Category: 14602-86-9

On October 25, 2017, Chen, Dian-Feng; Chu, John C. K.; Rovis, Tomislav published an article.Category: chlorides-buliding-blocks The title of the article was Directed γ-C(sp3)-H alkylation of carboxylic acid derivatives through visible light photoredox catalysis. And the article contained the following:

Visible light photoredox catalysis enables direct γ- C(sp3)-H alkylation of saturated aliphatic carbonyl compounds Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated in situ. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks

The Article related to aliphatic carboxylic acid carbamate regioselective alkylation photocatalysis photoredox, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 5, 2020, Blangetti, Marco; O’Shea, Donal F. published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Chiral auxiliary-mediated synthesis of planar chiral [2.2]metacyclophanes. And the article contained the following:

The synthesis of planar chiral [2.2]metacyclophanes, e.g., I was readily accomplished in a single synthetic step via the directed ortho metalation of a pro-chiral substituted metacyclophane. The use of (-)-menthyl chloroformate as a chiral auxiliary allowed the introduction of the useful carbonyl functional group into the aryl ring, giving access to carboxy-substituted diastereomeric mixture of planar chiral [2.2]metacyclophanes. The separation of diastereoisomers was easily accomplished by semipreparative HPLC, allowing the structural anal. of a single diastereoisomer by X-ray crystallog. and NMR spectroscopy. The structural features of the planar chiral metacyclophanes and their high inversion barriers, determined at 473 K, encourage future investigations as chiral catalysts and ligands. This synthetic route complements previously reported enantioselective synthesis by avoiding the restrictive use of (-)-sparteine as the chiral inducer. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to planar chiral metacyclophane preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Higher-Membered Ring Systems, Including Cyclophanes and Fullerenes and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2015, Hassan, Kamrul; Yamashita, Ken-ichi; Hirabayashi, Kazunori; Shimizu, Toshio; Nakabayashi, Kazuki; Imai, Yoshitane; Matsumoto, Takashi; Yamano, Akihito; Sugiura, Ken-ichi published an article.Product Details of 14602-86-9 The title of the article was π-Expanded axially chiral biaryls and their emissions: molecular design, syntheses, optical resolution, absolute configuration, and circularly polarized luminescence of 1,1′-bipyrene-2,2′-diols. And the article contained the following:

Axially chiral biaryls based on pyrene, 1,1′-bipyrene-2,2′-diol derivatives, were designed and synthesized from 2-hydroxypyrene. Simple optical resolution was carried out and the absolute configuration was determined by diffraction study. Title compounds (I) and corresponding menthylcarbonate (II) showed clear circularly polarized luminescence (CPL) spectra. The degree of dimensionless Kuhn’s anisotropy in the photoexcited state (|gem|) of compounds I and II were ca. 3.6 x 10-4 and ca. 1.2 x 10-3, resp. High fluorescent quantum yields of compounds I and II, 0.57 and 0.80, resp., in marked contrast to that of BINOL, 0.04 and bathochromic shifts of λCPL were noteworthy properties. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to axially chiral bipyrene preparation optical resolution luminescence, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Higher-Membered Ring Systems, Including Cyclophanes and Fullerenes and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On November 30, 2010, Alberico, Elisabetta; Karandikar, Satyajit; Gladiali, Serafino published an article.Application of 14602-86-9 The title of the article was Dimethoxydibenzophosphepine: An Axially Chiral Monophosphane for Efficient Asymmetric Catalysis. And the article contained the following:

A dimethoxydibenzophosphepine chiral ligand was prepared for use in the rhodium-catalyzed enantioselective hydrogenation of unsaturated esters and palladium-catalyzed allylic alkylation reactions. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application of 14602-86-9

The Article related to dimethoxydibenzophosphepine chiral ligand preparation catalyst stereoselective hydrogenation allylic alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lefranc, Julien; Minassi, Alberto; Clayden, Jonathan published an article in 2013, the title of the article was Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

N-(alkenyl)urea derivatives and N-(alkenyl)carbamates, like other N-acyl enamines, are typically nucleophilic at their β-carbon. However, by incorporating an α-aryl substituent, the authors show that they will also undergo attack at the β-carbon by organolithium nucleophiles, leading to the products of carbolithiation. The carbolithiation of (E)-(alkenyl)urea and (Z)-(alkenyl)urea derivatives is diastereoselective and N-tert-butoxycarbonyl N-alkenyl carbamates give carbolithiation products that may be deprotected in situ to provide a new connecting route to hindered amines. The title compounds thus formed included rel-N-(4-methoxyphenyl)-N,N’-dimethyl-N’-[(1R,2R)-2-methyl-1-phenylhexyl]urea (I) and related substances, such as carbamate esters, N-methyl-N-(3-methyl-1-phenylbutyl)carbamic acid 1,1-dimethylethyl ester. The synthesis of the target compounds was achieved by a reaction of (butyl)lithium, (tert-butyl)lithium, etc. with N,N’-dimethyl-N-phenyl-N’-(1-phenylethenyl)urea derivatives, [N(E)]-N-(1-phenylethylidene)methanamine, N-[(phenyl)alkenyl]carbamic acid esters. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to carbamate urea carbometalation lithiation stereoselective synthesis, carbamate, carbolithiation, carbometallation, organolithium, stereospecificity, styrene, urea, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 18, 2014, He, Shuzhong; Hsung, Richard P.; Presser, William R.; Ma, Zhi-Xiong; Haugen, Bryan J. published an article.Synthetic Route of 14602-86-9 The title of the article was An Approach to Cyclohepta[b]indoles through an Allenamide [4+3] Cycloaddition-Grignard Cyclization-Chugaev Elimination Sequence. And the article contained the following:

A strategy for synthesizing highly functionalized cyclohepta[b]indoles through a concise [4+3] cycloaddition-cyclization-elimination sequence is described. The cycloaddition features nitrogen-stabilized oxyallyl cations derived from epoxidations of N-aryl-N-sulfonyl-substituted allenamides, while the cyclization and elimination employed an intramol. Grignard addition and a one-step Chugaev process, resp. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Synthetic Route of 14602-86-9

The Article related to allenamide epoxide diene cycloaddition intramol grignard cyclization chugaev elimination, cycloheptaindole preparation nitrogen stabilized oxyallyl cation intermediate, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 19, 2010, Narasimhan, Sri Kamesh; Kerwood, Deborah J.; Wu, Lei; Li, Jun; Han, Yongbin; Zhu, Shifa; Shah, Akshay; Lombardi, Rosina; Freedman, Teresa B.; Luk, Yan-Yeung published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Induced folding by chiral nonplanar aromatics. [Erratum to document cited in CA151:336592]. And the article contained the following:

In view of their relevant contributions to this work, Yongbin Han, Shifa Zhu, and Akshay Shah have been added as coauthors for this article. The correct version of the Author list is given. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to erratum folding chiral nonplanar aromatic, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 14, 2016, Murphy, John J.; Bastida, David; Paria, Suva; Fagnoni, Maurizio; Melchiorre, Paolo published an article.Product Details of 14602-86-9 The title of the article was Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals. And the article contained the following:

An important goal of modern organic chem. is to develop new catalytic strategies for enantioselective carbon-carbon bond formation that can be used to generate quaternary stereogenic centers. Whereas considerable advances have been achieved by exploiting polar reactivity, radical transformations have been far less successful. This is despite the fact that open-shell intermediates are intrinsically primed for connecting structurally congested carbons, as their reactivity is only marginally affected by steric factors. Here we show how the combination of photoredox and asym. organic catalysis enables enantioselective radical conjugate additions to β,β-disubstituted cyclic enones to obtain quaternary carbon stereocenters with high fidelity. Critical to our success was the design of a chiral organic catalyst, containing a redox-active carbazole moiety, that drives the formation of iminium ions and the stereoselective trapping of photochem. generated carbon-centered radicals by means of an electron-relay mechanism. We demonstrate the generality of this organocatalytic radical-trapping strategy with two sets of open-shell intermediates, formed through unrelated light-triggered pathways from readily available substrates and photoredox catalysts-this method represents the application of iminium ion activation (a successful catalytic strategy for enantioselective polar chem.) within the realm of radical reactivity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to asym catalysis formation quaternary carbon iminium ion trapping radical, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 29, 2017, Bahamonde, Ana; Murphy, John J.; Savarese, Marika; Bremond, Eric; Cavalli, Andrea; Melchiorre, Paolo published an article.Computed Properties of 14602-86-9 The title of the article was Studies on the Enantioselective Iminium Ion Trapping of Radicals Triggered by an Electron-Relay Mechanism. And the article contained the following:

A combination of electrochem., spectroscopic, computational, and kinetic studies was used to elucidate the key mechanistic aspects of the previously reported enantioselective iminium ion trapping of photochem. generated carbon-centered radicals. The process, which provides a direct way to forge quaternary stereocenters with high fidelity, relies on the interplay of two distinct catalytic cycles: the aminocatalytic electron-relay system, which triggers the stereoselective radical trap upon iminium ion formation, and the photoredox cycle, which generates radicals under mild conditions. Critical to reaction development was the use of a chiral amine catalyst, bearing a redox-active carbazole unit, which could rapidly reduce the highly reactive and unstable intermediate generated upon radical interception. The carbazole unit, however, is also involved in another step of the electron-relay mechanism: the transiently generated carbazole radical cation acts as an oxidant to return the photocatalyst into the original state. By kinetic and spectroscopic studies, the authors have identified the last redox event as being the turnover-limiting step of the overall process. This mechanistic framework is corroborated by the linear correlation between the reaction rate and the reduction potential of the carbazole unit tethered to the aminocatalyst. The redox properties of the carbazole unit can thus be rationally tuned to improve catalytic activity. This knowledge may open a path for the mechanistically driven design of the next generation of electron-relay catalysts. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Computed Properties of 14602-86-9

The Article related to enantioselective iminium trapping radical triggered electron relay safety, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Computed Properties of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 21, 2011, Voss, Felix; Herdtweck, Eberhardt; Bach, Thorsten published an article.Product Details of 14602-86-9 The title of the article was Hydrogen bond induced enantioselectivity in Mn(salen)-catalyzed sulfoxidation reactions. And the article contained the following:

A chiral Mn(salen) complex exhibiting two lactam binding sites at two rigid 1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-2-one skeletons is capable of enantioselective sulfoxidation due to spatially remote substrate hydrogen bonding. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Product Details of 14602-86-9

The Article related to hydrogen bond induced enantioselectivity sulfoxidation manganese salen catalyst, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Product Details of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics