Category: 14602-86-9

Kandukuri, Sandeep R.; Jiao, Lin-Yu; Machotta, Axel B.; Oestreich, Martin published an article in 2014, the title of the article was Diastereotopic group selection in hydroxy-directed intramolecular C-H alkenylation of indole under oxidative palladium(II) catalysis.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Group-selective Pd(II)-catalyzed ring closures involving C-H bond alkenylation are reported. The cyclization precursors contain a prochiral bis(homoallylic) alc. unit tethered to either an arene or an indole. The homobenzylic HO group in these substrates is positioned to act as a directing group in the ortho-selective C-H bond activation prior to the cyclization event. Arene-derived precursors reacted poorly, even when applying a protocol that had proven effective in intermol. HO-directed C-H bond alkenylations. No asym. induction was obtained with chiral ligands, mono-N-protected amino acids in particular. Conversely, the cyclization of indole-derived precursors was substantially more efficient, and installation of a substituent in the benzylic position rendered these intramol. C-H bond alkenylations diastereoselective. The diastereotopic group selection is high with diastereomeric ratios ranging from dr = 91:9 to 94:6. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to indole diastereoselective oxidative intramol carbon hydrogen alkenylation palladium catalyst, hydrocarbazole diastereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 21, 2020, Sun, Guodong; Wang, Zhongqing; Luo, Zhonghua; Lin, Yicao; Deng, Zhuofei; Li, Ridong; Zhang, Jiancun published an article.Application of 14602-86-9 The title of the article was Design, Synthesis, and Resolution of Spirocyclic Bisoxindole-Based C2-Symmetric Diols. And the article contained the following:

A new type of spirocyclic bisoxindole-based C2-sym. diols (SBIDOLs) was designed and synthesized. A series of racemic SBIDOL derivatives were readily synthesized from com. available 2-halo-5-methoxyanilines (X = Cl or Br) through N-mono alkylation, acylation, oxidation, double intramol. Friedel-Crafts reaction, and demethylation reactions. The optical resolution of racemic SBIDOL was achieved via fractional crystallization of their bis-L-menthoxycarboxylates. Further modifications of SBIDOLs were investigated, leading to 5,5′-diaryl SBIDOL derivatives through Pd-catalyzed Suzuki coupling and DM-SBIDOL 12 by Pd/C-catalyzed hydrogenative dechlorination reactions. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application of 14602-86-9

The Article related to halo methoxyaniline alkylation acylation oxidation friedel crafts demethylation resolution, spirocyclic bisoxindole diol preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Periasamy, Mariappan; Edukondalu, Athukuri; Ramesh, Eagala published an article in 2017, the title of the article was Synthesis and Desymmetrization of meso-2,3-Diphenylpiperazine for Application in Asymmetric Transformations.Electric Literature of 14602-86-9 And the article contains the following content:

The meso-2,3-diphenylpiperazine was prepared in 86 % yield with 99:1 dr from the readily accessible 5,6-diphenyl-2,3-dihydropyrazine by NaBH4/MeOH reduction The corresponding diastereomeric amides prepared using (R)-(-)-menthyl chloroformate, after separation, benzylation and hydrolysis gave both isomers of optically active N-benzyl-2,3-diphenylpiperazine samples in up to 94% ee which after further enrichment using the simple achiral oxalic acid afforded samples of both enantiomers in 99% ee. Reaction of the chiral optically active N-benzyl-2,3-diphenylpiperazine with terminal alkynes and aldehydes in the presence of ZnCl2 gave the corresponding propargylamines with very high diastereoselectivities (up to 99:1 dr) from which both enantiomers of chiral allenes were obtained in up to 82-86% ee by reaction with ZnBr2 in toluene at 120°. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Electric Literature of 14602-86-9

The Article related to meso diphenylpiperazine preparation desymmetrization chiral propargylamine allene stereoselective, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 5, 2018, Shan, Huanyu; Zhou, Qiaoxia; Yu, Jinglu; Zhang, Shuoqing; Hong, Xin; Lin, Xufeng published an article.Related Products of 14602-86-9 The title of the article was Rhodium-Catalyzed Asymmetric Addition of Organoboronic Acids to Aldimines Using Chiral Spiro Monophosphite-Olefin Ligands: Method Development and Mechanistic Studies. And the article contained the following:

The synthesis of a novel type of chiral spiro monophosphite-olefin (SMPO) ligands based on a hexamethyl-1,1′-spirobiindane scaffold was accomplished starting from Bisphenol C. The optimal ligand could serve as an elegant chiral bidentate ligand in the Rh-catalyzed asym. 1,2-addition of organoboronic acids to various acyclic/cyclic aldimines, leading to chiral amines with high yields and excellent enantioselectivities. Detailed stereochem. models for enantioselective induction were elucidated through DFT calculations and postulated the origins of the higher enantioselectivity of phosphite-olefin ligands. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Related Products of 14602-86-9

The Article related to chiral spiro monophosphite olefin ligand preparation asym addition catalyst, addition boronic acid aldimine chiral spiro monophosphite olefin ligand, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Related Products of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 6, 2012, Jierry, Loic; Harthong, Steven; Aronica, Christophe; Mulatier, Jean-Christophe; Guy, Laure; Guy, Stephan published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Efficient Dibenzo[c]acridine Helicene-like Synthesis and Resolution: Scaleup, Structural Control, and High Chiroptical Properties. And the article contained the following:

Herein, an expeditious synthesis of dibenzo[c]acridine helicene-like compounds on a large scale in pure enantiomeric form is described. This flexible synthesis allows for variation at several positions on the skeleton. Geometrical parameters related to these compounds have been obtained from monocrystal X-ray structure resolution Addnl., chiroptical parameters have been recorded, highlighting the versatility of this family showing for example optical rotation at 589 nm varying between 135 and 150 deg g-1cm2. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to dibenzoacridine helicene scaleup synthesis crystal structure chiroptical property, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Acridines, Quinolizines, etc.) and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 1, 2016, Shyam Sundar, M.; Sahoo, Sibaprasad; Bedekar, Ashutosh V. published an article.Formula: C11H19ClO2 The title of the article was Synthesis and study of the structural properties of oxa[5]helicene derivatives. And the article contained the following:

The preparation of the (-)-menthyl carbonate of 2-hydroxy-7-oxa[5]helicene and its structural characterization is reported. Single crystal X-ray diffraction anal. established the relatively flat structure of oxa[5]helicene unit thus indicating the absence of stable helical isomers. The unit cell of the crystal includes one mol. in the P-conformation and another in the M-isomer. However, its nitro derivative, 1-nitro-2-hydroxy-7-oxa[5]helicene, provides sufficient steric crowding to observe two helical isomers at low temperature, as confirmed by 1H NMR at -20 °C. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to oxahelicene menthyl carbonate preparation structure conformation, Terpenes and Terpenoids: Monoterpenes (C10), Including Cannabinoids, Chrysanthemic Acids, and Iridoid Aglycons and other aspects.Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 31, 2019, Zhou, Qiaoxia; Pan, Rihuang; Shan, Huanyu; Lin, Xufeng published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Synthesis and Optical Resolution of 3,3,3′,3′-Tetramethyl-1,1′-spirobiindane-7,7′-diol. And the article contained the following:

A novel chiral C2-sym. spiro diol, 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol (TMSIOL), was conveniently prepared via practical seven-step route from Bisphenol A in 45.1% overall yield. L-Menthyl chloroformate was used as optical resolving agent for the separation of the two enantiomers of TMSIOL. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to tetramethyl spirobiindanediol preparation optical resolution enantioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Benzocyclopropenes, Benzocyclobutenes, and Indenes and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 21, 2013, Budovska, Mariana; Kutschy, Peter; Kozar, Tibor; Gondova, Tatana; Petrovaj, Jan published an article.Category: chlorides-buliding-blocks The title of the article was Synthesis of spiroindoline phytoalexin (S)-(-)-spirobrassinin and its unnatural (R)-(+)-enantiomer. And the article contained the following:

The stereoselective syntheses of the cruciferous indole phytoalexin (S)-(-)-spirobrassinin and its unnatural (R)-(+)-enantiomer were achieved by bromine-induced spirocyclization of (-)- and (+)-1-(8-phenylmenthoxycarbonyl)brassinin in the presence of water to give the corresponding spirobrasinol derivatives, followed by oxidation to the derivatives of spirobrassinin and finally removal of the chiral auxiliary. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks

The Article related to spirobrassinin stereoselective synthesis spirocyclization, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qureshi, Zafar; Weinstabl, Harald; Suhartono, Marcel; Lui, Hongqiang; Thesmar, Pierre; Lautens, Mark published an article in 2014, the title of the article was Application of the Palladium-Catalyzed Norbornene-Assisted Catellani Reaction Towards the Total Synthesis of (+)-Linoxepin and Isolinoxepin.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

The authors’ ongoing effort towards the development of highly selective transition-metal-catalyzed carbon hydrogeb bond (C-H bond) activation processes has led to the expansion of a Catellani reaction. In a Pd0/PdII/PdIV-catalyzed tandem reaction (domino reaction), an aryl iodide, alkyl iodide and tert-Bu acrylate were combined to synthesize a carbon framework of the novel lignan (+)-linoxepin. The enantioselective synthesis highlights the work accomplished in the authors’ group and provides an excellent procedure for a reliable and scalable synthesis of architecturally complex scaffolds. This report outlines the synthetic approaches towards this interesting class of biol. active mols. After a key Catellanireaction/Heck reaction, the synthesis features a Leimeux-Johnson oxidation and a titanium tetrachloride mediated aldol condensation. Finally, a tuneable Mizoroki-Heck reaction was performed to furnish not only the natural product (+)-linoxepin but also its isoform, which we have named isolinoxepin. The synthesis of the target compounds was achieved using 8-[(5-bromo-1,3-benzodioxol-4-yl)methoxy]-3a,4-dihydro-7-(methoxy)naphtho[2,3-c]furan-1(3H)-one as a key intermediate. The title compounds thus formed included (9aR)-9a,10-dihydro-6-methoxy-4H-1,3-benzodioxolo[4,5-c]isobenzofuro[4,5,6-ef][1]benzoxepin-12(9H)-one [(+)-linoxepin] and 10,12b-dihydro-6-methoxy-4H-1,3-benzodioxolo[4,5-c]isobenzofuro[4,5,6-ef][1]benzoxepin-12(9H)-one [racemic isolinoxepin]. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to linoxepin isolinoxepin lignan preparation total synthesis, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 25, 2017, Bender, Matthias; Turnbull, Ben W. H.; Ambler, Brett R.; Krische, Michael J. published an article.Electric Literature of 14602-86-9 The title of the article was Ruthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds: Entry to type II polyketides. And the article contained the following:

Current catalytic processes involving carbon-carbon bond activation rely on π-unsaturated coupling partners. Exploiting the concept of transfer hydrogenative coupling, we report a ruthenium(0)-catalyzed cycloaddition of benzocyclobutenones that functionalizes two adjacent saturated diol carbon-hydrogen bonds. These regio- and diastereoselective processes enable convergent construction of type II polyketide substructures. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Electric Literature of 14602-86-9

The Article related to benzocyclobutenone cycloaddition ruthenium catalyzed, polyketide preparation cycloaddition ruthenium catalyzed, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Electric Literature of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics