Application of 14793-00-1,Some common heterocyclic compound, 14793-00-1, name is 6-Chloro-2-methylimidazo[1,2-b]pyridazine, molecular formula is C7H6ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of 3-bromo-6-chloro-2-methylimidazo[1,2-b]pyridazine To a solution of 6-chloro-2-methylimidazo[1,2-b]pyridazine (2.00 g, 11.9 mmol, 1.0 equiv) in chloroform (50 mL) was added N-bromosuccinimide (2.55 g, 14.3 mmol, 1.2 equiv). The reaction was stirred at room temperature for 15 h. Purification by column chromatography using 50% ethyl acetate in hexanes elution gave 2.64 g of the yellow solid, 90%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Chloro-2-methylimidazo[1,2-b]pyridazine, its application will become more common.
Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
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