Category: 14862-52-3

Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, HPLC of Formula: C6H3Br2Cl

14 g of compound 2-1 (35 mmol), 10 g of 1,3-dibromo-5-chlorobenzene (39 mmol), 2.2 g of copper powder (35 mmol), 14 g of potassium carbonate (106 mmol), and 180 mL of nitrobenzene were introduced into a flask, and the mixture was refluxed for 12 hours. After completion of the reaction, an organic layer was extracted with methylene chloride, and the remaining moisture was removed by using magnesium sulfate. The resulting product was then dried, and separated by column chromatography to obtain5.3 g of compound 2-2 (yield: 30%).

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Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; JUN, Ji-Song; YANG, Jeong-Eun; (45 pag.)WO2017/188672; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 14862-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14862-52-3 as follows.

1,3-dibromo-5-chlorobenzene (100 g, 370 mmol) was dissolved in THF (2 L) in a nitrogen environment, phenylboronic acid (47.3 g, 388 mmol) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (1.5 g, 1.36 mmol) were added thereto, and the mixture was stirred. Potassium carbonate (K2CO3) (127 g, 925 mmol) saturated in water was added thereto, and the resulting mixture was heated and refluxed at 80 C. for 12 hours. When the reaction was complete, water was added to the reaction solution, the mixture was extracted with dichloromethane (DCM), and an extract therefrom was filtered and concentrated under a reduced pressure after removing moisture with anhydrous MgSO4. The obtained residue was separated and purified through flash column chromatography to obtain an intermediate I-6 (49 g, 50%). HRMS (70 eV, EI+): m/z calcd for C12H8BrCl: 265.9498, found 266 Elemental Analysis: C, 54%; H, 3%

According to the analysis of related databases, 14862-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SAMSUNG SDI CO., LTD.; KANG, Giwook; KIM, Younhwan; KIM, Youngkwon; KIM, Dongyeong; KIM, Hun; OH, Jaejin; CHO, Pyeongseok; YU, Eun Sun; (176 pag.)US2017/92873; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 14862-52-3,Some common heterocyclic compound, 14862-52-3, name is 3,5-Dibromochlorobenzene, molecular formula is C6H3Br2Cl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Synthesis Example 4: Synthesis of Intermediate I-4 (0144) (0145) Intermediate I-3 (50 g, 98 mmol) was dissolved in THF (1 L) under a nitrogen environment, 1-bromo-3-iodobenzene (33 g, 117 mmol, Sigma Aldrich Co., Ltd.) and tetrakis(triphenylphosphine)palladium (1 g, 0.98 mmol) were added thereto, and the mixture was stirred. Potassium carbonate saturated in water (34 g, 245 mmol) was added thereto, and the obtained mixture was heated and refluxed at 80 C. for 12 hours. When the reaction was complete, water was added to the reaction solution, and the mixture was extracted with dichloromethane (DCM), filtered after removing moisture with anhydrous MgSO4, and concentrated under a reduced pressure. This obtained residue was separated and purified through column chromatography to obtain Intermediate I-4 (50 g and 95%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromochlorobenzene, its application will become more common.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JUNG, Ho-Kuk; OH, Jae-Jin; RYU, Dong-Wan; HAN, Su-Jin; KANG, Gi-Wook; KANG, Eui-Su; KIM, Youn-Hwan; KIM, Hun; PARK, Jae-Han; YANG, Yong-Tak; YU, Eun-Sun; LEE, Han-ILL; JEONG, Woo-Seok; (124 pag.)US2017/222158; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14862-52-3, name is 3,5-Dibromochlorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 14862-52-3

In the round bottom flask was charged with 1,3-dibromo-5-chlorobenzene 25g (92.47mmol) and biphenyl-4-yl-phenyl amine 45.4g (184.9mmol) into a sodium t- butoxide 26.7g (277.41mmol) was added to 463ml toluene dissolved. Here Pd (dba)2 0.266g (0.462mmol) and tri-tert-butylphosphine was put 0.187g (0.924mmol) in turn and the mixture was stirred under reflux for 4 hours under a nitrogen atmosphere. After the reaction the organic layer was then extracted with ethyl acetate dry distilled over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. Silica gel with: a product n- hexane / dichloromethane (2 volume ratio of 8) The desired compound was purified by column chromatography of the intermediate M-12 to give the 44.9g (81% yield) as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Chei Industries Inc.; Ryu, Dong Wan; Heo, Dal Ho; Jung, Seong Hyeon; Hong, Jin Seok; Kim, Jun Seok; Yoo, Dong Kyu; Lee, Seung Jae; Lee, Han Il; Chang, Yu Na; Cho, Yeong Kyeong; Chae, Mi Yeong; (44 pag.)KR2016/8651; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14862-52-3, name is 3,5-Dibromochlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: chlorides-buliding-blocks

Compound (M-3) (270 g, 1.0 mol, 1.0 eq) was added to a 5 L four-necked round bottom flask under nitrogen protection.Compound (N-12) (238g, 1.0mol, 1.0eq) and 2500mL of toluene, then add sodium carbonate (212g, 2.0mol, 2.0eq) and purified water (360g, 20mol, 20eq), nitrogen purge for 30mins, then Tetrakis (triphenylphosphine) palladium (11.5g, 0.01mol, 0.01eq), heated to 110 C for 15h,The reaction was monitored by HPLC for completion. Filtered with diatomaceous earth, washed the organic phase with 2000 mL of saturated brine, and dried over anhydrous sodium sulfate. Distilled to 400 mL under reduced pressure, and 2000 mL of ethanol was added dropwise to precipitate most of the solid, filtered,Drying under vacuum gave 257 g of the target compound (D-12) as an off-white solid.Yield: 67%.

The synthetic route of 14862-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ningbo Lumilan New Materials Co., Ltd.; Ningbo Dinghao Optoelectric Materials Technology Co., Ltd.; Zhang Yuxiang; Zhang Qingyun; Ding Huanda; Chen Zhikuan; (41 pag.)CN110551154; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 14862-52-3, The chemical industry reduces the impact on the environment during synthesis 14862-52-3, name is 3,5-Dibromochlorobenzene, I believe this compound will play a more active role in future production and life.

(3-cyanophenyl)boronic acid (25.0 g, 0.17 mol) and 1,3-dibromo-5-chlorobenzene (23.0 g, 0.08 mol),(triphenylphosphine)palladium (3.94 g, 0.34 mmol) was added thereto, followed by heating and stirring for 13 hours. The temperature was lowered to room temperature, the water layer was separated and removed, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, recrystallized using chloroform and ethanol, and dried to prepare an intermediate f (44.7 g, 83% yield, MS:[M+H]+=315).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromochlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Cho Seong-mi; Jeong Min-u; Lee Dong-hun; Park Tae-yun; Moon Jeong-uk; Chae Mi-yeong; (39 pag.)KR2018/32519; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H3Br2Cl

Intermediate 1-2 (2.8 g, 0.010 mol) was added intermediate 1-3 (4.2 g, 0.011 mol),Pd (dba) 2 (0.5 g, 0.0005 mol), 100 mL of Toluene was added to sodium-tert-butoxide (1.9 g, 0.020 mol), and the mixture was reacted at 95 C. for 4 hours with stirring.After completion of the reaction, the mixture was separated into H 2 O: MC and purified by column (N-HEXANE: MC) to obtain 3.6 g (yield: 62%) of Intermediate 1-4. To 1,3-dibromo-5-chlorobenzene (2.7 g, 0.010 mol) was addedN-phenylbiphenyl-4-amine (5.4 g, 0.022 mol) was added to the reaction mixture to obtain 4.4 g (yield 73%) of Intermediate 7-1.

The synthetic route of 14862-52-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; P&H Tech Co.,Ltd; Hyun, Sao Yong; Jung, Sung Wook; Kim, Ha Yeon; (48 pag.)KR2016/79514; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics