Category: 15258-72-7

On March 30, 1967, Hackmann, Johannes T.; Yates, John; Willcox, Trevor J.; Haken, Pieter T.; Wood, Derek Alexander published a patent.Recommanded Product: 15258-72-7 The title of the patent was 2,6-Dichlorobenzal chloride, 2,6-dichlorobenzyl chloride. And the patent contained the following:

2-Nitro-6-chlorotoluene (I) is treated with Cl at 160-85° and the H2O formed removed continuously to give the title compounds Thus, 500 g. I is heated and Cl is introduced into the molten mass. The aqueous phase containing HCl and HNO3 is removed continuously. At a reaction temperature of 180°, Cl introduction of 0.17 mole/hr./mole I, and 35 hrs. reaction time, 62% 2,6-dichlorobenzal chloride and 15% 2,6-dichlorobenzyl chloride are obtained. The experimental process involved the reaction of 1-Chloro-2-(chloromethyl)-3-nitrobenzene(cas: 15258-72-7).Recommanded Product: 15258-72-7

1-Chloro-2-(chloromethyl)-3-nitrobenzene(cas:15258-72-7) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Recommanded Product: 15258-72-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On December 31, 1996, Peng, Xioojun; Pan, Shiwei; Zhou, Zhuohua published an article.SDS of cas: 15258-72-7 The title of the article was GC/MS study of synthesis of α,α,2,6-tetrachlorotoluene. And the article contained the following:

The chlorination mechanism of 2-chloro-6-nitrotoluene (A) to α,α,2,,6-tetrachlorotoluene (D) has been studied by CM/MS. It is found that Cl attacks α-H of A at first with the formation of an intermediate, α,2-dichloro-6-nitro-toluene (B) which turns subsequently to α,2,6-trichlorotoluene (C) through denitrochlorination. C is then chlorinated on α-H and forms D. The experimental process involved the reaction of 1-Chloro-2-(chloromethyl)-3-nitrobenzene(cas: 15258-72-7).SDS of cas: 15258-72-7

The Article related to chlorotoluene preparation, toluene tetrachloro preparation, chloronitrotoluene chlorination gc ms, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.SDS of cas: 15258-72-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 4, 2007, Urban, Andreas; Brohm, Dirk; Birkmann, Alexander; Schohe-Loop, Rudolf; Koletzki, Diana; Harrenga, Axel; Stoll, Friederike; Mundt, Stefan; Paulsen, Daniela published a patent.HPLC of Formula: 15258-72-7 The title of the patent was Substituted N-benzyl-N-phenylbenzenesulfonamides as antiviral agents, their preparation, pharmaceutical compositions, and use in therapy. And the patent contained the following:

The invention relates to substituted N-benzyl-N-phenylbenzenesulfonamides of formula I, which are antiviral agents. In compounds I, R1 is OH or NR9R10, where R9 and R10 are independently selected from H, C1-6 alkyl, (un)substituted benzyl, (un)substituted phenethyl, and C3-6 cycloalkyl; R2 is H, halo, cyano, OH, NH2, CF3, CF3O, (un)substituted C1-4 alkyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylamino, or 5- to 7-membered heterocyclylamino, or R1R2 is -OCH2-; and R3 is H, halo, cyano, OH, NH2, CF3, CF3O, (un)substituted C1-4 alkyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylamino, or (un)substituted 5- to 7-membered heterocyclylamino. Further, in compounds I, R4 is halo, cyano, Me, Et, or cyclopropyl; R5 is selected from H, (un)substituted C1-4 alkyl, (un)substituted C2-4 alkenyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, (un)substituted C1-4 alkylamino, and (un)substituted 5- to 10-membered heteroaryl-Y-CH2, where Y is -O-, -S-, or -N(R11)-, and R11 is H, C1-4 alkyl, or C3-6 cycloalkyl; R6 is halo, cyano, nitro, Me, Et, CF3, CF3O, or 2-cyanovinyl; R7 is selected from H, (un)substituted C1-4 alkyl, (un)substituted C2-4 alkenyl, (un)substituted C1-4 alkoxy, (un)substituted C1-4 alkylthio, and C1-4 alkylamino; and R8 is halo, cyano, nitro, Me, Et, CF3, or CF3O; including salts and solvates thereof. The invention also relates to the preparation of I, pharmaceutical compositions comprising a compound I and a pharmaceutically acceptable adjuvant and optionally comprising an addnl. active ingredient, as well as to the use of the compositions for the treatment of viral infections, especially against hepatitis C viruses. Amidation of 3-chlorobenzenesulfonyl chloride with 6-amino-1,3-dihydroisobenzofuran-1-one followed by N-alkylation with 2,6-dichlorobenzyl bromide resulted in the formation of benzenesulfonamide II. The compounds of the invention are antiviral agents, e.g., compound II expressed an EC50 value of 1 μM and a CC50 value for cytotoxicity of more than 100 μM. The experimental process involved the reaction of 1-Chloro-2-(chloromethyl)-3-nitrobenzene(cas: 15258-72-7).HPLC of Formula: 15258-72-7

The Article related to benzenesulfonamide benzyl phenyl preparation antiviral, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.HPLC of Formula: 15258-72-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics