《Effect of alkyl substitution in drugs. XVII. Synthesis on pharmacological properties of alkyl-substituted benzhydryl derivatives of piperazine》 was written by Gootjes, J.; Funcke, A. B. H.; Tersteege, H. M.; Nauta, Wijbe T.. Product Details of 14258-40-3 And the article was included in Arzneimittel-Forschung in 1966. The article conveys some information:
Benzhydryl piperazin-2-ylmethyl ethers, benzhydryl 2-(4-phenylpiperazino)ethyl ethers, benzhydryl 2-(2-piperazinoethoxy)ethyl ethers, and bis(benzhydryl ethers) of 1,4-bis(hydroxyethoxyethyl)piperazines are prepared Benzhydryl 1,4-dimethylpiperazin-2-ylmethyl ether (I) shows papaverine-like action on isolated guinea pig ileum. The compounds prepared are (b.p./mm. and m.p. given): 1,4-bis(p-toluenesulfonyl)-2-piperazinemethanol, -, 174-5°; 2-piperazinemethanol, 140-1°/15, – (maleate m. 149.5-50°); 1,4-dimethyl-2-piperazinemethanol (II), 102-4°/15, -, (maleate m. 144-6°); 4-diphenylmethyl-1-phenylpiperazine, -, -; ClCH2CH2OCH2CH2OAc, 97°/10, -; 2-(2-piperazinoethoxy)ethanol, 150-5°/2, – (maleate m. 121.5-3°); 2-[2-(4-methylpiperazino)ethoxy]ethanol, 115-20°/2, – (HCl salt m. 213-15°); 2,2′-[1,4-piperazinediylbis(ethyleneethoxy)]diethanol, 180-210°/0.1, – (HCl salt m. 179-81°); trans-2,2′-[2,5-dimethyl-1,4-piperazinediylbis(ethyleneoxy)]diethanol, 192-6°/3, 57-60°. A mixture of Ph2CHOH, II, and K2CO3 is heated 1 hr. at 180° to give 47% I di-oxalate, m. 185.5-6°. Similarly prepared are (m.p. and % yield given): o-methylbenzhydryl 1,4-dimethylpiperazin-2-ylmethyl ether di-oxalate hydrate, 119-20°, 31; o-tert-butylbenzhydryl, 1,4-dimethylpiperazin-2-ylmethyl ether di-oxalate, 184.5-5°, 27; III (n = 0, R1 = R2 = R3 = R4 = R5 = R6 = R8 = H), 125-6°, 49; the following III (n = 1, R7 = OCH2CH2)(R1, R2, R3, R4, R5, R6, R8, m.p., and salt m.p. given): H, H, H, H, H, H, H, -, oxalate hemihydrate 177-9°; Me, H, H, H, H, H, H, -, oxalate hemihydrate 162-3°; H, MeO, H, H, MeO, H, H, -, hemioxalate 197-8°; Me, H, Me, Me, H, Me, H, 98-9°, -; H, H, H, H, H, H, Me, -, HCl 153-4°; the following IV (R1, R2, R3, R4, R5, R6, R7, R8, and salt m.p. given): H, H, H, H, H, H, H, Me, 2HCl 179-81.5°; Me, H, H, H, H, H, H, Me, 2HCl 180-2°; H, Me, H, H, H, H, H, Me, 2HCl 137-9°; Me, H, Me, Me, Me, H, H, Me, -; Et, H, Et, Et, Et, H, H, Me, -; H, H, H, H, H, Me, Me, Me, 2HCl 177-9° (trans); Me, H, H, H, H, Me, Me, Me, 2HCl 167-8.5° (trans); H, H, H, H, H, H, H, O(CH2CH2O)2H, dimaleate 137.5-9°; Me, H, H, H, H, H, H, O(CH2CH2O)2H, dimaleate 138.5-40°; Me, H, Me, Me, Me, H, H, O(CH2CH2O)2H, dimaleate 143-4°; the following V (R1, R2, R3, R4, and m.p. salt given): tert-Bu, H, H, H, dimaleate 150-1.5°; Me, Me, H, H, dimaleate 153.5-5°; H, H, Me, Me, 2HCl 186-7.5° (trans); Me, H, Me, Me, 2HCl 182-3° (trans). In the part of experimental materials, we found many familiar compounds, such as 2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3Product Details of 14258-40-3)
2-(2-Chloroethoxy)ethyl acetate(cas: 14258-40-3) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Product Details of 14258-40-3
Referemce:
Chloride – Wikipedia,
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