Category: 14862-52-3

Electric Literature of 14862-52-3, The chemical industry reduces the impact on the environment during synthesis 14862-52-3, name is 3,5-Dibromochlorobenzene, I believe this compound will play a more active role in future production and life.

A solution of 1,3-dibromo-5-chlorobenzene (10 mmol, 3.2 g)Diphenylamine (40 mmol, 6.7 g) was added to a 100 mL three-necked flask,A cuprous iodide (4 mmol, 0.8 g) was added under nitrogen,Potassium carbonate (40 mmol, 2.8 g),Phenanthroline (4 mmol, 0.8 g),50 mL of DMF,The reaction was carried out at 155 C for 3 days,The resulting reaction product is subjected to extraction,The extracted organic phase was evaporated to dryness with ethanol,And then recrystallized from ethyl acetate and petroleum ether to give 3.57 g of intermediate A-4,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromochlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jilin Aolai De Optoelectronic Materials Co., Ltd.; Gao, Chunji; Cui, Dunzhu; Sun, Yi; Zhang, Chengcheng; (52 pag.)CN104892434; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 14862-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14862-52-3 name is 3,5-Dibromochlorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of compound (1-1) Intermediate (A-1): Synthesis of N^N’.N’-Tetrakis-biphenyl^-yl-S- chloro-benzene-1,3-diamine Tri-ieri-butylphosphine (11.1 mL of a 1.0 M solution in toluene, 11.1 mmol), palladium acetate (1.25 g, 5.55 mmol) and cesium carbonate (75.0 g, 232 mmol) are added to a solution of bis-biphenyl-4-yl-amine (CAS Nr. 102113- 98-4) (59.0 g, 185 mmol) and ,3-Dibromo-5-chloro-benzene (25 g, 92 mol) in degassed toluene (600 ml), and the mixture is heated under reflux for 2 h. The reaction mixture is cooled to room temperature, extended with toluene and filtered through Celite. The filtrate is evaporated in vacuo, and the residue is crystallised from heptane/toluene. Yield: 67.7g, 75%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromochlorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; MERCK PATENT GMBH; MUJICA-FERNAUD, Teresa; MONTENEGRO, Elvira; PFISTER, Jochen; (103 pag.)WO2016/78738; (2016); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 14862-52-3, The chemical industry reduces the impact on the environment during synthesis 14862-52-3, name is 3,5-Dibromochlorobenzene, I believe this compound will play a more active role in future production and life.

3,5-dibromochlorobenzene (2.7 g, 10 mmol)9-phenylcarbazole-3-boronic acid (6.0 g, 21 mmol)Sodium carbonate (10.2 g, 96 mmol),Pd2 (dba) 3 (0.4 g, 0.4 mmol), toluene,Ethanol, water 50ml in turn added to the reaction bottle,The reaction was refluxed under nitrogen for 10 hours, cooled to room temperature,The aqueous layer was extracted with ethyl acetate,The organic layers were combined, washed with saturated brine and water, respectively,The organic layer was dried over magnesium sulfate, filtered,Filtrate spin dry, over silicone column,4.4 g of product was obtained, HPLC purity 99.2%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromochlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Yu Kaichao; Zhang Zhaochao; Wang Lichun; (35 pag.)CN107056806; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, Formula: C6H3Br2Cl

General procedure: Typically, TDPP (200 mg, 0.27 mmol), dibromobenzene derivatives 0.11 mmol, anhydrous Cs2CO3(200 mg, 0.61 mmol), PivOH (7.9 mg, 0.08 mmol), Pd2(dba)3 (4.00 mg, 1.5 mol%), tris(o-methoxyphenyl)phosphine (3.08 mg, 3 mol%) were successively added into a Schlenk tube. The tube was purged by three repetitions of vacuum and argon filling. Then, 5 mL anhydrous toluene was added via syringe.The reaction solution was deoxygenated using three freeze-vacuum-thaw cycles, and then rigorouslystirred at 100 C for 24 h under argon atmosphere. Removal of the toluene by rotary evaporatoraorded the crude product, which was then purified by chromatogragh column (CC) on silica gelusing a mixture of CH2Cl2 and hexane as eluent, giving the target molecules Ms1~9.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Liu, Hui; Zhang, Xiao-Feng; Cheng, Jing-Zhao; Zhong, Ai-Guo; Wen, He-Rui; Liu, Shi-Yong; Molecules; vol. 24; 9; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 14862-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14862-52-3 name is 3,5-Dibromochlorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of compound 7-1 After dissolving 1,3-dibromo-5-chlorobenzene (20 g, 73.98 mmol), phenyl boronic acid (22 g, 177.55 mmol), and Pd(PPh3)4(4.3 g, 3.699 mmol) in a mixture solvent of 2 M K3PO4aqueous solution 100 mL, toluene 400 mL, and 1,4-dioxane 100 mL in a flask, the mixture was stirred under reflux at 120C for 5 hours. After completing the reaction, an organic layer was extracted with ethyl acetate, and the remaining moisture was removed using magnesium sulfate. The residue was dried and separated with column chromatography to obtain compound 7-1 (23 g, 70%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromochlorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; KANG, Hee-Ryong; KANG, Hyun-Ju; HONG, Jin-Ri; MOON, Doo-Hyeon; LIM, Young-Mook; KIM, Bitnari; KIM, Nam-Kyun; WO2015/178731; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 14862-52-3, name is 3,5-Dibromochlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3,5-Dibromochlorobenzene

Compound 1 (30 g, 100 mmol) was dissolved in anhydrous i-Pr2O (300.0 mL) in a dried flask under nitrogen. The reaction mixture was cooled to -78 C and stirred under nitrogen atmosphere. A 2.5 M solution of n-BuLi in hexanes (40 mL, 100 mmol) was added dropwise to the above solution and the reaction mixture was stirred at -78 C for 30 min after complete addition of n-BuLi. N-methoxy-N-methylacetamide (12 g, 120.0 mmol) was added to the above reaction mixture, while keeping the reaction mixture below -78 C. After addition of N-methoxy-N-methylacetamide was completed, the reaction mixture was warmed slowly to room temperature for 30 min. The reaction mixture was poured into 40 mL of aqueous NH4Cl and the reaction mixture was stirred for 15 min. The organic phase was separated, dried over anhydrous MgSO4, filtered and evaporated in vacuo to give the compound 2 (25 g, crude) as a pale yellow viscous liquid.

The synthetic route of 3,5-Dibromochlorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SAINT LOUIS UNIVERSITY; RUMINSKI, Peter; GRIGGS, David; WO2014/15054; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14862-52-3, name is 3,5-Dibromochlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: chlorides-buliding-blocks

General procedure: A mixture of 1,3-dibromo-5-chlorobenzene (2 g, 7.41 mmol), 9Hcarbazole(2.60 g, 15.56 mmol), tris(dibenzylideneacetone)dipalladium(339 mg, 0.37 mmol), 2-dicyclohexylphosphino-2?,6?-dimethoxy-1,1?-biphenyl (457 mg, 1.11 mmol) and sodium tert-butoxide (2.85 g,29.64 mmol) in 100 ml of toluene were heated at 80 C for 4 h underargon. After cooling down to room temperature, the mixture was extractedwith dichloromethane. The combined organic extracts weredried over Na2SO4 and evaporated under reduced pressure. The crudeproduct was purified by column chromatography on silica gel usingpetroleum ether/dichloromethane (PE/DCM, 8/1, v/v) as the eluent toafford the target compound (2.46 g, 75%).

The synthetic route of 14862-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ran, Quan; Zhang, Yuan-Lan; Hua, Xiaochen; Fung, Man-Keung; Liao, Liang-Sheng; Fan, Jian; Dyes and Pigments; vol. 162; (2019); p. 632 – 639;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14862-52-3 as follows. Quality Control of 3,5-Dibromochlorobenzene

Under an argon atmosphere, 1,3-dibromo-5-chlorobenzene (2.70 g, 10.0 mmol) was dissolved in THF (38 mL). The mixture was cooled to -15 C., a THF solution (0.86 M, 12.3 mL, 10.5 mmol) of isopropyl magnesium chloride / lithium chloride complex was added, and the temperature was raised to 0 C. over 3 hours. Cyanuric chloride (5.53 g, 30.0 mmol) was added to the reaction mixture at the same temperature, then the temperature was raised to room temperature and stirred for 24 hours. Saturated ammonium chloride aqueous solution was added to the reaction mixture to stop the reaction, and then ethyl acetate was added. The organic layer was separated and the aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, washed with water and dried over sodium sulfate.After filtering off the solid, the low-boiling fraction was removed under reduced pressure and the resulting residue was dried under vacuum to give crude product (6.74 g). The obtained crude product (6.6 g) was heated to 40 C. for 4 hours under reduced pressure (8 Pa), then heated to 50 C. and heated for 12 hours. After cooling to room temperature, purification by silica gel chromatography (eluent: hexane / ethyl acetate) gave the desired 2- (3-bromo-5-chlorophenyl) -4,6- dichloro-1,3,5- Triazine (82%, 2.80 g, 8.2 mmol).

According to the analysis of related databases, 14862-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; AIHARA, HIDENORI; SHONO, TOMOHIRO; (35 pag.)JP2017/160145; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 14862-52-3, A common heterocyclic compound, 14862-52-3, name is 3,5-Dibromochlorobenzene, molecular formula is C6H3Br2Cl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3 -Bromo-5 -chlorophenvDmethylformamide l,3-Dibromo-5-chlorobenzene (1.0 g, 3.7 mmol), N-methylformamide (0.26 mL, 4.4 mmol), CuI (35 mg, 0.02 mmol), N,N’-dimethyl ethylenediamine (0.04 mL, 0.37 mmol) and K2CO3 (1.02 g, 7.4 mmol) in 1,4-dioxane (4 mL) were heated to 110 0C in a sealed tube for 20 h. The blue slurry was diluted with EtOAc (10 mL) and filtered through a short silica plug that was washed with several portions of EtOAc. The solvent was removed by evaporation and the resulting yellow oil was purified by flash chromatography using 70 g silica and a gradient of 0%EtOAc to 50%EtO Ac/Heptane. The subtitle compound was obtained as a colourless solid (385 mg, 41%).1H-NMR (CDCl3): delta 8.52 (IH, s), 7.43 (IH, t), 7.24 (IH, t), 7.13 (IH, t), 3.30 (3H, s); GC-MS m/z: 247/249/251 [M+].

The synthetic route of 14862-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7747; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, Computed Properties of C6H3Br2Cl

In a 200 mL three-neck flask, a mixture of 5.0 g (19 mmol) of 1,3-dibromo-5-chlorobenzene, 6.5 g (39 mmol) of carbazole, 370 mg (1.9 mmol) of copper iodide, 510 mg (1.94 mmol) of 18-crown-6-ether, 8.9 g (47 mmol) of potassium carbonate, and 20 mL of 1,3-dimethyl-3,4,5,6-tetrahydro-2-(1H)pyrimidinone was deaerated while being stirred under reduced pressure and then heated and stirred at 170 C. in a nitrogen atmosphere for 11 hours to cause a reaction. After the reaction, this reaction mixture was washed with water, and an organic layer and an aqueous layer were separated. Then, magnesium sulfate was added to the organic layer to remove moisture. This suspension was filtered to obtain a filtrate. The obtained filtrate was concentrated and purified by silica gel column chromatography. A mixed solvent of toluene and hexane (toluene: hexane=1:5) was used as a developing solvent for the chromatography. The Rf value of the substance that was the object of the synthesis was 0.35, which was obtained by silica gel thin layer chromatography (TLC) (with a developing solvent containing ethyl acetate and hexane in a 10:1 ratio). The obtained fraction was concentrated, and hexane was added thereto. The mixture was irradiated with ultrasonic waves and then recrystallized to give 6.6 g of white powder that was the object of the synthesis in a yield of 80%. A scheme of the synthesis of Step 1 is shown in (a-1). The compound obtained in Step 1 was subjected to a nuclear magnetic resonance (NMR) measurement. The measurement data are as follows: 1H NMR (CDCl3, 300 MHz): delta(ppm)=7.31-7.64 (m, 12H), 7.71-7.72 (m, 1H), 7.75-7.76 (m, 1H), 7.84-7.85 (m, 1H), 8.15(d, J=7.8 Hz, 4H). are 1H NMR charts. Note that is a chart where the range of from 7.00 ppm to 8.50 ppm in is enlarged. The above results reveal that 9-[3-(9H-carbazol-9-yl)-5-chloro]phenyl-9H-carbazole (abbreviation: mCP-Cl) that was the object of the synthesis was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromochlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; TAKASU, Takako; OHSAWA, Nobuharu; US2013/75705; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics