Category: 17082-09-6

Walby, Grant D.; Martin, Stephen F. published the artcile< Preparation of novel analogs of 2-arylpiperidines and evaluation of their sigma receptor binding affinities>, Safety of (E)-Cinnamoyl chloride, the main research area is arylpiperidine preparation mol docking sigma receptor binding affinity; Binding affinities and selectivities; Computational docking; Scaffold simplification; Sigma receptors; Synthesis.

A number of substituted norbenzomorphans was previously identified as high affinity ligands for the two known sigma receptors σ1R and σ2R/TMEM97, and some norbenzomorphans that were selective for σ2R/TMEM97 exhibited promise in animal models of several neurol. disorders. Toward further assessing the effects of simplifying the norbenzomorphan scaffold, sets of 6-membered heterocycles were designed and prepared, and their binding affinities for σ1R and σ2R/TMEM97 were determined Consistent with the design strategy, N-acyl-2-arylpiperidines showed high affinity for σ2R/TMEM97, whereas those derived from morpholine and N-methylpiperazine had lower affinities. However, most of these 6-membered heterocycles unexpectedly exhibited even higher affinity for σ1R and were thus σ1R-selective. Computational docking studies showed that representative 6-membered heterocycles bind and interact with σ2R/TMEM97 in a manner similar to that of a docked structure of their norbenzomorphan parent. Collectively, these binding and computational studies supported our design strategy for developing simplified analogs of norbenzomorphans as σ2R/TMEM97 ligands, but they also underscore the challenges associated with developing selective modulators of σ2R/TMEM97.

European Journal of Medicinal Chemistry published new progress about Buchwald-Hartwig reaction. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Safety of (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hao, Wenyan; Xu, Zhaotao; Zhou, Zebiao; Cai, Mingzhong published the artcile< Recyclable Heterogeneous Palladium-Catalyzed Cyclocarbonylation of 2-Iodoanilines with Acyl Chlorides in the Biomass-Derived Solvent 2-Methyltetrahydrofuran>, HPLC of Formula: 17082-09-6, the main research area is green palladium catalyzed cyclocarbonylation iodoaniline acyl chloride benzoxazinone synthesis.

A highly efficient, green palladium-catalyzed cyclocarbonylation of 2-iodoanilines with acyl chlorides has been developed that proceeds smoothly in a biomass-derived solvent 2-methyltetrahydrofuran with N,N-diisopropylethylamine as base at 100°C under 20 bar of carbon monoxide using an 2-aminoethylamino-modified MCM-41-anchored palladium acetate complex [2N-MCM-41-Pd(OAc)2] as a heterogeneous catalyst, yielding a wide variety of 2-substituted 4H-3,1-benzoxazin-4-one derivatives in good to excellent yields. This supported palladium catalyst could be facilely obtained by a two-step procedure from easily available starting materials and readily recovered via a simple filtration process and recycled at least 8 times without any apparent decrease in catalytic efficiency. The developed methodol. not only avoids the use of toxic solvents such as THF and DMF but also solves the basic problem of expensive palladium catalyst recovery and reuse and prevents effectively palladium contamination of the desired product.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Chengcheng; Guo, Lin; Gao, Han; Luo, Mengqi; Yang, Chao; Xia, Wujiong published the artcile< Highly Diastereoselective Synthesis of γ-Lactams Enabled by Photoinduced Deaminative [3 + 2] Annulation Reaction>, Category: chlorides-buliding-blocks, the main research area is gamma lactam diastereoselective preparation; aminopyridinium alkene photochem cycloaddition.

The photoinitiated deaminative [3 + 2] annulation reaction of N-aminopyridinium salts with alkenes for the synthesis of functionalized γ-lactams is described. This transformation shows good functional group tolerance as well as excellent diastereoselectivity. Preliminary studies suggest that the employed N-aminopyridinium salts generate the key amidyl radical intermediates through N-N bond cleavage via a photoinduced single-electron transfer (SET) process. The amidyl radical species would add to the double bond of alkenes, followed by a radical-mediated annulation process, to afford the desired γ-lactams.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (photochem.). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lou, Qin-Xin; Li, Jing-Yu; Yang, Shang-Dong published the artcile< Iridium(III)-Catalyzed C-H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives>, Application In Synthesis of 17082-09-6, the main research area is arylated dicarbonyl compound preparation iridium catalyst; triarylphosphine oxide diazo dicarbonyl compound arylation; di ketone acyl chloride acetamidobenzenesulfonyl azide diazotization.

A novel (pentamethylcyclopenta-1,3-dienyl)iridium(III)-catalyzed direct C-H functionalization of triarylphosphine oxides with diazo dicarbonyl compounds through carbene insertion has been developed. This strategy provides a simple and efficient route to the construction of α-arylated 1,3-dicarbonyl compounds I (R1 = Me, Ph, 4-FC6H4, etc.; R2 = Ph, 3-MeC6H4, 2-thienyl, etc.; R3 = t-Bu, Ph, 2-naphthyl, etc.; R4 = Me, OEt, t-Bu, etc.; R = H, 4-Me, 5-OMe, etc.) which are important building blocks in pharmaceutical chem.

Synlett published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bhatt, Divya; Chae, Soyeon; Kim, Hun Young; Oh, Kyungsoo published the artcile< One-Pot Synthesis of N-Hydroxypyrroles via Soft α-Vinyl Enolization of (E)-β-Chlorovinyl Ketones: A Traceless Arylsulfinate Mediator Strategy>, Quality Control of 17082-09-6, the main research area is hydroxypyrrole preparation one pot; beta chlorovinyl ketone sodium arylsulfinate alpha enolization tandem.

A traceless arylsulfinate mediator strategy has been developed to switch the reaction course of β-chlorovinyl ketones with N-hydroxyamine. The soft α-vinyl enolization of (E)-β-chlorovinyl ketones was conducted in the presence of sodium arylsulfinate to give transient alkenyl sulfones that in turn reacted with NH2OH to give novel access to N-hydroxypyrroles. The mechanistic studies revealed the initial formation of oxazine intermediates that rearranged to thermodynamically stable aromatic products, N-hydroxypyrroles, under microwave-assisted heating conditions.

Organic Letters published new progress about Enolization. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tryniszewski, Michal; Barbasiewicz, Michal published the artcile< Gram-Scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles>, HPLC of Formula: 17082-09-6, the main research area is acyl fluoride preparation reaction with hindered nucleophile; aqueous bifluoride acyl chloride halogen exchange.

A series of acyl fluorides was synthesized at 100 mmol scale using phase-transfer-catalyzed halogen exchange between acyl chlorides and aqueous bifluoride solution The convenient procedure consists of vigorous stirring of the biphasic mixture at room temperature, followed by extraction and distillation Isolated acyl fluorides (usually 7-20 g) display excellent purity and can be transformed into sterically hindered amides and esters when treated with lithium amide bases and alkoxides under mild conditions.

Synthesis published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jiajia; Xia, Yuanzhi; Lee, Sunwoo published the artcile< Coupling of amides with ketones via C-N/C-H bond cleavage: a mild synthesis of 1,3-diketones>, Application In Synthesis of 17082-09-6, the main research area is diketone preparation; amides ketone coupling.

A variety of aryl and alkyl-substituted tertiary amides reacted with ketones in the presence of LiHMDS and a variety of primary and secondary amides in one pot to gave the corresponding 1,3-diketone products R1C(O)CH(R3)C(O)R2 [R1 = octyl, Ph, 4-MeC6H4, etc.; R2 = t-Bu, Ph, 2-BrC6H4, etc.; R3 = H, Me, n-Pr, hexyl] in good to excellent yields via C-N cleavage of amides and deprotonation of ketones. The reaction was conducted at room temperature under transition-metal-free conditions. N-Tosyl-, N-triflyl-, N-mesyl-, and N-Boc-substituted tertiary amides including N-benzoyl saccharin and N-benzoyl succinimide showed good activity in the reaction. The broad scope, good functional group tolerance of substrates and gram-scale synthesis showed the great importance and potential of this protocol in organic synthesis and industrial manufacture

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mu, Wen-Wen; Li, Peng-Xiao; Liu, Yue; Yang, Jie; Liu, Guo-Yun published the artcile< The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity>, HPLC of Formula: 17082-09-6, the main research area is piperlongumine dihydropyridin anticancer activity.

Piperlongumine (PL), a potent anticancer agent from the plant long pepper (Piper longum), contains the 5,6-dihydropyridin-2(1H)-one heterocyclic scaffold and cinnamoyl unit. In this paper, we synthesized a series of PL analogs and evaluated their cytotoxicity against cancer cells for the sake of exploring which pharmacophore plays a more potent role in enhancing the anticancer activities of PL. These results illustrated that the position effect, not the electronic effect, of substituents plays a certain role in the cytotoxicity of PL and its analogs. More important, the 5,6-dihydropyridin-2(1H)-one unit, a potent pharmacophore in enhancing the antiproliferative activities of PL, could react with cysteamine and lead to ROS generation, and then bring about the occurrence of ROS-induced downstream events, followed by cell cycle arrest and apoptosis. This work suggests that introducing a lactam unit containing Michael acceptors may be a potent strategy to enhancing the anticancer activity of drugs.

RSC Advances published new progress about Antiproliferative agents. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sun, Rui; Yang, Xiao; Ge, Yicen; Song, Jintong; Zheng, Xueli; Yuan, Maolin; Li, Ruixiang; Chen, Hua; Fu, Haiyan published the artcile< Visible-Light-Induced Oxazoline Formations from N-Vinyl Amides Catalyzed by an Ion-Pair Charge-Transfer Complex>, Synthetic Route of 17082-09-6, the main research area is oxazoline preparation photochem green chem; vinyl amide alc anhydride cyclization alkoxylation heteroarenium iodide catalyst.

Visible-light photoredox catalysis plays an important role in various reactions which are inaccessible under typical thermal conditions. Distinctly different from common visible-light photoredox catalysis which often involves transition-metal complexes, conjugated organic dyes, or electron donor-acceptor complexes, herein, the use of ion-pair charge-transfer (IPCT) complex-induced visible-light photoredox catalytic reactions are described, wherein the cyclization-methoxylation of N-vinyl amides in methanol was achieved under irradiation with blue LEDs. The reaction employs a heteroarenium iodide as the photocatalyst and can be extended to cyclization-alkoxylation, -acyloxylation, and -hydroxylation. This protocol provides an eco-friendly synthetic route to a wide range of oxazoline derivatives Mechanistic investigations with UV-visible spectroscopy and control experiments confirm the existence of the IPCT absorption band in the visible region for the heteroarenium iodide, which is responsible for the observed reactivity.

ACS Catalysis published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hammoud, Fatima; Giacoletto, Nicolas; Nechab, Malek; Graff, Bernadette; Hijazi, Akram; Dumur, Frederic; Lalevee, Jacques published the artcile< 5,12-Dialkyl-5,12-dihydroindolo[3,2-a]carbazole-Based Oxime-Esters for LED Photoinitiating Systems and Application on 3D Printing>, Quality Control of 17082-09-6, the main research area is carbazole ester lead emitting diode potoinitiating tree dimentional printing.

In order to expand the application of oxime-esters (OXEs) and to introduce a one-component photoinitiating system of high performance in visible light photopolymerization, a series of 5,12-dialkyl-5,12-dihydroindolo[3,2-a]carbazole-based oxime-esters with visible light absorption abilities is designed and synthesized. Notably, when irradiated with light-emitting diodes at 405 nm, the proposed structures can undergo a direct cleavage of the NO bond followed by decarboxylation, generating free radicals capable to efficiently initiate free radical photopolymerizations (FRP). Furthermore, the new OXEs showed good thermal initiation abilities and can be used as dual photo and thermal initiators. An interesting structure/reactivity/efficiency relationship can be obtained by comparing the reactivity of the different radicals generated upon photoexcitation at identical chromophore but also by comparing the photoinitiating ability of the hexyl derivatives (1)-(10) with that of Me derivatives (1′)-(10′) characterized by a lower solubility than the previous series in resins. Chem. mechanisms are studied through different techniques including real-time Fourier transform IR spectroscopy, UVvisible absorption spectroscopy, fluorescence (time-resolved or steady-state) as well as mol. modeling calculations To finish, OXEs are incorporated in new photosensitive 3D printing resins, furnishing 3D objects with a remarkable spatial resolution

Macromolecular Materials and Engineering published new progress about Absorption. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics