Category: 1435-50-3

Reference of 1435-50-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Compound 4 – (4 – (1 – (phenyl-sulfonyl) -3 – vinyl – 1H – pyrrolo [2, 3 – b] pyridine -5 – yl) – 1H – pyrazole -1 – yl) piperidine -1 – carboxylic acid tert-butyl ester (205 mg, 0 . 95 mmol), 2 – bromo – 1, 4 – dichlorobenzene (500 mg, 0.9 mmol), Pd (OAc)2 (4 Mg, 0 . 018 mmol), PPh3 (9 Mg, 0 . 036 mmol), K2 CO3 (310 Mg, 2 . 25 mmol), TBAI (0.09 mmol, 33 mg) and anhydrous DMF (5 ml) the mixture under microwave conditions, for 170 C stirring reaction for 1 hour, cooled to the room temperature, the reaction liquid water (15 ml) washing, using EtOAc (10 mLx 3) extraction, the combined organic phase for salt water (30 ml) washing, anhydrous Na2 SO4 Drying, concentrated under reduced pressure, the residue by silica gel column chromatography (PE/EtOAc (v/v)=1/1) to obtain the title compound as a yellow solid (160 mg, 32%).

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1,4-dichlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; (88 pag.)CN104119331; (2018); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 1435-50-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-50-3 as follows.

Reference Example 76 1-(2,5-dichlorophenyl)-6-methoxyindan-1-ol To a solution of 1-bromo-2,5-dichlorobenzene (4.18 g, 18.5 mmol) in THF (25 mL) was added dropwise 1.6 M n-butyllithium hexane solution (13.8 mL, 22.1 mmol) at -78C, and the mixture was stirred for 30 min. Then, a solution of 6-methoxyindan-1-one (2.00 g, 12.3 mmol) in THF (15 mL) was added dropwise, and the mixture was stirred for 1 hr. To the reaction mixture was added saturated aqueous ammonium chloride solution and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the title compound (1.95 g, yield 51%) as an oil. 1H-NMR (CDCl3) delta: 2.29 – 2.42 (1H, m), 2.52 (1H, s), 2.79 – 3.00 (2H, m), 3.04 – 3.23 (1H, m), 3.73 (3H, s), 6.53 (1H, d, J = 2.4 Hz), 6.87 (1H, dd, J = 8.3, 2.4 Hz), 7.16 – 7.30 (3H, m), 7.70 (1H, d, J = 2.3 Hz).

According to the analysis of related databases, 1435-50-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2298731; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1435-50-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-Bromo-2,5-dichloronitrobenzene A solution of 2-bromo-1,4-dichlorobenzene (1.000 g, 4.443 mmol, Aldrich, used as received) in fuming HNO3 (7.0 mL) was stirred at 50 C. for 1.5 h and poured into ice (80 g). The yellowish precipitate was filtered, washed with water (10 mL) and dried under vacuum to give 1.14 g (95%) of pure title compound as a yellowish powder; m.p. 50-53 C.; 1 H NMR (CDCl3):7.863 (s, 1H), 8.030 (s, 1H).

The synthetic route of 2-Bromo-1,4-dichlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California; US5514680; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 1435-50-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

25.4 g of 2-bromo-1,4-dichlorobenzene, 8.9 ml of iodoethane and 13.3 ml of DMPU are dissolved in 230 ml of THF, and a solution of 16.2 g of lithium tetramethylpiperidide in THF is added dropwise at -70 C. After a further 2 h at -70 C., the reaction mixture is allowed to warm to ambient temperature, and the batch is hydrolysed using water and worked up by extraction. The crude product is purified by fractional distillation. [0126] b.p.: 73 C./0.1 bar. Colourless liquid.

The synthetic route of 2-Bromo-1,4-dichlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; Reiffenrath, Volker; Jasper, Christian; Manabe, Atsutaka; Montenegro, Elvira; Pauluth, Detlef; US2013/221274; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-50-3, SDS of cas: 1435-50-3

(1) 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2,5-dichlorophenyl)oxindole The title compound (137 mg, 51%) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodoisatin (200 mg, 0.454 mmol) and 2,5-dichlorobromobenzene by the procedure similar to that described Example 92(1). 1H-NMR (CDCl3) delta 8.08 (brs, 1H), 7.61 (s, 1H), 7.55 (s, 1H), 7.27 (dd, 1H, J=2.4, 8.6 Hz), 7.15 (d, 1H, J=8.6 Hz), 3.93-4.03 (m, 1H), 3.70-3.80 (m, 1H), 2.53-2.82 (m, 6H), 1.02 (t, 6H, J=7.1 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Sumitomo Pharmaceuticals Co., Ltd.; US6576656; (2003); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1435-50-3, A common heterocyclic compound, 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, molecular formula is C6H3BrCl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound4-(4-(3-ethynyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester (0.20 g) , 0.51 mmol) was suspended in DMF (15 mL), and then Pd(PPh3)2Cl2 (36 mg, 0.051 mmol), CuI (10 mg, 0.051 mmol) and1,4-Dichloro-2-bromobenzene (0.12 g, 0.51 mmol). After the reaction liquid is exchanged for three times (nitrogen),Et3N (1.4 mL, 10.2 mmol) was added. After the reaction solution was stirred at 75 C for 2 hours under a nitrogen atmosphere,The organic layer was concentrated under reduced pressure. EtOAc (EtOAc)The organic phase obtained by liquid separation was dried over anhydrous Na2SO?The residue was subjected to silica gel column chromatography(PE/EtOAc(v/v)=1/2)Purification to give the title compound as a yellow solid(0.17 g, 62%).

The synthetic route of 1435-50-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Xiaobo; Zhou Shiqing; (62 pag.)CN103833753; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 1435-50-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Compound 4 – (4 – (1 – (phenyl-sulfonyl) -3 – vinyl – 1H – pyrrolo [2, 3 – b] pyridine -5 – yl) – 1H – pyrazole -1 – yl) piperidine -1 – carboxylic acid tert-butyl ester (205 mg, 0 . 95 mmol), 2 – bromo – 1, 4 – dichlorobenzene (500 mg, 0.9 mmol), Pd (OAc)2 (4 Mg, 0 . 018 mmol), PPh3 (9 Mg, 0 . 036 mmol), K2 CO3 (310 Mg, 2 . 25 mmol), TBAI (0.09 mmol, 33 mg) and anhydrous DMF (5 ml) the mixture under microwave conditions, for 170 C stirring reaction for 1 hour, cooled to the room temperature, the reaction liquid water (15 ml) washing, using EtOAc (10 mLx 3) extraction, the combined organic phase for salt water (30 ml) washing, anhydrous Na2 SO4 Drying, concentrated under reduced pressure, the residue by silica gel column chromatography (PE/EtOAc (v/v)=1/1) to obtain the title compound as a yellow solid (160 mg, 32%).

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1,4-dichlorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; (88 pag.)CN104119331; (2018); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 1435-50-3, These common heterocyclic compound, 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a flask containing Mg turnings (0.29 g, 12 mmol) was added1-bromo-4-methylbenzene (1.37 g, 8.0 mmol) in THF (8 mL) at room temperature. After being stirred for 2 h, DMF (1.3 mL,12 mmol) was added to the reaction mixture. The obtained mixturewas stirred for 2 h at 0 C. Then, aq NH3 (7 mL, 28-30%) and I2 (4.06 g, 16 mmol) were added to the reaction mixture. After beingstirred for 2 h at room temperature, the reaction mixture waspoured into satd aq Na2SO3 solution and was extracted with CHCl3 (3*30 mL). The organic layer was dried over Na2SO4 and filtered.After removal of the solvent, the residue was purified by shortcolumn chromatography on silica gel (eluent: hexane/ethylacetate=9:1, v/v) to provide pure 4-methyl-1-benzonitrile (0.77 g) in 82% yield.

The synthetic route of 1435-50-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron; vol. 69; 5; (2013); p. 1462 – 1469;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-50-3, Computed Properties of C6H3BrCl2

EXAMPLE 1 To a 300 ml four-necked flask equipped with a stirrer, a thermometer and a condenser were charged 24.9 g (0.110 mol) of 1-bromo-2,5-dichlorobenzene, 13.19 g (0.143 mol) of thioglycolic acid, 12.06 g (0.286 mol) of 95% sodium hydroxide and 100 g of dimethylsulfoxide, followed by stirring at 120 C. for 4 hours. Then, after distilling off the dimethylsulfoxide under reduced pressure, 100 g of water was added to the residue. After dissolving the residue therein at 100 C., the solution was cooled for crystallization and filtered to yield sodium 2,5-dichlorophenylthioglycolate, which was then dissolved in 100 g of water with heating and acidized with concentrated hydrochloric acid, filtered and dried to yield 19.6 g of a light yellowish white powder of 2,5-dichlorophenylthioglycolic acid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Sumitomo Seika Chemicals Co., Ltd.; US5210291; (1993); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 1435-50-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1435-50-3 as follows.

Step 4) tert-butyl 4-(4-(3-((2.5-dichlorophenyl ethvnyl -lH-pyrrolor2.3-b1pyridin-5-yl -lH- pyrazol- 1 -yPpiperidine- 1 -carboxylate To a suspension of tert-butyl 4-(4-(3-ethynyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-lH-pyrazol-l- yl)piperidine-l -carboxylate (0.20 g, 0.51 mmol) in DMF (15 mL) was added Pd(PPh3)2Cl2 (36 mg, 0.051 mmol), Cul (10 mg, 0.051 mmol) and l,4-dichloro-2-bromobenzene (0.12 g, 0.51 mmol). The mixture was degassed and charged with nitrogen for three times, then Et3 (1.4 mL, 10.2 mmol) was added. The mixture was stirred at 75 C for 2 hours. After the removal of the solvent, the residue was diluted with DCM (100 mL), and then washed with brine (100 mL x 2). The separated organic phase was dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 1/2) to give the title compound as a yellow solid (0.17 g, 62%). MS (ESI, pos. ion) m/z: 536.1 (M+l); FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, CDC13): delta 1.42 (s, 9H), 1.86 (m, 2H), 2.04 (m, 2H), 2.95 (m, 2H), 4.05 (m, 2H), 4.39 (m, 1H), 7.47 (dd, J=8.7 Hz, 2.6 Hz, 1H), 7.61 (d, J=8.7 Hz, 1H), 7.83 (d, J=2.5 Hz, 1H), 7.97 (d, J=2.6 Hz, 1H), 8.01 (s, 1H), 8.21 (d, J=1.9 Hz, 1H), 8.39 (s, 1H), 8.62 (s, 1H), 12.27 (s, 1H).

According to the analysis of related databases, 1435-50-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Xiaobo; ZHOU, Shiqing; WO2014/89280; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics