Category: 150444-93-2

Elrod, Lee Jr.; Spanton, Stephen G.; Cirovic, Mike; Shaffer, Dean I.; Golich, Timothy G.; Linton, Cathie L.; Vievia, Douglas R.; Kalaritis, Panos; Schmand, Horst published their research in Analytica Chimica Acta on August 2 ,1993. The article was titled 《Determination of 2-chloro-4,5-difluorobenzoic acid and related impurities by liquid chromatography》.Reference of 2-Chloro-3,4-difluorobenzoic acid The article contains the following contents:

2-Chloro-4,5-difluorobenzoic acid (CDFBA) and related impurities are determined using liquid chromatog. (LC). Separations are achieved using a reversed-phase isocratic system with an ion-pair reagent (tetrabutylammonium hydroxide). Unique isomeric impurities observed in com. produced CDFBA were isolated and identified by NMR and single crystal x-ray diffraction. The method has relative standard deviations of ±0.55% to ±1.26% for the CDFBA determination and from ±4.3% to ±12% for impurities below 0.3% in CDFBA. Impurities are determinable to at least 0.03% by weight The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2Reference of 2-Chloro-3,4-difluorobenzoic acid)

2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties.Reference of 2-Chloro-3,4-difluorobenzoic acid Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hameed, Shehryar; Kanwal; Seraj, Faiza; Rafique, Rafaila; Chigurupati, Sridevi; Wadood, Abdul; Rehman, Ashfaq Ur; Venugopal, Vijayan; Salar, Uzma; Taha, Muhammad; Khan, Khalid Mohammed published their research in European Journal of Medicinal Chemistry on December 1 ,2019. The article was titled 《Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in-vitro: Structure-activity relationship, molecular docking and kinetic studies》.Quality Control of 2-Chloro-3,4-difluorobenzoic acid The article contains the following contents:

Benzotriazoles were synthesized which were further reacted with different substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives I [R1 = R2 = H, Me, Cl; R3 = H, 4-Br, 3-Me-4-NO2, etc.] and II [R4 = R5 = H, Me, Cl; R6 = H, 2-OH, 4-Ph, etc.]. The synthetic compounds I and II were characterized via different spectroscopic techniques including EI-MS, HREI-MS, 1H- and 13C-NMR. These mols. were examined for their anti-hyperglycemic potential hence were evaluated for α-glucosidase and α-amylase inhibitory activities. All benzotriazoles displayed moderate to good inhibitory activity in the range of IC50 values of 2.00-5.6 and 2.04-5.72 μM against α-glucosidase and α-amylase enzymes, resp. The synthetic compounds were divided into two categories “”A”” and “”B””, in order to understand the structure-activity relationship. Compounds II [R4 = R5 = H; R6 = 4-Cl] (IC50 = 2.41 ± 1.31 μM), (IC50 = 2.5 ± 1.21 μM), II [R4 = R5 = Me; R6 = 3,4-di-Cl] (IC50 = 2.12 ± 1.35 μM), (IC50 = 2.21 ± 1.08 μM) and II [R4 = R5 = Me; R6 = 4-Cl] (IC50 = 2.00 ± 1.22 μM), (IC50 = 2.04 ± 1.4 μM) with chloro substitution/s at aryl ring were found to be most active against α-glucosidase and α-amylase enzymes. Mol. docking studies on all compounds were performed which revealed that chloro substitutions were playing a pivotal role in the binding interactions. The enzyme inhibition mode was also studied and the kinetic studies revealed that the synthetic mols. showed competitive mode of inhibition against α-amylase and non-competitive mode of inhibition against α-glucosidase enzyme. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2Quality Control of 2-Chloro-3,4-difluorobenzoic acid)

2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. Quality Control of 2-Chloro-3,4-difluorobenzoic acid The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

HPLC of Formula: 150444-93-2On May 21, 1995 ,《Directed lithiation of unprotected benzoic acids》 appeared in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. The author of the article were Bennetau, Bernard; Mortier, Jacques; Moyroud, Joeel; Guesnet, Jean-Luc. The article conveys some information:

Benzoic acid gives the ortho-lithiated species (2-carboxyphenyl)lithium (lithium salt) under standard conditions. Reaction of (2-carboxyphenyl)lithium (lithium salt) at -78 °C with either Me iodide, di-Me disulfide, hexachloroethane, or 1,2-dibromotetrachloroethane gives the ortho-substituted product. Intramol. competition between the carboxylic acid and methoxy, chloro, fluoro, or diethylamino functions in ortho- and para-substituted benzoic acids establishes the carboxylic acid group to be of intermediate capacity in directing metalation. Complimentarity of directing effects is observed with the chloro and fluoro groups in the meta-substituted benzoic acids but not with the methoxy and trifluoromethyl groups. Electrophile introduction into meta- and para-lithiated benzoates occurs with equal efficacy and comparable scope. The 2,4-dihalobenzoic acids undergo hydrogen/metal exchange at the position flanked by both halogen substituents. 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid undergoes lithiation adjacent to the oxygen atom. By use of such methods, routes to benzoic acids contiguously tri- and tetra-substituted with a variety of functionalities have been developed. The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2HPLC of Formula: 150444-93-2)

2-Chloro-3,4-difluorobenzoic acid(cas: 150444-93-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. HPLC of Formula: 150444-93-2 Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics