Category: 17082-09-6

Solas, Marta; Suarez-Pantiga, Samuel; Sanz, Roberto published the artcile< Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov Cyclization: Enantioselective Access to Cyclopentenones>, Quality Control of 17082-09-6, the main research area is cyclopentachromenone preparation enantioselective; alkenynone asym gold catalyst tandem antiMichael hydroarylation nazarov cyclization; Asymmetric Catalysis; Cyclopentenones; Gold; Hydroarylation; Nazarov Cyclization.

The asym. synthesis of cyclopentachromenones from gold-catalyzed reaction of readily available skipped alkenynones is described. This cascade reaction involves an initial anti-Michael hydroarylation of the ynone moiety to form a gold-functionalized dialkenylketone intermediate, followed by a Nazarov cyclization that proceeds in an unprecedented enantioselective manner. Excellent enantiomeric ratios and chem. yields are obtained under mild reaction conditions.

Angewandte Chemie, International Edition published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Yingying; Huang, Xin; Lv, Guanghui; Lai, Ruizhi; Lv, Songyang; Li, Jianglian; Hai, Li; Wu, Yong published the artcile< Iridium-Catalyzed Carbenoid Insertion of Sulfoxonium Ylides for Synthesis of Quinoxalines and β-Keto Thioethers in Water>, Product Details of C9H7ClO, the main research area is keto thioether green preparation carbenoid insertion annulation water; quinoxaline green preparation carbenoid insertion annulation water.

Sulfoxonium ylides as safe carbene precursors are described for iridium-catalyzed carbene insertions and annulation, providing a facile and green approach to access a variety of quinoxaline derivatives in water. This water-mediated method also allows the preparation of β-keto thioethers under mild condition.

European Journal of Organic Chemistry published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent) (ortho). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Product Details of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Matin, Priyanka; Rahman, Rezaur Md; Huda, Durul; Bakri, Muhammad Khusairy Bin; Uddin, Jamal; Yurkin, Yuriy; Burkov, Andrey; Kuok, Kuok King; Matin, Mohammed Mahbubul published the artcile< Application of synthetic acyl glucopyranosides for white-rot and brown-rot fungal decay resistance in aspen and pine wood>, HPLC of Formula: 17082-09-6, the main research area is acyl glucopyranoside fungi decay resistance wood.

Due to its non-toxicity and environmentally friendly nature, carbohydrate based fatty acid (CFA) esters are encouragingly used as antimicrobials and synthetic intermediates. They also are notably applied in food, surfactant, and pharmaceutical industries. In this respect, Me 2,6-di-O-isopentanoyl-α-D-glucopyranoside (2), synthesized in a single step from Me α-D-glucopyranoside (1), was converted into four other 3,4-di-O-acyl esters (3 – 6). All the newly synthesized CFA esters (2 – 6) were applied for the first time to study decay resistances of aspen (Populus tremula) and pine (Pinus sibirica) wood from decay caused by white-rot (Polyporous versicolor L.ex. Fr.) and brown-rot (Postia placenta (Fr). Cke.) fungi. Most of these CFA esters protected these woods from fungal attack, reduced deterioration, and preserved the weight percentage of woods at a certain point. It is noted that the CFA esters compounds reduced the deterioration and suppressed the weight percentage loss of wood at a certain point and from low to moderate decay resistances against the selected fungi.

BioResources published new progress about Fungi, brown rot. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, HPLC of Formula: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koo, Hyungmo; Kim, Hun Young; Oh, Kyungsoo published the artcile< (E)-Selective Friedel-Crafts acylation of alkynes to β-chlorovinyl ketones: Defying isomerizations in batch reactions by flow chemistry approaches>, Related Products of 17082-09-6, the main research area is beta chlorovinyl ketone diastereoselective preparation; alkyne acyl chloride Friedel Crafts acylation trichloroaluminum promoted flow.

The Friedel-Crafts acylation of alkynes stereoselectively provides (Z)-β-chlorovinyl ketones, whereas the AlCl3-promoted reaction yields a mixture of stereoisomeric β-chlorovinyl ketones. To develop the (E)-selective synthesis of β-chlorovinyl ketones (E)-RC(Cl):C(R2)COR1 [R = n-pentyl, c-hexyl, (CH2)2Ph, etc., R1 = cyclopropyl, Ph, 2-thienyl, etc., R2 = H, n-propyl], a flow chem. approach was devised for the Friedel-Crafts acylation of alkynes with acyl chlorides that defied the facile (E) → (Z) isomerization under AlCl3-promoted reaction conditions. Compared to batch reactions, the flow chem. approach provided a fast, clean, high yielding and stereoselective synthetic route to (E)-β-chlorovinyl ketones.

Organic Chemistry Frontiers published new progress about Acid halides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dana, Srikanta; Valissery, Praveesh; Kumar, Sharvan; Gurung, Sumiran Kumar; Mondal, Neelima; Dhar, Suman Kumar; Mukhopadhyay, Pritam published the artcile< Synthesis of Novel Ciprofloxacin-Based Hybrid Molecules toward Potent Antimalarial Activity>, Related Products of 17082-09-6, the main research area is chloroquinolone ciprofloxacin hybrid pharmacophore antimalarial.

Antimalarial drug resistance is a serious obstacle in the persistent quest to eradicate malaria. There is a need for potent chem. agents that are able to act on drug-resistant Plasmodium falciparum populations at reasonable concentrations without any related toxicity to the host. By rational drug design, we envisaged to address this issue by generating a novel hybrid drug possessing two pharmacophores that can act on two unique and independent targets within the cell. We synthesized a new class of ciprofloxacin-based hybrid mols., which have been integrated with acridine, quinolone, sulfonamide, and cinnamoyl pharmacophores. We realized a potent chloroquinolone-ciprofloxacin-based antimalarial hybrid (CQ-CFX) whose mechanism of action is unlike that of its parent mols. indicating a unique biol. target. CQ-CFX is not only potent against CQ-resistant and susceptible strains of Plasmodium falciparum at low nanomolar concentrations (IC50 values are 63.17 ± 1.2 nM and 25.52 ± 4.45 nM, resp.) but is also not toxic to mammalian and bacterial systems up to 20μM and 1μM, resp.

ACS Medicinal Chemistry Letters published new progress about Antimalarials. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rajan, Ida Angel Priya Samuel; Subramani, Muthuraman; Pushparathinam, Gopinath; Rajendran, Saravanakumar published the artcile< Environmentally Benign Transamidation Protocol for Weakly Nucleophilic Aromatic Amines with N-Acyl-2-piperidinones: Catalyst-, Additive-, Base- and Solvent-Free Condition>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is amide chemoselective green preparation; amine acyl piperidinone transamidation.

Transamidation of weakly nucleophilic aromatic amines was achieved under melt conditions and in absence of catalyst, activating agent, base and solvent to obtain amides RC(O)NHR1 [R = Me, Ph, 4-ClC6H4, etc.; R1 = 4-MeC6H4, 4-FC6H4, 2-OHC6H4, etc.]. Chemoselectivity of the protocol was demonstrated with transamidation of aniline-bearing protic carboxylic acid group and wide range of anilines. Broad applicability of the process was demonstrated with the synthesis of bioactive natural product amide, Avenanthranamide-A. Byproduct was isolated for re-use in synthesis of starting amide, manifests atom economy and sustainability of the protocol. The developed protocol was environmentally benign, operationally simple yet versatile for protection-deprotection free synthesis of amides, peptides and amide-based drugs.

Asian Journal of Organic Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jiajia; Xia, Yuanzhi; Lee, Sunwoo published the artcile< Transamidation for the Synthesis of Primary Amides at Room Temperature>, Related Products of 17082-09-6, the main research area is primary amide synthesis transamidation tosyl amide lactam benzamide.

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25°C, the desired primary amide product is formed in good yield with good functional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Related Products of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lyu, Xue-Li; Huang, Shi-Sheng; Huang, Yuan-Qiong; Song, Hong-Jian; Liu, Yu-Xiu; Li, Yong-Qiang; Yang, Shao-Xiang; Wang, Qing-Min published the artcile< Rhodium(III)-Catalyzed Cross-Coupling of Sulfoxonium Ylides with Quinoline-8-carboxaldehydes for Synthesis of Quinoline-1,3-diketones>, COA of Formula: C9H7ClO, the main research area is quinoline diketone preparation; sulfoxonium ylide quinoline carboxaldehyde coupling reaction rhodium catalyst.

Herein, a protocol for rhodium(III)-catalyzed aldehydic C(sp2)-H acylmethylation reactions of quinoline-8-carboxaldehydes I (R = H, 6-(4-methoxyphenyl), 5-(naphthalen-1-yl), etc.) using sulfoxonium ylides R1C(O)CH=S(O)Me2 (R1 = Ph, propan-2-yl, adamantan-1-yl, etc.) as carbene precursors to afford 1,3-diketones II, which readily tautomerized to their enol forms was reported. The reaction mechanism was determined by synthesizing the key intermediate, a five-membered-ring acylrhodium species were determined

Asian Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fioravanti, Rossella; Tomassi, Stefano; Bello, Elisabetta Di; Romanelli, Annalisa; Plateroti, Andrea Maria; Benedetti, Rosaria; Conte, Mariarosaria; Novellino, Ettore; Altucci, Lucia; Valente, Sergio; Mai, Antonello published the artcile< Properly substituted cyclic bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 inhibitors and induced apoptosis in cancer cells>, Reference of 17082-09-6, the main research area is cyclic bisbromobenzylidene compound preparation diastereoselective antitumor activity; drug discovery; epigenetics; histone acetylation; histone methylation; multi-target agents.

The 1-benzyl-3,5-bis((E)-3-bromobenzylidene)piperidin-4-one displayed dual p300/EZH2 inhibition joined to cancer-selective cell death in a panel of tumor cells and in in-vivo xenograft models, a series of bis((E)-2-bromobenzylidene) cyclic compounds I (X = CH2) and I (X is NR, where R = H, Me, Bn, etc.) were prepared to test in biochem. (p300, PCAF, SIRT1/2, EZH2, and CARM1) and cellular (NB4, U937, MCF-7, SH-SY5Y) assays. The majority of I exhibited potent dual p300 and CARM1 inhibition, sometimes reaching the submicromolar level, and induction of apoptosis mainly in the tested leukemia cell lines. The most effective compounds in both enzyme and cellular assays carried a 4-piperidone moiety and a Me, benzyl, or acyl substituent at N1 position I [X is NR, where R = H, Me, Bn, 2-oxo-2-phenylethyl, 2-oxo-3-phenylpropyl, 2-oxo-4-phenylbutyl]. Elongation of the benzyl portion to I [X is NR, where R = 2-phenylethyl, 3-phenylpropyl] decreased the potency of compounds at both the enzymic and cellular levels, but the activity was promptly restored by introduction of a ketone group into the phenylalkyl substituent I [X is NR, where R = 2-oxo-2-phenylethyl, 3-oxo-3-phenylpropyl, 4-oxo-4-phenylbutyl]. Western blot analyses performed in NB4 and MCF-7 cells on selected compounds confirmed their inhibition of p300 and CARM1 through decrease of the levels of acetyl-H3 and acetyl-H4, marks for p300 inhibition, and of H3R17me2, mark for CARM1 inhibition.

Molecules published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Reference of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xiong, Wenzhang; Shi, Qiu; Liu, Wenbo H. published the artcile< Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature>, Recommanded Product: (E)-Cinnamoyl chloride, the main research area is aryl carboxylic acid chlorobenzoicacid decarboxylative oxygenation; aromatic alc preparation.

Herein, an efficient and practical approach to prepare phenols from benzoic acids via simple organic reagents at room temperature was reported. This approach was compatible with various functional groups and heterocycles and can be easily scaled up. To demonstrate its synthetic utility, bioactive mols. and unsym. hexaarylbenzenes was prepared by leveraging this transformation as strategic steps. Mechanistic investigations suggest that the key migration step involve a free carbocation instead of a radical intermediate. Considering the abundance of benzoic acids and the utility of phenols, it was anticipated that this method will find broad applications in organic synthesis.

Journal of the American Chemical Society published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Recommanded Product: (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics