Category: 14602-86-9

On November 30, 2016, Jin, Yan; Zhao, Jing; Rhyman, Lydia; Ramasami, Ponnadurai; Shin, Yujin; Jeong, Kyung Min; Lee, Jeongmi published an article.Computed Properties of 14602-86-9 The title of the article was Ultrasound-assisted chiral derivatization of etodolac with (1R)-(-)-menthyl chloroformate for the determination of etodolac enantiomers. And the article contained the following:

This study presents the first report of an ultrasound-assisted derivatization reaction between a carboxylic acid of etodolac (ETO) and a chiral derivatization reagent, (1R)-(-)-menthyl chloroformate (R-MCF). Fifty μL of deproteinated mouse serum containing ETO enantiomers was derivatized with 125 μL of 200 mM R-MCF and 17 μL of pyridine (a catalyst), with the reaction facilitated by ultrasonic radiation for 13 min, which were the optimal conditions as determined by response surface methodol. After quenching the reaction by adding an aqueous L-proline solution, the mixture was subjected to salting-out assisted liquid-liquid extraction (SA-LLE), which provided phase separation for sample concentration as well as cleanup. The ETO diastereomers were separated on a Phenomenex Gemini C18 column (150 × 4.6 mm, 5 μm) under a simple gradient elution of a mobile phase containing a mixture of methanol: acetonitrile (10:1, V/V) and 10 mM acetic acid at a flow rate of 1.0 mL min-1, followed by fluorescence detection with excitation and fluorescence emission wavelengths of 235 nm and 345 nm, resp. The developed method was validated for specificity, sensitivity, linearity, accuracy, precision, stability, and matrix effect. A good linearity in the range of 0.5-50.0 μg mL-1 for each ETO enantiomer with r2 > 0.998 and acceptable values for the intra-day and inter-day accuracy and precision as well as negligible matrix effects supported the suitability and reliability of the method. Finally, this method was used to analyze real samples taken from mice treated with (±)-ETO. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Computed Properties of 14602-86-9

The Article related to etodolac chiral derivatization enantiomer linearity accuracy precision, Pharmacology: Methods and other aspects.Computed Properties of 14602-86-9

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shen, Yi; Sun, Yufeng; Sang, Zhipei; Sun, Chengjun; Dai, Ya; Deng, Yong published an article in 2012, the title of the article was Synthesis, characterization, antibacterial and antifungal evaluation of novel monosaccharide esters.Formula: C11H19ClO2 And the article contains the following content:

A novel series of 3-(2-furyl)acrylate monosaccharide esters and menthyloxycarbonyl monosaccharide esters were designed and synthesized. The target compounds were investigated for their in-vitro antibacterial and antifungal activities. The 3-(2-furyl)acrylate monosaccharides were either inactive or only weakly active against Gram-pos. bacteria, whereas the menthyloxycarbonyl monosaccharides exhibited higher levels of activity, with the xyloside being especially potent. In the antifungal screening some compounds of both series displayed potent in vitro activities, whereas xylosides of both series showed promising activities against all of the microorganisms tested, with the 3-(2-furyl)acrylate derivative exhibiting levels of activity deserving of further investigation. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to furylacrylate monosaccharide ester preparation antibacterial antifungal, menthyloxycarbonyl monosaccharide ester preparation antibacterial antifungal, Carbohydrates: Glycosides and other aspects.Formula: C11H19ClO2

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Listunov, Dymytrii; Joly, Etienne; Duhayon, Carine; Saffon-Merceron, Nathalie; Fabing, Isabelle; Genisson, Yves; Maraval, Valerie; Chauvin, Remi published an article in 2018, the title of the article was Methinylogation Approach in Chiral Pharmacophore Design: from Alkynyl- to Allenyl-carbinol Warheads against Tumor Cells.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Extension of a structure-activity relationship study of the antitumor cytotoxicity of lipidic dialkynylcarbinols (DACs) is envisaged by formal methinylogation of one of the ethyndiyl moieties of the DAC warhead into the corresponding allenylalkynylcarbinol (AllAC) counterpart. External AllACs were directly obtained by methinylation of the parent DACs with formaldehyde in either the racemic or scalemic series. Isomers containing external propargyl and propynyl motifs were also prepared Internal AllACs were obtained as racemic statistical mixtures of stereoisomers in two steps from the key C5-DAC rac-TIPS-C C-CH(OH)-C CH and aldehydes. Kinetic resolution of the (S)-C5-DAC in 97 % ee and (R)-C5-DAC in 99 % ee was achieved by sequential lipase-mediated acetylation/hydrolysis using the Candida antartica lipase (Novozyme 435). The four internal AllAC stereoisomers were prepared by asym. methinylation with (R)- or (S)-diphenylprolinol as chiral auxiliary. Cytotoxicity assays on HCT116 cancer cells showed that the most active (eutomeric) external or internal AllAC exhibits an S configuration, a fatty chain length of n=12, and a 50 % inhibitory concentration IC50≈1.0 μM. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to methinylogation chiral pharmacophore alkynyl allenyl carbinol preparation antitumor, alkynes, allenes, antitumor agents, asymmetric synthesis, lipidic alkynylcarbinols, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tobiszewski, Marek; Namiesnik, Jacek; Pena-Pereira, Francisco published an article in 2017, the title of the article was A derivatisation agent selection guide.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

The study reported herein is aimed at the greenness assessment of 267 derivatization agents that are frequently applied in anal. chem. and related disciplines. Multicriteria decision anal. allowed obtaining three rankings of derivatization agents applied in liquid chromatog., gas chromatog. and chiral anal. The criteria of assessment included the safety information obtained from material safety data sheets and physicochem. and environmental parameters predicted with relevant models. As for some of the agents predicted data were not available, these agents were assessed with a smaller number of criteria, within the ranking of low confidence. The results of the study will help to apply greener derivatization agents, wherever the green chem. principle of avoiding derivatization cannot be fulfilled. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to derivatization agent selection guide chromatog green chem safety, Organic Analytical Chemistry: Reagents and other aspects.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 9, 2015, Agapiou, A.; Zorba, E.; Mikedi, K.; McGregor, L.; Spiliopoulou, C.; Statheropoulos, M. published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Analysis of volatile organic compounds released from the decay of surrogate human models simulating victims of collapsed buildings by thermal desorption-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry. And the article contained the following:

Field experiments were devised to mimic the entrapment conditions under the rubble of collapsed buildings aiming to investigate the evolution of volatile organic compounds (VOCs) during the early dead body decomposition stage. Three pig carcasses were placed inside concrete tunnels of a search and rescue (SAR) operational field terrain for simulating the entrapment environment after a building collapse. The exptl. campaign employed both laboratory and on-site anal. running in parallel. The current work focuses only on the results of the laboratory using thermal desorption coupled to comprehensive two-dimensional gas chromatog. with time-of-flight mass spectrometry (TD-GC × GC-TOF MS). The flow-modulated TD-GC × GC-TOF MS provided enhanced separation of the VOC profile and served as a reference for the evaluation of the on-site anal. in the current exptl. campaign. Bespoke software was used to deconvolve the VOC profile to extract as much information as possible into peak lists. In total, 288 unique VOCs were identified (i.e., not found in blank samples). The majority were aliphatics (172), aromatics (25) and nitrogen compounds (19), followed by ketones (17), esters (13), alcs. (12), aldehydes (11), sulfur, miscellaneous and acid compounds The TD-GC × GC-TOF MS proved to be a sensitive and powerful system for resolving the chem. puzzle of above-ground “scent of death”. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to volatile organic compound analysis human decay model gc ms, decomposition, forensic chemistry, pig carcass, two-dimensional gas chromatography, volatiles, Toxicology: Methods (Including Analysis) and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shiva; Singh, Sumitra; Singh, Shailendra Kumar published an article in 2018, the title of the article was Investigation of phytoconstituents in stem bark of Ficus benghalensis linn. using GC-MS technique.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Objective of the present study is to investigate the chem. composition of methanol extract of stem bark of Ficus benghalensis Linn. (Indian Banyan Tree). Shade and air dried stem bark were powd. and extract was prepared according to selective sequential extraction using different solvents of increasing polarity. Methanol extract of stem bark of this plant was further subjected to gas chromatog. and mass spectrometry as to the best of authors’ s knowledge no published literature exist about the characterization of chem. constituents of methanol extract by GC-MS technique. Total 63 compounds were reported by GCMS studies out of which two were never reported earliar. Qual. and quant. presence of different biol. important phytoconstituents were reported and two new phytoconstituents were investigated. Results of this study suggested the phytopharmacol. importance of reported constituents of stem bark extract of Ficus benghalensis Linn. and justify the use of Ficus benghalensis Linn. in ancient literature of Ayurveda. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to ficus phytoconstituent silanol stem bark phytopharmacol, Pharmaceuticals: Pharmacognostic Products and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2018, Cao, Zhong-Yan; Ghosh, Tamal; Melchiorre, Paolo published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Enantioselective radical conjugate additions driven by a photoactive intramolecular iminium-ion-based EDA complex. And the article contained the following:

The photochem. activity of electron donor-acceptor (EDA) complexes provides a way to generate radicals under mild conditions. This strategy has found application in chem. synthesis and recently in enantioselective catalysis. Reported methods classically relied on the formation of intermol. EDA complexes, generated upon aggregation of two suitable reagents. Herein, we further expand the synthetic utility of this strategy demonstrating that an intramol. EDA complex can trigger a photochem. catalytic enantioselective radical process. This approach enables radical conjugate additions to β-substituted cyclic enones to form quaternary carbon stereocenters with high stereocontrol using visible light irradiation Crucial for success is the use of an amine catalyst, adorned with a carbazole moiety, which generates, upon condensation with enones, chiral iminium ions that show a broad absorption band in the visible region. This optical property originates from an intramol. charge transfer π-π interaction between the electron-rich carbazole nucleus and the electron-deficient iminium double bond. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to intramol iminium ion electron donor acceptor complex enantioselective catalysis, Placeholder for records without volume info and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, M.; Galindo-Murillo, R.; Cheatham, T. E. III; Franzini, R. M. published an article in 2017, the title of the article was Dissociative reactions of benzonorbornadienes with tetrazines: scope of leaving groups and mechanistic insights.COA of Formula: C11H19ClO2 And the article contains the following content:

Bioorthogonal dissociative reactions boast diverse potential applications in chem. biol. and drug delivery. The reaction of benzonorbornadienes with tetrazines to release amines from carbamate leaving groups was recently introduced as a bioorthogonal bond-cleavage reaction. The present study aimed at investigating the scope of leaving groups that are compatible with benzonorbornadienes. Synthesis of several benzonorbornadienes with different releasable groups is reported, and the reaction of these mols. with tetrazine was found to be rapid and afforded high release yields. The tetrazine-induced release of mols. proceeds in a cascade of steps including inverse-electron demand cycloaddition and cycloreversion reactions that form unstable isoindoles/isobenzofuran intermediates and spontaneously eliminate a leaving group of interest. In the case of oxygen-bridged BNBDs at room temperature, we observed the formation of an unproductive byproduct. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).COA of Formula: C11H19ClO2

The Article related to dissociative reaction benzonorbornadiene tetrazine reaction mechanism mol modeling, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 7, 2016, Murphy, Stephen K.; Zeng, Mingshuo; Herzon, Seth B. published an article.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Stereoselective Multicomponent Reactions Using Zincate Nucleophiles: β-Dicarbonyl Synthesis and Functionalization. And the article contained the following:

A general strategy for conjugate addition-C-acylation that enables the synthesis of enantioenriched β-dicarbonyl compounds is described. A novel method for derivatizing these adducts by stereo- and site-selective zinc-catalyzed addition of alkyllithium reagents is also reported. These reactions can be performed in tandem to achieve an enantio- and diastereoselective four-component coupling. The in situ generation of weakly basic lithium zincate species is central to the success of all three transformations. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to stereoselective conjugate addition acylation zinc catalyst alkyl lithium enone, multicomponent reaction, beta dicarbonyl stereoselective synthesis, General Organic Chemistry: Synthetic Methods and other aspects.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Haeggman, Nicklas O.; Zank, Benjamin; Jun, HyunJune; Kaldre, Dainis; Gleason, James L. published an article in 2018, the title of the article was Diazepane Carboxylates as Organocatalysts in the Diels-Alder Reaction of α-Substituted Enals.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Et diazepane carboxylate efficiently catalyzes the Diels-Alder cycloaddition of α-substituted-α,β-unsaturated aldehydes via iminium ion organocatalysis. The reaction is applicable to a range of dienes and dienophiles and generally proceeds at room temperature in the presence of 5 mol-% catalyst and 2.5 mol-% triflic acid co-catalyst. The incorporation of a stereogenic center on the diazepane backbone in combination with a menthyl carbamate produces a catalyst which affords enantioselectivities of 70-95 % ee for the cycloaddition of cyclopentadiene with a range of dienophiles. The enantioselectivity is rationalized via a transition state in which electrostatic stabilization by the carboxylate directs the diene to the more hindered face of the dienophile. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to diazepane carboxylate organocatalyst preparation stereoselective diels alder cycloaddition, stereoselective diels alder cycloaddition enal mol modeling, General Organic Chemistry: Synthetic Methods and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics