Category: 17082-09-6

Swain, Baijayantimala; Angeli, Andrea; Singh, Priti; Supuran, Claudiu T.; Arifuddin, Mohammed published the artcile< New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation>, Safety of (E)-Cinnamoyl chloride, the main research area is aryl oxo chromenyl acrylamide preparation carbonic anhydrase inhibitor human; dioxidobenzooxathiinyl aryl acrylamide preparation carbonic anhydrase inhibitor human; Carbonic anhydrase; Coumarin; Hypoxia tumor; Phenylacrylamide; Sulfocoumarin; XII isoform; hCA IX.

Two novel series of phenylacrylamide linked coumarins I [R = H, Me; Ar = Ph, 4-FC6H4, 4-MeOC6H4, etc.] and sulfocoumarins II [Ar1 = 4-FC6H4, 3-F3CC6H4, 4-NCC6H4, etc.] were synthesized and evaluated against four physiol. relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I, hCA II, hCA IX and hCA XII for their inhibitory action. Compounds I and II when screened for carbonic anhydrase inhibitory activity, they showned selective inhibition toward the tumor associated isoforms hCA IX and XII over CA I and II, with inhibition constants in the submicromolar to low nanomolar range. Compound I [R = H; Ar = 4-FC6H4] and II [Ar1 = 4-NCC6H4] exhibited significant inhibition with low nanomolar potency against hCA IX, whereas I [R = H; Ar = 3,4-(OMe)2C6H3] was effective against hCA XII. Compounds I [R = H; Ar = 4-FC6H4, 3,4-(OMe)2C6H3] and II [Ar1 = 4-NCC6H4] might be considered as lead mols. for future development of cancer therapeutics based on a novel mechanism of action.

Bioorganic & Medicinal Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Safety of (E)-Cinnamoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bojanowski, N. Maximilian; Huck, Christian; Veith, Lisa; Strunk, Karl-Philipp; Baeuerle, Rainer; Melzer, Christian; Freudenberg, Jan; Wacker, Irene; Schroeder, Rasmus R.; Tegeder, Petra; Bunz, Uwe H. F. published the artcile< Electron-beam lithography of cinnamate polythiophene films: conductive nanorods for electronic applications>, COA of Formula: C9H7ClO, the main research area is polythiophene nanorod electron beam lithog structural electrochem property.

We report the electron-beam induced crosslinking of cinnamate-substituted polythiophene proceeding via excited state [2+2]-cycloaddition Network formation in thin films is evidenced by IR spectroscopy and film retention experiments For the polymer studied herin, the electron-stimulated process appears to be superior to photo (UV)-induced crosslinking as it leads to less degradation Electron beam lithog. (EBL) patterns cinnamate-substituted polythiophene thin films on the nanoscale with a resolution of around 100 nm. As a proof of concept, we fabricated nanoscale organic transistors using doped and cross-linked P3ZT as contact fingers in thin film transistors.

Chemical Science published new progress about Binding energy. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liou, Yan-Cheng; Karanam, Praneeth; Jang, Yeong-Jiunn; Lin, Wenwei published the artcile< Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/O-Acylation/Wittig Pathway>, Application In Synthesis of 17082-09-6, the main research area is benzofuran preparation para quinone methide reactant; one pot phospha addition acylation Wittig reaction.

An efficient synthesis of functionalized benzofurans is achieved under mild and metal-free conditions from stable para-quinone methides by treatment with phosphine, acyl chloride, and a base. This one-pot phospha-1,6-addition/O-acylation/Wittig reaction is also demonstrated under catalytic conditions with similar efficacy.

Organic Letters published new progress about Acylation. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hu, Xiaojun; Zhou, Bingwei; Jin, Hongwei; Liu, Yunkui; Zhang, Liming published the artcile< Bifunctional phosphine ligand-enabled gold-catalyzed direct cycloisomerization of alkynyl ketones to 2,5-disubstituted furans>, COA of Formula: C9H7ClO, the main research area is disubstituted furan preparation phosphinyl gold catalyst; alkynyl ketone cycloisomerization.

An efficient synthesis of 2,5-disubstituted furans I (R1 = H, 4-Me, 4-F, etc.; R2 = Pr, C6H5, Bn, etc.) directly from alkynyl ketones has been developed via tandem gold(I)-catalyzed isomerization of alkynyl ketones to allenyl ketones and cycloisomerization. The key to the success of this chem. is the use of a biphenyl-2-ylphosphine ligand featuring a critical remote tertiary amino group.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vashisth, N.; Sharma, S. P.; Kumar, S.; Aruna published the artcile< One-Pot Green Synthesis of 2-Hydroxybenzoyl(cinnamoyl)methanes and 2-Styrylchromones Using Dual-Frequency Ultrasonication>, Synthetic Route of 17082-09-6, the main research area is styrylchromone preparation green chem ultrasound; hydroxybenzoyl cinnamoyl methane preparation heterocyclization; hydroxyacetophenone cinnamoyl chloride ultrasonication Baker Venkataraman rearrangement.

One-pot green synthesis of (2-hydroxybenzoyl)(cinnamoyl)methanes (E)-I (R1 = H, OMe; R2 = H, Me; R3 = H, OMe) has been performed by reacting 2-hydroxyacetophenones 2-OH-4-R1-5-R2C6H2C(O)CH3 with cinnamoyl chlorides (E)-4-R3C6H4CH=CHC(O)Cl using activated Ba(OH)2, followed by Baker-Venkataraman rearrangement assisted by dual-frequency ultrasonication. Cyclization of (2-hydroxybenzoyl)(cinnamoyl)methanes I using methanesulfonic acid along with dual-frequency ultrasound irradiation resulted in the formation of 2-strylchromones (E)-II in a single step.

Russian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics