Some common heterocyclic compound, 1435-50-3, name is 2-Bromo-1,4-dichlorobenzene, molecular formula is C6H3BrCl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1435-50-3
After 1-bromo-2,5-dichlorobenzene (15.6 g, 69.1 mmol) and 2-formylphenylboronic acid (11.4 g, 76 mmol) were dissolved in tetrahydrofuran (THF) (200 mL), 2M potassium carbonate aqueous solution (70 mL) was added thereto, and tetrakistriphenylphosphino palladium (Pd(PPh3)4 (1.6 g, 2 mol%) was put thereinto, agitated and refluxed for 5 hours. The temperature was lowered to normal temperature, the water layer was removed, and the organic layer was dried with anhydrous magnesium sulfate (MgS04) and filtered. The filtered solution was concentrated under the reduced pressure, and columned with tetrahydrofuran:hexane = 1:10 to prepare the compound A-1 (13.9 g, 80%), MS: [M+H]+=251
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1435-50-3, its application will become more common.
Reference:
Patent; LG Chem, Ltd.; EP2311826; (2011); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics