Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups was written by Oezden, Seckin;Atabey, Dilek;Yildiz, Sulhiye;Goeker, Hakan. And the article was included in Bioorganic & Medicinal Chemistry in 2005.SDS of cas: 16588-16-2 This article mentions the following:
A series of benzimidazole-5-carboxylic acid alkyl ester derivatives, e.g., I, carrying amide or amidine substituted Me or Ph groups at the position C-2 were synthesized and evaluated for antibacterial and antifungal activities against S. aureus, methicillin resistant S. aureus (MRSA), S. faecalis, methicillin resistant S. epidermidis (MRSE), E. coli and C. albicans. The results showed that all simple acetamides were essentially inactive, while aromatic amides and amidines have potent antibacterial activities. The aromatic amidine derivatives exhibited the best inhibitory activity with 1.56-0.39 μg/mL MIC values against MRSA and MRSE. In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2SDS of cas: 16588-16-2).
Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 16588-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics