Category: 17082-09-6

Sari, Sait; Unalan, Seda; Yilmaz, Mehmet published the artcile< Synthesis and characterization of unsaturated diacyl and alkyl-acyl piperazine derivatives>, COA of Formula: C9H7ClO, the main research area is unsaturated diacyl alkyl acyl piperazine preparation.

The aim of this study is to obtain new unsaturated piperazine compounds by the reaction of piperazine derivatives with acyl chlorides. Methacryloyl piperazine was synthesized from the reaction of methacrylic anhydride with piperazine. Few acyl chlorides were prepared by the reaction of thionyl chloride with carboxylic acids which were obtained as a result of the reaction of malonic acid and suitable aldehydes. The remaining acyl chlorides were synthesized by the reaction of thionyl chloride with carboxylic acids which were obtained from hydrolyzation of esters. Sym. diacyl piperazine compounds were obtained from the reaction of Methacryloyl piperazine with corresponding acyl chlorides. In addition, from the reaction of Methacryloyl piperazine and corresponding acyl chlorides, nonsym. diacyl piperazine compounds were synthesized in medium to good yields (63%-84%). Also, alkyl-acyl piperazine compounds were obtained from the reaction of allyl piperazine and cinnamyl piperazine with corresponding acyl chlorides.

Turkish Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Feng-Wei; Mao, Yang-Jie; Pu, Jun; Li, Huan-Le; Ye, Peng; Xu, Zhen-Yuan; Lou, Shao-Jie; Xu, Dan-Qian published the artcile< Ni-catalyzed deamidative fluorination of amides with electrophilic fluorinating reagents>, Application In Synthesis of 17082-09-6, the main research area is acyl fluoride preparation; amide selectfluor deamidative fluorination nickel catalyst.

Here, a Ni-catalyzed deamidative fluorination of diverse acylglutarimides I (R = 4-propylphenyl, 2-naphthyl, (2E)-3-phenylprop-2-en-1-yl, etc.) with electrophilic fluorinating reagents (selectfluor) has been described. Different types of amides including aromatic amides and olefinic amides I were well compatible, affording the corresponding acyl fluorides RC(O)F in good to excellent yields.

Organic & Biomolecular Chemistry published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Xiaofang; Zhou, Lei; Yang, Ruoqi; Guo, Fengzhe; Tang, Zi-Long; Xiao, Jing published the artcile< A practical chlorination of tert-butyl esters with PCl3 generating acid chlorides>, SDS of cas: 17082-09-6, the main research area is acid chloride preparation; tert butyl ester phosphorus trichloride chlorination.

For the first time, using PCl3, a range of tert-Bu esters is chlorinated successfully, allowing access of both aromatic acid chlorides and aliphatic acid chlorides RCOCl (R = Ph, 4-FC6H4, 4-MeC6H4, etc.) in good yields. The method features simple reaction conditions and wide substrate scope. Various tert-Bu esters including aryl esters, alkenyl esters, and alkyl esters were tolerated well in the reaction. A plausible mechanism is proposed.

Journal of Chemical Research published new progress about Acid chlorides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, SDS of cas: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Meng; Wang, Fangfang; Ding, Wenjuan; Xu, Zhipeng; Li, Xiaosan; Tian, Danmei; Zhang, Youwei; Tang, Jinshan published the artcile< Synthesis of sorbicillinoid analogues with anti-inflammation activities>, Safety of (E)-Cinnamoyl chloride, the main research area is sorbicillinoid preparation antinflammatory SAR; Anti-inflammatory effects; LPS; NO production; Sorbicillinoids; Structural modification; iNOS.

The synthesis of a series of new sorbicillinoid I [R1 = R2 = R3 = H, 3-methylbut-2-enoyl, (2E,4E)-hexa-2,4-dienoyl, (E)-3-(4-chlorophenyl)prop-2-enoyl, etc.; R2 = R3 = Me] analogs was reported and assessed their anti-inflammatory activities. Results reveal that side chain substitution with (E)-2-butenoyl, (E)-3-(4-fluorophenyl)-2-propenoyl, and (E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl significantly enhanced the inhibitory effects of the derivatives on nitric oxide (NO) production and inducible NO synthesis (iNOS) expression stimulated by lipopolysaccharides (LPS) in mouse macrophage. Further chem. derivatization showed that the monomethylresorcinol skeleton worked better than the dimethylresorcinol skeleton in inhibiting LPS-induced inflammatory response in cultured cells. Among the synthesized sorbicillinoid analogs, compounds I [R1 = (E)-but-2-enoyl, R2 = R3 = Me; R1 = (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl, R2 = R3 = Me] exhibited the strongest anti-inflammatory activities, holding the promise of being developed into lead compounds that was explored as potent anti-inflammation agents.

Bioorganic & Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Safety of (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shen, Yao-Bin; Zhao, Jian-Qiang; Ge, Zhen-Zhen; Wang, Zhen-Hua; You, Yong; Zhou, Ming-Qiang; Yuan, Wei-Cheng published the artcile< HFIP-promoted intramolecular dearomative annulation of pyridylacetate derivatives to access functionalized 3,4-dihydroquinolizin-2-ones>, Application of C9H7ClO, the main research area is hydroxy nitropyridinylalkadiene hexafluoroisopropanol intramol dearomative annulation; aryl quinolizine preparation.

HFIP-promoted transition metal-free intramol. dearomative annulation reaction of 2-pyridylacetate derivatives was successfully developed under mild conditions, affording structurally diverse substituted 3,4-dihydroquinolizin-2-ones decorated with a range of functional groups in moderate to good yields. The key to the success of this reaction was the existence of the substrates 2-pyridylacetate derivatives in complete enol forms as well as the utilization of HFIP as the solvent.

Tetrahedron published new progress about 1,3-Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Klepp, Julian; Podversnik, Harald; Puschnig, Johannes; Wallace, Andrew; Greatrex, Ben W. published the artcile< Diastereoselective sulfa-Michael reactions controlled by a biomass-derived chiral auxiliary>, HPLC of Formula: 17082-09-6, the main research area is dioxabicyclo octanyl phenylpropenoate preparation thiophenol sulfa Michael addition; propanoate dioxabicyclo octanyl diphenyl diastereoselective green preparation.

A family of chiral auxiliaries derived from the lignocellulosic biomass pyrolysis product levoglucosenone (LGO) was screened in the sulfa-Michael reaction. When promoted by inorganic bases with potassium counterions, the auxiliary with geminal benzyl substituents showed diastereoselectivity up to 90:10 for a broad range of α,β-unsaturated esters.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shen, Yao-Bin; Zhao, Jian-Qiang; Ge, Zhen-Zhen; Wang, Zhen-Hua; You, Yong; Zhou, Ming-Qiang; Yuan, Wei-Cheng published the artcile< HFIP-promoted intramolecular dearomative annulation of pyridylacetate derivatives to access functionalized 3,4-dihydroquinolizin-2-ones>, Application of C9H7ClO, the main research area is hydroxy nitropyridinylalkadiene hexafluoroisopropanol intramol dearomative annulation; aryl quinolizine preparation.

HFIP-promoted transition metal-free intramol. dearomative annulation reaction of 2-pyridylacetate derivatives was successfully developed under mild conditions, affording structurally diverse substituted 3,4-dihydroquinolizin-2-ones decorated with a range of functional groups in moderate to good yields. The key to the success of this reaction was the existence of the substrates 2-pyridylacetate derivatives in complete enol forms as well as the utilization of HFIP as the solvent.

Tetrahedron published new progress about 1,3-Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Klepp, Julian; Podversnik, Harald; Puschnig, Johannes; Wallace, Andrew; Greatrex, Ben W. published the artcile< Diastereoselective sulfa-Michael reactions controlled by a biomass-derived chiral auxiliary>, HPLC of Formula: 17082-09-6, the main research area is dioxabicyclo octanyl phenylpropenoate preparation thiophenol sulfa Michael addition; propanoate dioxabicyclo octanyl diphenyl diastereoselective green preparation.

A family of chiral auxiliaries derived from the lignocellulosic biomass pyrolysis product levoglucosenone (LGO) was screened in the sulfa-Michael reaction. When promoted by inorganic bases with potassium counterions, the auxiliary with geminal benzyl substituents showed diastereoselectivity up to 90:10 for a broad range of α,β-unsaturated esters.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pawar, Hari R.; Kamble, Narendra R.; Kamble, Vinod T. published the artcile< Chemoselective, room temperature and solvent-free synthesis of thio-esters using effective synergistic catalytic system>, Computed Properties of 17082-09-6, the main research area is thioester preparation chemoselective green chem; acyl chloride thiol acylation silver perchlorate niobium chloride solventless.

A simple and highly efficient room temperature catalytic protocol was developed towards the synthesis of thioesters R1C(O)SR2 (R1 = Me, Ph, 2-phenylethenyl, etc.; R2 = Ph, 4-methylphenyl, Et, propyl) from acyl chlorides R1C(O)Cl and thiols R2SH under solvent-free conditions. Ambient reaction conditions, short reaction time, and excellent product yields are notable features of this methodol.

Rasayan Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kim, Sou Hyun; Kim, Minwoo; Kwon, Doyoung; Pyo, Jae Sung; Kim, Joo Hyun; Kwak, Jae-Hwan; Jung, Young-Suk published the artcile< N-phenyl cinnamamide derivatives protect hepatocytes against oxidative stress by inducing cellular glutathione synthesis via nuclear factor (erythroid-derived 2)-like 2 activation>, HPLC of Formula: 17082-09-6, the main research area is phenyl cinnamamide preparation antioxidant hepatocyte Nrf2 ARE agonistic activity; N-phenyl cinnamamide; antioxidant response element; glutathione; nuclear factor (erythroid-derived 2)-like 2.

Substituted N-Ph cinnamamide derivatives I (R = OMe, OEt, CN, Cl, N(Me)2) were designed and synthesized to confirm activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway by the electronic effect on beta-position of Michael acceptor according to introducing the R1 and R2 group. Compounds were screened using the Nrf2/antioxidant response element (ARE)-driven luciferase reporter assay. Compound II (R = N(Me)2) showed desirable luciferase activity in HepG2 cells without cell toxicity. MRNA and protein expression of Nrf2/ARE target genes such as NAD(P)H quinone oxidoreductase 1, hemeoxygenase-1, and glutamate-cysteine ligase catalytic subunit (GCLC) were upregulated by compound II (R = N(Me)2) in a concentration-dependent manner. Treatment with compound II (R = N(Me)2) resulted in increased endogenous antioxidant glutathione, showing strong correlation with enhanced GCLC expression for synthesis of glutathione. In addition, tert-Bu hydroperoxide (t-BHP)-generated reactive oxygen species were significantly removed by compound II (R = N(Me)2) , and the results of a cell survival assay in a t-BHP-induced oxidative cell injury model showed a cytoprotective effect of compound II (R = N(Me)2) in a concentration dependent manner. In conclusion, the novel compound II (R = N(Me)2) can be utilized as an Nrf2/ARE activator in antioxidative therapy.

Molecules published new progress about Antioxidants. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics