Category: 145349-62-8

Salvanna, N. published the artcilePd(OAc)₂ catalyzed C-H activation of 1,3,4-oxadiazoles and their direct oxidative coupling with benzothiazoles and aryl boronic acids using Cu(OAc)₂ as an oxidant, Recommanded Product: 2-Chloro-4-methylphenylboronic acid, the publication is Tetrahedron (2013), 69(9), 2220-2225, database is CAplus.

The first direct oxidative coupling of 1,3,4-oxadiazoles with benzothiazoles has been accomplished using Pd(OAc)₂ as a catalyst and Cu(OAc)₂ as an oxidant. The similar combination of the catalyst and the oxidant has also been applied for direct arylation of 1,3,4-oxadiazoles with aryl boronic acids. Several novel oxadiazole derivatives e. g., I. II have been prepared in high yields following both the methods.

Tetrahedron published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Recommanded Product: 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Kewang published the artcileAdsorption of Cu²⁺ by modified chitosan microspheres and its application in homocoupling of arylboronic acid, Synthetic Route of 145349-62-8, the publication is Arabian Journal of Chemistry (2022), 15(10), 104170, database is CAplus.

The modified chitosan microspheres were first prepared by emulsification and investigated the performance of the chitosan adsorbent for the adsorption of copper ions. The catalytic performance of chitosan-supported copper microspheres in the self-coupling of arylboronic acids using 4-methoxybenzene as the model substrate was evaluated, while exploring a wide range of substrates including aryl boronic acid derivatives and heterocyclic arylboronic acids, including aldehyde, nitro, and aldehyde groups. The exptl. results show that good to excellent yields (55%-95%) of the desired dimer products were obtained under mild conditions at room temperature and in air, and the catalytic material could be reused up to five times with no significant decrease in catalytic activity.

Arabian Journal of Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C15H24S, Synthetic Route of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tsoung, Jennifer published the artcileMulticomponent-Multicatalyst Reactions (MC)²R: Efficient Dibenzazepine Synthesis, Quality Control of 145349-62-8, the publication is Organic Letters (2014), 16(1), 110-113, database is CAplus and MEDLINE.

A Rh^I/Pd⁰ catalyst system was applied to the multicomponent synthesis of azadibenzazepines from vinylpyridines, arylboronic acids, and amines in a domino process with no intermediate isolation or purification E.g., a combination of 3-chloro-5-(trifluoromethyl)-2-vinylpyridine, 2-chlorophenylboronic acid, and p-toluidine was added to a catalyst solution containing Pd precatalyst (I, L = RuPhos), XPhos, and [Rh(cod)OH]₂ to give a 67% yield of 5-(p-tolyl)-3-(trifluoromethyl)-10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepine (II).

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C5H6BNO2, Quality Control of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stadler, Marco published the artcileDesign, Synthesis, and Pharmacological Evaluation of Novel β2/3 Subunit-Selective γ-Aminobutyric Acid Type A (GABA_A) Receptor Modulators, Category: chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2019), 62(1), 317-341, database is CAplus and MEDLINE.

Subunit-selective modulation of γ-aminobutyric acid type A receptors (GABA_AR) is considered to exert fewer side effects compared to unselective clin. used drugs. Here, the β2/3 subunit-selective GABA_AR modulators valerenic acid (VA) and loreclezole (LOR) guided the synthesis of novel subunit-selective ligands with simplified structures. We studied their effects on GABA_ARs expressed in Xenopus laevis oocytes using two-microelectrode voltage clamp technique. Five compounds showed significantly more efficacious modulation of GABA-evoked currents than VA and LOR with retained potency and selectivity. Compound 18 [(E)-2-Cyano-3-(2,4-dichlorophenyl)but-2-enamide] induced the highest maximal modulation of GABA-induced chloride currents (E_max: 3114 ± 242%), while 12 [(Z)-3-(2,4-dichlorophenyl)but-2-enenitrile] displayed the highest potency (EC₅₀: 13 ± 2 μM). Furthermore, in hippocampal neurons 12 facilitated phasic and tonic GABAergic inhibition, and in vivo studies revealed significantly more potent protection against pentylenetetrazole (PTZ)-induced seizures compared to VA and LOR. Collectively, compound 12 constitutes a novel, simplified, and subunit-selective GABA_AR modulator with low-dose anticonvulsant activity.

Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C10H10O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ioannidou, Heraklidia A. published the artcileThree-Step Synthesis of Ethyl Canthinone-1-carboxylates from Ethyl 4-Bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a Pd-Catalyzed Suzuki-Miyaura Coupling and a Cu-Catalyzed Amidation Reaction, COA of Formula: C7H8BClO2, the publication is Journal of Organic Chemistry (2011), 76(12), 5113-5122, database is CAplus and MEDLINE.

Et canthin-6-one-1-carboxylate (I) and nine analogs were prepared from readily prepared Et 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a three-step non-classical approach that focused on construction of the central pyrrole (ring B) using Pd-catalyzed Suzuki-Miyaura coupling followed by Cu-catalyzed C-N coupling. Furthermore, treatment of I with NaOH in DCM/MeOH (9:1) gave the canthin-6-one-1-carboxylic acid in high yield. All compounds are fully characterized.

Journal of Organic Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, COA of Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Su, Jia-Yi published the artcileIndolo[2,3-b]carbazole Synthesized from a Double-Intramolecular Buchwald-Hartwig Reaction: Its Application for a Dianchor DSSC Organic Dye, Recommanded Product: 2-Chloro-4-methylphenylboronic acid, the publication is Organic Letters (2014), 16(12), 3176-3179, database is CAplus and MEDLINE.

A new synthetic strategy for indolo[2,3-b]carbazole via a double-intramol. Buchwald-Hartwig reaction has been established. The N-alkylated indolo[2,3-b]carbazole then was adopted as the geometry-fixed core for the synthesis of a new mol. (ICZDTA) bearing two bithiophene π-bridged 2-cyanoacrylic acid groups as the bidentate anchor. The bidentate anchoring together with efficient HOMO (indolo[2,3-b]carbazole) â†?LUMO (TiO₂ nanocluster) electron transfer leads to the successful development of ICZDTA-based DSSC with a power conversion efficiency of 6.02%.

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C24H20Ge, Recommanded Product: 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ling published the artcileDiscovery of Thieno[2,3-d]pyrimidine-based KRAS G12D inhibitors as potential anticancer agents via combinatorial virtual screening, Computed Properties of 145349-62-8, the publication is European Journal of Medicinal Chemistry (2022), 114243, database is CAplus and MEDLINE.

A series of novel thieno[2,3-d]pyrimidine analogs were designed and synthesized as KRAS G12D inhibitors via combinatorial virtual screening approach. Most compounds exhibited potent antiproliferative activity on KRAS G12D mutated cancer cell lines (Panc1, SW1990 and CT26) with IC₅₀ values in the low micromolar range. Among them, I (R = 2-OCH₃-5-CF₃) showed the highest antiproliferative activity with an average IC₅₀ of 2.1μM against three KRAS G12D-mutated cells (Panc1, SW1990 and CT26). CompoundI (R = 2-OCH₃-5-CF₃) decreased the active form of KRAS (KRAS-GTP) in KRAS G12D mutated cancer cell lines (CT26 and SW1990) but not in KRAS G13D mutated cancer cells (HCT116). Moreover, I (R = 2-OCH₃-5-CF₃) down-regulated the phosphorylated Raf and Erk in CT26 and SW1990 cancer cell lines but not in HeLa cells (KRAS WT). The binding affinity of I (R = 2-OCH₃-5-CF₃) was further confirmed by the isothermal titration calorimetry (ITC) assay in which I (R = 2-OCH₃-5-CF₃) exhibited a K_D of 33 nM for binding to KRAS G12D protein. In addition, I (R = 2-OCH₃-5-CF₃) (40 mg/kg or 60 mg/kg) exhibited significant antitumor efficacy in a CT26 tumor model with a tumor growth inhibition (TGI) of 42% or 53% without causing apparent toxicity. Taken together the above results suggest that I (R = 2-OCH₃-5-CF₃) is a promising KRAS G12D inhibitor deserving further investigation.

European Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cai, Liangzhen published the artcileSynthesis of diarylaminofluorenes through tandem copper and palladium catalyzed coupling-cyclizing reactions, SDS of cas: 145349-62-8, the publication is Youji Huaxue (2015), 35(8), 1682-1690, database is CAplus.

A convenient method of tandem copper and palladium catalyzed coupling-cyclizing reactions was developed for the preparation of diarylaminofluorenes, I, II(R¹ = H, Me, R² = H, Me) . Methylbromotriphenylamines prepared by the copper-catalyzed reaction of substituted iodobenzenes and methylbromoanilines, coupled with chlorophenylboronic acid under palladium catalyst to obtain the chlorophenylmethyltriphenylamines (V). A series of diarylaminofluorenes could be generated in good yields through palladium-catalyzed activation of benzylic C(sp³)-H bond of compound V. It was found that the 2-diarylaminofluorenes or 3-diarylaminofluorenes could be efficiently gotten. These compounds were characterized by¹H NMR, ¹³C NMR, HRMS, IR and UV-vis.

Youji Huaxue published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gollner, Andreas published the artcileTwo-Step Total Syntheses of Canthin-6-one Alkaloids: New One-Pot Sequential Pd-Catalyzed Suzuki-Miyaura Coupling and Cu-Catalyzed Amidation Reaction, SDS of cas: 145349-62-8, the publication is Organic Letters (2010), 12(6), 1352-1355, database is CAplus and MEDLINE.

Canthin-6-one (I; R¹ = R² = H) and nine analogs including the naturally occurring 9-methoxycanthin-6-one (I; R¹ = OMe, R² = H) and amaroridine (I; R¹ = H, R² = OMe) are prepared rapidly and in high yields via a convergent “non-classical” strategy that focuses on construction of the central ring B. The strategy relies on concomitant Pd-catalyzed Suzuki-Miyaura C-C coupling followed by a Cu-catalyzed C-N coupling that can be achieved either stepwise or in a new one-pot protocol starting from the appropriate 8-bromo-1,5-naphthyridine.

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Broumidis, Emmanouil published the artcileA one-pot, two-step synthesis of 3-deazacanthin-4-ones via sequential Pd-catalyzed Suzuki-Miyaura and Cu-catalyzed Buchwald-Hartwig reactions, Category: chlorides-buliding-blocks, the publication is Tetrahedron Letters (2017), 58(27), 2661-2664, database is CAplus.

3-Deazacanthin-4-one and nine analogs, including the 8-aza analog, were prepared rapidly and in high yields from 8-iodoquinolones and 2-chloro(het)arylboronic acids. The strategy involves construction of the central B ring via sequential Pd-catalyzed Suzuki-Miyaura C-C and Cu-catalyzed Buchwald-Hartwig C-N coupling reactions [e.g., Suzuki reaction of iodoquinolone I with (2-chlorophenyl)boronic acid followed by intramol. Buchwald-Hartwig → II (90%)].

Tetrahedron Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics