Category: 14070-51-0

Kinetics of oxidation of substituted 纬-ketoacid by N-chlorosaccharin in aqueous acetic acid medium was written by Farook, N. A. Mohamed;Alhaji, N. M. I.. And the article was included in International Journal of Chemical Sciences in 2004.Synthetic Route of C7H4ClNO3S This article mentions the following:

The kinetics of oxidation of a 纬-ketoacid namely, 4-oxo-4-(3′-4′-dimethylphenyl)butanoic acid by N-chlorosaccharin in aqueous acetic acid medium in the presence of perchloric acid have been investigated potentiometrically. The observed rate of oxidation is first order each in [KA], [NCSA] and [H⁺]. The main product of the oxidation is 3,4-dimethylbenzoic acid. The rate decreases with the addition of saccharin, one of the products of the reaction. Variation in ionic strength of the reaction medium has no significant effect on the rate of oxidation, but the rate of the reaction is enhanced by lowering the dielec. constant of the reaction medium. Hypochlorous acidium ion (H₂O⁺Cl), has been postulated as the reactive oxidizing species. A suitable mechanism consistent with the exptl. results has been proposed. The activation parameters have been computed with respect to slow step of the mechanism. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Synthetic Route of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorination of ketones with N-chlorosaccharin was written by Panchatsharam, V. S.;Sundaram, S.;Venkatasubramanian, N.. And the article was included in Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical in 1981.Related Products of 14070-51-0 This article mentions the following:

A Taft LFER for the title reaction gave 蟻^* = -0.49 which is in accordance with an enolization mechanism that involves the development of pos. charge in the transition state. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Related Products of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Homolytic displacement at carbon centers. XII. Regiospecific formation of N-allyl and N-cyclopropylcarbinyl sulfonamides and of allyl and cyclopropyl halides in the reaction of N-halo compounds with organocobaloximes was written by Johnson, Michael D.;Lampman, Gary M.;Koops, Roger W.;Das Gupta, B.. And the article was included in Journal of Organometallic Chemistry in 1987.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

Reaction of RCo(dmgH)₂py [I, dmgH = dimethylglyoximato; R = R¹CR²:CHCH₂, H₂C:CR¹(CH₂)₂; R¹ = H, Me; R² = H, Me, Ph] with R³SO₂NMeCl (II, R³ = Me, Ph) gave R⁴CR¹R²CH:CH₂ (III) and cyclopropanes IV (R⁴ = R³SO₂NMe, Cl), resp., by attack of an N-centered radical on the terminal unsaturated carbon of I. Reaction of I [R = R¹CH:CHCH₂, H₂C:CR¹(CH₂)₂; R¹ = H, Me] with AcNHBr, NBS, N-chlorosuccinimide, and N-chlorosaccharin gave III and IV (R⁴ = Br, Cl) by attack of a halogen-containing free radical on the terminal unsaturated carbon of I. Bromination of Me(CH₂)₅CH:CH₂ with AcNHBr in the presence of 0.3 mol % I (R = MeCHEt) gave BrCH₂CHBr(CH₂)₅Me in 92% yield after 1 h. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of oxidation of 4-oxoacids by N-chlorosaccharin in aqueous acetic acid medium was written by Farook, N. A. Mohamed. And the article was included in Asian Journal of Chemistry in 2007.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

Kinetics of oxidation of substituted and unsubstituted 4-oxoacids (S) by N-chlorosaccharin (NCSA) in aqueous acetic acid medium were studied. The reaction follows first-order kinetics, each in 4-oxoacids, NCSA and H⁺. The effect of changes in the electronic nature of the substrate reveals that there is a development of pos. charge in the transition state. From the kinetic results and product anal., a suitable mechanism was proposed for the reaction of NCSA with 4-oxoacids. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics and mechanism of phosphotungstic acid catalyzed oxidation of citric acid by N-chlorosaccharin was written by Singh, Sanjay K.;Gujral, Harjeet;Kaur, Raman Deep;Arora, Monika;Kaur, Gurpreet;Gupta, H. D.. And the article was included in Journal of Chemical, Biological and Physical Sciences in 2012.Product Details of 14070-51-0 This article mentions the following:

The kinetics of oxidation of citric acid (CA) with N-chlorosaccharin (NCSA) in the presence of phosphotungstic acid (PTA) was measured at 293, 298, 303 and 308 K. The order with respect to NCSA is unity while with CA and PTA was fractional. The effects of temperature, composition of solvent medium and concentration of added mineral acid on the rate of reaction were also studied. The mechanism for the catalyzed oxidation probably proceeds through the formation of a ternary complex between PTA, CA and NCSA which is being decomposed and gives product in slow rate-determining step. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Product Details of 14070-51-0).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 14070-51-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxidation of triethylene glycol by N-chlorosaccharin in cetyltrimethylammonium bromide catalyzed system: a kinetics and mechanistic study was written by Sharma, Vandana;Sharma, K. V.;Bhagwat, V. W.. And the article was included in Physical Chemistry: An Indian Journal in 2008.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

The kinetics and mechanistic study of cetyltrimethylammonium bromide catalyzed oxidation of triethylene glycol [2,2′-ethylene dioxybis(ethanol)] by N-chlorosaccharin in aqueous acetic acid medium in presence of perchloric acid were studied at 303-323K temperature range. The reaction has first order dependence on N-chlorosaccharin concentration The reaction rate follows first order kinetics with respect to [triethylene glycol] with excess concentration of other reactants. The micelle effect due to cetyltrimethylammonium bromide- a cationic surfactant was studied. The change in ionic strength shows negligible salt effect. The dielec. effect is pos. Addition of one of (saccharin) retards the reaction rate. Activation parameters are calculated from the Arrhenius plot. A suitable mechanism was proposed in consistence with the kinetic data. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Visible-light promoted intermolecular halofunctionalization of alkenes with N-halogen saccharins was written by Song, Lu;Luo, Sanzhong;Cheng, Jin-Pei. And the article was included in Organic Chemistry Frontiers in 2016.Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

A simple and efficient visible-light promoted intermol. haloamination and haloetherification of alkenes using N-halosaccharin as the halogen and nitrogen/oxygen source (halo = Br, Cl) was reported. The reaction was applied to a very broad range of alkenes to generate haloamines and haloethers with high isolated yields. With DBU as the base, metal-free C-H amination of aryl olefins was achieved with good yields. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) was written by Misal, Balu;Palav, Amey;Ganwir, Prerna;Chaturbhuj, Ganesh. And the article was included in Tetrahedron Letters in 2021.Synthetic Route of C7H4ClNO3S This article mentions the following:

N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) was explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and com. available N-chloro reagents to reveal the reactivity on a theor. viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-Bu hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Synthetic Route of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetic and mechanistic approach of N-chlorosaccharin oxidation of some non vicinal polyhydroxy alcohols was written by Kaur, Raman Deep;Arora, Monika;Gujral, Harjeet;Kaur, Gurpreet;Nayak, S. N.;Singh, S. K.. And the article was included in International Journal of ChemTech Research in 2010.Electric Literature of C7H4ClNO3S This article mentions the following:

The kinetics of oxidation of propane-1,3-diol and butane-1,4-diol by N-chlorosaccharin was carried out in aqueous acetic acid medium. The reactions exhibit first order dependence in oxidant and the Michaelis-Menten’s kinetics in substrate. Increase in the concentration of added perchloric acid increases the rate of oxidation Addition of the reaction product, saccharin, exhibits retarding effect. Decrease in dielec. constant of the medium decreased the rate constant Various activation parameters have been evaluated. Mechanism proposed and the derived rate law is in agreement with the observed kinetics. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Electric Literature of C7H4ClNO3S).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C7H4ClNO3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mechanistic investigation of oxidation of metronidazole with N-chlorosaccharin in acid medium: a kinetic approach was written by Singh, Santosh Kumar;Khan, M. U.;Dwivedi, H. P.;Chauhan, D. B. S.;Gupta, H. D.. And the article was included in International Journal of Green and Herbal Chemistry in 2013.Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide This article mentions the following:

A kinetic study of oxidation of Mitronidazole (MTZ) is an anti-bacterial and anti-protozoal drug, with N-chlorosaccharin (NCSA) has been carried out in presence of HClO₄ in aqueous acetic acid medium at 308 K. The reaction is fully HClO₄ acid catalyzed and retardation was observed when saccharin was added in reaction mixture Variation of ionic strength of the medium shows negligible effect on rate of reaction. Increase in dielec. permittivity of the medium increases the rate of oxidation The stoichiometry of the reaction was found to be 1:1. The reported oxidation product of MTZ was identified as the 2-methyl-5-nitro imidazole-N¹-acetaldehyde which was detected by conventional methods and spot test. Various activation parameters have been evaluated. The reaction constants involved in the proposed mechanisms were computed. The proposed mechanisms were in good consistent with the observed exptl. results. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide).

2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (cas: 14070-51-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics