Category: 162046-61-9

Richards, Mark L.; Lio, Shirley Cruz; Sinha, Anjana; Banie, Homayon; Thomas, Richard J.; Major, Michael; Tanji, Mark; Sircar, Jagadish C. published the artcile< Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy>, COA of Formula: C8H4ClF3O2, the main research area is phenyl benzimidazole derivative marker allergy.

The pharmacotherapy of allergy and asthma has traditionally focused on the effecter mols. of the allergic cascade, while neglecting targets that play an early role in their development. Reasoning that IgE is central to the expansion of atopic diseases, we identified and extended a novel family of 2-(substituted phenyl)-benzimidazole inhibitors of IgE response. Pharmacol. activity depends on an intact phenylbenzimidazole-bis-amide backbone, and is optimized by the presence of lipophilic terminal groups composed of either bis cycloalkyl or combinations of aliphatic and halogen-substituted aromatic groups. These compounds also inhibit IL-4 and IL-5 responses in T cells and CD23 expression on B cells, with potencies that parallel their inhibition of IgE. The broad profile of these compounds thus underscores their potential for treating the multifarious pathol. of asthma.

European Journal of Medicinal Chemistry published new progress about Allergy. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, COA of Formula: C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hoque, Emdadul Md; Bisht, Ranjana; Unnikrishnan, Anju; Dey, Sayan; Mahamudul Hassan, Mirja Md; Guria, Saikat; Rai, Rama Nand; Sunoj, Raghavan B.; Chattopadhyay, Buddhadeb published the artcile< Iridium-Catalyzed Ligand-Controlled Remote para-Selective C-H Activation and Borylation of Twisted Aromatic Amides>, SDS of cas: 162046-61-9, the main research area is regioselective remote para borylation CH activation twisted aromatic amide; aryl boronate preparation regioselective remote para borylation aromatic amide; potential energy surface para CH borylation twisted aromatic amide; Borylation; C−H Activation; Density Functional Calculations; Iridium Catalyst; Para Selectivity.

A method of para-selective borylation of fully twisted aromatic amides ArCONBoc2 is described, yielding boronamides 4-pinBC6HnX4-nCONBoc2 (X = alkyl, alkoxy, aryl, halo, CN). The borylation proceeded via an unprecedented substrate-ligand distortion between the twisted aromatic amides and a newly designed ligand framework, 4,5-diaza-9H-fluorene (defa) that is different from the traditionally used ligand (dtbpy) for the C-H borylation reactions. The designed ligand defa has led to the development of a new type of catalytic system that shows excellent para selectivity for a range of aromatic amides. Moreover, the designed ligand has shown excellent reactivity and selectivity for a range of heterocyclic aromatic amides. The identification of key transition states and intermediates using the DFT computations associated with the three regio-isomeric pathways revealed that the most efficient catalytic pathway with the defa ligand leads to the para borylation while in the case of bpy the borylation at the para and meta sites compete.

Angewandte Chemie, International Edition published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, SDS of cas: 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Carter, Malcolm C.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Jo; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Henderson, Elisa A.; Keegan, Sally J.; Kelsey, Richard D.; Lockyer, Michael J.; Stables, Jeremy N.; Wilson, Lara J.; Powell, Kenneth L. published the artcile< 1,4-Benzodiazepines as Inhibitors of Respiratory Syncytial Virus>, Product Details of C8H4ClF3O2, the main research area is respiratory syncytial virus benzodiazepine derivative SAR preparation RSV.

Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as a serious threat to patient groups with poorly functioning immune systems. Our approach to finding a novel inhibitor of this virus was to screen a 20 000-member diverse library in a whole cell XTT assay. Parallel assays were carried out in the absence of virus in order to quantify any associated cell toxicity. This identified 100 compounds with IC50’s less than 50 μM. A-33903 (18), a 1,4-benzodiazepine analog, was chosen as the starting point for lead optimization. This mol. was moderately active and demonstrated good pharmacokinetic properties. The most potent compounds identified from this work were A-58568 (47), A-58569 (44), and A-62066 (46), where modifications to the aromatic substitution enhanced potency, and A-58175 (42), where the amide linker was modified.

Journal of Medicinal Chemistry published new progress about Immunodeficiency. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Saito, Masato; Kawamata, Yu; Meanwell, Michael; Navratil, Rafael; Chiodi, Debora; Carlson, Ethan; Hu, Pengfei; Chen, Longrui; Udyavara, Sagar; Kingston, Cian; Tanwar, Mayank; Tyagi, Sameer; McKillican, Bruce P.; Gichinga, Moses G.; Schmidt, Michael A.; Eastgate, Martin D.; Lamberto, Massimiliano; He, Chi; Tang, Tianhua; Malapit, Christian A.; Sigman, Matthew S.; Minteer, Shelley D.; Neurock, Matthew; Baran, Phil S. published the artcile< N-Ammonium Ylide Mediators for Electrochemical C-H Oxidation>, Product Details of C8H4ClF3O2, the main research area is ketone preparation regioselective chemoselective; aldehyde preparation regioselective chemoselective; hydrocarbon electrochem oxidation; ammonium ylide preparation.

Herein, a rationally designed platform that provides a step toward this challenge using N-ammonium ylides e.g., acetamidotrimethylazanium-tetrafluoroboranuide as electrochem. driven oxidants for site-specific, chemoselective C(sp3)-H oxidn was presented. By taking a first-principles approach guided by computation, these new mediators were identified and rapidly expanded into a library using ubiquitous building blocks and trivial synthesis techniques. The ylide-based approach to C-H oxidation exhibits tunable selectivity that is often exclusive to this class of oxidants and can be applied to real-world problems in the agricultural and pharmaceutical sectors.

Journal of the American Chemical Society published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Qian; Mgimpatsang, Kumchok C.; Konstantinidou, Markella; Shishkina, Svitlana V.; Doemling, Alexander published the artcile< 1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction>, Product Details of C8H4ClF3O2, the main research area is oxadiazole aminoalkyl metal free multicomponent preparation; Ugi reaction amine aldehyde azidotrimethylsilane isonitrile; Huisgen reaction aminoalkyl tetrazole acyl chloride pyridine solvent.

Amines, aldehydes, Me3SiN3, and tert-octyl isonitrile t-BuCH2CMe2N+C- underwent Ugi reactions to yield aminoalkyltetrazoles such as I; acid cleavage of the tert-octyl group followed by Huisgen reactions with acyl chlorides in pyridine yielded oxadiazoles such as II.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Blaser, Adrian; Palmer, Brian D.; Sutherland, Hamish S.; Kmentova, Iveta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Thompson, Andrew M.; Denny, William A. published the artcile< Structure-Activity Relationships for Amide-, Carbamate-, And Urea-Linked Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)>, Name: 2-(Trifluoromethoxy)benzoyl chloride, the main research area is structure activity relationship Mycobacterium tuberculosis infection drug imidazooxazine preparation; PA 824 analog preparation SAR tuberculosis infection drug.

Analogs of clin. tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824, I), in which the OCH2 linkage was replaced with amide, carbamate, and urea functionality, were investigated as an alternative approach to address oxidative metabolism, reduce lipophilicity, and improve aqueous solubility Several soluble monoaryl examples displayed moderately improved (∼2- to 4-fold) potencies against replicating Mycobacterium tuberculosis but were generally inferior inhibitors under anaerobic (nonreplicating) conditions. More lipophilic biaryl derivatives mostly displayed similar or reduced potencies to these in contrast to the parent biaryl series. The leading biaryl carbamate demonstrated exceptional metabolic stability and a 5-fold better efficacy than the parent drug in a mouse model of acute M. tuberculosis infection but was poorly soluble Bioisosteric replacement of this biaryl moiety by arylpiperazine resulted in a soluble, orally bioavailable carbamate analog providing identical activity in the acute model, comparable efficacy to OPC-67683 in a chronic infection model, favorable pharmacokinetic profiles across several species, and enhanced safety.

Journal of Medicinal Chemistry published new progress about Homo sapiens. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Name: 2-(Trifluoromethoxy)benzoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sarkate, Aniket P.; Shinde, Devanand B. published the artcile< Synthesis and docking studies of ethyl 4-(4-((2-(nitrooxy)ethoxy)carbonyl)phenyl)-2-substituted-6-substitutedphenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate as anti-inflammatory, analgesic and nitric oxide releasing agents>, SDS of cas: 162046-61-9, the main research area is pyrimidine derivative anti inflammatory analgesic nitric oxide.

In the present study, a series of pyrimidine derivatives (6a-6z) was synthesized and tested for its anti-inflammatory, analgesic and nitric oxide releasing activity. The main aim of this study was to develop new chem. entities as potential anti-inflammatory agents. In this article, synthesis of a series of mols. containing important pharmacophore substituted diaryl rings on 6-membered heterocycle similar to coxibs and nitric oxide releasing moiety are described. All the synthesized compounds were tested in vivo for their anti-inflammatory, analgesic studies and in vitro for their nitric oxide-releasing properties. Out of the twenty six synthesized compounds, four compounds showed significant anti-inflammatory and analgesic activity which was compared with standard All the synthesized compounds exhibited significant nitric oxide-releasing activity.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about Analgesics. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, SDS of cas: 162046-61-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zeng, Yan; Nie, Lifei; Bozorov, Khurshed; Ruzi, Zukela; Song, Buer; Zhao, Jiangyu; Aisa, Haji Akber published the artcile< 2-Substituted tricyclic oxazolo[5,4-d]pyrimidine library: Design, synthesis and cytotoxicity activity>, Formula: C8H4ClF3O2, the main research area is tetrahydrooxazolopyridopyrimidinone preparation cytotoxicity human.

Design, synthetic route and cytotoxicity of a library of 49 newly synthesized tricyclic oxazolo[5,4-d]pyrimidines I [R = Me, Ph, 4-BrC6H4, etc.] was reported. The condensed pyrimidinones were constructed from Et 5-aminooxazole-4-carboxylate building blocks. A tricyclic ring system was built using the naturally occurring mackinazolinone alkaloid with a focus on the mol. diversity at position C-2 of the oxazole ring. Synthesized compounds were evaluated against a panel of human cancer cell lines including MCF-7 (breast), HeLa (cervical) and A549 (lung) in vitro. The results revealed that substitution of halogen-related aromatic fragments at position C-2 of the oxazole ring may serve as promising anticancer drug candidates.

Journal of Heterocyclic Chemistry published new progress about Antitumor agents. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Formula: C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rosen, Brandon R.; Ul Sharif, Ehesan; Miles, Dillon H.; Chan, Nicholas S.; Leleti, Manmohan R.; Powers, Jay P. published the artcile< Improved synthesis of sterically encumbered heteroaromatic biaryls from aromatic β-keto esters>, Product Details of C8H4ClF3O2, the main research area is sterically hindered aryl aminopyrimidine preparation keto ester guanidine condensation.

A protocol for the synthesis of hindered 4-aryl 2-aminopyrimidines from β-keto esters is described. The process employs trifluoroethanol as an essential additive to promote the guanidine condensation reaction, enabling the synthesis of 25 aryl- and heteroaryl substituted aminopyrimidines in good yields and high purities with no column chromatog. The conditions described herein are readily scalable and have been employed in the large-scale synthesis of the clin. A2a/A2bR antagonist AB928.

Tetrahedron Letters published new progress about Aminopyrimidines Role: SPN (Synthetic Preparation), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Product Details of C8H4ClF3O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dockendorff, Chris; Aisiku, Omozuanvbo; VerPlank, Lynn; Dilks, James R.; Smith, Daniel A.; Gunnink, Susanna F.; Dowal, Louisa; Negri, Joseph; Palmer, Michelle; MacPherson, Lawrence; Schreiber, Stuart L.; Flaumenhaft, Robert published the artcile< Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor>, Category: chlorides-buliding-blocks, the main research area is preparation of antithrombotic agent platelet activation inhibition PAR1.

A high-throughput screen of the NIH-MLSMR compound collection, along with a series of secondary assays to identify potential targets of hit compounds, previously identified a 1,3-diaminobenzene scaffold that targets protease-activated receptor 1 (PAR1). We now report addnl. structure-activity relationship (SAR) studies that delineate the requirements for activity at PAR1 and identify plasma-stable analogs with nanomolar inhibition of PAR1-mediated platelet activation. Compound 4 was declared as a probe (ML161) with the NIH Mol. Libraries Program. This compound inhibited platelet aggregation induced by a PAR1 peptide agonist or by thrombin but not by several other platelet agonists. Initial studies suggest that ML161 is an allosteric inhibitor of PAR1. These findings may be important for the discovery of antithrombotics with an improved safety profile.

ACS Medicinal Chemistry Letters published new progress about Anticoagulants. 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics