Some common heterocyclic compound, 166176-45-0, name is 6-Chloroimidazo[1,2-b]pyridazin-3-amine, molecular formula is C6H5ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6-Chloroimidazo[1,2-b]pyridazin-3-amine
To a solution 6-chloroimidazo[1,2-b]pyridazin-3-amine and triethylamine (0.8 ml, 6.0 mmol)in DCM (25 ml) was added acetyl chloride dropwise and stirred at rt for overnight. The mixture was30 concentrated and purified by ISCO column chromatography (10% MeOH/DCM) to give not very pure N-(6-chloroimidazo[1,2-b]pyridazin-3-yl)acetamide (500 mg, 95% yield). 60 mg of non-pure materialwas further purified by Prep HPLC (neutral) to give pure N-(6-chloroimidazo[1,2-b]pyridazin-3-yl)acetamide. 1H NMR (400 MHz, METHANOL-d4) 8 ppm 8.01 (d, J=9.35 Hz, 1 H), 7.94 (s, 1 H), 7.26(d, J=9.35 Hz, 1 H), 2.29 (s, 3 H); LRMS (ESI) mje 210.9 [(M +H)+, calcd for CsHsCIN40 211.6].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 166176-45-0, its application will become more common.
Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; BI, Yingzhi; CARSON, Kenneth Gordon; CIANCHETTA, Giovanni; GREEN, Michael Alan; KUMI, Godwin; LIANG, Zhi; LIU, Ying Jade; MAIN, Alan; ZHANG, Yulian; ZIPP, Glenn Gregory; WO2013/134219; (2013); A1;,
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