Application of 1513-25-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1513-25-3, name is 2-Chloro-1-fluoro-4-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of (lR,2^-l-(4-fluoro-2-methoxyphenyl)-2-((4- methoxybenzyl)oxy)propan-l-ol (190 mg, 0.593 mmol) in anhydrous DMSO (2.97 mL) was added NaH (29.7 mg, 0.741 mmol, 60 wt % in mineral oil). After stirring for 10 min, 2-chloro-l-fluoro-4- methylbenzene (686 mg, 4.74 mmol) was added, and the reaction mixture was heated to 60 C for 15 h. The reaction was quenched by slow addition of H20. The mixture was extracted Et20 (3 x 50 mL) and the combined organic layers were dried by passing through a phase separator. Volatiles were removed under a gentle stream of N2 and the resulting residue was purified via flash column chromatography (Si02, 0- 30% acetone in hexanes) to afford the title compound (217 mg, 82%) as a colorless oil: 1H NMR (400 MHz, CDC13) delta 7.34 (dd, J = 9.2, 6.8 Hz, 1H), 7.19 (d, J = 8.7 Hz, 2H), 7.14 (d, J = 1.7 Hz, 1H), 6.85 – 6.77 (m, 3H), 6.62 – 6.55 (m, 3H), 5.63 (d, J = 3.8 Hz, 1H), 4.63 (d, J = 11.9 Hz, 1H), 4.57 (d, J = 11.9 Hz, 1H), 3.89 (qd, J = 6.4, 3.9 Hz, 1H), 3.83 (s, 3H), 3.79 (s, 3H), 2.19 (s, 3H), 1.25 (d, J = 6.4 Hz, 3H); 19F NMR (376 MHz, CDC13) delta -112.06 (s); ESIMS m/z 467 ([M+Na]+).
The chemical industry reduces the impact on the environment during synthesis 2-Chloro-1-fluoro-4-methylbenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; DOW AGROSCIENCES LLC; BUCHAN, Zachary; DEKORVER, Kyle A.; JONES, David M.; HERRICK, Jessica; WILMOT, Jeremy; RIGOLI, Jared; LOY, Brian; LU, Yu; MEYER, Kevin G.; YAO, Chenglin; (308 pag.)WO2016/109305; (2016); A1;,
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