Category: 16629-19-9

Ding, Ran; Fu, Jian-Ming; Tian, Hai-Yu; Chen, Nian-Shou; Liu, Lei; Guo, Yu; Wang, Pei-Long published their research in New Journal of Chemistry in 2021. The article was titled 《Sulfonyl radical-induced regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides to produce 1,2-dihydropyridines by copper catalysis》.Recommanded Product: Thiophene-2-sulfonyl chloride The article contains the following contents:

A Cu-catalyzed regioselective cyclization of 3-aza-1,5-enynes with sulfonyl chlorides for the synthesis of 1,2-dihydropyridines I [R = 4-MeC6H4, 3-ClC6H4, 2-thienyl, etc.; R1 = Me, Ph, 3-MeC6H4, 4-MeOC6H4, 2-NCC6H4, 2-thienyl; R2 = H, Me, Et; R3 = Ph, 4-BrC6H4, 2-naphthyl, etc.] was described. This present method provided a new pathway for the construction of 1,2-dihydropyridines from 3-aza-1,5-enynes in reasonable yields and an alternative method for the synthesis of 3-functionalized multi-substituted pyridines. In the experimental materials used by the author, we found Thiophene-2-sulfonyl chloride(cas: 16629-19-9Recommanded Product: Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Recommanded Product: Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksIn 2020 ,《The continuous-flow electrosynthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under metal-free and oxidant-free conditions》 was published in Organic Chemistry Frontiers. The article was written by Xu, Jia; Yang, Zhao; Hua, Jiawei; Lin, Yang; Bian, Mixue; Li, Yuguang; Liu, Chengkou; He, Wei; Fang, Zheng; Guo, Kai. The article contains the following contents:

An efficient and green electrochem. continuous-flow approach was developed for the synthesis of 4-(sulfonylmethyl)isoquinoline-1,3(2H,4H)-diones I [R1 = H, 8-Fe, 5,7-di-Me, etc.; R2 = Me, Et, Ph, etc.; R3 = Me, Ph, 2-thienyl, etc.] through the sulfonylation of alkenes with sulfonylhydrazides. The reaction proceeded in a continuous-flow electrolytic cell under metal-free and oxidant-free conditions. A series of activated alkenes were suitable for this system, and the corresponding products I were obtained in moderate to good yields. Moreover, reaction scale-up was smoothly achieved using the electrochem. continuous-flow system without changing the reaction conditions. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Product Details of 16629-19-9In 2022 ,《Click inspired novel pyrazole-triazole-persulfonimide & pyrazole-triazole-aryl derivatives; Design, synthesis, DPP-4 inhibitor with potential anti-diabetic agents》 appeared in Bioorganic Chemistry. The author of the article were Nidhar, Manisha; Khanam, Shaziya; Sonker, Priyanka; Gupta, Priya; Mahapatra, Archisman; Patil, Swaraj; Yadav, Brijesh Kumar; Singh, Rahul Kumar; Kumar Tewari, Ashish. The article conveys some information:

This work presented the first report on designing, synthesizing of novel pyrazole-triazole-persulfonimide and pyrazole-triazole-aryl derivatives via click reaction using CuI catalyst and evaluated for their anti-diabetic activity and DPP-4 inhibitory effect. Click reactions went smoothly with CuI catalyst in the presence of tridentate chelating ligands and produced copper-free target pyrazole-triazole-persulfonimide analogs in excellent yield at RT. The designed compounds were docked against DPP-4 enzyme and showed excellent interaction with active amino acids residue. Further, all novel pyrazole-triazole-persulfonimide and pyrazole-triazole derivatives were subjected to enzyme-based in vitro DPP-4 inhibitory activity. Based on the SAR study DPP-4 inhibitory capacity compounds 6N-((1-(3-((1,3-diphenyl-1H-pyrazol-5-yl)oxy)propyl)-1H-1,2,3-triazol-4-yl)methyl)4-methyl-N-(3-nitrobenzyl)benzenesulfonamide (9.52 nM) and 8h (4.54 nM) possessed the significant inhibition of DPP-4. Finally compounds 6N-((1-(3-((1,3-diphenyl-1H-pyrazol-5-yl)oxy)propyl)-1H-1,2,3-triazol-4-yl)methyl)4-methyl-N-(3-nitrobenzyl)benzenesulfonamide and (3-((3-methyl-1-phenyl-1H-pyrazol-5-yl)oxy)propyl)-4-(thiophen-3-yl)-1H-1,2,3triazole were evaluated for their in vivo anti-diabetic activity using STZ induced diabetic mice model, and 8h showed a significant diabetic control effect compared to the sitagliptin drug. These studies demonstrated that the novel pyrazole-triazole-persulfonimide and pyrazole-triazole-aryl derivatives might be used as the leading compounds to develop novel DPP-4 inhibitors as potential anti-diabetic agents. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Product Details of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Product Details of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Che, Zhiping; Guo, Xiaolong; Li, Yuanhao; Zhang, Song; Zhu, Lina; He, Jiaxuan; Sun, Di; Guo, Yihao; Liu, Yibo; Wei, Ruxue; Huang, Xiaobo; Liu, Shengming; Chen, Genqiang; Tian, Yuee published an article in Pest Management Science. The title of the article was 《Synthesis of paeonol ester derivatives and their insecticidal, nematicidal, and anti-oomycete activities》.Safety of Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

Paeonol is extracted and isolated as a rich and sustainable natural bioresource from the root bark of Paeonia suffruticosa, the derivatives of which exhibit numerous biol. activities. It is well known that ester compounds play a very important role in pest control, such as organophosphorus, carbamate and pyrethroid pesticides. To discover biorational natural product-based pesticides, three series of (60) paeonol ester derivatives (7a-t, 8g,p, 9g,p, 10g-j,n-u, 11g,u, 12g,u, 13a-p, 14b,c, and 15b,c) were prepared by structural modification of paeonol, and their structures were well characterized by proton NMR (1H-NMR), carbon-13 NMR (13C-NMR), high-resolution mass spectrometry (HRMS), and m.p. Furthermore, we assessed the compounds as insecticidal, nematicidal, and anti-oomycete agents against three serious agricultural pests, Mythimna separata, Heterodera glycines, and Phytophthora capsici. Among all tested compounds: (i) compound 8p showed more significant insecticidal activity than toosendanin, and the final mortality rates of 8p and toosendanin against M. separata (1 mg mL-1) were 70.4%, and 51.9%, resp.; (ii) compound 7a exhibited more promising nematicidal activity than paeonol, and the median lethal concentration (LC50) values of 7a and 1 against H. glycines were 15.47 and 50.80 mg L-1, resp.; (iii) compounds 7n and 13m displayed more significant anti-oomycete activity compared to zoxamide against Phytophthora capsici, and the median effective concentration (EC50) values of 7n, 13m, and zoxamide were 23.72, 24.51, and 26.87 mg L-1, resp.; and the protective effect of the compounds against Phytophthora capsici in vivo further confirmed the effectiveness of the agents. This study suggested that the introduction of a nitro at the C5 or C3 position of paeonol could improve its bioactivity against M. separata, H. glycines, and Phytophthora capsici. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Safety of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Safety of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Sun, Bin; Tian, Hai-Xia; Ni, Zhi-Gang; Huang, Pan-Yi; Ding, Hao; Li, Bing-Qian; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu published an article in Organic Chemistry Frontiers. The title of the article was 《Photocatalyst-, metal- and additive-free regioselective radical cascade sulfonylation/cyclization of benzimidazole derivatives with sulfonyl chlorides induced by visible light》.Reference of Thiophene-2-sulfonyl chloride The author mentioned the following in the article:

Herein, an environmentally friendly and practical protocol for the visible-light-triggered regioselective radical cascade sulfonylation/cyclization of unactivated alkenes towards the synthesis of polycyclic benzimidazoles containing the sulfone group has been developed. Notably, the control experiments demonstrated that a radical pathway was involved in this reaction, and a sulfonyl radical center was initially generated via self-homolysis of sulfonyl chloride upon irradiation Moreover, this protocol features a wide substrate scope, high atom economy, and excellent regioselectivity, and is easy to scale up. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Reference of Thiophene-2-sulfonyl chloride)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Reference of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ding, Ran; Liu, Ya-Li; Hao, Hui; Chen, Chuan-Yi; Liu, Lei; Chen, Nian-Shou; Guo, Yu; Wang, Pei-Long published an article in 2021. The article was titled 《Regioselective, copper(I)-catalyzed, tandem sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides》, and you may find the article in Organic Chemistry Frontiers.Category: chlorides-buliding-blocks The information in the text is summarized as follows:

A copper(I)-catalyzed sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides was developed. This transformation demonstrated a broad substrate scope and presented excellent regioselectivity after radical addition and subsequent deprotonation to form the derivatized 1,5-dihydro-2H-pyrrol-2-one scaffold in one pot. The experimental process involved the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Category: chlorides-buliding-blocks)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 16629-19-9In 2022 ,《1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade》 appeared in Nature Communications. The author of the article were Radhoff, Niklas; Studer, Armido. The article conveys some information:

Here a simple, efficient and scalable method for the preparation of sterically hindered and valuable α-quaternary amides RNHC(O)C(R1)(R2)(R3) (R = i-Pr, Ph, 2,2-dimethyl-1,3-dioxan-5-yl, etc.; R1 = Me, Et, Ph; R2 = Me, Ph, 4-iodophenyl, etc; R1R2 = -(CH2)6-; R3 = Ph, 4-chlorophenyl, thiophen-2-yl, etc.) via a polar-radical crossover-enolate oxidation-aryl migration pathway was reported. A variety of easily accessible N-alkyl and N-arylsulfonamides RNHS(O)2R3 is reacted with disubstituted ketenes R1(R2)C=C=O to give the corresponding amide enolates, which undergo upon single electron transfer oxidation, a 1,4-aryl migration, desulfonylation, hydrogen atom transfer cascade to provide α-quaternary amides in good to excellent yields. Various mono- and di-substituted heteroatom-containing polycyclic arenes engage in the aryl migration reaction. Functional group tolerance is excellent and substrates as well as reagents are readily available rendering the method broadly applicable. In the experiment, the researchers used many compounds, for example, Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Che, Zhiping; Li, Yuanhao; Guo, Xiaolong; He, Jiaxuan; Zhang, Song; Zhu, Lina; Liu, Yibo; Wei, Ruxue; Yang, Yingjun; Huang, Xiaobo; Liu, Shengming; Chen, Genqiang; Tian, Yuee published an article in Chemistry & Biodiversity. The title of the article was 《Synthesis and Anti-Oomycete Activity of Sulfonate Derivatives of Fenjuntong》.Related Products of 16629-19-9 The author mentioned the following in the article:

In order to discover highly active fungicides, sixteen novel sulfonate derivatives of Fenjuntong were synthesized by structural modification of 2′-hydroxybutyrophenone, and their anti-oomycete activity against Phytophthora capsici Leonian was determined in this study. Among all tested compounds, compound I displayed more significant anti-oomycete activity than the precursor Fenjuntong against P. capsici, and the EC50 values of I and Fenjuntong were 84.50 and 517.25 mg/L, resp. By comparing the anti-oomycete activity of compounds the following conclusions were drawn: (1) Hydroxy group is well tolerated, and sulfonylation of hydroxy group enhances its anti-oomycete activity. (2) The proper length of the ketone carbonyl chain is very important for their anti-oomycete activity. (3) The presence of a site methoxy group in the structural skeleton is closely related to the anti-oomycete activity. These important results will pave the way for further modification of Fenjuntong to develop potential new fungicides. The results came from multiple reactions, including the reaction of Thiophene-2-sulfonyl chloride(cas: 16629-19-9Related Products of 16629-19-9)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Related Products of 16629-19-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lv, Yunhe; Han, Wanru; Pu, Weiya; Xie, Jinhui; Wang, Axue; Zhang, Mengyue; Wang, Jin; Lai, Junrong published an article in 2022. The article was titled 《Copper-catalyzed regioselective 1,4-sulfonylcyanation of 1,3-enynes with sulfonyl chlorides and TMSCN》, and you may find the article in Organic Chemistry Frontiers.Computed Properties of C4H3ClO2S2 The information in the text is summarized as follows:

A novel and practical copper-catalyzed reaction for the 1,4-sulfonylcyanation of 1,3-enynes under mild conditions was described. This protocol provided efficient and straightforward access to a variety of 5-sulfonylpenta-2,3-dienenitrile derivatives with excellent functional group tolerance and good regioselectivity from readily available 1,3-enynes and com. available sulfonyl chlorides and TMSCN. A mechanism involving sulfonyl and allenyl radical species was proposed. After reading the article, we found that the author used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Computed Properties of C4H3ClO2S2)

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Computed Properties of C4H3ClO2S2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application In Synthesis of Thiophene-2-sulfonyl chlorideIn 2022 ,《Propargyl Chalcones’ Radical Annulation/Sulfonation Reaction: Efficient Synthesis of Benzo[b]oxepin-5(2H)-one and Chromane Derivatives》 was published in Journal of Organic Chemistry. The article was written by Yu, Qiuyu; Zhang, Jinghang; Wu, Fan; Liu, Xiaoqin; Wang, Chang; Zhang, Jinpeng; Rong, Liangce. The article contains the following contents:

A novel and facile methodol. for the synthesis of sulfonated benzo[b]oxepinones I (R = H, F, Br; R1 = H, MeO; R2 = Ph, 3-methoxyphenyl, 2-thienyl, etc.; Ar = Ph, 4-methylphenyl, 4-bromophenyl, etc.) and chromane derivatives II (R3 = H, MeO, F, Cl, Br; R4 = H, MeO; R3R4 = -CH=CH-CH=CH-; R5 = Ph, 2-fluorophenyl, 4-methylphenyl; Ar1 = Ph, 2-fluorophenyl, biphenyl-4-yl, etc.) was reported by the reaction of propargyl chalcones 3-R-4-R1-6-OCH2CCHC6H2C(O)CH=CHR2/3-R3-4-R4-6-OCH2CCHC6H2CH=CHC(O)R5 with arylsulfonyl chlorides Ar/Ar1SO2Cl via radical cascade annulation/sulfonation under laboratory conditions. Readily available propargyl chalcones, commercialized arylsulfonyl chlorides, and simple reaction conditions make this six(seven)-membered oxygen-containing heterocycles’ synthetic strategy more attractive and with significant application values. In addition to this study using Thiophene-2-sulfonyl chloride, there are many other studies that have used Thiophene-2-sulfonyl chloride(cas: 16629-19-9Application In Synthesis of Thiophene-2-sulfonyl chloride) was used in this study.

Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Application In Synthesis of Thiophene-2-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics