Category: 16629-19-9

Wang, Jin-Lin; Liu, Mei-Ling; Zou, Jian-Yu; Sun, Wen-Hui; Liu, Xue-Yuan published an article in 2022. The article was titled 《Copper-Catalyzed Aminoarylation of Alkenes via Aminyl Radical Addition and Aryl Migration》, and you may find the article in Organic Letters.SDS of cas: 16629-19-9 The information in the text is summarized as follows:

A new strategy for aminoarylation of alkenes by copper-catalyzed Smiles rearrangement using O-benzoylhydroxylamines as the amine reagent was described.. This method affords various β-amino amide derivatives possessing a quaternary carbon center with wide functional group tolerance and high regioselectivity. The mechanistic studies indicate that the transformation can involve aminyl radical intermediates under acid-free condition. The experimental part of the paper was very detailed, including the reaction process of Thiophene-2-sulfonyl chloride(cas: 16629-19-9SDS of cas: 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. SDS of cas: 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Haiqian; Zheng, Hanliang; Zhang, Junhua; Feng, Jian; Kong, Lichun; Zhang, Fang; Xue, Xiao-Song; Zhu, Gangguo published their research in Chemical Science in 2021. The article was titled 《Solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes: access to cyclopentenones and dihydropyranols》.Application of 16629-19-9 The article contains the following contents:

Divergent synthesis is a powerful strategy for the fast assembly of different mol. scaffolds from identical starting materials. Herein, a solvent-controlled photocatalytic divergent cyclization of alkynyl aldehydes with sulfonyl chlorides for the direct construction of highly functionalized cyclopentenones and dihydropyranols that widely exist in bioactive mols. and natural products has been described. D. functional theory calculations suggest that a unique N,N-dimethylacetamide-assisted 1,2-hydrogen transfer of alkoxy radicals is responsible for the cyclopentenone formation, whereas a C-C cleavage accounts for the selective production of dihydropyranols in acetonitrile and water at 50°C. Given the simple and mild reaction conditions, excellent functional group compatibility, forming up to four chem. bonds, and tunable selectivity, it may find wide applications in synthetic chem. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes under photocatalyst- and additive-free conditions》 was written by Meng, Xiao-Xiao; Kang, Qing-Qing; Zhang, Jun-Yao; Li, Qiang; Wei, Wen-Ting; He, Wei-Min. Application In Synthesis of Thiophene-2-sulfonyl chloride And the article was included in Green Chemistry in 2020. The article conveys some information:

Without employing any photocatalyst and additive, an economical, eco-friendly and practical strategy was developed for the visible-light-initiated regioselective sulfonylation/cyclization of 1,6-enynes in a biomass-derived green solvent 2-methylTHF from easily accessible sulfonyl chlorides under open-air conditions at room temperature Compared with conventional heating conditions, the use of a 3 W blue light-emitting diode (LED) or sunlight not only reduces energy consumption but also minimizes side reactions. This transformation showed excellent regioselectivity, mild reaction conditions, broad substrate scope and ease of scale-up. Moreover, mechanistic studies indicated that a sulfonyl radical pathway was involved in this reaction. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sedenkova, Kseniya N.; Andriasov, Kristian S.; Eremenko, Marina G.; Grishin, Yuri K.; Alferova, Vera A.; Baranova, Anna A.; Zefirov, Nikolay A.; Zefirova, Olga N.; Zarubaev, Vladimir V.; Gracheva, Yulia A.; Milaeva, Elena R.; Averina, Elena B. published an article in Molecules. The title of the article was 《Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity》.Synthetic Route of C4H3ClO2S2 The author mentioned the following in the article:

Among the works of the last decade, a literature search revealed spirothiazamenthane, which has served as a lead in the development of derivatives active against resistant viral strains. In this work, the novel mol. scaffold, which resembles spirothiazamenthane, but combines isoxazoline as a heterocycle and cyclooctane ring as a hydrophobic part of the structure is reported. The synthesis of new 3-nitro- and 3-aminoisoxazolines containing spiro-fused or 1,2-annelated cyclooctane fragments was achieved by employing 1,3-dipolar cycloaddition of 3-nitro-4,5-dihydroisoxazol-4-ol 2-oxide or tetranitromethane-derived alkyl nitronates with non-activated alkenes. A series of spiro-sulfonamides was obtained by the reaction of 3-aminoisoxazoline containing a spiro-fused cyclooctane residue with sulfonyl chlorides. Preliminary screening of the compounds for antiviral, antibacterial, antifungal and antiproliferative properties in vitro revealed 1-oxa-2-azaspiro[4.7]dodec-2-en-3-amine and 3a,4,5,6,7,8,9,9a-octahydrocycloocta[d]isoxazol-3-amine with activity against the influenza A/Puerto Rico/8/34 (H1N1) virus in the submicromolar range, and high values of selectivity index. Further study of the mechanism of the antiviral action of these compounds, and the synthesis of their analogs, is likely to identify new agents against resistant viral strains. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumari, Arram Haritha; Kumar, Jangam Jagadesh; Krishna, Gamidi Rama; Reddy, Raju Jannapu published their research in Synthesis in 2021. The article was titled 《Nickel-Catalyzed Difunctionalization of Alkynyl Bromides with Thiosulfonates and N -Arylthio Succinimides: A Convenient Synthesis of 1,2-Thiosulfonylethenes and 1,1-Dithioethenes》.Reference of Thiophene-2-sulfonyl chloride The article contains the following contents:

An efficient nickel-catalyzed vicinal thiosulfonylation of 1-bromoalkynes with thiosulfonates in the presence of cesium carbonate was described. An operationally simple and highly regioselective atom transfer radical addition (ATRA) of alkynyl bromides provides a wide range of ( E)-1,2-thiosulfonylethenes (α-aryl-β-thioarylvinyl sulfones) in moderate to high yields. The extensive substrate scope of both alkynyl bromides and thiosulfonates was explored with a broad range of functional groups. Indole-derived 1,1-bromoalkenes were also successfully explored in this 1,2-thiosulfonylation process. Moreover, the nickel-catalyzed geminal-dithiolation of alkynyl bromides with N-arylthio succinimides provides 1,1-dithioalkenes in high yields. The present protocol was reliable on gram scale, and a sequential one-pot bromination and thiosulfonylation of phenylacetylene is achieved in a scale-up synthesis. Following control experiments, a plausible mechanism was proposed to rationalize the exptl. outcome and the vicinal thiosulfonylation. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Thiophene-2-sulfonyl chlorideIn 2021 ,《Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres》 was published in Nature Chemistry. The article was written by Hervieu, Cedric; Kirillova, Mariia S.; Suarez, Tatiana; Muller, Marco; Merino, Estibaliz; Nevado, Cristina. The article contains the following contents:

The asym. construction of all-carbon quaternary centers within acyclic settings represents a long-standing challenge for synthetic chemists. Alongside polar and radical methods, rearrangement reactions represent an attractive platform, but still broadly applicable methods are in high demand. Here we report an asym., radical sulfinyl-Smiles rearrangement to access acyclic amides that bear an α-all-carbon quaternary center. Our strategy uses enantioenriched N-arylsulfinyl acrylamides such as I as acceptors for a variety of radicals produced in situ under mild photoredox conditions. The sulfinamido group not only directs the 1,4-migration of the aryl moiety onto the α-carbon of the amide, which thus governs its absolute configuration, but also functions as a traceless chiral auxiliary. The amides obtained in this multicomponent process such as II are prevalent in pharmaceuticals, agrochems. and bioactive natural products, and can be transformed into valuable chiral α,α-disubstituted acids, oxindoles as well as into β,β-disubstituted amines, highlighting the synthetic potential of this transformation. In the experiment, the researchers used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of C4H3ClO2S2In 2021 ,《Visible-Light-Induced 1,4-Hydroxysulfonylation of Vinyl Enynes with Sulfonyl Chlorides: The Bridge of Chloride Linking Water and Enynes》 was published in Organic Letters. The article was written by Zhang, Cheng-Yun; Zhu, Jie; Cui, Su-Hang; Xie, Xiao-Yu; Wang, Xiao-Dong; Wu, Lei. The article contains the following contents:

A novel visible-light-induced 1,4-hydroxysulfonylation of vinyl enynes I (R1 = R2 = Ph, 4-MeC6H4, 4-ClC6H4, 4-FC6H4; R1 = Ph, R2 = Me; R3 = H, n-hexyl, Ph, 4-MeOC6H4, 1-naphthyl, 3-pyridinyl, 3-thienyl, etc.) with sulfonyl chlorides R4SO2Cl (R4 = Et, Me2N, Ph, 4-MeC6H4, 2-thienyl, etc.) has been established, providing a highly efficient protocol to access multisubstituted sulfonyl allenic alcs. II. Control experiments and mechanistic studies disclose that the target products result from sequential reactions of hydroxyl and tosyl radicals, among which chloride anion plays a key role to generate the requisite hydroxyl radical, thus bridging water and enynes. Moreover, the vinyl pendant is believed to decisively affect the site-selectivity of hydroxyl radical.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Electric Literature of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Electric Literature of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Khamis, Noha; Clarkson, Guy J.; Wills, Martin published an article in Dalton Transactions. The title of the article was 《Heterocycle-containing Noyori-Ikariya catalysts for asymmetric transfer hydrogenation of ketones》.Formula: C4H3ClO2S2 The author mentioned the following in the article:

Synthesis of a range of N-(heterocyclesulfonyl)-functionalized Noyori-Ikariya catalysts was described. These complexes were prepared through a short sequence starting from C2-sym. 1,2-diphenylethylene-1,2-diamine and were characterized by a range of methods including X-ray crystallog. These complexes were active catalysts for the asym. transfer hydrogenation of a range of ketones to afford alcs. RCHOHR1 [R = Ph, 4-ClC6H4, 2-thienyl, etc.; R1 = Me, CH2Cl, CH2Ph] with high ee in most cases and notably good results for ortho-substituted acetophenones. In the part of experimental materials, we found many familiar compounds, such as Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Zhuoxiong; Yu, Hui published an article in 2022. The article was titled 《Synthesis of (E)-α-chloromethyl vinyl sulfones by 1, 2-radical difunctionalization of allenes with sodium sulfinates and iron(III) chloride hexahydrate》, and you may find the article in Tetrahedron Letters.Formula: C4H3ClO2S2 The information in the text is summarized as follows:

An efficient radical chlorosulfonylation of allenes was disclosed and vinylsulfones were prepared smoothly under mild conditions. By using sodium sulfinates as radical precursors, iron(III) chloride hexahydrate (FeCl3.6H2O) as oxidant and chloride source, allenes were converted into (E)-α-chloromethyl vinylsulfones I [R = Me, Ph, 4-FC6H4, etc., R1 = Ph, R2 = H, X = Cl, Br; R = Ph, R1 = 2-MeC6H4, 4-FC6H4, 4-ClC6H4, etc., R2 = H, Me, X = Cl] via regioselective 1,2-radical difunctionalization process in moderate to good yields. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Formula: C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Formula: C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Carbene-catalyzed atroposelective synthesis of axially chiral styrenes》 was written by Yan, Jia-Lei; Maiti, Rakesh; Ren, Shi-Chao; Tian, Weiyi; Li, Tingting; Xu, Jun; Mondal, Bivas; Jin, Zhichao; Chi, Yonggui Robin. Synthetic Route of C4H3ClO2S2This research focused onynal sulfinic acid phenol heterocyclic carbene catalyst addition; axially chiral styrene preparation enantioselective click chem. The article conveys some information:

Axially chiral styrenes bearing a chiral axis between a sterically non-congested acyclic alkene and an aryl ring are difficult to prepare due to the low rotational barrier of the axis. Disclosed here is an N-heterocyclic carbene (NHC) catalytic asym. solution to this problem. The reaction involves ynals, sulfinic acids, and phenols as the substrates with an NHC as the catalyst. Key steps involve selective 1,4-addition of sulfinic anion to acetylenic acylazolium intermediate and sequential E-selective protonation to set up the chiral axis. The reaction affords axially chiral styrenes bearing a chiral axis as the product with up to > 99:1 e.r., > 20:1 E/Z selectivity, and excellent yields. The sulfone and carboxylic ester moieties in the styrene products are common moieties in bioactive mols. and asym. catalysis.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics