Category: 14602-86-9

Vrbicky, Martin; Macek, Karel; Pochobradsky, Jaroslav; Svoboda, Jan; Sedlak, Milos; Drabina, Pavel published an article in 2022, the title of the article was The asymmetric Henry reaction as synthetic tool for the preparation of the drugs linezolid and rivaroxaban.Recommanded Product: 14602-86-9 And the article contains the following content:

The human drugs – the antibiotic linezolid and the anticoagulant rivaroxaban – belong among modern pharmaceutics, which contain an oxazolidine-2-one moiety bearing a stereogenic center. The chirality of these drugs is a fundamental attribute for their biol. activity. Herein, one of the efficient asym. syntheses of these drugs was studied in detail. Highly enantioselective catalysts were tested in the key step of the synthetic procedure, i.e., the asym. Henry reaction, under different reaction conditions, using several starting aldehydes. The corresponding nitroaldols as chiral intermediates in the syntheses of these drugs were obtained in high yields and enantiomeric excesses of up to 91% ee. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: 14602-86-9

The Article related to linezolid rivaroxaban preparation enantioselective, asymmetric henry reaction, enantioselective catalysis, linezolid, oxazolidine-2-one derivatives, rivaroxaban, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Recommanded Product: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 15, 2021, Giofre, Sabrina; Keller, Manfred; Lo Presti, Leonardo; Beccalli, Egle M.; Molteni, Letizia published an article.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Switchable Oxidative Reactions of N-allyl-2-Aminophenols: Palladium-Catalyzed Alkoxyacyloxylation vs an Intramolecular Diels-Alder Reaction. And the article contained the following:

The Pd(II)-catalyzed reaction of N-allyl-2-aminophenols in the presence of PhI(OCOR)2 as the oxidant resulted in an alkoxyacyloxylation process, with the formation of functionalized dihydro-1,4-benzoxazines. The reaction performed in the absence of palladium catalyst switched to an intramol. Diels-Alder reaction (IMDA) pathway, which was the result of an oxidative dearomatization of the 2-aminophenol, nucleophilic addition, and Diels-Alder reaction cascade, highlighting the role of the oxidant as both a nucleophilic donor and an oxidizing agent. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to dihydrobenzoxazine tricyclic methanoindole preparation, allyl tosyl aminophenol tandem, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 16, 2021, Cai, Wei; Zhou, Yiming; He, Yanlin; Chen, Kaihong; Yu, Cui; Huang, You published an article.COA of Formula: C11H19ClO2 The title of the article was Designing and Accurately Developing a [6 + 2] Dipolar Cycloaddition for the Synthesis of Benzodiazocines. And the article contained the following:

Herein, a concept for the design of 1,6-dipoles that bypasses the regioselectivity was described. Through the introduction of an amino group into Morita-Baylis-Hillman (MBH) carbonates, unprecedented [6 + 2] dipolar cycloadditions were accurately developed with Cs2CO3, efficiently delivering a series of benzodiazocines I (R1 = 9-Cl, 10-Me, 8-OMe, etc., R2 = Me, Et, i-Bu, etc.; R3 = OMe, OAllyl, Ph, etc.; R4 = 4-MeC6H4, 2,4-F2C6H3, 1-naphthyl, etc.) in mild conditions. Computational studies bring a deeper understanding of this reaction. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).COA of Formula: C11H19ClO2

The Article related to benzodiazocine preparation, morita baylis hillman carbonate isocyanate dipolar cycloaddition, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.COA of Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 17, 2020, Guo, Weicong; Liu, Qinzhe; Jiang, Jijun; Wang, Jun published an article.Related Products of 14602-86-9 The title of the article was Development of a C2-Symmetric Chiral aza Spirocyclic Diol. And the article contained the following:

A C2-sym. chiral spirocyclic diol aza-SPINOL containing a spirooxindole scaffold has been designed, synthesized, and optically resolved. The product could be synthesized on gram scale in an overall yield of 22%. Moreover, elaborations of aza-SPINOL to other chiral ligands as well as the preliminary investigation of the related bisphosphine ligand in the desymmetrization of bisallylic amide were reported. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Related Products of 14602-86-9

The Article related to chiral aza spirocyclic diol enantioselective preparation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Related Products of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 19, 2013, Senczyszyn, Jemma; Brice, Heloise; Clayden, Jonathan published an article.Formula: C11H19ClO2 The title of the article was Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides. And the article contained the following:

On treatment with acylating or sulfonylating agents, N-alkenyl pyridinecarboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramol. trapping of the resulting pyridinium cation (e.g., I → II). The products are spirocyclic dihydropyridines which may be further elaborated to spirocyclic heterocycles with drug-like features. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to electrophile induced dearomatizing spirocyclization alkenylpyridinecarboxamide, spirocyclic hydropyridine preparation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 15, 2011, Sukchol, Kulthida; Thongyai, Supakanok; Praserthdam, Piyasan published an article.HPLC of Formula: 14602-86-9 The title of the article was Preparation and characterization of novel polyimide with chiral side chain for twist nematic liquid crystal display. And the article contained the following:

The synthesis of novel polyimide (PI) films containing chirals in side chain was investigated for utilizing in twist nematic (TN) liquid crystal display (LCD). The polyimide with amine side groups (PI4 a.m.) was prepared by two steps copolymerization of 4,4′-hexafluoroisopropylidene diphthalic anhydride (6FDA), 4,4′-oxydianiline (ODA), and 3,3′-diaminobezidine (4AM) in N-methyl-2- pyrrolidinone (NMP). In the first step, the oligomer of 6FDA-ODA with mole ratio 4:3 was synthesized. In the second step, the oligomer was reacted with 4AM by gradually dropping the oligomer into 4AM solution with the mole ratio 4:5 to obtain amino groups containing polyimide P14AM. By reacting chiral compounds, mandelic acid, menthyl chloroformate, and menthyl glyoxylate hydrate using condensation reaction with amine groups along polyimide mols., the novel polyimides can be synthesized. Their chem. structures were confirmed by Fourier transform IR spectroscopy and NMR spectroscopy (1H-NMR). The coated glass slides pairs were coated with PI4AM and with each polyimide/chiral. The liquid crystals (LCs) were inserted between two coated glass slides at above the nematic temperature under the polarized light microscope to observe the alignment of LCs. The results showed the alignment of LCs in some certain direction under polyimide/chiral pair, regardless of the type of the chiral mol. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to polyimide chiral side chain alignment liquid crystal display, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Other and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 16, 2018, Yasukouchi, Hiroaki; Nishiyama, Akira; Mitsuda, Masaru published an article.Computed Properties of 14602-86-9 The title of the article was Safe and Efficient Phosgenation Reactions in a Continuous Flow Reactor. And the article contained the following:

Phosgene is widely used in organic synthesis owing to its high reactivity, utility, and cost efficiency. However, the use of phosgene in batch processes on the industrial scale is challenging owing to its toxicity. An effective method to minimize reaction volumes and mitigate the safety risks associated with hazardous chems. is the use of flow reactors. Consequently, we have established a flow reaction system using triphosgene and tributylamine, which affords a homogeneous reaction that avoids clogging issues. In addition, we have demonstrated that this methodol. can be applied to a wide variety of phosgene reactions, including the preparation of pharmaceutical intermediates, in good to excellent yields. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Computed Properties of 14602-86-9

The Article related to phosgenation reactor, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Computed Properties of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On May 21, 2022, Bhalodi, Esha H.; Patel, Krupa N.; Bedekar, Ashutosh V. published an article.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Synthesis and resolution of 2-amino-5-aza[6]helicene. And the article contained the following:

The synthesis of 2-amino-5-aza[6]helicene and its derivatives is reported. The diastereomeric (R)-menthylcarbamate derivative of this aza[6]helicene is prepared and its isomers were phys. separated by column chromatog. and their optical properties were measured. Optically pure isomer (P)-2-amino-5-aza[6]helicene was generated and its Boc-derivative was prepared The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to azahelicene preparation chiral resolution, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ayad, Suliman; Posey, Victoria; Das, Anjan; Montgomery, Jason M.; Hanson, Kenneth published an article in 2019, the title of the article was Enantioenrichment of racemic BINOL by way of excited state proton transfer.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Here the authors report a method for enantioenriching BINOL using a chiral auxiliary and an excited state proton transfer (ESPT) event. Regardless of the starting enantiomeric excess (ee), after irradiation the solution reaches a photostationary state whose ee is dependent solely on the identity of the chiral auxiliary group. The enantioenriched BINOL is easily recovered by cleaving the auxiliary group in mild conditions. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to enantioenrichment racemic binol excited state proton transfer, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 15, 2011, Rogers, Steven A.; Lindsey, Erick A.; Whitehead, Daniel C.; Mullikin, Trey; Melander, Christian published an article.Category: chlorides-buliding-blocks The title of the article was Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents. And the article contained the following:

The successful marriage of structural features from the 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators. The compounds were evaluated against a panel of four bacterial strains for anti-biofilm and anti-microbial activity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks

The Article related to menthyl imidazolylalkyltriazolylalkylcarbamate preparation antimicrobial biofilm inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics