effects of ligands on the selectivity helps to develop a catalyst for hydroaminocarbonylation of alkenes.

New Journal of Chemistry published new progress about 1375325-77-1. 1375325-77-1 belongs to chlorides-buliding-blocks, auxiliary class Palladium, name is Chloro[(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2-amino-1,1-biphenyl)]palladium(ii), and the molecular formula is C51H42ClNOP2Pd, SDS of cas: 1375325-77-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics