Category: 139502-80-0

In 2019,ChemMedChem included an article by Campanico, Andre; Carrasco, Marta P.; Njoroge, Mathew; Seldon, Ronnett; Chibale, Kelly; Perdigao, Joao; Portugal, Isabel; Warner, Digby F.; Moreira, Rui; Lopes, Francisca. Related Products of 139502-80-0. The article was titled 《Azaaurones as potent antimycobacterial agents active against MDR- and XDR-TB》. The information in the text is summarized as follows:

Herein we report the screening of a small library of aurones and their isosteric counterparts, azaaurones and N-acetylazaaurones, against Mycobacterium tuberculosis. Aurones were found to be inactive at 20 μM, whereas azaaurones and N-acetylazaaurones emerged as the most potent compounds, with nine derivatives displaying MIC99 values ranging from 0.4 to 2.0 μM. In addition, several N-acetylazaaurones were found to be active against multidrug-resistant (MDR) and extensively drug-resistant (XDR) clin. M. tuberculosis isolates. The antimycobacterial mechanism of action of these compounds remains to be determined; however, a preliminary mechanistic study confirmed that they do not inhibit the mycobacterial cytochrome bc1 complex. Addnl., microsomal metabolic stability and metabolite identification studies revealed that N-acetylazaaurones are deacetylated to their azaaurone counterparts. Overall, these results demonstrate that azaaurones and their N-acetyl counterparts represent a new entry in the toolbox of chemotypes capable of inhibiting M. tuberculosis growth. In the experimental materials used by the author, we found 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0Related Products of 139502-80-0)

4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Related Products of 139502-80-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hauke, Tobias J.; Hoefner, Georg; Wanner, Klaus T. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4》.Quality Control of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde The author mentioned the following in the article:

The γ-aminobutyric acid (GABA) transporter mGAT4 represents a promising drug target for the treatment of epilepsy and other neurol. disorders; however, the lack of highly potent and selective inhibitors for mGAT4 still retards its pharmacol. elucidation. Herein, the generation and screening of pseudostatic combinatorial hydrazone libraries at the murine GABA transporter mGAT4 for the search of novel GABA uptake inhibitors is described. The hydrazone libraries contained more than 1100 compounds derived from nipecotic acid derivatives substituted at the 5-position instead, as common, at the 1-position of the core structure. Two hits were found and evaluated, which display potencies in the lower micromolar range at mGAT4 and its human equivalent hGAT3. These compounds possess a lipophilic moiety derived from a biphenyl residue attached to the 5-position of the hydrophilic nipecotic acid moiety via a three-atom spacer. Thus, the novel structures with potencies close to that of the bench mark mGAT4 inhibitor (S)-SNAP-5114 add new insights into the structure-activity relationship of mGAT4 inhibitors and could provide a promising starting point for the development of new mGAT4 inhibitors with even higher potencies. The experimental part of the paper was very detailed, including the reaction process of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0Quality Control of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde)

4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Quality Control of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Microwave-assisted organic acid-base-co-catalyzed tandem Meinwald rearrangement and annulation of styrylepoxides》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Shi, Yi; Li, Siqi; Lu, Yang; Zhao, Zizhen; Li, Pingfan; Xu, Jiaxi. HPLC of Formula: 139502-80-0 The article mentions the following:

A novel organic acid-base-co-catalyzed conversion of styrylepoxides I [R = Ph, 2,3-dichlorophenyl, 3-(trifluoromethyl)phenyl, etc.; R1 = H, Me] into [1,1′-biaryl]-3-carbaldehydes 3-RC6H4CHO was realized under microwave irradiation Styrylepoxides I first underwent an acid-catalyzed Meinwald rearrangement followed by a tandem base-catalyzed Michael addition, aldol addition, and aromatization sequence to generate [1,1′-biaryl]-3-carbaldehydes. The experimental process involved the reaction of 4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0HPLC of Formula: 139502-80-0)

4′-Chloro-[1,1′-biphenyl]-3-carbaldehyde(cas: 139502-80-0) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.HPLC of Formula: 139502-80-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics