16629-19-9 Archives - Page 2 of 11 - Chlorides-buliding-blocks

Zhang, Yaohong’s team published research in Tetrahedron in 2020 | CAS: 16629-19-9

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Name: Thiophene-2-sulfonyl chloride

Name: Thiophene-2-sulfonyl chlorideIn 2020 ,《One-pot synthesis of β-ketosulfones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water》 was published in Tetrahedron. The article was written by Zhang, Yaohong; Luo, Mengqiang; Li, Yan; Shen, Runfu; Qi, Chenze; Wang, Hai; Cheng, Kai. The article contains the following contents:

A novel, facile and efficient strategy for the one-pot synthesis of β-ketosulfones from readily available sulfonyl chloride, hydrazine hydrate and vinyl azides was described. The reaction proceeded very smoothly by affording diverse β-ketosulfones in moderate to good yields. This new procedure had the advantages of environmental benign, easy and simple operation, low cost and wide tolerance of functional groups, which provided a highly fascinating protocol to access β-ketosulfones. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Uma priya, K.’s team published research in RSC Advances in 2021 | CAS: 16629-19-9

Computed Properties of C4H3ClO2S2In 2021 ,《Design, synthesis, characterization and in vitro, in vivo and in silico antimicrobial and antiinflammatory activities of a new series of sulfonamide and carbamate derivatives of a nebivolol intermediate》 was published in RSC Advances. The article was written by Uma priya, K.; Venkataramaiah, Ch.; Sreedhar, N. Y.; Raju, C. Naga. The article contains the following contents:

A series of new sulfonamide and carbamate derivatives of Nebivolol drug intermediate (5) were designed and synthesized by reacting various biopotent sulfonylchlorides and chloroformates. The synthesized compounds are structurally characterized by spectral (IR, 1H & 13C NMR and mass) and screened for their in vitro antimicrobial activity against four bacterial and three fungal strains, in vitro and in vivo antiinflammatory activity against LPS-induced inflammation in RAW 264.7, in vitro COX-1 and COX-2 inhibition potentiality, antagonistic profiles of carrageenan induced paw edema and cotton pellet induced granuloma in rat. Further, the compounds were screened for their antimicrobial and antiinflammatory activity against DNA gyrase A, COX-1 and COX-2 by using mol. docking approach. The bioactivity and toxicity risks were analyzed through Mol. Operating Environment. The results revealed that the compounds 8b, 8c, 8d, 8e, 8f, 8g and 9a exhibited the most promising antimicrobial activity against all the bacterial and fungal strains tested when compared with the standard drugs streptomycin and fluconazole. In view of in antiinflammatory activity, the compounds, 8b, 8c, 8d, 8e, 8f, 8g and 9a have shown potent antiinflammatory activity by inhibiting the LPS-induced inflammation in RAW 264.7 cell line, concentration dependent inhibition of COX-1 and COX-2, dose response dependent antagonism of carrageenan induced paw edema and granuloma tissue in rat. Mol. docking, ADMET and QSAR studies predicted that the recorded in silico profiles are in strong correlation with in vitro and in vivo antimicrobial and antiinflammatory results. In addition, the elevated toxicol. risks of the title compounds are identified with in the potential limits of drug candidates. Hence, it is suggested that the synthesized derivatives will stand as the promising antimicrobial and anti-inflammatory drug candidates in future. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Berg, Mika E. A.’s team published research in ACS Omega in 2020 | CAS: 16629-19-9

Category: chlorides-buliding-blocksIn 2020 ,《Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes》 was published in ACS Omega. The article was written by Berg, Mika E. A.; Naams, Jette-Britt; Hautala, Laura C.; Tolvanen, Tuomas A.; Ahonen, Jari P.; Lehtonen, Sanna; Wahala, Kristiina. The article contains the following contents:

A series of substituted sulfonanilide analogs were prepared and evaluated as novel potent inhibitors of SH2 domain-containing inositol polyphosphate 5′-phosphatase 2 (SHIP2). SHIP2 has been shown to be a new attractive target for the treatment of insulin resistance in type 2 diabetes mellitus (T2D), which can lead to life-threatening diabetic kidney disease (DKD). Amongst the synthesized compounds, the two most promising candidates, 10 and 11, inhibited SHIP2 significantly. Addnl., these compounds induced Akt activation in a dose-dependent manner, increased the presence of glucose transporter 4 at the plasma membrane, and enhanced glucose uptake in cultured myotubes in vitro at lower concentrations than metformin, the most widely used antidiabetic drug. These results show that the novel SHIP2 inhibitors have insulin sensitizing capacity and provide prototypes for further drug development for T2D and DKD. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks) was used in this study.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Wansoo’s team published research in Organic Letters in 2020 | CAS: 16629-19-9

《Electrochemical Radical-Radical Cross-Coupling Approach between Sodium Sulfinates and 2H-Indazoles to 3-Sulfonylated 2H-Indazoles》 was written by Kim, Wansoo; Kim, Hun Young; Oh, Kyungsoo. Recommanded Product: Thiophene-2-sulfonyl chloride And the article was included in Organic Letters in 2020. The article conveys some information:

A direct cross-coupling between sodium sulfinates and 2H-indazoles has been developed under electrochem. conditions. The utilization of a graphite anode and platinum cathode in an undivided cell with a constant current of 7 mA allowed the concurrent oxidations of sulfinates and 2H-indazoles to sulfonyl radical and radical cationic 2H-indazoles, facilitating the direct radical-radical coupling strategy to 3-sulfonylated 2H-indazole derivatives The transition-metal- and redox-reagent-free synthetic approach should serve as a valuable synthetic tool to achieve heteroaromatic compounds In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xie, Wenjiao’s team published research in Organic Letters in 2022 | CAS: 16629-19-9

Xie, Wenjiao; Ma, Pengju; Zhang, Yujun; Xi, Longyi; Qiu, Shengqi; Huang, Xuan; Yang, Bo; Gao, Yuan; Zhang, Junmin published an article in 2022. The article was titled 《Visible Light-Induced Highly Regioselective and Stereoselective Oxysulfonylation of Alkynes for the Synthesis of (E)-β-Phenoxy Vinylsulfones》, and you may find the article in Organic Letters.SDS of cas: 16629-19-9 The information in the text is summarized as follows:

A highly efficient visible light-induced regioselective and stereoselective oxysulfonylation of alkynes with arylsulfonate phenol esters was developed. This photocatalyst- and metal-free method proceeded smoothly under very mild conditions and exhibits a broad substrate scope, providing (E)-β-phenoxy vinylsulfones in moderate to excellent yields. Mechanistic studies indicated the involvement of an electron donor-acceptor complex-mediated radical process. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gadde, Karthik’s team published research in ACS Catalysis in 2020 | CAS: 16629-19-9

《Thiosulfonylation of Unactivated Alkenes with Visible-Light Organic Photocatalysis》 was published in ACS Catalysis in 2020. These research results belong to Gadde, Karthik; Mampuys, Pieter; Guidetti, Andrea; Ching, H. Y. Vincent; Herrebout, Wouter A.; Van Doorslaer, Sabine; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.. Application of 16629-19-9 The article mentions the following:

A metal-free method for the vicinal thiosulfonylation of unactivated alkenes R1CH=CHR (R = H, Me; R1 = benzyl, (trimethylsilyl)methyl, (prop-2-en-1-yloxy)methyl, 3-cyanopropyl, etc.; RR1 = -(CH2)4-, -(CH2)3-, -(CH2)2(O)-, etc.) with thiosulfonates R2S(O)2SR3 (R2 = Me, 4-methylphenyl, 4-fluorophenyl, thiophen-2-yl, etc.; R3 = Ph, Bu, 2-[methoxy(oxo)methane]phenyl, thiophen-2-yl, etc.) using 9-mesityl-10-methylacridinium perchlorate as photo-organocatalyst with visible-light irradiation has been developed. The method can be performed in di-Me carbonate under air at room temperature and features a broad functional group compatibility. Metrics indicate the green potential of the developed vs. the state-of-the-art methodologies. Mechanistic studies revealed no single electron transfer but involvement of an energy transfer from the excited photo-organocatalyst to thiosulfonate reactant, subsequently providing a sulfenyl and a sulfonyl radical via homolytic cleavage. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Fangfang’s team published research in Organic Letters in 2020 | CAS: 16629-19-9

《Cu-Catalyzed Dehydrogenative Olefinsulfonation of Alkyl Arenes》 was published in Organic Letters in 2020. These research results belong to Li, Fangfang; Zhang, Guang-an; Liu, Yingguo; Zhu, Bingke; Leng, Yuting; Wu, Junliang. Application of 16629-19-9 The article mentions the following:

A copper-catalyzed reaction protocol for the dehydrogenation of ethylbenzenes into styrene derivatives has been developed. This reaction procedure proceeded well under mild reaction conditions, providing a practical and efficient strategy for the rapid assembly of biol. and pharmaceutically significant mols., such as vinyl sulfone. Simple alkyl arenes were functionalized via consecutive β-elimination in the presence of N-sulfonylbenzo[d]imidazole with broad substrate scope and good functional group tolerance. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Chengkou’s team published research in Organic Letters in 2020 | CAS: 16629-19-9

《C- to N-Center Remote Heteroaryl Migration via Electrochemical Initiation of N Radical by Organic Catalyst》 was written by Liu, Chengkou; Jiang, Qiang; Lin, Yang; Fang, Zheng; Guo, Kai. Electric Literature of C4H3ClO2S2 And the article was included in Organic Letters in 2020. The article conveys some information:

Herein an exogenous oxidant- and metal-free electrochem. heteroaryl migration triggered by N radicals to construct new N-C bonds was developed. This methodol. features a high atom economy and utilization rate of energy, and it is insensitive to water and air. Moreover, a user-friendly undivided cell was employed. The use of an organic catalyst makes it more efficient, green, and practical. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Wenjuan’s team published research in Organic Letters in 2022 | CAS: 16629-19-9

In 2022,Zhu, Wenjuan; Xi, Hui; Jiao, Wenyang; Huang, Lihua; Wang, Lianjie; Wu, Junliang published an article in Organic Letters. The title of the article was 《Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones》.Name: Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

Visible-light-promoted R1CH=CF2 (R1 = 2H-1,3-benzodioxol-5-yl, 3-bromo-4-methoxyphenyl, 4-(benzyloxy)phenyl, etc.) using sulfonyl chlorides R2S(O)OCl (R2 = 4-tert-butylphenyl, naphthalen-1-yl, thiophen-2-yl, cyclopropyl, etc.) and alcs. R3OH (R3 = Me, Bn, i-Pr, etc.) has been developed. The reaction exhibits a relatively broad substrate scope with excellent functional group compatibility. This synthesis method includes an atom transfer radical addition-like process. The products R1CH(O)R2CF2S(O)OR3 can be used as platform mols. for further modification. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Name: Thiophene-2-sulfonyl chloride)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Yi-Xuan’s team published research in Organic Letters in 2021 | CAS: 16629-19-9

《Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol》 was written by Chen, Yi-Xuan; Wang, Zhu-Jun; Xiao, Jun-An; Chen, Kai; Xiang, Hao-Yue; Yang, Hua. Computed Properties of C4H3ClO2S2This research focused ontrifluoromethyl sulfonyl tertiary alc preparation; sodium sulfinate trifluoromethylstyrene sulfonation. The article conveys some information:

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcs. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant mols. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics