Category: 14602-86-9

On February 29, 2020, Dhabbah, Abdulrhman M. published an article.Category: chlorides-buliding-blocks The title of the article was Determination of chiral cathinone in fresh samples of Catha edulis. And the article contained the following:

The main psychoactive compound in Khat is cathinone which consists of two enantiomers, S-(-)-cathinone being more stimulant than its R antipode. This study aimed to the enantioseparation and determination of these two stereoisomers in different parts of fresh Catha edulis. The samples were solvent extracted and cathinone was derivatized with menthyl chloroformate. The separation of the two diastereomeric derivatives was carried out by gas chromatog. and showed an excellent resolution, while their structure was confirmed by mass spectrometry. The quant. determination of both enantiomers showed a different distribution in various investigated parts of the plant, as shown in their enantiomeric excess. Unlike the results published in some previous articles, the current study confirmed the presence of both S and R cathinone in all parts of the fresh plant. The concentration of S-cathinone was higher in stems while its values were lower in leaves. The obtained concentrations were in the ranges 0.081-0.290 and 0.087-0.211 mg/g for S and R antipodes, resp. Also, S-cathinone which is the most psychoactive stereoisomer showed an increasing concentration from lower to upper stems of the plant. The present study is the first quant. investigation of the two cathinone enantiomers in different parts of fresh Catha edulis. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks

The Article related to catha cathinone menthyl chloroformate enantiomer, catha edulis, derivatization, enantioseparation, gc–ms, menthyl chloroformate, s/r-cathinone, Plant Biochemistry: Composition and Products and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 23, 2011, Andre, Virginie; Vidal, Anne; Ollivier, Jean; Robin, Sylvie; Aitken, David J. published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Rapid access to cis-cyclobutane γ-amino acids in enantiomerically pure form. And the article contained the following:

The (+)-(1R,2S) and (-)-(1S,2R) stereoisomers of 2-(aminomethyl)cyclobutane-1-carboxylic acid have been prepared using a short and efficient strategy, which employs the photochem. [2+2] cycloaddition reaction between ethylene and an unsaturated γ-lactam as the key step. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to aminomethyl cyclobutane cyclobutane amino acid enantiopure enantioselective synthesis, ethylene photochem cycloaddition unsaturated lactam, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 1, 2021, Ocenasova, Lucia; Budovska, Mariana; Ocenas, Peter; Tomaskova, Natasa; Pilatova, Martina Bago; Mojzis, Jan published an article.Product Details of 14602-86-9 The title of the article was The first synthesis of natural alkaloid capparine A. And the article contained the following:

Substances containing a spirooxindole framework display important biol. activities. Natural alkaloid capparine A [(S)-(-)-1, I] has an anti-inflammatory effect. In the present study, attention has been paid to the first total synthesis of natural capparine A [(S)-(-)-1]. Racemic capparine A [(±)-1] was synthesized by bromospirocyclization of 6-methoxy-1-Boc-brassinin (II) with water, followed by oxidation of obtained spirobrassinol derivatives and removal of the Boc group. Synthesized racemic capparine A [(±)-1] was enantioresolved by derivatization with (1R,2S,5R)-menthyl chloroformate, chromatog. separation of diastereoisomers and the cleavage of the chiral auxiliary using sodium methoxide. Screening of anti-proliferative activity against human cancer cells revealed no anti-proliferative activity of the capparine A [(S)-(-)-1]. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to total synthesis capparine a bromospirocyclization enantioresoln, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 5, 2010, Peixoto, Sabrina; Nguyen, Tuan Minh; Crich, David; Delpech, Bernard; Marazano, Christian published an article.Computed Properties of 14602-86-9 The title of the article was One-Pot Formation of Piperidine- and Pyrrolidine-Substituted Pyridinium Salts via Addition of 5-Alkylaminopenta-2,4-dienals to N-Acyliminium Ions: Application to the Synthesis of (±)-Nicotine and Analogs. And the article contained the following:

Addition of 5-alkylaminopenta-2,4-dienals onto N-acyliminium ions, generated in situ from α-hydroxycarbamates derived from pyrrolidine or piperidine, in the presence of zinc triflate, followed by dehydrative cyclization, allowed the formation of pyridinium salts substituted at their 3-position by a five- or six-membered nitrogen heterocycle. Subsequent N-dealkylation of the pyridinium moiety and deprotection of the secondary amine or reduction of the carbamate function led to (±)-nicotine and analogs. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Computed Properties of 14602-86-9

The Article related to nitrogen heterocycle preparation addition cyclization alkylaminopetadienal hydroxycarbamae, nicotine analog synthesis, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Computed Properties of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2012, Koo, Christina; Cox, Matthew; Klass, Gunter; Johnston, Martin published an article.Product Details of 14602-86-9 The title of the article was Stereochemical analysis of methorphan using (-)-menthyl chloroformate. And the article contained the following:

Forensic laboratories around the world have seen an increase in the number of drug seizures containing methorphan. Levomethorphan is a narcotic and a controlled substance, and its enantiomer dextromethorphan is an antitussive agent used in over-the-counter medications. For the forensic anal. of seized drugs containing methorphan, it is important to report the stereochem. composition of the drug. Ideally, a method based on common forensic laboratory instrumentation is desirable. The use of the chiral derivatizing agent (-)-menthyl chloroformate followed by routine gas chromatog.-mass spectrometry anal. of the derivative was shown to successfully determine the stereochem. composition of methorphan. This approach was applied to a street seizure containing methorphan proving that it was pure dextromethorphan. The derivatives of dextro- and levomethorphan were subjected to mass spectroscopic and NMR anal., which confirmed that the structure of the derivatives remained unchanged as a result of the derivatization process. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to forensic methorphan menthyl chloroformate stereochem, Toxicology: Forensic Chemistry (Including Analysis) and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 2, 2020, Stentzel, Michael R.; Klumpp, Douglas A. published an article.SDS of cas: 14602-86-9 The title of the article was Michael Addition with an Olefinic Pyridine: Organometallic Nucleophiles and Carbon Electrophiles. And the article contained the following:

The conjugate addition reactions of trans-1,2-di(2-pyridyl)ethylene have been studied. This substrate reacts with organolithium nucleophiles, and the resulting anionic intermediates may be trapped by proton or various carbonyl-based electrophiles. It is suggested that the dipyridyl structure stabilizes the intermediate carbanion, allowing the Michael adduct to be captured by an added electrophile. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to michael addition olefinic pyridine organolithium nucleophile, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guo, Yuchuan; Wang, Lizhen; Guo, Jiatong; Gu, Guofeng; Guo, Zhongwu published an article in 2017, the title of the article was Biochemical studies of inositol N-acetylglucosaminyltransferase involved in mycothiol biosynthesis in Corynebacterium diphtheria.Computed Properties of 14602-86-9 And the article contains the following content:

Mycothiol (MSH) is the predominant low mol. weight thiol produced by actinomycetes, and it plays a pivotal role in the bacterial detoxication process. 1L-myo-Inositol-1-phosphate (1L-Ins-1-P) α-N-acetylglucosaminyltransferase (GlcNAc-T), known as MshA, is the only glycosyltransferase involved in MSH biosynthesis. In this work, the MshA from Corynebacterium diphtheria, named as CdMshA, was expressed, purified, and studied in detail. Its enzymic activity to transfer GlcNAc to 1L-Ins-1-P was confirmed by the isolation and rigorous characterization of its reaction product 3-phospho-1-D-myo-inositol-2-acetamido-2-deoxy-α-D-glucopyranoside. CdMshA was shown to accept only UDP-GlcNAc and 1L-Ins-1-P as its substrates among various tested glycosyl donors, such as UDP-GlcNAc, UDP-Gal, UDP-Glc, UDP-GalNAc and UDP-GlcA, and glycosyl acceptors, such as myo-inositol, 1L-Ins-1-P and 1D-Ins-1-P. The results have demonstrated the strict substrate selectivity of CdMshA. Furthermore, its reaction kinetics with UDP-GlcNAc and 1L-Ins-1-P as substrates were characterized, while site-directed mutagenesis of CdMshA disclosed that its amino acid residues N28, K81 and R157 were essential for its enzymic activity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Computed Properties of 14602-86-9

The Article related to corynebacterium purification inositol phosphate acetylglucosaminyltransferase msha substrate selectivity, Enzymes: Separation-Purification-General Characterization and other aspects.Computed Properties of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 2010, Sagratini, Gianni; Angeli, Piero; Buccioni, Michela; Gulini, Ugo; Marucci, Gabriella; Melchiorre, Carlo; Poggesi, Elena; Giardina, Dario published an article.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues. And the article contained the following:

Tamsulosin [I, R = Et (II)] is the most utilized α1-adrenoceptor antagonist in benign prostatic hyperplasia therapy owing to its uroselective antagonism and capability in relieving both obstructive and irritative lower urinary tract symptoms. Here, homochiral analogs I (R = i-Pr, PhCH2, CF3CH2) and III (cis-dioxane ring) were synthesized and their influence on the affinity profile for α1-adrenoceptor subtypes evaluated. Benzyl analog I (R = PhCH2) displayed a preferential antagonist profile for α1A-than α1D-and α1B-adrenoceptors, and a 12-fold higher potency at α1A-adrenoceptors with respect to the α1B subtype, and may have improved uroselectivity compared to II. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to tamsulosin analog preparation adrenoceptor antagonist activity benign prostatic hyperplasia, Heterocyclic Compounds (More Than One Hetero Atom): Dioxanes and other aspects.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Prech, Jan; Matousek, Vacla; Vaclavik, Jiri; Pechacek, Jan; Syslova, Kamila; Sot, Petr; Januscak, Jakub; Vilhanova, Beata; Kuzma, Marek; Toman, Jaromir; Kacer, Petr published an article in 2013, the title of the article was Determination of enantiomeric composition of substituted tetrahydroisoquinolines based on derivatization with menthyl chloroformate.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

A method for the anal. of the optical purity of a series of chiral substituted tetrahydroisoquinolines (THIQs) was developed. The method is based on pre-column derivatization of the analytes with the derivatization reagent (-)-(1R)-menthyl chloroformate. The derivatization reaction selectively gives diastereomeric carbamates that are resolvable on an achiral non-polar GC column. The developed technique covers variously substituted THIQs, which differ significantly in volatility, steric and electronic properties. In all cases, the resolution factors (R) exceeded the value of 1.5. The method represents a robust way of anal. of mixtures of THIQs, which are often present in various matrixes such as body fluids, tissues and reaction mixtures The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to enantiomer tetrahydroisoquinoline menthyl chloroformate derivatization gc ei ms, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 3, 2021, Zou, Ying; Huang, Zhi-Cheng; Xiang, Min; Li, Chen-Yi; Li, Xia; Tian, Fang; Wang, Li-Xin published an article.SDS of cas: 14602-86-9 The title of the article was Spiro-Scaffold Chiral Organocatalyst of 3,2′-Pyrrolidinyl Spiro-oxindole Amine and its Catalytic Evaluation in the Enantioselective Aldol Condensation between 3-(3-hydroxy-1H-pyrazol-1-yl)-Oxindole and Paraformaldehyde. And the article contained the following:

Spirocyclic chiral organocatalyst based on (R)-spiro[indoline-3,2′-pyrrolidine]-2-one was successfully prepared from racemic 1,2-dihydrospiro[indole-3,2′-pyrrolidine]-2-one using L-menthol as chiral auxiliary in 4 steps in 28%-40% overall yield with at least 99% ee in scale up preparation and its catalytic activity was evaluated in the enantioselective aldol condensation between 3-(3-hydroxy-1H-pyrazol-1-yl)oxindoles I (R1 = H, 5-Me, 5-MeO, 5-Cl, 7-Me; R2 = Me, H2C:CHCH2, n-Bu, Ph, PhCH2, 4-BrC6H4CH2) and paraformaldehyde. The spiro organocatalyst showed superior catalytic activity and selectivity compared with its counterparts, and most substrates offered good to excellent results with up to 96% yield and 96% ee. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to oxindole hydroxymethyl hydroxypyrazolyl asym synthesis, hydroxypyrazolyl oxindole enantioselective aldol condensation paraformaldehyde spiro pyrrolidine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics