Category: 157590-59-5

Synthetic Route of 157590-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Intermediate II (300 mg, 0.887 mmol) and triethylamine (500 mg, 5 mmol) in DMF (5 mL) was added HATU (370 mg, 0.97 mmol) at 0 C. After the mixture was stirred for 15 min, 4-chloro-5-(trifluoromethyl)benzene-1,2-diamine (228 mg, 1.09 mmol) in DMF (1 mL) was added to the reaction. The mixture was allowed to warm to room temperature and stirred for 20 hrs. The reaction was diluted with water (50 mL) and the white solid was precipitated. The mixture was filtered and the solid was dried enough under reduced pressure. The solid was dissolved in acetic acid (5 mL) and the mixture was stirred at 85 C. for 5 hrs. Solvent was removed. The residue was purified by silica gel chromatography (eluted with DCM: MeOH=50:120:1) to give the title compound (205 mg, 45%) as a light yellow solid.

The synthetic route of 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BeiGene Ltd.; Zhou, Changyou; Wang, Zhiwei; Zhang, Guoliang; (95 pag.)JP2016/196446; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., Formula: C7H6ClF3N2

318 mg (3 MMOL) BRCN are dissolved in 0.6 ml acetonitrile and treated with 6 ML water. To this solution, 575 mg (2.73 MMOL) 5-CHLORO-6-TRIFLUOROMETHYL- benzene-1, 2-diamine, dissolved in 6 ML METHANOL, are added dropwise within 30 min. After 2 hrs of stirring at room temperature, the reaction mixture is concentrated and the water solution extracted 2X with ethyl acetate. The combined organic phases where RE-EXTRACTED 1x with water. The combined water phases where made alkaline (pH=8) with saturated NAHC03-SOLUTION and extracted 2x with ethyl acetate. The combined organic phases where dried, filtered and evaporated. Yield : 611 MG (95 %) 7, red solid

The synthetic route of 157590-59-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; WO2005/4864; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 157590-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

E. 6-Chloro-7-trifluoromethyl, 4-dihydro-2,3-quinoxalinedione A mixture of 3,4-diamino-6-chlorobenzotrifluoride (185 mg, 0.88 mmol) and oxalic acid dihydrate (117 mg, 0.93 mmol, used as received) in 2N HCl (4 mL) was refluxed at 170-5 C. for 3 h, then cooled to room temperature. The mixture was centrifuged and the liquid layer was removed. The yellow solid was washed twice by cold water (2*2 mL), collected by filtration, and dried at 60 C. with reduced pressure for 2 h, affording 180 mg of crude title compound (77.3%) as a light yellow powder. The crude product was dissolved in 1N NaOH (6 mL) and filtered. The filtrate was acidified to pH=6, affording 138 mg of title compound. It was recrystallized from DMSO/H2 O twice to give 102 mg of pure compound (43.9%) as yellow microcrystals. mp:>360 C. (dec. from 295 C.). IR (KBr, cm-1) 3425, 3200, 1731, 1706, 1625; 1400. 1 H NMR (DMSO-d6): delta7.274 (s, 1H); 7.478 (s, 1H); 12.145 (s, 2H). HRMS: calcd for C9 H4 ClF3 N2 O2 (M+) m/z: 263.9912; found: 263.9919.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California; US5514680; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 157590-59-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157590-59-5 name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: Synthesis of 4-[6-chloro-5-(trifluoromethyl)-lH-l,3-benzodiazol-2- yl]butan-l-ol [0593] 4-chloro-5-(trifluoromethyl)benzene-l,2-diamine (5.00 g, 23.74 mmol) was dissolved in HC1 solution (4 M solution) (18.85 ml) at r.t. and delta-valerolactone (2.62g,26.12 mmol) was added slowly. The reaction was heated to 135 C for 2 hrs then slowly cooled to r.t. The reaction was quenched by the addition of sat. NaHC03 solution (200 ml) to pH 8. The mixture was extracted with EtOAc (3 x 150 ml) and the combined organic layers were dried over Na2S04, filtered and concentrated in vacuo to give the crude product as a brown solid which was triturated with ether (100 ml) to give the pure product (5.88 g,84%): MS (ESI+) for Ci2Hi2ClF3N20 m/z 293.4 [M+H]+; LC purity 90% (ret. time, 1.49 min); 1H NMR (250 MHz, CHLOROFORM-d) delta ppm 1.39 – 1.72 (2 H, m), 1.71 – 1.94 (2H, m), 2.87 (2 H, t, 7=7.61 Hz), 3.58 (2 H, t, 7=6.09 Hz), 7.42 – 7.96 (2H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, and friends who are interested can also refer to it.

Reference:
Patent; EPIZYME, INC.; OLHAVA, Edward James; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; WO2012/75492; (2012); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 157590-59-5, The chemical industry reduces the impact on the environment during synthesis 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, I believe this compound will play a more active role in future production and life.

To a solution of Intermediate II (300 mg, 0.887 mmol) and triethylamine (500 mg, 5 mmol) in DMF (5 mL) was added HATU (370 mg, 0.97 mmol) at 0 C. After the mixture was stirred for 15 min, 4-chloro-5-(trifluoromethyl)benzene-l,2-diamine (228 mg, 1.09 mmol) in DMF (1 mL) was added to the reaction. The mixture was allowed to warm to room temperature and stirred for 20hrs. The reaction was diluted with water (50 mL) and the white solid was precipitated. The mixture was filtered and the solid was dried enough under reduced pressure. The solid was dissolved in acetic acid (5 mL) and the mixture was stirred at 85 C for 5hrs. Solvent was removed. The residue was purified by silica gel chromatography (eluted with DCM:MeOH = 50: 1~ 20: 1) to give the title compound (205 mg, 45%) as a light yellow solid. 1H- NMR (400 MHz, DMSO-ifc) delta 10.48 (s, 1H), 7.96 (d, J = 4.1 Hz, 2H), 7.82 (s, 1H), 7.37 (d, J = 2.6 Hz, 1H), 7.07 (d, J = 8.7 Hz, 1H), 7.01 (dd, J = 8.7, 2.6 Hz, 1H), 6.26 (d, J = 5.8 Hz, 1H), 5.42 (d, J = 5.3 Hz, 1H), 3.57 – 3.51 (m, 1H), 2.93 (t, J = 7.7 Hz, 2H), 2.58 – 2.50 (m, 2H), 1.98 (d, J = 2.1 Hz, 1H) ppm. MS: M/e 513 (M+l)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BEIGENE, LTD.; ZHOU, Changyou; WANG, Shaohui; ZHANG, Guoliang; WO2013/97224; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 157590-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 157590-59-5, name is 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Intermediate II (300 mg, 0.887 mmol) and triethylamine (500 mg, 5 mmol) in DMF (5 mL) was added HATU (370 mg, 0.97 mmol) at 0 C. After the mixture was stirred for 15 min, 4-chloro-5-(trifluoromethyl)benzene-1,2-diamine (228 mg, 1.09 mmol) in DMF (1 mL) was added to the reaction. The mixture was allowed to warm to room temperature and stirred for 20 hrs. The reaction was diluted with water (50 mL) and the white solid was precipitated. The mixture was filtered and the solid was dried enough under reduced pressure. The solid was dissolved in acetic acid (5 mL) and the mixture was stirred at 85 C. for 5 hrs. Solvent was removed. The residue was purified by silica gel chromatography (eluted with DCM: MeOH=50:120:1) to give the title compound (205 mg, 45%) as a light yellow solid.

The synthetic route of 4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BeiGene Ltd.; Zhou, Changyou; Wang, Zhiwei; Zhang, Guoliang; (95 pag.)JP2016/196446; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics