Category: 141109-14-0

Iridium and bis(4-nitrophenyl)phosphoric acid catalysed amination of diol by hydrogen-borrowing methodology for the synthesis of cyclic amine: Synthesis of clopidogrel was written by Swain, Sharada Prasanna;Shri, Om;Ravichandiran, V.. And the article was included in Molecular Catalysis in 2021.HPLC of Formula: 141109-14-0 The following contents are mentioned in the article:

The borrowing hydrogen method is an environmentally benign process for the synthesis of amines, as H₂O is the side product. A new green process for the amination of diol by [Ir] catalyst and bis(4-nitrophenyl)phosphoric acid for the synthesis of cyclic amine is reported. This method was successfully applied for the synthesis of antiplatelet drug clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0HPLC of Formula: 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of isomer of clopidogrel was written by Li, Dong-xing;Pu, Tong;Zhong, Wei-hui. And the article was included in Zhejiang Huagong in 2010.Related Products of 141109-14-0 The following contents are mentioned in the article:

The Me 2-(2-chlorophenyl)-2-(4,5-dihydrothieno [2,3-c]-pyridin-6 (7H)-yl)acetate, an isomer of clopidogrel, was achieved from 2-chlorophenylglycine Me ester and 2-(3-thiophenyl)ethyl para-toluenesulfonate via amino substitution, Mannich reaction and formation of sulfate salt in 56%. The advantages of our method are com. available starting materials, mild reaction condition and high yield. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Related Products of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel: A Practical Application of a New Discovery was written by van der Meijden, Maarten W.;Leeman, Michel;Gelens, Edith;Noorduin, Wim L.;Meekes, Hugo;van Enckevort, Willem J. P.;Kaptein, Bernard;Vlieg, Elias;Kellogg, Richard M.. And the article was included in Organic Process Research & Development in 2009.Synthetic Route of C9H10ClNO2 The following contents are mentioned in the article:

The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Synthetic Route of C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Improved synthesis of clopidogrel was written by Liang, Meihao;Shen, Zhengrong. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2007.Electric Literature of C9H10ClNO2 The following contents are mentioned in the article:

The synthetic procedure of clopidogrel, a platelet aggregation inhibitor, was improved. The target compound was synthesized from alpha-amino-(2-chloro phenyl)-acetic acid via resolution, esterification, SN₂ substitution, and cyclization. A new racemizaton and resolution procedure was developed in the preparation of (+)-alpha-amino-(2-chloro phenyl)-acetic acid. The overall yield is 26.9%. The improved synthetic procedure has the advantage of low cost and is suitable for industrial production This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Electric Literature of C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of (αS)-α-amino-2-chlorobenzeneacetic acid methyl ester was written by Ding, Gui-li;Zhao, Min;Wu, Fan-hong;Yu, De-fei;Chen, Jian-zhon. And the article was included in Guangzhou Huagong in 2007.Product Details of 141109-14-0 The following contents are mentioned in the article:

A method for the synthesis of the title compound and a resolution method are reported here. L-(+)-tartaric acid was used as resolving agent. Optimum resolution process conditions were: 30°, 5 h, a mixture of acetone and methanol solvent volume ratio 1:4 and the mol ratio of α-amino-2-chlorobenzeneacetic acid Me ester to L-(+)-tartaric 1:1.1. The resolution process provide a yield above 90% (optical rotation 88°). This process may have industrial applications. The above-mentioned title compound is an intermediate in the synthesis of clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemo-enzymatic approach to the synthesis of the antithrombotic clopidogrel was written by Ferraboschi, Patrizia;De Mieri, Maria;Galimberti, Fiorella. And the article was included in Tetrahedron: Asymmetry in 2010.Recommanded Product: 141109-14-0 The following contents are mentioned in the article:

The (S)-2-chlorophenylglycine moiety is well recognized in the structure of (S)-clopidogrel, a known antithrombotic drug. An enantiomerically pure chiral building block was prepared via an enzyme-catalyzed resolution of (RS)-N-Boc-2-chlorophenylglycine Me ester. The best results were obtained by means of an immobilized subtilisin, the cross-linked enzyme aggregate (Alcalase-CLEA). The high enantiomeric excess of the synthon obtained remained the same over the course of clopidogrel synthesis; the simplicity of the process makes this pathway suitable for large-scale preparation This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparative studies of novel triazole derivative having chiral center and their antimicrobial activities was written by Mistry, Bhavnaben D.;Desai, Kishor R.;Intwala, Sanket M.. And the article was included in Pharma Chemica in 2013.Formula: C9H10ClNO2 The following contents are mentioned in the article:

The compounds 1,2,4-triazole-3-thiol derivatives (-) and (+)-I [R = H, 3-CH₃, 2-OH, 3,5-(NH₂)₂] have been synthesized by the reaction of 1,3,4-oxadiazole-2-thiol derivatives (-) and (+)-II with concentrate H₂SO₄, L-(+) tartaric acid, D-(-) tartaric acid, hydrazine hydrate, carbon disulfide and various aromatic amine resp.. The synthesized compounds have been screened for their antibacterial and antifungal activities against different microorganisms. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Formula: C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An asymmetric synthesis of clopidogrel hydrogen sulfate was written by Sashikanth, Suthrapu;Raju, Veeramalla;Somaiah, Sripathi;Rao, Peddi Srinivasa;Reddy, Karnati Venugopal. And the article was included in Synthesis in 2013.Electric Literature of C9H10ClNO2 The following contents are mentioned in the article:

An asym. synthesis of (S)-(+)-clopidogrel hydrogen sulfate was developed through application of a Strecker reaction with [(1S)-1-(4-methoxyphenyl)ethyl]amine.HCl (I) as a chiral auxiliary. Addition of 2-ClC₆H₄CHO to a solution of NaCN and I gave diastereoisomerically pure (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile.HCl. Cleavage of the chiral auxiliary and concomitant hydrolysis of the nitrile group then gave enantiomerically pure (2S)-2-(2-chlorophenyl)glycine.HCl, a key intermediate for (S)-(+)-clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Electric Literature of C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development [Erratum to document cited in CA163:218209] was written by Shaw, Scott A.;Balasubramanian, Balu;Bonacorsi, Samuel;Caceres Cortes, Janet;Cao, Kevin;Chen, Bang-Chi;Dai, Jun;Decicco, Carl;Goswami, Animesh;Guo, Zhiwei;Hanson, Ronald;Humphreys, W. Griffith;Lam, Patrick Y. S.;Li, Wenying;Mathur, Arvind;Maxwell, Brad D.;Michaudel, Quentin;Peng, Li;Pudzianowski, Andrew;Qiu, Feng;Su, Shun;Sun, Dawn;Tymiak, Adrienne A.;Vokits, Benjamin P.;Wang, Bei;Wexler, Ruth;Wu, Dauh-Rurng;Zhang, Yingru;Zhao, Rulin;Baran, Phil S.. And the article was included in Journal of Organic Chemistry in 2015.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

Other work on clopidogrel metabolite synthesis was omitted from the reference list; a corrected reference 13 is given. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New and Efficient Synthetic Approaches for the Regioisomeric and Iminium Impurities of Clopidogrel Bisulfate was written by Aalla, Sampath;Gilla, Goverdhan;Anumula, Raghupathi Reddy;Charagondla, Kavitha;Vummenthala, Prabhakar Reddy;Padi, Pratap Reddy. And the article was included in Organic Process Research & Development in 2012.Related Products of 141109-14-0 The following contents are mentioned in the article:

New and concise synthetic routes have been devised for the regioisomeric and iminium impurities of clopidogrel bisulfate. The synthesis features utilization of com. available starting materials and simple reactions. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Related Products of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics