Category: 1450877-56-1

In 2017,Research Journal of Chemical Sciences included an article by Mali, Anil C.; Deshmuh, Dattatray G.; Medhane, Vijay J.; Math, Vijayavitthal T.. Recommanded Product: 1450877-56-1. The article was titled 《Practical synthetic approach to related substances of Rivaroxaban; an anticoagulant drug substance》. The information in the text is summarized as follows:

During the process development of an anticoagulant drug, Rivaroxaban (1), three related substances were detected by a gradient high performance liquid chromatotog. (HPLC) method. Liquid chromatog. mass spectrometry (LC-MS) was performed to identify the mol. mass of these impurities. A detailed study was undertaken to characterize the impurities. Based on the spectral data (1 H NMR, 13C NMR and MS), these impurities were characterized as [(2S)-2,3-dihydroxypropyl]-1H-indene-1,3(2H)-dionn(impurity-1), -({[[{[(5-chloro-2-thienyl)carbonyl]amino}oxo-1,3-oxazolidin-3-yl]phenyl}amino ethoxy]acetic acid (impurity)) and {[(5-chloro-N-oxomorpholin-4-yl)phenyl]amino}propylsynthesis of these impurities with good yields and purities by HPLC is described in this report. The structures of the synthesized impurities (impurity-1, impurity-2 and impurity-3) were further confirmed by co-injecting these impurities with the standard Rivaroxaban sample containing all the three impurities. The retention times of synthesized impurities matches (co-eluted) with the retention times of the impurities present in the standard sample. In the experiment, the researchers used many compounds, for example, 4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1Recommanded Product: 1450877-56-1)

4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Recommanded Product: 1450877-56-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2017,Research Journal of Chemical Sciences included an article by Mali, Anil C.; Deshmuh, Dattatray G.; Medhane, Vijay J.; Math, Vijayavitthal T.. Recommanded Product: 1450877-56-1. The article was titled 《Practical synthetic approach to related substances of Rivaroxaban; an anticoagulant drug substance》. The information in the text is summarized as follows:

During the process development of an anticoagulant drug, Rivaroxaban (1), three related substances were detected by a gradient high performance liquid chromatotog. (HPLC) method. Liquid chromatog. mass spectrometry (LC-MS) was performed to identify the mol. mass of these impurities. A detailed study was undertaken to characterize the impurities. Based on the spectral data (1 H NMR, 13C NMR and MS), these impurities were characterized as [(2S)-2,3-dihydroxypropyl]-1H-indene-1,3(2H)-dionn(impurity-1), -({[[{[(5-chloro-2-thienyl)carbonyl]amino}oxo-1,3-oxazolidin-3-yl]phenyl}amino ethoxy]acetic acid (impurity)) and {[(5-chloro-N-oxomorpholin-4-yl)phenyl]amino}propylsynthesis of these impurities with good yields and purities by HPLC is described in this report. The structures of the synthesized impurities (impurity-1, impurity-2 and impurity-3) were further confirmed by co-injecting these impurities with the standard Rivaroxaban sample containing all the three impurities. The retention times of synthesized impurities matches (co-eluted) with the retention times of the impurities present in the standard sample. In the experiment, the researchers used many compounds, for example, 4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1Recommanded Product: 1450877-56-1)

4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Recommanded Product: 1450877-56-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pyun, Sang Yong; Cho, Bong Rae published an article in Bulletin of the Korean Chemical Society. The title of the article was 《Reactions of 4-nitrophenyl 2-thiophenecarboxylates with R2NH/R2NH2+ in 20 mol % DMSO (aq). Effects of 5-thienyl substituent and base strength》.Recommanded Product: 1450877-56-1 The author mentioned the following in the article:

Reactions of 4-nitrophenyl 2-thiophenecarboxylate (1a-e) with R2NH/R2NH2+ in 20 mol % DMSO (aq) have been studied kinetically. The 2nd order kinetics, βnuc = 0.88-0.98, and linear Hammett and Yukawa-Tsuno plots observed for these reactions indicate an addition-elimination mechanism in which the 2nd step is rate limiting. The βnuc value increased with a stronger electron-withdrawing 5-thienyl substituent, the Hammett plots are linear except for X = MeO, and Yukawa-Tsuno plots are linear with ρ = 0.79-1.32 and r = 0.28-0.93, resp. The ρ value increased and r value decreased with a stronger nucleophile, indicating an increase in the electron d. at the C = O bond and a decrease in the resonance demand. These results have been interpreted with enhanced N-C bond formation in the transition state with the reactivity increase. The results came from multiple reactions, including the reaction of 4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1Recommanded Product: 1450877-56-1)

4-Nitrophenyl 5-chlorothiophene-2-carboxylate(cas: 1450877-56-1) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1450877-56-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics