Category: 14602-86-9

On May 7, 2021, Shyam Sundar, M.; Lo, Rabindranath; Dracinsky, Martin; Klepetarova, Blanka published an article.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Synthesis and Stereochemical Behavior of Dioxa[6]helicene Derivatives. And the article contained the following:

We constructed a helically chiral dioxa[6]helicene by assembling simple phenol building blocks by a combination of two simple reactions involving oxidative cross-coupling followed by dehydrative cyclization. X-ray anal. and d. functional calculations (DFT) revealed that the compound dioxa[6]helicene has a helical structure that undergoes helical inversion rapidly at room temperature We were able to detect the presence of resolvable helical isomers of (-)-menthyloxycarbonyl derivative of dioxa[6]helicene by recording 1H NMR spectra below 0°C. The investigations of photophys. properties by cyclic voltammetry, UV/Vis- and fluorescence spectroscopy with the aid of time-dependent DFT calculations were undertaken. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to dioxahelicene crystal structure helical inversion uv spectra fluorescence voltammetry, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Name: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 1, 2017, Patel, Krishnakant; Song, Fengling; Andreana, Peter R. published an article.HPLC of Formula: 14602-86-9 The title of the article was Synthesis of substrate analogues as potential inhibitors for Mycobacterium tuberculosis enzyme MshC. And the article contained the following:

Mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis and a promising target for developing new anti-mycobacterial compounds Herein, we report on the synthesis of substrate analogs, as potential inhibitors, for the MshC enzyme. The target mols. were synthesized employing a Schmidt glycosylation strategy using an enantiomerically pure inositol acceptor and 2-deoxy trichloroacetimidate glycosyl donors with glycosylation yields greater than 70% and overall yields >5%. The inositol acceptor was obtained via chiral resolution of (±)-myo-inositol. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to mycothiol cysteine ligase mshc mycobacterium substrate analog inhibitor tuberculosis, chiral resolution, glucosamine inositol, mshc, mycothiol, substrate analogues, tuberculosis and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On July 22, 2022, Verdhi, Lenin Kumar; Fridman, Natalia; Szpilman, Alex M. published an article.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Copper- and Chiral Nitroxide-Catalyzed Oxidative Kinetic Resolution of Axially Chiral N-Arylpyrroles. And the article contained the following:

A readily prepared C2-sym., α-hydrogen-substituted chiral hydroxylamine served as a precatalyst to generate a chiral nitroxide in situ. This chiral nitroxide catalyst in combination with a copper co-catalyst functions as an oxidant for an unprecedented enantioselective oxidative kinetic resolution (OKR) of racemic axially chiral N-arylpyrrole alcs. using atm. oxygen as an environmentally friendly terminal oxidant. The OKR process provided the axially chiral N-arylpyrroles in er up to 3.5:96.5 and with s factors up to 24. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to racemic arylpyrrole alc copper catalyst oxidative kinetic resolution, arylpyrrole alc enantioselective green preparation, aryl pyrrole aldehyde enantioselective green preparation and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 10, 2013, Watanabe, Yutaka; Uemura, Tsuyoshi; Yamauchi, Satoe; Tomita, Kousei; Saeki, Takafumi; Ishida, Ryousuke; Hayashi, Minoru published an article.Recommanded Product: 14602-86-9 The title of the article was Regioselective functionalization of unprotected myo-inositol by electrophilic substitution. And the article contained the following:

Unprotected myo-inositol was treated with various electrophiles, such as aroyl chlorides, tosyl chloride and tert-butyldiphenylsilyl chloride in a solution of LiCl/DMA or DMSO to afford regioselectively 1,3-di-O-substituted or racemic 1-O-substituted derivatives, e.g. I, depending on a quantity of reagents and reaction time. reaction with the solvents. α-Unbranched alkanoic acid anhydrides in LiCl/DMA in the presence of triethylamine were suitable for acylation of myo-inositol, in contrast to the fact that acylation using alkanoyl chlorides in aprotic polar solvents generally does not proceed well due to decomposition of the reagents by the. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: 14602-86-9

The Article related to acylation inositol alkanoyl chloride regioselective electrophilic substitution cyclitol preparation, regioselective electrophilic substitution inositol aroyl chloride alkanoic acid anhydride and other aspects.Recommanded Product: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 9, 2013, Garner, A. Christopher; Hodgkinson, Roy C.; Wallis, John D. published an article.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Menthyloxycarbonyl phosphonium chlorides: new derivatives for determining the enantiomeric excess of chiral tertiary phosphines. And the article contained the following:

The direct alkoxycarbonylation of tertiary phosphines with alkyl chloroformates was examined and the products characterized by NMR and x-ray crystallog. anal. The derivation of representative chiral tertiary phosphines with enantiopure menthyl chloroformate allows the determination of the enantiomeric excess of scalemic mixtures by 31P NMR spectroscopic anal. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to menthyloxycarbonyl phosphonium chloride derivative tertiary phosphine enantiomeric excess determination, menthyl chloroformate derivation tertiary phosphine enantiomer determination p31 nmr and other aspects.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 1, 2019, Modha, Sachin G.; Poethig, Alexander; Dreuw, Andreas; Bach, Thorsten published an article.Formula: C11H19ClO2 The title of the article was [6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope. And the article contained the following:

Upon irradiation at λ = 366 nm, tertiary N-alkoxycarbonyl-N-aryl-β-enaminones, e.g., I, furnished exclusively the trans-hexahydrocarbazol-4-ones, e.g., II, by a conrotatory [6π] photocyclization but epimerized on silica to cis-hexahydrocarbazol-4-ones, e.g., III (14 examples, 44-98% yield). The acceptor substitution on the nitrogen atom enhanced the stability of the cyclized products compared to N-alkyl-N-aryl-β-enaminones reported previously. The mechanism of the [6π] photocyclization was investigated by quenching experiments, deuterium-labeling experiments, and DFT calculations, suggesting a triplet pathway for the conrotatory ring closure followed by a suprafacial [1,4] hydrogen migration. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Formula: C11H19ClO2

The Article related to cis hexahydrocarbazolone preparation intramol diastereoselective photocyclization alkoxycarbonylarylenaminone, hexahydrocarbazolone cis trans epimerization mechanistic study dft homo lumo and other aspects.Formula: C11H19ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Jing; Jin, Yan; Shin, Yujin; Jeong, Kyung Min; Lee, Jeongmi published an article in 2016, the title of the article was Indirect enantioseparation of fluoxetine in mouse serum by derivatization with 1R-(-)-menthyl chloroformate followed by ultra high performance liquid chromatography and quadrupole time-of-flight mass spectrometry.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

Here we describe a simple and sensitive anal. method for the enantioselective quantification of fluoxetine in mouse serum using ultra high performance liquid chromatog. with quadrupole time-of-flight mass spectrometry. The sample preparation method included a simple deproteinization with acetonitrile in 50 μL of serum, followed by derivatization of the extracts in 50 μL of 2 mM 1R-(-)-menthyl chloroformate at 45 C for 55 min. These conditions were statistically optimized through response surface methodol. using a central composite design. Under the optimized conditions, neither racemization nor kinetic resolution occurred. The derivatized diastereomers were readily resolved on a conventional sub-2 μm C18 column under a simple gradient elution of aqueous methanol containing 0.1% formic acid. The established method was validated and found to be linear, precise, and accurate over the concentration range of 5.0-1000.0 ng/mL for both R and S enantiomers (r2 > 0.993). Stability tests of the prepared samples at three different concentration levels showed that the R- and S-fluoxetine derivatives were relatively stable for 48 h. No significant matrix effects were observed Last, the developed method was successfully used for enantiomeric anal. of real serum samples collected at a number of time points from mice administered with racemic fluoxetine. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to fluoxetine determination enantioseparation serum menthyl chloroformate uplc qtof ms, chiral derivatization reagent, enantioseparation, fluoxetine, menthyl chloroformate, response surface methodology and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fujiwara, Shinichi; Cadou, Romain; Yamaoka, Yousuke; Takasu, Kiyosei; Yamada, Ken-ichi published an article in 2015, the title of the article was Hydrostannylation-cross-coupling strategy for the stereoselective synthesis of alkylidenemalonates and related α,β-unsaturated esters.SDS of cas: 14602-86-9 And the article contains the following content:

A method for the stereoselective synthesis of alkylidenemalonates and related α,β-unsaturated esters by hydrostannylation-cross coupling process was developed. Regio- and diastereoselective Pd-catalyzed hydrostannylation of propiolate derivatives provided α-alkoxycarbonyl (E)- and (Z)-vinylstannanes which were then converted into resp. alkylidenemalonates by the Stille coupling reaction with corresponding chloroformates. A one-pot process was also realizable for the Pd-catalyzed reactions. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9

The Article related to alkylidenemalonate alpha beta unsaturated ester preparation, vinyl stannane preparation chloroformate stille coupling, propiolate tributylstannane hydrostannylation regioselective diastereoselective and other aspects.SDS of cas: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Race, Nicholas J.; Faulkner, Adele; Fumagalli, Gabriele; Yamauchi, Takayuki; Scott, James S.; Ryden-Landergren, Marie; Sparkes, Hazel A.; Bower, John F. published an article in 2017, the title of the article was Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters.Recommanded Product: 14602-86-9 And the article contains the following content:

The first examples of highly enantioselective Narasaka-Heck cyclizations were described. A SPINOL-derived P,N-ligand system enabled Pd-catalyzed 5-exo cyclization of a range of oxime esters with sterically diverse trisubstituted alkenes to generate dihydropyrroles containing tetrasubstituted nitrogen-bearing stereocenters in 56 to 86% yield and 90 : 10 to 95 : 5 e.r. These processes were rare examples of reactions that proceeded via enantioselective migratory insertion of alkenes into Pd-N bonds, and the first where trisubstituted alkenes were used to generate tetrasubstituted stereocenters with high enantioselectivity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: 14602-86-9

The Article related to benzyl diphenylphosphanyl octahydrobinaphthalenyl oxazole palladium catalyst preparation, perfluorobenzoyl oxime alkenyl preparation narasaka heck cyclization, alkenyl dihydropyrrole enantioselective preparation and other aspects.Recommanded Product: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Lei; Zhong, Jialing; Lin, Xufeng published an article in 2019, the title of the article was Atroposelective Phosphoric Acid Catalyzed Three-Component Cascade Reaction: Enantioselective Synthesis of Axially Chiral N-Arylindoles.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

An efficient organocatalytic atroposelective three-component cascade reaction of 2,3-diketoesters, aromatic amines, and 1,3-cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N-arylindoles. The success of this method derives from the use of a newly developed second-generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to atroposelective phosphoric acid catalyst three component cascade reaction, enantioselective synthesis axially chiral arylindole, atroposelectivity, indoles, multicomponent reaction, organocatalysis, synthetic methods and other aspects.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics