Category: 17082-09-6

Zhou, Yin; Gao, Cheng-Feng; Ma, Hai; Nie, Jing; Ma, Jun-An; Zhang, Fa-Guang published the artcile< Quadruple Functionalized Pyrazole Pharmacophores by One-pot Regioselective [3+2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes>, HPLC of Formula: 17082-09-6, the main research area is difluoromethyl aryl hydrazonyl chloride dicyanialkene regioselective cycloaddition cyclooxygenase inhibition; aryl difluoromethyl cyanopyrazole preparation; trifluroromethylaryl hydrazonyl chloride dicyanialkene regioselective cycloaddition cyclooxygenase inhibition; trifluoromethyl aryl cyanopyrazole preparation; COX-2 inhibitors; cycloaddition; di/trifluoromethyl group; pharmacophores; pyrazoles.

A quadruple functionalization approach for the modular construction of fully substituted N1-aryl 3-di/trifluoro-methyl-4/5-cyanopyrazole pharmacophores from readily available hydrazonyl chlorides and dicyanoalkenes was presented. The realization of this [3+2] cycloaddition reaction hinges upon the employment of N-aryl di/trifluoromethyl nitrile imines as the 1,3-dipoles to bypass external synthetic steps and dicyanoalkenes as the dipolarophiles to tune the regioselectivity. This one-pot strategy offered access to a divergent library of cyano analogs of prevalent 3-di/trifluoromethyl pyrazole pharmacophores, among which several compounds have shown potent inhibitory activity towards cyclooxygenase 2 (COX-2) compared with marketed drug Celecoxib.

Chemistry – An Asian Journal published new progress about [3+2] Cycloaddition reaction (regioselective). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kajimoto, Chihiro; Yamada, Shigeyuki; Konno, Tsutomu published the artcile< Novel multi-functionalized fluorine-containing organometallics: Preparation and applications of tetrafluoroethylenated zinc reagent>, Application In Synthesis of 17082-09-6, the main research area is bromotetrafluorobutene zinc bromide preparation acid chloride copper coupling reaction; bromo tetrafluoropentenone preparation; iodoarene bromotetrafluorobutene zinc bromide cross coupling reaction; tetrafuoro bromo arylbutene preparation.

On treating 2,4-dibromo-3,3,4,4-tetrafluorobut-1-ene, readily prepared from com. available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, with 2.0 equivalent of zinc-silver alloy at 40 C in CH3CN, zinc insertion at the terminal C(sp3)-Br site proceeded selectively, giving the corresponding (3-bromo-1,1,2,2-tetrafluorobut-3-en-1-yl)zinc bromide in high yield. This organozinc reagent was found to be thermally stable and easily handled. It was found that this organozinc reagent was participated in the cross-coupling reaction with various acyl chlorides or iodoarenes to give the corresponding CF2CF2-containing organic mols. in good yields. It was also revealed that Suzuki-Miyaura cross-coupling reactions at the C(sp2)-Br site of these CF2CF2-substituted products also proceeded in good to excellent yields.

Journal of Fluorine Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lei, Tianmeng; Wang, Yefei; Zhang, Heng; Cao, Jie; Xiao, Chuanmin; Ding, Mingchen; Chen, Wuhua; Chen, Mifa; Zhang, Zhenyu published the artcile< Preparation and performance evaluation of a branched functional polymer for heavy oil recovery>, COA of Formula: C9H7ClO, the main research area is functional polymer heavy oil viscosity reduction synergistic effect.

To solve the problem of chromatog. separation encountered in surfactant-polymer composite systems, a branched functional polymer (PEM) was prepared from acrylamide, acrylic acid, polyethyleneimine, and a newly synthesized functional monomer (XN) to realize high efficient displacement of heavy oil in oil reservoir conditions. Proton NMR (1HNMR) anal., elemental anal., and Fourier-transform IR spectroscopy verified the synthesis of PEM. The thickening performance, salt resistance, interfacial activity, ability of heavy oil viscosity reduction by emulsification, and core-flooding performance of PEM were systematically studied, with linear functional polymer PXM containing XN and conventional polymer HPAM as the control group. Under the synergistic effect of functional monomer XN and the branched structure, PEM demonstrated better thickening performance and more ideal heavy oil viscosity reduction compared with those of PXM and HPAM. The branched structure of PEM enhanced the interaction between mols. and the strength of the spatial network structure; notably, the thickening performance of PEM improved by 34.6% and 141.7%, and the salt resistance performance improved by 31.5% and 89.4%, compared with those of PXM and HPAM, resp. Furthermore, PEM formed a relatively tight interfacial adsorption layer at the oil-water interface, leading to the reduction of interfacial tension. The heavy oil viscosity reduction rate of PEM (87.0%) was higher than that of PXM (79.5%). The emulsion formed was more stable than PXM, and the oil-water separation rate was slower. Owing to the better heavy oil viscosity reduction effect of PEM, the recovery factor of PEM (21.4%) was higher than that of PXM (17.2%) under the same polymer viscosity condition. These findings indicate that PEM and its functional mechanism are suitable for the enhancement of heavy oil recovery.

Journal of Molecular Liquids published new progress about Dehydration process. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ma, Yu-Hong; He, Xiao-Yu; Wang, Long; Yang, Qing-Qing published the artcile< PPh3-Triggered Tandem Synthesis of 2,3-Disubstituted Benzofuran Derivatives from o-Quinone Methides with Acyl Chlorides>, SDS of cas: 17082-09-6, the main research area is benzofuran preparation; quinone methide acyl chloride phospha Michael acylation intramol Wittig.

A PPh3-triggered tandem strategy for the efficient synthesis of valuable 2,3-disubstituted benzofuran derivatives in generally good to high yields from aryl or alkyl acyl chlorides and o-quinone methides has been developed. This method features mild reaction conditions, simple operation, and a broad substrate scope.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, SDS of cas: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khairnar, Pankaj V.; Lung, Tsai-Hui; Lin, Yi-Jung; Wu, Chi-Yi; Koppolu, Srinivasa Rao; Edukondalu, Athukuri; Karanam, Praneeth; Lin, Wenwei published the artcile< An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes>, Synthetic Route of 17082-09-6, the main research area is diversity oriented synthesis pyrazole isoxazole chromenone oxime; intramol Wittig reaction alpha halohydrazone ketoxime.

α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramol. Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.

Organic Letters published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Echemendia, Radell; de Oliveira, Kleber T.; Burtoloso, Antonio C. B. published the artcile< Visible-Light-Promoted Synthesis of 1,3-Dicarbonyl Sulfoxonium Ylides>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is dicarbonyl sulfoxonium ylide green preparation; diazoketone sulfoxonium ylide coupling visible light promoted.

A novel visible-light-promoted synthesis of 1,3-dicarbonyl sulfoxonium ylides I [R = Ph, 2-ClC6H4, 4-MeC6H4, etc.; R1 = Ph, 4-MeOC6H4, 4-O2NC6H4, etc.; R2 = H, Me] via coupling of diazoketones with sulfoxonium ylides was described in both batch and continuous flow conditions. This transformation permitted the direct synthesis of synthetically useful 1,3-dicarbonyl sulfoxonium ylides I (33 examples, 21-85% yields), by means of an acylation reaction from the in situ and selective generation of ketenes. The reaction performed under flow conditions proved to be very efficient, providing the 1,3-dicarbonyl sulfoxonium ylides with higher yields and shorter reaction times.

Organic Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (sulfoxonium ylides). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sitte, Nikolai A.; Bursch, Markus; Grimme, Stefan; Paradies, Jan published the artcile< Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation>, Electric Literature of 17082-09-6, the main research area is carboxylic amide hydrogen borane oxalyl chloride hydrogenation catalyst; amine tertiary preparation.

A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. D. functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (carboxylic amides). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Electric Literature of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Qu, Erdong; Li, Shangzhang; Bai, Jin; Zheng, Yan; Li, Wanfang published the artcile< Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides>, Category: chlorides-buliding-blocks, the main research area is amide preparation; acyl benzotriazole nitro compound reductive cross coupling nickel catalyzed; sulfonamide preparation; sulfonyl benzotriazole nitro compound reductive cross coupling nickel catalyzed.

Herein, a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope was reported. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Zhi; Zhuang, Xinming; Chen, Yao; Wang, Binghao; Yu, Junsheng; Huang, Wei; Marks, Tobin J.; Facchetti, Antonio published the artcile< Cinnamate-Functionalized Natural Carbohydrates as Photopatternable Gate Dielectrics for Organic Transistors>, COA of Formula: C9H7ClO, the main research area is cinnamate functionalized natural carbohydrate photopatternable gate dielec organic transistor.

Photolithog.-defined films play an important role in modern optoelectronics and are crucial for the development of advanced organic thin-film transistors (OTFTs). Here, we explore a facile photoresist-free photopatterning technique with natural carbohydrates and its use as an OTFT gate dielec. The effects of the cross-linkable chem. structure on the crosslinking chem. and dielec. strength of the corresponding films are investigated in cinnamate-functionalized carbohydrates from monomeric (glucose) to dimeric (sucrose) to polymeric (cellulose) backbones. UV illumination of the cinnamate esters of these carbohydrates leads to [2 + 2] cycloaddition and thus the formation of robust cross-linked dielec. films in the irradiated areas. Using propylene glycol monomethyl ether acetate as the solvent/developer, patterned dielec. films with micrometer-sized features can be readily fabricated. P- and N-type OTFTs are successfully demonstrated using unpatterned/patterned cross-linked films as the gate dielec. and pentacene and N,N’-1H,1H-perfluorobutyl dicyanoperylenecarboxydiimide (PDIF-CN2) as the p- and n-channel semiconducting layers, resp. These results demonstrate that natural-derived polymer gate dielecs., which are soluble and patternable using biomass-derived solvents, are promising for the realization of a more sustainable OTFT technol.

Chemistry of Materials published new progress about Carbohydrates Role: PRP (Properties) (natural). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yu, Hailin; Zhu, Gang; Wang, Yinghan published the artcile< Preparation of polyimide alignment films with high photosensitivity and low solid content>, Formula: C9H7ClO, the main research area is polyimide alignment film photosensitivity liquid crystal display.

In order to reduce the cost, a polyimide (BF-CA) with high photosensitivity and low solid content was prepared by one-step method using 2,2-bis (3-amino-4-hydroxyphenyl) propane (BAP), 4,4′- (hexafluoroisopropyl) phthalic anhydride (6FDA) as monomer and cinnamoyl chloride as photosensitive group. The BF-CA films exhibit good alignment performance after non-polarised UV light (NPUVL) irradiation for 20 min. Meanwhile, the effect of solid content on the alignment performance is mainly discussed, because reducing solid content helps to reduce costs. In addition, the BF-CA shows good thermal stability. The pretilt angle of the liquid crystal cells is 0.5°, which meet the requirements of practical application in In-Plane Switching liquid crystal display.

Liquid Crystals published new progress about Anisotropy. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics