Category: 14602-86-9

On September 2, 2011, Curti, Claudio; Battistini, Lucia; Sartori, Andrea; Lodola, Alessio; Mor, Marco; Rassu, Gloria; Pelosi, Giorgio; Zanardi, Franca; Casiraghi, Giovanni published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan-Based Silyl Enolates. And the article contained the following:

Vinyl, butadienyl, and hexatrienyl siloxyfurans such as I (TBS = tert-butyldimethylsilyl) are prepared; in the presence of silicon tetrachloride and nonracemic bis(dinaphthodiazaphosphepine) II, I undergo regioselective, stereoselective, and enantioselective vinylogous Mukaiyama aldol addition reactions with aryl aldehydes to yield nonracemic hydroxyalkylidenefuranones such as III in 42-92% yields, in 55:45->95:5 olefin stereoselectivities, and in 89:11->99:1 er. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to vinyl butadienyl hexatrienyl siloxyfuran preparation regioselective stereoselective aldol addition, hydroxyalkylidenefuranone regioselective stereoselective preparation, silicon chloride dinaphthodiazaphosphepine catalyst regioselective enantioselective hypervinylogous aldol addition, vinylogous mukaiyama aldol addition vinyl siloxyfuran aryl aldehyde and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 16, 2021, Xu, Changming; Qi, Yinsheng; Yang, Xinshuang; Li, Xiangfan; Li, Zhenpeng; Bai, Lei published an article.HPLC of Formula: 14602-86-9 The title of the article was Development of C2-Symmetric Chiral Spirocyclic Phase-Transfer Catalysts: Synthesis and Application to Asymmetric Alkylation of Glycinate Schiff Base. And the article contained the following:

A class of C2-sym. chiral spirocyclic phase-transfer catalysts based on the tetramethyl-1,1′-spirobiindane scaffold such as I·Br- was synthesized from com. available bisphenol A in 12 steps in 22-25% total yields; the scaffold features a more rigid and stable backbone and smaller dihedral angles and can be easily modified. These catalysts show high catalytic performance in the asym. alkylation of tert-Bu glycinate Schiff base Ph2C:NCH2CO2t-Bu at only 2 mol % catalyst loading, giving nonracemic protected α-amino acid esters such as (R)-Ph2C:NCH(CH2Ph)CO2t-Bu in up to 92% yield and 98% ee. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to spirobiindanoazocinium nonracemic preparation catalyst enantioselective phase transfer alkylation, diphenylmethyleneamino ester enantioselective preparation, nonracemic spirobiindanoazocinium bromide enantioselective phase transfer alkylation catalyst, alkyl bromide enantioselective alkylation diphenylmethyleneamino ester spirobiindanoazocinium catalyst and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Albrecht, Dominik; Vogt, Florian; Bach, Thorsten published an article in 2010, the title of the article was Diastereo- and Enantioselective Intramolecular [2+2] Photocycloaddition Reactions of 3-(ω’-Alkenyl)- and 3-(ω’-Alkenyloxy)-Substituted 5,6-Dihydro-1H-pyridin-2-ones.Electric Literature of 14602-86-9 And the article contains the following content:

3-(ω’-Alkenyl)-substituted 5,6-dihydro-1H-pyridin-2-ones I (n = 1-3) were prepared as photocycloaddition precursors either by cross-coupling from 3-iodo-5,6-dihydro-1H-pyridin-2-one or, more favorably, from the corresponding α-(ω’-alkenyl)-substituted δ-valerolactams by a selenylation/elimination sequence (56-62% overall yield). 3-(ω’-Alkenyloxy)-substituted 5,6-dihydro-1H-pyridin-2-ones II (n = 1, 2) were accessible in 43 and 37% overall yield from 3-diazopiperidin-2-one by an α,α-chloroselenylation reaction at the 3-position followed by nucleophilic displacement of a chloride ion with an ω-alkenolate and oxidative elimination of selenoxide. Upon irradiation at λ = 254 nm, the precursor compounds underwent a clean intramol. [2+2] photocycloaddition reaction. The substrates tethered by a two-atom chain exclusively delivered the resp. crossed products III (X = CH2, O), and the substrates tethered by longer chains, gave the straight products IV (n = 1, X = CH2, O; n = 2, X = CH2). The completely regio- and diastereoselective photocycloaddition reactions proceeded in 63-83% yield. Irradiation in the presence of the chiral templates (-)-V and (+)-VI at -75° in toluene rendered the reactions enantioselective with selectivities varying between 40 and 85% ee. Truncated template rac-VI was prepared as a noranalogue of the well-established template V in eight steps and 56% yield from the Kemp triacid. Subsequent resolution delivered the enantiomerically pure templates (-)-ent-VI and (+)-VI. The outcome of the reactions is compared to the results achieved with 4-substituted 5,6-dihydro-1H-pyridin-2-ones and quinolones. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Electric Literature of 14602-86-9

The Article related to alkenyl substituted valerolactam selenylation elimination, dihydropyridinone alkenyl substituted derivative preparation photocycloaddition, piperidinone tricyclic derivative stereoselective preparation chiral complexing reagent, kemp triacid tetrahydroaminonaphthol chiral template preparation resolution and other aspects.Electric Literature of 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schwenk, R.; Togni, A. published an article in 2015, the title of the article was P-Trifluoromethyl ligands derived from Josiphos in the Ir-catalysed hydrogenation of 3,4-dihydroisoquinoline hydrochlorides.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate And the article contains the following content:

The synthesis of mono P-trifluoromethyl and therefore P-stereogenic Xyliphos-derived ligands CpFeC5H3(PPhCF3)(CMeHP(xyl)2) (5, xyl = C6H3Me2-3,5) and their application in the Ir-catalyzed enantioselective hydrogenation of 1-substituted 3,4-dihydroisoquinolinium species (DHIQ) are reported. The ligands were prepared following previous procedures involving the reaction of a bis(trifluoromethyl)phosphine with lithiated (R)-Ugi amine (R)-CpFeC5H3Li(CHMeNMe2) (1). Chloroiridium(I) cyclooctadiene precatalysts containing these new partially electron-poor ligands are poorly active in the hydrogenation of free 1-phenyl-3,4-dihydroisoquinoline (12a). However, the corresponding hydrochloride 12a·HCl was smoothly reduced at 55-60° and 100 bar H pressure. The (SP)-configured ligand (SP)-5 yielded significantly higher enantioselectivity in hydrogenation experiments than its P-stereoisomeric counterpart (RP)-5. These new ligands were subsequently applied in the hydrogenation of twelve different 1-substituted 3,4-DHIQ chlorides. Good to excellent enantioselectivity was observed for substrates bearing relatively large substituents in position 1, reaching 96% ee for 1-Ph-DHIQ chloride 12a·HCl without the help of any additives. Furthermore, an interesting counterion effect was found with chloride being the best and hexafluorophosphate being very detrimental to enantioselectivity. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to xyliphos fluoromethyl iridium catalyst preparation hydrogenation enantioselective dihydroisoquinoline hydrochloride, fluoromethyl phosphinylferrocenyl iridium preparation hydrogenation catalyst enantioselective hydroisoquinoline hydrochloride, crystal mol structure fluoromethyl xyliphos platinum iridium preparation and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 3, 2021, Pollack, Scott R.; Dion, Amelie published an article.HPLC of Formula: 14602-86-9 The title of the article was Metal-free stereoselective synthesis of (E)- and (Z)-N-monosubstituted β-aminoacrylates via condensation reactions of carbamates. And the article contained the following:

Two efficient, stereoselective methods for the preparation of (E)- or (Z)-β-aminoacrylates via acid- or base-promoted condensation reactions of carbamates are described. The base-promoted reaction is E-selective, while acid catalysis can, through the choice of solvent, selectively form E or Z. The acid-catalyzed E-selective process proceeds through a crystallization obviating the need for chromatog. purification The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to carbamate alkoxyacrylate acid catalyst metal free diastereoselective condensation reaction, dialkoxypropanoate carbamate acid catalyst metal free diastereoselective condensation reaction, propynoate carbamate base catalyst diastereoselective condensation reaction, aminoacrylate preparation stereoselective metal free and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schlauderer, Florian; Lammens, Katja; Nagel, Daniel; Vincendeau, Michelle; Eitelhuber, Andrea C.; Verhelst, Steven H. L.; Kling, Dale; Chrusciel, Al; Ruland, Juergen; Krappmann, Daniel; Hopfner, Karl-Peter published an article in 2013, the title of the article was Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase.Category: chlorides-buliding-blocks And the article contains the following content:

The authors report the crystal structure of ligand-free dimeric human MALT1casp-Ig3 in complex with the tricyclic phenothiazine derivative thioridazine. Unexpectedly, the structure reveals that the inhibitor binds in a pocket located on the opposite to the caspase active site, in the interface between the caspase domain and the Ig3 domain connecting helix α1Ig3 of MALT1. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Category: chlorides-buliding-blocks

The Article related to phenothiazine malt1 paracaspase allosteric inhibitor crystal mol structure design, antitumor multiple sclerosis enzyme inhibitor design phenothiazine derivative prepare, enantiomer resolution phenothiazine malt1 paracaspase allosteric inhibitor mol docking, cancer, inhibitors, medicinal chemistry, multiple sclerosis, thioridazine and other aspects.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 2, 2011, Curti, Claudio; Battistini, Lucia; Sartori, Andrea; Lodola, Alessio; Mor, Marco; Rassu, Gloria; Pelosi, Giorgio; Zanardi, Franca; Casiraghi, Giovanni published an article.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate The title of the article was Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan-Based Silyl Enolates. And the article contained the following:

Vinyl, butadienyl, and hexatrienyl siloxyfurans such as I (TBS = tert-butyldimethylsilyl) are prepared; in the presence of silicon tetrachloride and nonracemic bis(dinaphthodiazaphosphepine) II, I undergo regioselective, stereoselective, and enantioselective vinylogous Mukaiyama aldol addition reactions with aryl aldehydes to yield nonracemic hydroxyalkylidenefuranones such as III in 42-92% yields, in 55:45->95:5 olefin stereoselectivities, and in 89:11->99:1 er. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

The Article related to vinyl butadienyl hexatrienyl siloxyfuran preparation regioselective stereoselective aldol addition, hydroxyalkylidenefuranone regioselective stereoselective preparation, silicon chloride dinaphthodiazaphosphepine catalyst regioselective enantioselective hypervinylogous aldol addition, vinylogous mukaiyama aldol addition vinyl siloxyfuran aryl aldehyde and other aspects.Reference of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On January 1, 2010, Gonzalez, Ana Z.; Toste, F. Dean published an article.Recommanded Product: 14602-86-9 The title of the article was Gold(I)-Catalyzed Enantioselective [4+2]-Cycloaddition of Allene-dienes. And the article contained the following:

An enantioselective gold(I)-catalyzed intramol. [4+2]-cycloaddition of allenes and dienes is reported. The reactions allow for the asym. synthesis of trans-hexahydroindenes and pyrrolidine products using C3-sym. phosphitegold(I) and ortho-arylphosphoramiditegold(I) complexes as catalysts, resp. The x-ray crystal structures of two phosphoramiditegold(I) complexes and two C3-sym. phosphitegold(I) complexes are reported. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).Recommanded Product: 14602-86-9

The Article related to phosphite gold axially chiral catalyst preparation crystal mol structure, phosphoramidite gold axially chiral catalyst preparation crystal mol structure, allene diene substrate preparation chiral gold catalyst intramol cycloaddition, hexahydroindene derivative stereoselective preparation, pyrrolidine fused derivative stereoselective preparation and other aspects.Recommanded Product: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On April 16, 2021, Xu, Changming; Qi, Yinsheng; Yang, Xinshuang; Li, Xiangfan; Li, Zhenpeng; Bai, Lei published an article.HPLC of Formula: 14602-86-9 The title of the article was Development of C2-Symmetric Chiral Spirocyclic Phase-Transfer Catalysts: Synthesis and Application to Asymmetric Alkylation of Glycinate Schiff Base. And the article contained the following:

A class of C2-sym. chiral spirocyclic phase-transfer catalysts based on the tetramethyl-1,1′-spirobiindane scaffold such as I·Br- was synthesized from com. available bisphenol A in 12 steps in 22-25% total yields; the scaffold features a more rigid and stable backbone and smaller dihedral angles and can be easily modified. These catalysts show high catalytic performance in the asym. alkylation of tert-Bu glycinate Schiff base Ph2C:NCH2CO2t-Bu at only 2 mol % catalyst loading, giving nonracemic protected α-amino acid esters such as (R)-Ph2C:NCH(CH2Ph)CO2t-Bu in up to 92% yield and 98% ee. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).HPLC of Formula: 14602-86-9

The Article related to spirobiindanoazocinium nonracemic preparation catalyst enantioselective phase transfer alkylation, diphenylmethyleneamino ester enantioselective preparation, nonracemic spirobiindanoazocinium bromide enantioselective phase transfer alkylation catalyst, alkyl bromide enantioselective alkylation diphenylmethyleneamino ester spirobiindanoazocinium catalyst and other aspects.HPLC of Formula: 14602-86-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics