Category: 141109-14-0

Organocatalytic asymmetric intramolecular [3+2] cycloaddition: A straightforward approach to access multiply substituted hexahydrochromeno[4,3-b]pyrrolidine derivatives in high optical purity was written by Li, Nan;Song, Jin;Tu, Xi-Feng;Liu, Bin;Chen, Xiao-Hua;Gong, Liu-Zhu. And the article was included in Organic & Biomolecular Chemistry in 2010.Electric Literature of C9H10ClNO2 The following contents are mentioned in the article:

A chiral phosphoric acid-catalyzed intramol. 1,3-dipolar cycloaddition of 4-(2-formylphenoxy)butenoates with amino esters provides hexahydromeno[4,3-b]pyrrolidine derivatives, e.g., I in high enantioselectivity (up to 94% ee). This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Electric Literature of C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Method of splitting key intermediate of clopidogrel was written by Xu, Han-qing. And the article was included in Guangzhou Huagong in 2014.Recommanded Product: 141109-14-0 The following contents are mentioned in the article:

The racemic 2-(2-chlorophenyl)glycine as the starting material, through esterification to give racemic 2-(2-chlorophenyl)glycine Me ester, resolved by (L)-(+)-tartrate, Bu ketone as solvent, (S)-(+)-2-(2-chlorophenyl)glycine Me ester was obtained, and the solvent recovery yield was more than 95%. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development was written by Shaw, Scott A.;Balasubramanian, Balu;Bonacorsi, Samuel;Cortes, Janet Caceres;Cao, Kevin;Chen, Bang-Chi;Dai, Jun;Decicco, Carl;Goswami, Animesh;Guo, Zhiwei;Hanson, Ronald;Humphreys, W. Griffith;Lam, Patrick Y. S.;Li, Wenying;Mathur, Arvind;Maxwell, Brad D.;Michaudel, Quentin;Peng, Li;Pudzianowski, Andrew;Qiu, Feng;Su, Shun;Sun, Dawn;Tymiak, Adrienne A.;Vokits, Benjamin P.;Wang, Bei;Wexler, Ruth;Wu, Dauh-Rurng;Zhang, Yingru;Zhao, Rulin;Baran, Phil S.. And the article was included in Journal of Organic Chemistry in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Clopidogrel (I) is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y₁₂ and thus inhibit platelet activation. However, gaining an understanding of patient response has been limited due to imprecise understanding of metabolite activity and stereochem., and a lack of acceptable analytes for quantifying in vivo metabolite formation. Methods for the production of all bioactive metabolites of clopidogrel (II, mixture of four stereoisomers), their stereochem. assignment, and the development of stable analytes via three conceptually orthogonal routes are disclosed. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Category: chlorides-buliding-blocks).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Characterization of Impurity B of S-(+)-Clopidogrel Bisulfate: An Antiplatelet was written by Reddy, K. Tatendra;Kumar, K. Suneel;Omprakash, G.;Dubey, P. K.. And the article was included in Synthetic Communications in 2013.Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

S-(+)-Clopidogrel bisulfate [(S-(+)-Me 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature are also listed in the U.S. pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this article, a description of these impurities and their origins in the S-(+)-clopidogrel bisulfate process are presented along with the preparation of impurity B I·HCl. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An improved synthesis of clopidogrel bisulfate was written by Hu, Jia-peng;Lu, Xin;Liu, Zhi-bin. And the article was included in Zhejiang Huagong in 2012.Product Details of 141109-14-0 The following contents are mentioned in the article:

(S)-Me 2-amino-2-(2-chlorophenyl) acetate is obtained from racemic 2-amino-2-(2-chlorophenyl) acetic acid through esterification and optical resolution, which was subjected to condensation reaction with 2-(thiophen-2-yl)ethyl 4-Me benzene sulfonate to afford the critical intermediate (S)-Me 2-(2-chlorophenyl)-2-(2-thiophen-2-yl)ethylamino) acetate. The cyclization of (S)-Me 2-(2-chloropheny)-2-(2-(thiophen-2-yl) ethylamino) acetate with paraformaldehyde in the presence of anhydrous formic acid provided clopidogrel bisulfate. For this synthesis pathway, there are some advantages such as readily available starting material, moderate condition, high yield and good quality. This process is suitable for industrialization. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparative studies of novel oxadiazole derivative having chiral center and their anti-microbial activities was written by Mistry, Bhavnaben D.;Desai, Kishor R.;Intwala, Sanket M.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2014.Related Products of 141109-14-0 The following contents are mentioned in the article:

A series of oxadiazole derivatives I [X = H, Y = NH₂ or X = NH₂, Y = H, and R = H, 3-CH₃, 2-OH, 2,4-(Cl)₂, 2-NO₂, etc.] were synthesized by the reaction of (-)(2R)-2-amino-2-(2-chlorophenyl)acetohydrazide and (+)(2S)-2-amino-2-(2-chloro phenyl)acetohydrazide with con. H₂SO₄, L(+)-tartaric acid, D(-)-tartaric acid, hydrazine hydrate, POCl₃ and various aromatic acid resp. and screened for their antibacterial and antifungal activities against different microorganisms by micro dilution method. The synthesized compounds I indicate that some of them show better antibacterial and antifungal activity than compared to their reference drug. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Related Products of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Searching for New Cures for Tuberculosis: Design, Synthesis, and Biological Evaluation of 2-Methylbenzothiazoles was written by Huang, Qingqing;Mao, Jialin;Wan, Baojie;Wang, Yuehong;Brun, Reto;Franzblau, Scott G.;Kozikowski, Alan P.. And the article was included in Journal of Medicinal Chemistry in 2009.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The actual development and clin. use of new therapeutics for tuberculosis have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6 mo period. In this study, the chem. and biol. of a series of potent 5-(2-methylbenzothiazol-5-yloxymethyl)isoxazole-3-carboxamides, e.g. I [R = Me₂N, 1-piperidinyl, (S)-MeO₂CCH(Ph)NH, etc.] , which proved to be active against replicating Mycobacterium tuberculosis (Mtb) H₃₇Rv, are reported. The most potent compounds I [R = (S)- or (R)-MeO₂CCH(Ph)NH] were found to inhibit Mtb growth at micromolar concentrations, with MIC values of 1.4 and 1.9 μM, resp. Impressively, all active compounds were nontoxic toward Vero cells (IC₅₀ > 128 μM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum. These studies thus suggest that certain 2-methylbenzothiazole based compounds may serve as promising lead scaffolds for further elaboration as antitubercular drugs and as possible antimalaria drugs. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Category: chlorides-buliding-blocks).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents was written by Zhu, Yaoqiu;Zhou, Jiang;Jiao, Bo. And the article was included in ACS Medicinal Chemistry Letters in 2013.Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

Clopidogrel (CPG) is an antithrombotic prodrug that needs hepatic cytochrome P 450 (CYP) enzymes for its bioactivation. The clin. effects of CPG have been associated with high intersubject variability and a certain level of resistance. Recently, comprehensive biotransformation studies of CPG support that the observed clin. uncertainty stems from the low bioactivation efficiency, which is attributed to extensive attritional metabolism (e.g., hydrolysis of the Me ester functionality and oxidation of the piperidine moiety). With the goal of potentiating the desired thiophene 2-oxidation through minimal structural modification, we have adopted the strategy of targeted metabolism shift and have designed and synthesized deuterated piperidine analogs of CPG. In vitro studies showed that the prodrug activation percentages have been significantly increased for the deuterated analogs as a result of stability enhancement of the piperidine moiety. In a pharmacol. study with a rat model, oral administration of the deuterated analogs also demonstrated higher inhibitory activity than that of CPG against ADP (ADP) induced platelet aggregation. These deuterated analogs represent a new generation of antiplatelet agents with the potential to overcome the major clin. drawbacks of CPG. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Characterization of Potential Related Substances of the Antiplatelet Agent Clopidogrel Bisulfate was written by Metil, Dattatray S.;Sampath, Aalla;Reddy, Ch. Venkata Ramana;Bandichhor, Rakeshwar. And the article was included in ChemistrySelect in 2018.Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

Synthesis of antiplatelet agent clopidogrel bisulfate (I) used for the treatment of platelet aggregation to prevent blood clotting. During the laboratory process development of clopidogrel bisulfate, there was identification of six potential related substances methyl-2-(2-amino-2-(2-chlorophenyl)acetamido)-2-(2-chlorophenyl)acetate, Me 2-(bis (2-(thiophen-2-yl)ethyl)amino)-2-(2-chlorophenyl) acetate hydrochloride, Me (S)-2-(2-chlorophenyl)-2-(methyl(2-(thiophen-2-yl)ethyl)amino)acetate, (S)-methyl-2-(2-chlorophenyl)-2-(2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c]pyridin5(4H)-yl)acetatebisulfate, (S)-methyl-2-(2-chlorophenyl)-2-(2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c] pyridin-5(4H)-yl), (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c] pyridine-2-sulfonic acid which were formed at various stages of the preparation of clopidogrel bisulfate. Out of these, three related substances methyl-2-(2-amino-2-(2-chlorophenyl)acetamido)-2-(2-chlorophenyl)acetate, Me 2-(bis(2-(thiophen-2-yl)ethyl)amino)-2-(2-chlorophenyl) acetate hydrochloride, (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-sulfonic acid were found to be unprecedented. The present work detailed the synthesis of these related substances by employing efficient synthetic strategies and also their control strategies during clopidogrel manufacturing This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-step eantioselective bioresolution for (S)-2-chlorophenylglycine methyl ester catalyzed by the immobilized Protease 6SD on multi-walled carbon nanotubes in a triphasic system was written by Weng, Chun-Yue;Wang, Dan-Na;Ban, Shan-Yun;Zhai, Qiu-Yao;Hu, Xin-Yi;Cheng, Feng;Wang, Ya-Jun;Zheng, Yu-Guo. And the article was included in Journal of Biotechnology in 2021.Formula: C9H10ClNO2 The following contents are mentioned in the article:

(S)-2-chlorophenylglycine Me ester ((S)-1) is a key chiral building block of clopidogrel, which is a widely administered antiaggregatory and antithrombotic drug. Herein, Protease 6SD was covalently immobilized on multi-walled carbon nanotubes (MWCNT), and the as-prepared immobilizate P-6SD@NH₂-MWCNT was applied in the enantioselective resolution of (R,S)-1 to yield (S)-1. In order to overcome the poor solubility of (R,S)-1 in aqueous solution, a novel triphasic reaction system constituting P-6SD@NH₂-MWCNT, aqueous phase and Me tert-Bu ether (MTBE) as the organic phase was constructed, which simultaneously improved the substrate solubility and the immobilizate recyclability. Under the optimized reaction conditions, P-6SD@NH₂-MWCNT catalyzed 10 mM (R,S)-1 for 2 h, yielding optically pure (S)-1 (>99.0% ee_s) with 70.74% conversion of the (R,S)-1. Moreover, P-6SD@NH₂-MWCNT can be reused for 15 batches, displaying an exquisite recycling performance. It is for the first time that enantiomerically pure (S)-1 was successfully synthesized by protease-catalyzed one-step resolution This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Formula: C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics