Category: 1592-20-7

Sun, Jingjing; Chen, Yichao; Xu, Jieni; Song, Xiangping; Wan, Zhuoya; Du, Yuqian; Ma, Weina; Li, Xizhen; Zhang, Lin; Li, Song published the artcile< High loading of hydrophobic and hydrophilic agents via small immunostimulatory carrier for enhanced tumor penetration and combinational therapy>, Application of C9H9Cl, the main research area is enhanced tumor penetration combinational therapy small immunostimulatorycarrier hydrophobic hydrophilicagent; T-cell immune response; high loading capacity; patient derived xenograft (PDX); tumor penetration.

Development of small-sized nanoformulations for effective tumor penetration, particularly for those tumors with dense stroma is a major challenge in cancer nanomedicine. It is even more challenging to achieve effective co-loading of both hydrophobic and hydrophilic anticancer agents through a small-sized nanocarrier. In this work, we designed a novel redox-responsive gemcitabine (GEM)-conjugated polymer POEG-co-PVDGEM (PGEM) as a small-sized nanocarrier to co-deliver hydrophilic GEM and hydrophobic paclitaxel (PTX). The in vitro physicochem. and biol. properties of PTX/PGEM NPs were characterized. The efficiency of the PGEM carrier in selective codelivery of GEM and PTX in two murine tumor models as well as a patient derived xenograft model (PDX) was also evaluated. In addition, we investigated the changes in tumor immune microenvironment after treatment with PTX/PGEM nanoparticles. We discovered that GEM conjugation could significantly decrease the nanoparticle size from 160 nm to 13 nm. Moreover, different from most reported GEM-conjugated polymers, PGEM polymer could serve as a prodrug carrier to load a wide variety of hydrophobic agents with high drug loading capacity and excellent stability. More importantly, our strategy could be extended to various nucleotides-based drugs such as azacytidine, decitabine and cytarabine, suggesting a new platform for co-delivery of various first line hydrophilic and hydrophobic anticancer agents. Imaging showed that our small-sized carrier was much more effective in tumor accumulation and penetration compared to the relatively large-sized drug carrier. The PGEM prodrug-based carrier not only well retained the pharmacol. activity of GEM, but also boosted T-cell immune response. Furthermore, delivery of PTX via PGEM led to significantly improved antitumor activity in several murine cancer models and a PDX model of colon cancer. This work not only provided a small-sized carrier platform that was able to load multiple hydrophilic and hydrophobic drugs with high loading capacity, but also provided an effective regimen for enhanced tumor penetration and improved anti-tumor immunity.

Theranostics published new progress about Antitumor agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dunn, Collin A.; Shi, Zhangxing; Zhou, Rongfei; Gin, Douglas L.; Noble, Richard D. published the artcile< (Cross-Linked Poly(Ionic Liquid)-Ionic Liquid-Zeolite) Mixed-Matrix Membranes for CO2/CH4 Gas Separations Based on Curable Ionic Liquid Prepolymers>, Application of C9H9Cl, the main research area is carbon dioxide methane separation ionic liquid polymer zeolite membrane.

A three-component (crosslinked poly(ionic liquid) (PIL)-ionic liquid (IL)-zeolite), mixed-matrix membrane (MMM) platform based on curable IL prepolymers of controlled length has been developed for separating CO2 from CH4. Solutions of these curable prepolymers demonstrate increased resistance to support penetration compared to comparable solutions of analogous cross-linkable IL monomers. By adjusting the curable IL prepolymer chain length, it is possible to manipulate polymer susceptibility to support penetration, polymer solution gelation time, and gas separation performance in MMMs based on these materials. When a 50 wt % solution of the curable IL prepolymer with a d.p. (x) of 87 was cast on an ultrafiltration support membrane, only 3.7 wt % of the polymer penetrated into the support. As the d.p. of the curable IL prepolymer increases, the CO2/CH4 gas separation performance of the resulting MMM performance also improves. For example, an MMM synthesized using 64 wt % curable IL prepolymer (x = 87), 16 wt % [EMIM][Tf2N] as the IL, and 20 wt % SAPO-34 zeolite exhibited a CO2/CH4 selectivity of (42 ± 5) and a CO2 permeability of (47 ± 1) barrers. This CO2/CH4 separation performance is comparable to the previous generation of MMMs based on curable small-mol. IL monomers with the same IL and zeolite. However, this new MMM system also exhibits faster curing gelation times and the ability to be solution-cast onto a porous support for formation of thin-film composite membranes without significant selective layer soak-in.

Industrial & Engineering Chemistry Research published new progress about Gas separation membranes. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Ke; Liu, Qiang; Wen, Shuai; Zhuang, Tao published the artcile< Synthesis of branched polyisobutylenes via cationic copolymerization of p-chloromethylstyrene and isobutylene>, COA of Formula: C9H9Cl, the main research area is branched chloromethylstyrene polyisobutylene cationic copolymerization polydispersity kinetics.

Branched polyisobutylenes (PIBs) with relatively low dispersities (1.4-1.8) and benzylic halide functionalities are synthesized by self-condensing vinyl cationic copolymerization of p-chloromethylstyrene (p-CMS) and isobutylene (IB) coinitiated by TiCl4. It is found that the [IB]/[p-CMS] feed ratio plays a crucial role for the initiating behavior of p-CMS: the initiation arising from p-CMS is suppressed at [IB]/[p-CMS] ≥17; in contrast, the pendant benzyl chloride moiety of p-CMS monomer in the formed copolymer chains can initiate branching reactions. The resulting branched PIBs are of a gradient composition as well as a gradual increase in branching d. due to large disparity in reactivity ratios. This strategy is successfully employed to create branched PIBs with low to moderate mol. weights (Mn, 5 k-78 k Da) through controlling the monomer/initiator mole ratio. However, it is shown that this method failed to obtain branched PIBs with high Mn, bearing a complicated copolymerization mechanism.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Cationic polymerization. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ju, Changha; Kang, Shinwoo; Kim, Taehyung; Park, Chanhyuk; Kang, Hyo published the artcile< Vertical liquid crystal alignment of comb-like alkyl hydroxybenzoate-substituted polystyrene>, Reference of 1592-20-7, the main research area is alkyl hydroxybenzoate polystyrene vertical liquid crystal alignment.

We investigated the liquid crystal (LC) alignment behaviors of Bu hydroxybenzoate-substituted polystyrene (PBHB#; # = 20, 40, 60, 80, and 100, where # indicates the molar fraction of Bu hydroxybenzoate in the side chain), Me hydroxybenzoate-substituted polystyrene (PMHB100), and Et hydroxybenzoate-substituted polystyrene (PEHB100). Generally, LC cells made employing polymer films having longer alkyl groups in the side chain show vertical LC alignment. For instance, a LC cell fabricated with the PMHB100 film showed random planar LC alignment, while the LC cells made from the PEHB100 and PBHB100 films exhibited vertical LC alignment. Moreover, LC cells prepared from a polymer film having a higher molar content of Bu hydroxybenzoate in the side chain exhibited vertical LC alignment. The observed vertical LC alignment behaviors are closely related to the surface energy of these polymer films. For instance, vertical LC alignment was observed when the surface energy of the polymer film was less than ∼43.86 mJ/m2, which could result from the nonpolar alkyl groups of the alkyl hydroxybenzoate moiety. The LC cell prepared from PBHB100 as the LC alignment layer showed good electro-optical characteristics such as voltage holding ratio, residual DC voltage, and alignment stability at 200°C.

Crystals published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Delawder, Abigail O.; Natraj, Anusree; Colley, Nathan D.; Saak, Tiana; Greene, Angelique F.; Barnes, Jonathan C. published the artcile< Synthesis, self-assembly, and photomechanical actuator performance of a sequence-defined polyviologen crosslinker>, Safety of 1-(Chloromethyl)-4-vinylbenzene, the main research area is polyviologen crosslinker photochem reduction.

Although it is well known that viologen radical cations can self-assemble into stacks or complexes on account of radical-radical pairing interactions, it has only recently been demonstrated that reduction of main-chain polyviologens integrated into hydrogel networks can trigger actuation. In these earlier examples, hydrogels comprising oligoethylene glycol-based polyviologens and poly(ethylene glycol) were functionalized with terminal azide groups to prepare ‘click’-based gels. Here, we report a new structural design for the functional polyviologen that consists of main-chain viologen subunits separated by hexamethylene groups instead of glycols and is capped at each end with styrene groups. Activation of this viologen-based macrocrosslinker was achieved using chem.- and photoreduction methods and its ability to undergo intramol. chain-folding was monitored by absorption spectroscopy. Acrylate-based organogels and hydrogels were also prepared and a comparison was carried out to assess the actuator performance in each gel in terms of the rate of contraction and changes in stiffness.

Supramolecular Chemistry published new progress about Actuators. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Safety of 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Takada, Tomoya; Ushiromura, Ryoga; Fushiki, Takuto published the artcile< Fractal dimensional analysis on dispersion/aggregation state of MWCNT in poly(4-chloromethyl)styrene: effect of UV-induced polymer-MWCNT chemical bond formation and its influence on electrical conductivity of their composites>, Reference of 1592-20-7, the main research area is polychloromethyl styrene MWCNT composite chem bond elec conductivity.

The effects of UV-induced chem. bond formation on the dispersion/aggregation state of multi-walled carbon nanotubes (MWCNTs) in poly(4-chloromethyl)styrene/MWCNT composites and their elec. conductivity were examined using transmission electron microscopy (TEM) and fractal dimensional anal. of the TEM images. The composites prepared with UV irradiation exhibited lower elec. conductivity and denser aggregation of the trapped MWCNTs than those observed for unirradiated composites. Fractal dimensional anal. of the TEM images indicated that the difference in the dispersion/aggregation state associated with elec. conductivity could be correlated to the fractal dimension calculated by the box-counting method.

International Journal of Polymer Analysis and Characterization published new progress about Carbon nanotubes (multiwalled). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cazotti, Jaime C.; Fritz, Alexander T.; Garcia-Valdez, Omar; Smeets, Niels M. B.; Dube, Marc A.; Cunningham, Michael F. published the artcile< Graft modification of starch nanoparticles with pH-responsive polymers via nitroxide-mediated polymerization>, Name: 1-(Chloromethyl)-4-vinylbenzene, the main research area is starch nanoparticle graft modification nitroxide polymerization.

These macroalkoxyamines were then grafted to vinyl benzyl-functionalized SNP (SNP-VBC) to obtain pH-responsive materials. The grafting to approach and nitroxide-mediated polymerization (NMP) were used to graft modify starch nanoparticles (SNP) with pH-responsive polymers. SG1-capped poly(2-(dimethylamino)ethyl methacrylate-co-styrene), P(DMAEMA-co-S), and poly(2-(diethylamino)ethyl methacrylate-co-styrene), P(DEAEMA-co-S), with relatively low dispersity and high degree of livingness was synthesized in bulk via NMP using a com. available alkoxyamine. The grafted SNP were characterized by proton NMR spectroscopy, Fourier transform IR spectroscopy, thermogravimetric anal., and elemental anal. confirming the successful synthesis of these new materials. Low grafting efficiencies (∼6%) were observed for both SNP-grafted materials with pH-responsive polymers, as expected when using the grafting to approach. The pH-responsiveness of SNP-g-P(DMAEMA-co-S) and SNP-g-P(DEAEMA-co-S) was confirmed by measuring the ζ-potential at different pH values. At acidic conditions (pH 3-6) the grafted materials were protonated and exhibited pos. ζ-potential, whereas at basic conditions (pH 10-13) the same grafted materials were deprotonated and exhibited neg. ζ-potential.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Emulsions. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Name: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Banerjee, Palash; Jana, Somdeb; Mandal, Tarun K. published the artcile< Coulomb interaction-driven UCST in poly(ionic liquid) random copolymers>, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene, the main research area is Coulomb driven UCST polyionic liquid random copolymer.

Upper critical solution temperature (UCST)-type thermoresponsive phenomena is not very common in conventional hydrophobic or hydrophilic polymers in aqueous solution The incorporation of poly(triphenyl-4-vinylbenzylphosphonium chloride) (P[VBTP][Cl]), poly(ionic liquid) (PIL) segment with either hydrophobic poly(Me methacrylate)(PMMA)/polystyrene (PS) or hydrophilic poly(hydroxyethyl methacrylate)(PHEMA)/poly(N-iso-Pr acrylamide)(PNIPAM) segments via reversible addition-fragmentation chain transfer (RAFT) copolymerization is a simple, yet versatile approach for introducing UCST property in their random copolymers. These PIL copolymers exhibit UCST-type behaviors in aqueous or in methanol solution depending on their compositions in the presence of externally added halide anion (Cl- and I-). The cause of UCST is the formation of copolymer aggregates by anion-bridging Coulomb interactions followed by their disruption upon heating. The cloud points of these copolymers can easily be tuned with respect to the copolymer compositions as well as concentrations of anions. Whereas, the random copolymer of P[VBTP][Cl] and PNIPAM segments with low (ca. 1.1-19.3 wt%) ionic PIL content show lower critical solution temperature (LCST)-type behavior and its cloud point increases linearly with increasing ionic PIL content. More interestingly, P[VBTP][Cl]-ran-PNIPAM copolymer containing high (ca. 34.5 wt%) percentage of ionic PIL segment simultaneously show a LCST-type transition at lower temperature followed by an UCST-type transition at higher temperature in the presence of chloride ions. Tuning of both the LCST-/UCST-type cloud points is possible by varying the concentrations of copolymer and the added chloride ion.

European Polymer Journal published new progress about Cloud point. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Recommanded Product: 1-(Chloromethyl)-4-vinylbenzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jing, Ze; Xiu, Kemao; Sun, Yuyu published the artcile< Amide-Based Cationic Polymeric N-Halamines: Synthesis, Characterization, and Antimicrobial and Biofilm-Binding Properties>, Formula: C9H9Cl, the main research area is amide cationic polymer N halamine antimicrobial biofilm.

A series of amide-based N-halamine precursors, poly 3-(4′-vinylbenzyl) – 5, 5-dimethylhydantoin-co-trimethyl-2-methacryloxyethylammonium chloride (PVPT), were synthesized by copolymerizing 3-(4′-vinylbenzyl) – 5, 5-dimethylhydantoin (VBDMH) and trimethyl-2-methacryloxyethylammonium chloride (TMAC) with different compositions Chlorine bleach treatment was used to transform the VBDMH moieties in the copolymers into amide N-halamines (Cl-PVPT). 1H-NMR, FT-IR, and dynamic light scattering (DLS) anal. were used to characterize the copolymers. With lower than 50% of VBDMH, the Cl-PVPT copolymers could be dissolved in water, and provided powerful antimicrobial function in killing Gram-pos. as well as Gram-neg. bacteria. Furthermore, Cl-PVPTs rapidly bound onto preexisting bacterial biofilms and eradicated adherent bacteria. The biofilm-binding kinetics were studied, and the parameters of the kinetics were provided.

Industrial & Engineering Chemistry Research published new progress about Antibacterial agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rivera-Galvez, Francisco J.; Gonzalez-Ortiz, Luis J.; Lopez-Manchado, Miguel A.; Hernandez-Hernandez, Maria E.; Jasso-Gastinel, Carlos F. published the artcile< A methodology towards mechanical properties optimization of three-component polymers by the gradual variation of feed composition in semi-continuous emulsion-free radical polymerization>, SDS of cas: 1592-20-7, the main research area is emulsion radical polymerization mech property; gradient composition; methodology; multicomponent polymers; semi-continuous; three-component.

In this work, a new methodol. for the synthesis of three-component polymers (TCPs) was developed using a seeded, semi-continuous free-radical emulsion polymerization towards the optimization of the moduli-ultimate deformation performance and energy dissipation capacity for a styrene (S), Bu acrylate (BA), and 4-vinylbenzyl chloride (VBC) system. The three components were sequentially fed in pairs, varying feed composition along the conversion using S as the common monomer. To prepare a reference material, an industrial method was utilized with those monomers, using an equivalent global composition in a two-stage batch process (TS). Nanophase formation in the particles was observed by transmission electron microscopy (TEM), while the separation of the phases in the solid samples was observed by at. force microscopy (AFM). The changes in glass transition temperature were determined by differential scanning calorimetry (DSC) and dynamic mech. anal. (DMA). The latter was primarily used to compare mechanodynamic properties as a function of temperature for the two synthesis methods used. Thus, the higher toughness of the forced composition three-component polymeric materials was evaluated by means of their energy dissipation capacity, toughness, and stress-strain measurements at several temperatures

Polymers (Basel, Switzerland) published new progress about Glass transition temperature. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, SDS of cas: 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics