Category: 17082-09-6

Pokhodylo, N. T.; Shyyka, O. Ya.; Obushak, M. D. published the artcile< A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group>, Application In Synthesis of 17082-09-6, the main research area is tetrazole preparation.

A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biol. active substances, were obtained.

Russian Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mukherjee, Attreyee; Mahalanabis, Kumar K. published the artcile< Systematic study on acylation of methyl 3-aminocrotonate with acid chlorides of aliphatic, aromatic and α,β-unsaturated acids: a comparative evaluation of the preference for regio- and stereoselectivity vis-a'-vis 3-aminocrotononitrile>, Name: (E)-Cinnamoyl chloride, the main research area is methyl aminocrotonate regioselective diastereoselective acylation.

Acylation of Me 3-aminocrotonate in benzene with a variety of aliphatic and aromatic acid chlorides including α,β-unsaturated acid chloride in the presence of an added organic base, (either pyridine or triethylamine) was reported. The preferred N, C-site selectivity in these reactions was compared with the terminal selectivity of the products obtained previously on acylation of Me 3-aminocrotononitrile. A strong preference either for N- or C- selectivity in N, C-acylation was observed for both Me 3-aminocrotonate and Me 3-aminocrotononitrile based on the choice of acid chlorides and added organic base. Interestingly, irresp. of the enamine Me 3-aminocrotonate or Me 3-aminocrotononitrile, acylation with α,β-unsaturated acid chlorides in the presence of triethylamine afforded 3,4-dihydropyridin-(2H)-one via [3.3] sigmatropic rearrangement of the corresponding intermediary N(E)-enamide. Accrued results showed Me 3-aminocrotonate to be a better precursor for preparation of enamides (N-acylated products) whereas 3-aminocrotononitrile was found to be a preferred choice for preparation of enaminones (C-acylated products). An attempt was made to offer a preliminary theor. interpretation for observed site selectivity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Name: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhang, Hong; Di, Shu-Sheng; Huang, Xiao-Bo; Zhou, Yun-Bing; Liu, Miao-Chang; Wu, Hua-Yue published the artcile< Direct dilithiation of N-aryl heterocycles for the construction of condensed N-heterocycles>, Electric Literature of 17082-09-6, the main research area is condensed heterocycle preparation; aryl heterocycle direct dilithiation acyl chloride trapping.

A 1,4-dilithio intermediate can be prepared from N-heterocycles by n-BuLi-promoted direct C-H dilithiation. The subsequent trapping of the 1,4-dilithio intermediate with acyl chlorides affords condensed N-heterocycles in high yields in a one-pot fashion. This protocol features a broad substrate scope, good efficiency, and high atom economy. The control experiments support the presence of a 1,4-dilithio intermediate.

Organic Chemistry Frontiers published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Electric Literature of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ruan, Zhixiong; Huang, Zhixing; Xu, Zhongnan; Mo, Guangquan; Tian, Xu; Yu, Xi-Yong; Ackermann, Lutz published the artcile< Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones>, Synthetic Route of 17082-09-6, the main research area is acrylamide fluoroalkyl sodium sulfinate electrochem trifluoroalkylation difluoroalkylation cyclization; fluoroalkylated oxindole electrochem preparation; quinolinone fluoroalkylated electrochem preparation.

The catalyst-free electrochem. di- and trifluoromethylation/cyclization of N-substituted acrylamides was realized under external oxidant-free conditions. The strategy provides expedient access to fluoroalkylated oxindoles, e.g., I, and 3,4-dihydroquinolin-2(1H)-ones with ample scope and broad functional group tolerance by mild, direct electrolysis of sodium sulfinates in an undivided cell. Detailed mechanistic studies provided strong support for a SET-based reaction manifold.

Organic Letters published new progress about Acrylamides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kalani, Komal; Chaturvedi, Vinita; Trivedi, Priyanka; Tondon, Sudeep; Srivastava, Santosh Kumar published the artcile< Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents>, Application of C9H7ClO, the main research area is Mycobacterium dihydroartemisinin antitubercular agent; Anti-tubercular activity; Dihydroartemisinin; Semi-synthetic derivatives; Synergistic effect Artemisia annua; Tuberculosis..

Chem. transformation of dihydroartemisinin for anti-tubercular lead optimization. Dihydroartemisinin, a metabolite of artemisinin was chem. converted into eight acyl derivatives and were evaluated for anti-tubercular potential against H37Rv virulent strain of Mycobacterium tuberculosis by agar-based proportion assay. Further, synergistic activity of 12-O-m-anisoyl dihydroartemisinin was also studied with the front-line anti-TB drugs, isoniazid and rifampicin. Results: The results showed that all the derivatives were active but out of eight, 12-O-m-anisoyl dihydroartemisinin and 12-O-p-anisoyl dihydroartemisinin were significantly active (MIC 25.0μg/mL). In synergistic activity evaluation, the 12-O-m-anisoyl dihydroartemisinin derivative showed reduction in MIC (by 1/8th, i.e. 3.12μg/mL and that of rifampicin by 1/4th, i.e. 0.05μg/mL) with the front-line anti-TB drug, rifampicin. The sumfractional inhibitory concentration (Σ FIC) was 0.375. These results suggested a synergistic effect of the 12-O-m-anisoyl dihydroartemisinin with rifampicin and established its base for the development of anti-tubercular agents from an in-expensive and non-toxic natural product. To the best of our knowledge this is the first ever report on the anti-tubercular potential of dihydroartemisinin and its derivatives

Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Mycobacterium tuberculosis. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khan, Nazish; Pradhan, Alka published the artcile< Synthesis and characterization of some unique oxazolone analogs>, COA of Formula: C9H7ClO, the main research area is oxazolone preparation; phenylpropenoyl amino acetic acid aldehyde condensation.

A series of oxazolone derivatives have been prepared by the condensation of {[(2E)-3-phenylprop-2-enoyl]amino}acetic acid with different aldehydes in presence of ethanol, acetic anhydride and sodium acetate.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Regnier, Vianney; Romero, Erik A.; Molton, Florian; Jazzar, Rodolphe; Bertrand, Guy; Martin, David published the artcile< What Are the Radical Intermediates in Oxidative N-Heterocyclic Carbene Organocatalysis?>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is oxidative azaheterocyclic carbene organocatalysis radical intermediate.

The oxidation of the Breslow intermediate resulting from the addition of an N-heterocyclic carbene (NHC) to benzaldehyde triggers a fast deprotonation, followed by a second electron transfer, directly affording the corresponding acylium at E > -0.8 V (vs. Fc/Fc+). Similarly, the oxidation of the cinnamaldehyde analog occurs at an even higher potential and is not a reversible electrochem. process. As a whole, and contrary to previous beliefs, it is demonstrated that Breslow intermediates, which are the key intermediates in NHC-catalyzed transformations of aldehydes, cannot undergo a single electron transfer (SET) with mild oxidants (E < -1.0 V). Moreover, the corresponding enol radical cations are ruled out as relevant intermediates. It is proposed that oxidative NHC-catalyzed radical transformations of enals proceed either through SET from the corresponding electron-rich enolate or through coupled electron-proton transfer from the enol, in any case generating neutral capto-dative radicals. Relevant electrochem. surrogates of these paramagnetic species have been isolated. Journal of the American Chemical Society published new progress about Crystal structure. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Low, Chia Hui; Mohamad, Habsah; Mustafa, Siti Fatimah Zaharah; Mohd, Khamsah Suryati; Mat Nafi, Nor Elani published the artcile< Synthesis and computational study of 4-hydroxylbenzamide analogs as potential anti-breast cancer agent>, Computed Properties of 17082-09-6, the main research area is hydroxybenzamide preparation antitumor SAR mol docking; HDAC JAK2 EGFR inhibition.

In this work, several 4-hydroxybenzamide analogs, I [R = H, (E)-3-phenylprop-2-enoyl, 1,3-benzodioxole-5-carbonyl, etc.; R1 = H, 2-tert-butoxy-1,1-dimethyl-2-oxo-Et, 2-ethoxy-1,1-dimethyl-2-oxo-Et, etc.] , II [R2 = Me, tBu], III and IV coupled with 1,3-benzodioxole, α,β-unsaturated carbonyl and tert-Bu ester bases small mols. were synthesized via imidation, EDC coupling, and etherification reactions, then bio-active 4-hydroxybenzamide analogs, I,II, III and IV were studied using quantum calculations and mol. docking. The Frontier MOs and energy gap values were calculated using Time-Dependent D. Functional Theory (TD-DFT). Docking results showed I [R = (E)-3-phenylprop-2-enoyl, R1 = H] and IV as potent JAK2 inhibitors. I [R = 1,3-benzodioxole-5-carbonyl, 2-(1,3-benzodioxol-5-yl)ethyl, R1 = H] and I [R = H, R1 = (2-tert-butoxy-1,1-dimethyl-2-oxo-ethyl)] may be good HDAC II inhibitors. III may act as a potent EGFR inhibitor. These were followed by cytotoxic evaluation of 4-hydroxybenzamide analogs, I, II , III and IV on human estrogen receptor breast cancer cells (MCF-7), metastatic breast adenocarcinome cancer cells (MDA-MB-231) and fibroblast cells (NIH/3T3) resp. Mol. IV was found to have insignificant apoptosis against MCF 7 cell line and MDM-MD-231 cell lines with IC50 value 5.0μg/mL and 5.0μg/mL resp.

Arabian Journal of Chemistry published new progress about Antitumor agents. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Huanfeng; Zhang, Hao; Xiong, Wenfang; Qi, Chaorong; Wu, Wanqing; Wang, Lu; Cheng, Ruixiang published the artcile< Iridium-Catalyzed Three-component Coupling Reaction of Carbon Dioxide, Amines, and Sulfoxonium Ylides>, Application of C9H7ClO, the main research area is carbon dioxide amine sulfoxonium ylide three component coupling iridium; aryl oxoalkyl carbamate preparation mol crystal structure; steroid oxoalkyl carbamate preparation antitumor; iridium three component coupling catalyst.

The first iridium-catalyzed three-component coupling reaction of carbon dioxide, amines, and sulfoxonium ylides has been developed, providing an efficient and straightforward method for the construction of a range of structurally diverse O-β-oxoalkyl carbamates, e.g., I (X-rays single crystal structure shown), in moderate to excellent yields. This novel protocol features the use of readily available substrates, wide substrate scope, and good functional group tolerance. Moreover, the phosgene-free strategy was successfully applied to the synthesis of a potential antitumor agent via a a three-step procedure starting from a steroid carboxylic acid.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Song, Ziyu; Xu, Ke; Li, Jing; Xie, Yayun; Li, Xiang; Huang, Shuai; Gao, Feng; Chen, Lin; Zhou, Xianli published the artcile< SEmi-Synthetic Chasmanthinine Analogues With Antifeedant Effects Against Spodoptera Exigua>, Category: chlorides-buliding-blocks, the main research area is Spodoptera larvae antifeedant chasmanthinine.

The synthesis and structure modification of active natural lead compounds is an important approach for the discovery of novel green pesticides. Nineteen derivatives of chasmanthinine, a natural C19-diterpenoid alkaloids, were prepared, and their structures were unambiguously determined by 1H NMR, 13C NMR, and HR-ESI-MS. Moreover, the antifeedant activities of title compounds were evaluated against larvae of Spodoptera exigua (Hubner). The results illustrated that compounds p with a thienyl group at the C-14 position (EC50 = 0.10 mg/cm2) showed the strongest antifeedant activities among all tested compounds This present study is the first report on the antifeedant effects of synthetic chasmanthinine analogs aganist S. exigua (Hubner) larvae.

Heterocycles published new progress about Esterification. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics