Category: 17082-09-6

Zhao, Zhe; Tian, Xinzhe; Tang, Peichen; Ren, Yun-Lai; Zhao, Shuang; Zheng, Xianfu; Cheng, Xinqiang published the artcile< Autocatalytic Friedel-Crafts Acylation of Arenes without Additional Catalyst and Additive>, Formula: C9H7ClO, the main research area is acyl chloride arene autocatalysis regioselective Friedel Crafts acylation; aryl ketone preparation.

A new and autocatalytic method was developed for Friedel-Crafts acylation of arenes without addnl. catalyst and additive. A series of electron-rich arenes underwent the acylation to give the targeted product in low to high yields by using aryl, alkyl and vinyl acyl chlorides as the acylating reagent, which gave an effective method for the preparation of diaryl ketones, alkyl aryl ketones and α,β-unsaturated ketones. Preliminary mechanistic investigation suggested that the present acylation displayed an induction period and a sigmoid kinetic profile characteristic of autocatalytic systems, and the resulting H+ played a role of the catalyst.

ChemistrySelect published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Khairnar, Pankaj V.; Su, Yin-Hsiang; Chen, Yung-Chang; Edukondalu, Athukuri; Chen, Yi-Ru; Lin, Wenwei published the artcile< Organophosphane-Catalyzed Direct β-Acylation of 4-Arylidene Pyrazolones and 5-Arylidene Thiazolones with Acyl Chlorides>, Quality Control of 17082-09-6, the main research area is oxoarylidene pyrazolone preparation diastereoselective crystal structure mol; arylidene pyrazolone acyl chloride acylation organophosphane catalyst; oxo arylidene thiazolone preparation diastereoselective crystal structure mol; thiazolone arylidene acyl chloride acylation organophosphane catalyst.

An efficient method for the direct β-acylation of arylidene pyrazolones and thiazolones with acyl chlorides in the presence of a base catalyzed by organophosphanes was reported. A variety of oxoarylidene pyrazolones I [R1 = Me, i-Pr, Ph, etc.; R2 = Ph, 4-MeOC6H4, 4-FC6H4, etc.; R3 = Ph, 4-ClC6H4, 2-thienyl, etc.; R4 = Me, Ph, 2-thienyl, etc.] and oxoarylidene thiazolones II [R5 = Ph, 4-ClC6H4, 2-MeC6H4, etc.] were prepared under metal-free and mild conditions via a tandem phospha-Michael addition/O-acylation/intramol. cyclization/rearrangement sequence. Mechanistic investigations revealed that the reaction was highly stereospecific to provide exclusively cis-isomers and the methodol. could also be scaled up with similar efficacy.

Organic Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yin, Jinya; Rainier, Jon D. published the artcile< The one-pot synthesis of amidonaphthoquinones from aminonaphthoquinones>, Name: (E)-Cinnamoyl chloride, the main research area is amidonaphthoquinone preparation; aminonaphthoquinone acid chloride tandem hydrogenation coupling oxidation; amidoquinone; reduction; synthesis; tandem reaction.

One-pot method of synthesizing amidonaphthoquinones I [R = Ph, C(Me)=CH2, CH=CHMe, etc.; R1 = H, OMe, Cl] from the corresponding aminonaphthoquinones was described. The scope of amides that could be synthesized using this methodol. was relatively broad and the yield of product was higher than traditional methods of synthesizing these substrates.

Tetrahedron Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Name: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nurkenov, O. A.; Nurmaganbetov, Zh. S.; Seilkhanov, T. M.; Fazylov, S. D.; Satpayeva, Zh. B.; Turdybekov, K. M.; Talipov, S. A.; Seydakhmetova, R. B. published the artcile< Synthesis, Structure, and Biological Activity of Cinnamoyl-Containing Cytisine and Anabasine Alkaloids Derivatives>, Synthetic Route of 17082-09-6, the main research area is cytisine cinnamoyl derivative preparation antibacterial antifungal cytotoxic activity; anabasine cinnamoyl derivative preparation antibacterial antifungal activity cytotoxic.

The reactions of the cytisine and anabasine alkaloids with cinnamic acid chloride have been studied, and hydrazinolysis of the resulting N-cinnamoylcytisine and N-cinnamoylanabazine has been carried out. The reaction of cinnamoyl isothiocyanate with alkaloids has afforded the corresponding thiourea derivatives Antimicrobial and cytotoxic activity of cinnamoyl-containing derivatives of these alkaloids has been evaluated.

Russian Journal of General Chemistry published new progress about Alkaloids Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Hui; Zhang, Xia; Pu, Xiao-Jia; Zheng, Xi; Liu, Bei; Rao, Gao-Xiong; Wan, Chun-Ping; Mao, Ze-Wei published the artcile< 2-Benzoylbenzofuran derivatives possessing piperazine linker as anticancer agents>, Reference of 17082-09-6, the main research area is benzofuranylcarbonylphenyl piperazinylmethylcarbonyl piperazine antitumor antiinflammatory cytotoxicity apoptosis structure activity; 2-Benzoylbenzofuran; Anticancer activity; Apoptosis; Cytotoxicity.

A series of novel 2-benzoylbenzofuran derivatives possessing a piperazine linker, I [R = H, COCH2Cl, cyclopropylsulfonyl, COC6H4CF3-4, etc.], were prepared, and their in-vitro anticancer activity against a panel of human tumor cell lines by MTT assay was evaluated. The results demonstrated that tertiary amine derivatives exhibited better cytotoxic activity, and the SAR study revealed that electron-donating substituents on the Ph ring of the derivatization functionality contributed to potent anticancer activities. Among them, compounds I [R = H, COC6H3Cl2-3,5, COCH:CHPh, CH2C6H4CH:CHCO2Me-4, CH2COMe, CH2COC6H4OMe-4] displayed both better antitumor activity and lower cytotoxic effect on human normal liver cell L02. Further apoptosis anal. showed that compound I [R = CH2C6H4CH:CHCO2Me-4] significantly induced apoptosis in A549 cell, which was considered as the most potent anticancer agent.

Bioorganic & Medicinal Chemistry Letters published new progress about Amides Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Reference of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gunia-Krzyzak, Agnieszka; Zeslawska, Ewa; Sloczynska, Karolina; Zelaszczyk, Dorota; Sowa, Aleksandra; Koczurkiewicz-Adamczyk, Paulina; Ol, Justyna Popi; Nitek, Wojciech; Pekala, Elzbieta; Marona, Henryk published the artcile< S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): a novel cinnamamide derivative with anticonvulsant activity in animal models of seizures and epilepsy>, SDS of cas: 17082-09-6, the main research area is cinnamamide derivative anticonvulsant epilepsy seizure neurotoxicity mutagenicity; anticonvulsant; antiseizure, cinnamamide derivatives; crystallography; drug development; epilepsy; preclinical safety evaluation.

Epilepsy is one of the most frequent neurol. disorders affecting about 1% of the world’s human population. Despite availability of multiple treatment options including antiseizure drugs, it is estimated that about 30% of seizures still remain resistant to pharmacotherapy. Searching for new antiseizure and antiepileptic agents constitutes an important issue within modern medicinal chem. Cinnamamide derivatives were identified in preclin. as well as clin. studies as important drug candidates for the treatment of epilepsy. The cinnamamide derivative presented here: S(+)-(2E)-N-(2-hydroxypropyl)-3-phenylprop-2-enamide (S(+)-N-(2-hydroxypropyl)cinnamamide, compound KM-568) showed anticonvulsant activity in several models of epilepsy and seizures in mice and rats. It was active in genetic animal model of epilepsy (Frings audiogenic seizure-susceptible mouse model, ED50=13.21 mg/kg, i.p.), acute seizures induced elec. (max electroshock test ED50=44.46 mg/kg mice i.p., ED50=86.6 mg/kg mice p.o., ED50=27.58 mg/kg rats i.p., ED50=30.81 mg/kg rats p.o., 6-Hz psychomotor seizure model 32mA ED50=71.55 mg/kg mice i.p., 44 mA ED50=114.4 mg/kg mice i.p.). Chronic seizures induced elec. (corneal kindled mouse model ED50=79.17 mg/kg i.p., hippocampal kindled rat model ED50=24.21 mg/kg i.p., lamotrigine-resistant amygdala kindled seizure model in rats ED50=58.59 mg/kg i.p.), acute seizures induced chem. (s.c. metrazol seizure threshold test ED50=104.29 mg/kg mice i.p., ED50=107.27 mg/kg mice p.o., ED50=41.72 mg/kg rats i.p., seizures induced by picrotoxin in mice ED50=94.11 mg/kg i.p.) and pilocarpine-induced status epilepticus model in rats (ED50=279.45 mg/kg i.p., ED97=498.2 mg/kg i.p.). The chem. structure of the compound including configuration of the chiral center was confirmed by NMR spectroscopy, LC/MS spectroscopy, elemental anal., and crystallog. Compound KM-568 was identified as a moderately stable derivative in an in vitro mouse liver microsome system. According to the Ames microplate format mutagenicity assay performed, KM-568 was not a base substitution or frameshift mutagen. Cytotoxicity evaluation in two cell lines (HepG2 and H9c2) proved the safety of the compound in concentrations up to 100μM. Based on the results of anticonvulsant activity and safety profile S(+)-(2E)-N-(2-hydroxypropyl)-3-phenylprop-2-enamide could be proposed as a new lead compound for further preclin. studies on novel treatment options for epilepsy.

International Journal of Molecular Sciences published new progress about Anticonvulsants. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, SDS of cas: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tang, Yan-Ling; Zheng, Xi; Qi, Yan; Pu, Xiao-Jia; Liu, Bei; Zhang, Xia; Li, Xiao-Si; Xiao, Wei-Lie; Wan, Chun-Ping; Mao, Ze-Wei published the artcile< Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors>, Application In Synthesis of 17082-09-6, the main research area is bispiperazinochalcone preparation antitumor antiinflammatory activity interleukin inhibitor; Anti-inflammatory activity; Chalcone derivatives; Cytotoxicity; IL-1β inhibitors.

In this work, a series of novel chalcone derivatives I (n = 1,2; R = H, 3-chloropropanoyl, (3,5-dichlorophenyl)carbonyl, (4-nitrophenyl)methyl, etc.) bearing bispiperazine linker have been synthesized and in vitro anti-inflammatory, cytotoxic activity and anti-inflammatory mechanism have been screened. The results indicated that most bispiperazinochalcone derivatives I displayed good inhibition of NO (IC50 < 20μM) and low cytotoxicity (CC50 > 40μM), and selectively inhibited the production of IL-1β via inhibiting NLRP3 inflammasome activation, as promising candidate compounds for the treatment of NLRP3 inflammasome-driven diseases.

Bioorganic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yan; Dong, Mengke; Qu, Erdong; Bai, Jin; Wu, Xiao-Feng; Li, Wanfang published the artcile< Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source>, Formula: C9H7ClO, the main research area is benzooxazinone preparation; bromoaryl amide benzene triyltriformate carbonylative cross coupling catalyst palladium; benzoxazinone; carbonylation; heterocycles; palladium; synthetic methods.

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives I [R1 = 6-F, 8-Me, 7-Cl, etc.; R2 = Me, n-Pr, t-Bu, etc.] by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs could be constructed by this method.

Chemistry – A European Journal published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kubo, Yuji; Shimada, Takuma; Maeda, Kentaro; Hashimoto, Yuta published the artcile< Thieno[1,3,2]oxazaborinine-containing aza-BODIPYs with near infrared absorption bands: synthesis, photophysical properties, and device applications>, Product Details of C9H7ClO, the main research area is thienooxazaborinine containing aza BODIPY preparation crystal structure cyclic voltammetry; fluorescence DFT thienooxazaborinine containing aza BODIPY.

As part of an ongoing study of near IR (NIR) absorbing dyes applicable to optoelectronics, thieno[1,3,2]oxazaborinine-containing aza-BODIPYs were synthesized for the first time. 3,5-Di(thiophene)-substituted N2O2-type 1 showed a NIR absorption band centered at 780 nm, with a molar absorptivity (εmax) of 5.51 × 104 M-1 cm-1 in CH2Cl2; however, it was easily hydrolyzed in solution In comparison, 3-thiophene-containing N2O-type analogs 2 and 3 had greater stability, and NIR absorption bands at 768 nm (εmax = 8.62 × 104 M-1 cm-1) and 779 nm (εmax = 6.32 × 104 M-1 cm-1), resp., in CH2Cl2. Notably, these dyes had longer absorption bands than those of all of the structurally constraining aza-BODIPYs reported thus far. CV measurements and theor. calculations indicated that this shift was the result of a higher-lying HOMO energy level generated by incorporation of thiophene into the aza-BODIPY core. As a potential device application, the 3-loaded film was prepared on indium tin oxide (ITO). The film showed a NIR absorption band at 827 nm, with a wide spectral range, and a λonset value of 897 nm; thus, its applicability as a NIR photodetector was evaluated through fabrication of a single-component device. The ITO/3 (85 nm)/Al (100 nm) device produced a photocurrent of 9.57 × 10-7 A cm-2 at a bias potential of 1 V upon illumination at 850 nm and a fluence of 130 μW cm-2. This demonstrated the potential of thieno[1,3,2]oxazaborinine-containing aza-BODIPY materials in optoelectronic applications such as NIR photodetectors.

New Journal of Chemistry published new progress about Crystal structure. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Product Details of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Xiu; Wang, Zhenhua; Ishida, Takumi; Nishihara, Yasushi published the artcile< Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions>, Computed Properties of 17082-09-6, the main research area is methyl ester preparation; methoxylation acyl fluoride methoxyphenylphosphine.

Aryl fluorides (prepared from the corresponding aryl chlorides) underwent methoxylation reactions with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) (in the absence of added metal catalysts or reagents) in toluene to yield Me esters.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Computed Properties of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics