Category: 16766-30-6

Aulakh, Manpreet Kaur; Pal, Bonamali; Vaishnav, Alisha; Prakash, N. Tejo published the artcile< Biosynthesized monodispersed spherical Se co-catalyst nanoparticles impregnated over ZnO for 4-chloroguaiacol degradation under solar irradiations>, Product Details of C7H7ClO2, the main research area is chloroguaiacol selenium zinc oxide cocatalyst nanoparticle degradation solar irradiation.

The present study outlines the importance of biosynthesized selenium (Se) nanoparticles as co-catalyst for enhanced photoactivity of Se@ZnO nanocomposites under solar irradiations. The selenium-rich Bacillus sp. bacteria were isolated and used to synthesize extracellular Se nanoparticles (Se NPs), and structural characterization was carried out using various techniques. Different amounts (0.5-2 wt%) of Se NPs were loaded over ZnO followed by calcination at 200° C for 120 min to form Se@ZnO nanocomposites. The optical absorption of Se@ZnO showed a slight red shift as compared to bare ZnO and a new broadband in 500-700 nm range appeared with increasing the amount of Se. HR-TEM anal. showed spherical shaped, highly monodispersed Se NPs with size less than 100 nm. Further, 1 wt% Se@ZnO nanocomposites exhibited the highest degradation efficiency (93%) of 4-chloroguaiacol (4-CG) as compared to bare ZnO (8%) under natural sunlight. The reaction followed first-order kinetics with an apparent rate constant k = 0.16 min-1. Moreover, the environmental applicability of the synthesized Se@ZnO was also tested for real pharmaceutical industrial effluent degradation It was observed that the COD (COD) level decreased from 1140 mgL-1 to 500 mgL-1 after 240 min of sunlight exposure.

Journal of Environmental Chemical Engineering published new progress about Absorption spectra. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Product Details of C7H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Armstrong, Tom; Lamont, Malcolm; Lanne, Alice; Alderwick, Luke J.; Thomas, Neil R. published the artcile< Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives>, COA of Formula: C7H7ClO2, the main research area is triclosan triazole preparation regioselective InhA inhibitor docking; InhA; Isoniazid; Mycobacterium tuberculosis; TB; Triazole; Triclosan.

A library of new 1,5-triazoles I [R = H, Me, pyrrolidin-1-yl, etc.], designed to mimic the structures of both triclosan mols. uniquely bound to InhA was synthesized. The inhibitory activity of these compounds was evaluated using isolated enzyme assays with I [R = 4-chloro-2-hydroxyphenoxy] exhibiting an IC50 of 5.6μM. Whole-cell evaluation was also performed, with I [R = cyclopropylmethoxy] showing the greatest potency, with an MIC99 of 12.9μM against M. bovis.

Bioorganic & Medicinal Chemistry published new progress about Alkynes, aryl Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, COA of Formula: C7H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Javed, Erman; Guthrie, Jacob D.; Neu, Justin; Chirayath, George S.; Huo, Shouquan published the artcile< Introducing an α-Keto Ester Functional Group through Pt-Catalyzed Direct C-H Acylation with Ethyl Chlorooxoacetate>, Recommanded Product: 4-Chloro-2-methoxyphenol, the main research area is aryloxy pyridine chlorooxoacetate platinum catalyst regioselective acylation; aryl oxoacetate preparation.

Platinum-catalyzed selective C-H acylation of 2-aryloxypyridines with Et chlorooxoacetate provided an efficient way of introducing an α-keto ester functional group. The reaction is oxidant-free, additive-free and more significantly free of any decarbonylative side reactions. The reaction tolerated a variety of substituents from strongly electron-donating to strongly electron-withdrawing groups. Double acylation was feasible for 2-phenoxypyridine and its derivatives with only one substituent at the para position. Although the reaction of 2-(2-methylphenoxy)pyridine with Et malonyl chloride did not produce the desired β-keto ester, the reaction with Et succinyl chloride proceeded smoothly to give the γ-keto ester. Et chlorooxoacetate was much more reactive than Et succinyl chloride in this Pt-catalyzed C-H acylation reaction.

ACS Omega published new progress about Acylation catalysts (regioselective). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Recommanded Product: 4-Chloro-2-methoxyphenol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gallagher, Rory T.; Basu, Souradeep; Stuart, David R. published the artcile< Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers>, Synthetic Route of 16766-30-6, the main research area is diaryl ether preparation chemoselective; aryl iodonium salt arylation.

Herein, a synthetic approach for arylation that exploits the in situ formation and reaction of an unsym. diaryliodonium salt is described. In this way, aryl iodides are used as reagents in a metal-free reaction with phenols, and a trimethoxyphenyl (TMP) group is used as a “”dummy”” group to facilitate transfer of a wide range of aryl moieties. The scope of aryl electrophiles and phenol nucleophiles is broad (>30 examples) and the yields are high (52-95%, 80% avg.). One-pot coupling reactions avoid the synthesis of diaryliodonium salts and provide opportunities for sequential reactions and novel chemoselectivity.

Advanced Synthesis & Catalysis published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Synthetic Route of 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Bo; Sun, Jianfei; Mei, Qiong; An, Zexiu; Wang, Xueyu; Cao, Haijie; Han, Dandan; He, Maoxia published the artcile< Feasibility of carbon-doped BN nanosheets as photocatalyst for degradation of 4-chloroguaiacol and ecotoxicity fate during indirect photochemical transformation>, Recommanded Product: 4-Chloro-2-methoxyphenol, the main research area is chloroguaiacol water degradation oxidation photocatalyst carbon boron nitride ecotoxicity.

Although carbon-doped BN nanosheet (BCN) has been successfully synthesized and used, it has not been reported as a photocatalyst for the degradation of organic pollutants. In this study, 4-chloroguaiacol (4-CG) was selected as a representative substance to investigate the potential of utilizing BCN as photocatalyst for organic removal by use of computational simulation. The adsorption mechanisms, degradation mechanisms, and kinetics of 4-CG with the presence of different catalysts were determined The adsorption energy of 4-CG on BCN was 10.71 kcal mol-1, and the ΔG≠s of initial reactions of 4-CG with ·OH were also reduced onto the BCN substrate. The band gap of BCN was 1.54 eV. Our computations depicted that the doping of aromatic carbon into BN narrows bandgap, and retains well catalytic performance and adsorption properties. Therefore, BCN nanosheet is a promising photocatalyst for organic pollutants removal. Possible degradation pathways of 4-CG and aquatic toxicity assessment during degradation were also carried out. More toxic products would be formed and the transformation products were still harmful to three trophic levels of aquatic organisms (fish, green algae, and daphnia).

Journal of Catalysis published new progress about Adsorption. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Recommanded Product: 4-Chloro-2-methoxyphenol.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ippolito, Joseph A.; Niu, Haichan; Bertoletti, Nicole; Carter, Zachary J.; Jin, Shengyan; Spasov, Krasimir A.; Cisneros, Jose A.; Valhondo, Margarita; Cutrona, Kara J.; Anderson, Karen S.; Jorgensen, William L. published the artcile< Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead>, SDS of cas: 16766-30-6, the main research area is covalent inhibitor HIV1 RT fluorosulfate warhead preparation.

Covalent inhibitors of wild-type HIV-1 reverse transcriptase (CRTIs) are reported. Three compounds derived from catechol diether non-nucleoside inhibitors (NNRTIs) with addition of a fluorosulfate warhead are demonstrated to covalently modify Tyr181 of HIV-RT. X-ray crystal structures for complexes of the CRTIs with the enzyme are provided, which fully demonstrate the covalent attachment, and confirmation is provided by appropriate mass shifts in ESI-TOF mass spectra. The three CRTIs and six noncovalent analogs are found to be potent inhibitors with both IC50 values for in vitro inhibition of WT RT and EC50 values for cytopathic protection of HIV-1-infected human T-cells in the 5-320 nM range.

ACS Medicinal Chemistry Letters published new progress about Anti-HIV agents (anti-HIV-1 agents, Anti-HIV-1 drugs). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, SDS of cas: 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chetty, Sarentha; Armstrong, Tom; Kharkwal, Shalu Sharma; Drewe, William C.; De Matteis, Cristina I.; Evangelopoulos, Dimitrios; Bhakta, Sanjib; Thomas, Neil R. published the artcile< New InhA inhibitors based on expanded triclosan and Di-triclosan analogues to develop a new treatment for tuberculosis>, COA of Formula: C7H7ClO2, the main research area is triclosan preparation InhA Inhibition mol docking SAR; InhA; Mycobacterium bovis BCG; Mycobacterium tuberculosis; isoniazid; molecular modelling; structure-based drug-design; triazole; triclosan; tuberculosis.

This work aimed to design new ‘direct’ InhA inhibitors that obviate the need for activation by KatG, circumventing pre-existing resistance. In silico mol. modeling was used as part of a rational structure-based drug-design approach involving inspection of protein crystal structures of InhA:inhibitor complexes, including the broad spectrum antibiotic triclosan (TCS). One crystal structure exhibited the unusual presence of two triclosan mols. within the Mycobacterium tuberculosis InhA binding site. This became the basis of a strategy for the synthesis of novel inhibitors. A series of new, flexible ligands were designed and synthesized, expanding on the triclosan structure. Low Min. Inhibitory Concentrations (MICs) were obtained for benzylphenyl compounds I [R = MeO, acetoxy, acetyl; R1 = MeO, methanesulfonyloxy; X = F, Cl, Br; Y =NH, O] and di-triclosan derivative II [R2 = MeO, R3 = Me], against Mycobacterium bovis BCG although these may also be inhibiting other enzymes. The ether linked di-triclosan derivative II [R2 = OH, R3 = 4-chloro-2-hydroxyphenyl] displayed excellent in-vitro isolated enzyme inhibition results comparable with triclosan, but at a higher MIC (125μg mL-1). These compounds offered good opportunities as leads for further optimization.

Pharmaceuticals published new progress about Drug design. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, COA of Formula: C7H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Garba, Zaharaddeen N.; Ibrahim, I.; Abdul Rahim, Afidah published the artcile< Equilibrium isotherms and kinetics modelling for an efficient removal of 4-chloro-2-methoxyphenol from aqueous solution using optimal activated carbon>, Synthetic Route of 16766-30-6, the main research area is activated carbon adsorbent chloromethoxyphenol kinetic model adsorption wastewater treatment.

A surface area of 1085.92 m2/g and a monolayer adsorption capacity of 497.66 mg/g were obtained from the optimum activated carbon derived using Prosopis africana seed hulls (PASH-AC) at the activation temperature of 795°C, activation time of 62 min, and impregnation ratio of 2.45. Five different forms of the linearized Langmuir equations along with two other models (Freundlich and Temkin) were tested on the adsorption data. The best adsorption model was selected using correlation coefficient (R2) and chi-square (χ2) was used for assessing the validity of each isotherm model. Langmuir-2 along and pseudo-second-order models were found to be the most suitable model for describing the equilibrium and kinetic processes, resp.

Avicenna Journal of Environmental Health Engineering published new progress about Adsorbents. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Synthetic Route of 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Xiao; Li, Shaochen; Yang, Yandong; Zhao, Yuanhui; Qu, Jiao; Li, Chao published the artcile< Predicting reaction rate constants of ozone with ionic/non-ionic compounds in water>, Reference of 16766-30-6, the main research area is nonylphenol chloroguaiacol ozone reaction rate drinking water purification; Ionic/non-ionic compounds; Ozonation; Partial least squares (PLS); Quantitative structure–activity relationship; Reaction rate constant.

Ozonation is a significant technol. for the mitigation of pollutants in water. The second-order reaction rate constant (kO3) of ozone (O3) with compounds is essential for measuring their reactivity toward O3 and understanding their fate during ozonation. However, there is a huge gap between the number of existing chems. and the available exptl. kO3 values. Moreover, the reactivity of ionizable compounds with different ionization forms toward O3 may differ greatly. In this study, two quant. structure activity relationship (QSAR) models for non-ionic and ionic species, are resp. established with partial least squares (PLS) and support vector machine (SVM) methods based on the large datasets (324 non-ionic states and 188 ionic states). These models exhibit good fitting ability (non-ionic model: R2tr > 0.760; ionic model: R2tr > 0.780), robustness (Q2CUM > 0.700), predictive performance (non-ionic model: R2ext > 0.760; ionic model: R2ext > 0.810) and wide applicability domain. The mol. parameters in two models are revealed to be significantly different, which may be attributed to the significant difference in mol. structures in two datasets and different reactivities of uncharged and charged states toward O3. Addnl., the overall kO3 for compounds at certain pH can be estimated by combining the two single QSAR models. These models and methods can become the effective tools for predicting the conversion rate of pollutants by O3 in the urban sewage and drinking water treatment.

Science of the Total Environment published new progress about Drinking water pollution. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Reference of 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sang, Dayong; Tian, Juan; Tu, Xiaodong; He, Zhoujun; Yao, Ming published the artcile< Cleavage of Catechol Monoalkyl Ethers by Aluminum Triiodide-Dimethyl Sulfoxide>, SDS of cas: 16766-30-6, the main research area is catechol preparation; monoalkyl ether catechol demethylation aluminum triiodide dimethyl sulfoxide.

Using eugenol and vanillin as model substrates, a practical method is developed for the cleavage o-hydroxyphenyl alkyl ethers. Aluminum oxide iodide (O=AlI), generated in situ from aluminum triiodide and DMSO, is the reactive ether cleaving species. The method is applicable to catechol monoalkyl ethers as well as normal Ph alkyl ethers for the removal of Me, Et, iso-Pr, and benzyl groups. A variety of functional groups such as alkenyl, allyl, amide, cyano, formyl, keto, nitro, and halogen are well tolerated under the optimum conditions. Partial hydrodebromination was observed during the demethylation of 4-bromoguaiacol, and was resolved using excess DMSO as an acid scavenger. This convenient and efficient procedure would be a practical tool for the preparation of catechols.

Synthesis published new progress about C-O bond cleavage. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, SDS of cas: 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics