Category: 16629-19-9

《Synthesis of vinyl sulfones through sulfonylation of styrenes with sulfonyl chlorides under metal-free conditions》 was written by Wang, Xia; Hu, Bo; Yang, Peng; Zhang, Qian; Li, Dong. Recommanded Product: Thiophene-2-sulfonyl chlorideThis research focused onvinyl sulfone preparation diastereoselective chemoselective green chem; styrene sulfonyl chloride sulfonylation hypervalent iodine catalyst. The article conveys some information:

A hypervalent iodine reagent-mediated sulfonylation of styrenes RR1C=CH2 (R = Ph, 4-methoxyphenyl, 3-methylphenyl, etc.; R1 = H, Ph) with sulfonyl chlorides R2SO2Cl (R2 = 4-methylphenyl, Ph, Et, thiophen-2-yl, etc.) was developed for the synthesis of vinyl sulfones RR1C=CHSO2R2. The reaction proceeded under metal-free, mild and neutral conditions without extra oxidants or bases. It also exhibited good air and moisture tolerance, broad substrate scope and high chemo-selectivity, affording the vinyl sulfones in moderate to good yields. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides》 was written by Zhang, Guofu; Fan, Qiankun; Zhao, Yiyong; Wang, Huimin; Ding, Chengrong. Synthetic Route of C4H3ClO2S2This research focused onthiosulfonate preparation; sulfonyl hydrazide reductive coupling. The article conveys some information:

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO2.CH2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates RSO2SR (R = Ph, 3-chlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) using sulfonyl hydrazides RSO2NHNH2 with the assistance of reductant. Addnl., the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Facile One-Pot Access to α-Diazo-β-ketosulfones from Sulfonyl Chlorides and α-Haloketones》 was published in Synthesis in 2020. These research results belong to Dar’in, Dmitry; Kantin, Grigory; Bakulina, Olga; Krasavin, Mikhail. SDS of cas: 16629-19-9 The article mentions the following:

A convenient one-pot approach to the preparation of α-diazo-β-ketosulfones R1SO2C(=N2)C(O)R2 [R1 = Me, cyclohexyl, Ph, etc.; R2 = Me, Ph, 4-FC6H4, etc.] from sulfonyl chlorides was described. It involved the conversion of sulfonyl chloride to sodium sulfinate, alkylation of latter with α-haloketones followed by diazo transfer using ‘sulfonyl-azide-free’ (SAFE) protocol in aqueous medium. The simple and expedient method relied on readily available starting materials and provided facile access to a wide variety of valuable diazo reagents for organic synthesis. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Song, Xuyan; He, Yunlu; Wang, Bo; Peng, Sanwen; Pan, Xi; Wei, Min; Liu, Qiang; Qin, Hua-Li; Tang, Haolin published an article in Tetrahedron. The title of the article was 《Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO2F2) as fluoride provider》.Name: Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO2F [Ar = 4-MeC6H4, 4-PhC6H4, 4-ClC6H4, etc.] was developed from aryl sulfonyl chlorides using SO2F2 as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lin, Li; Yang, Zhonglie; Liu, Jianchen; Wang, Jingxia; Zheng, Jiale; Li, Jun-Long; Zhang, Xiaobin; Liu, Xiang-Wei; Jiang, Hezhong; Li, Jiahong published an article in 2021. The article was titled 《Visible-light-induced surfactant-promoted sulfonylation of alkenes and alkynes with sulfonyl chloride by the formation of an EDA-complex with NaI in water at room temperature》, and you may find the article in Green Chemistry.HPLC of Formula: 16629-19-9 The information in the text is summarized as follows:

A green and efficient visible-light-induced iodosulfonyl reaction of alkenes, e.g., cyclohexene in water using an EDA complex strategy at room temperature has been disclosed. The addition of a cationic surfactant allows for the easy formation of colored EDA complexes in water. The hydrophobic effect of the core in the surfactant aggregates, which act as a reaction medium formed by the surfactants themselves in water, plays a significant role in stabilizing the transition state and decreasing the activation energy of the reaction. Remarkably, transition-metal catalysts and organic solvents were not required in this transformation. Moreover, it displayed a broad substrate scope, good functional group tolerance, simple operation, scalability and high chem. selectivity. Thus, it not only provided a green and efficient synthetic strategy for the preparation of β-iodo-substituted sulfone derivatives, e.g., 1-((2-iodocyclohexyl)sulfonyl)-4-methylbenzene but also enriched the investigation of visible-light-induced reactions in water. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9HPLC of Formula: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. HPLC of Formula: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C4H3ClO2S2In 2022 ,《Boron-Promoted Umpolung Reaction of Sulfonyl Chlorides for the Stereospecific Synthesis of Thioglycosides via Reductive Deoxygenation Coupling Reactions》 was published in Organic Letters. The article was written by Li, Siyu; Wang, Yujuan; Zhong, Lei; Wang, Siyu; Liu, Zhengli; Dai, Yuanwei; He, Yun; Feng, Zhang. The article contains the following contents:

S-Glycosides have broad biol. activities and serve as stable mimics of natural O-glycoside counterparts and thus are of great therapeutic potential. Herein we disclose an efficient method for the stereospecific synthesis of 1-thioglycosides via a boron-promoted reductive deoxygenation coupling reaction from readily accessible sulfonyl chlorides and glycosyl bromides. Our protocol features mild conditions and excellent functional group tolerance and stereoselectivity. The translational potential of this metal-free approach is demonstrated by the late-stage glyco-diversification of natural products and drug mols. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

COA of Formula: C4H3ClO2S2In 2022 ,《Visible-Light-Catalyzed Tandem Radical Addition/1,5-Hydrogen Atom Transfer/Cyclization of 2-Alkynylarylethers with Sulfonyl Chlorides》 was published in Organic Letters. The article was written by Li, Long; Li, Jiao-Zhe; Sun, Yong-Bin; Luo, Chun-Mei; Qiu, Hui; Tang, Keqi; Liu, Hongxin; Wei, Wen-Ting. The article contains the following contents:

A novel visible-light-catalyzed tandem radical addition/1,5-hydrogen atom transfer/cyclization cascade of 2-alkynylarylethers 2-(CHC)-3-R-4-R1-C6H2OCH(R2)R3 (R = H, Me, Cl, C(O)OMe, etc.; R1 = H, C(O)OMe; R2 = Me, Et, Ph; R3 = Me, Et; R2R3 = -(CH2)5-, -(CH2)4-, -(CH2)3OCH2-) with sulfonyl chlorides R4S(O)2Cl (R4 = Ph, 4-bromophenyl, 4-methylphenyl, 4-methoxyphenyl, thiophen-2-yl) in 2-methyltetrahydrofuran was developed under photocatalyst- and additive-free conditions. This reaction relies on unique energy transfer and solvent-radical relay strategies to generate sulfonyl radicals for the preparation of a series of sulfonyl-functionalized dihydrobenzofurans I in moderate to high yields catalyzed by visible light or solar radiation.Thiophene-2-sulfonyl chloride(cas: 16629-19-9COA of Formula: C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. COA of Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xi; Wang, Qiang; Zhang, Zhe; Niu, Zhi-Jie; Shi, Wei-Yu; Gong, Xiao-Ping; Jiao, Rui-Qiang; Gao, Ming-Hui; Liu, Xue-Yuan; Liang, Yong-Min published an article in 2022. The article was titled 《Copper-Catalyzed Hydrogen Atom Transfer and Aryl Migration Strategy for the Arylalkylation of Activated Alkenes》, and you may find the article in Organic Letters.Recommanded Product: Thiophene-2-sulfonyl chloride The information in the text is summarized as follows:

Herein, the copper-catalyzed arylalkylation of activated alkenes, e.g., N-(benzenesulfonyl)-N-(4-methoxyphenyl)-2-methylprop-2-enamide via hydrogen-atom transfer and aryl migration strategy were described. The reaction was carried out through a radical-mediated continuous migration pathway using N-fluorosulfonamides, e.g., N-fluoro-4-methyl-N-octylbenzene-1-sulfonamide as the alkyl source. The primary, secondary, and tertiary alkyl radicals formed by intramol. hydrogen-atom transfer proceeded smoothly. This methodol. is an efficient approach for the synthesis of various amide derivatives possessing a quaternary carbon center, e.g., I with good yields and high regioselectivity. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides》 was written by Luo, Ziwei; Yang, Xinkan; Tsui, Gavin Chit. Recommanded Product: 16629-19-9 And the article was included in Organic Letters in 2020. The article conveys some information:

A practical synthesis of perfluoroalkyl sulfides is described. The method employs stable and readily accessible thiosulfonates as new electrophiles with com. nucleophilic perfluoroalkylating reagents. The mild reaction conditions allow access to a wide variety of both aryl- and alkyl-substituted perfluoroalkyl sulfides amenable to pharmaceutical development. Furthermore, the reaction operation is straightforward, odorless, does not produce toxic wastes, and, therefore should appeal to practitioners in industrial-scale productions. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Insight into catalytic properties of supported palladium nanoparticles catalyzed ortho-directed sulfonylation》 was published in Youji Huaxue in 2020. These research results belong to Li, Pengshuai; Wu, Yun; Bai, Chaolumen; Bao, Yongsheng. Product Details of 16629-19-9 The article mentions the following:

Catalyzed by supported palladium nanoparticles, an ortho-directed sulfonylation reaction between 2-phenylpyridine and arylsulfonyl chlorides has been developed. The full oxidation-state change of palladium was detected in the XPS anal. of the supported palladium nanoparticles catalyst before and after reaction, which confirmed that Pd-catalyzed ortho-directed sulfonylation reaction was performed via a PdII/IV catalytic cycle instead of Pd0/II. The hot filtration test and other tests of catalysts further confirmed the hypothesis. This report afforded the most straightforward approach to confirm the variation of valence of palladium in ortho-directed sulfonylation reaction. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Product Details of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Product Details of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics