Category: 1711-11-1

¹⁵N NMR chemical shifts of ring substituted benzonitriles was written by Zacek, Petr;Dransfeld, Alk;Exner, Otto;Schraml, Jan. And the article was included in Magnetic Resonance in Chemistry in 2006.Safety of 3-Cyanobenzoyl chloride This article mentions the following:

¹⁵N chem. shifts in an extensive series of para, meta, as well as ortho-substituted benzonitriles, X-C₆H₄-CN, were measured in deuteriochloroform solutions, using three different methods of referencing. The standard error of the average chem. shift was less than 0.03 ppm in most cases. The results are discussed for both empirical correlations with substituent parameters and quantum chem. calculations The ¹⁵N chem. shifts calculated at the GIAO/B3LYP/6-31+G*//B3LYP/6-31+G* level reproduce the exptl. values well, and include nitrogen atoms in the substituent groups (range of 300 ppm with slope 0.98 and R = 0.998, n = 43). The ¹⁵N shifts in hydroxybenzonitriles are affected by interaction with the OH group. Therefore, these derivatives are excluded from the correlation anal. The resultant ¹⁵N chem. shift correlates well with substituent constants, both in the simple Hammett or DSP relationships and the ¹³C substituent-induced chem. shifts of the CN carbon. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Safety of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Furanyl-1,3-thiazol-2-yl and benzoxazol-5-ylacetic acid derivatives: novel classes of heparanase inhibitor was written by Courtney, Stephen M.;Hay, Philip A.;Buck, Richard T.;Colville, Claire S.;Phillips, David J.;Scopes, David I. C.;Pollard, Faye C.;Page, Martin J.;Bennett, James M.;Hircock, Margaret L.;McKenzie, Edward A.;Bhaman, Maina;Felix, Robert;Stubberfield, Colin R.;Turner, Paul R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Product Details of 1711-11-1 This article mentions the following:

Using a furanylthiazoleacetic acid as a starting point, a novel series of benzoxazol-5-ylacetic acid derivatives have been identified as heparanase inhibitors. Several compounds, such as I, possess an IC₅₀ of 鈭?00 nM against heparanase. Several of the compounds show antiangiogenic properties. Improvement to the DMPK profile has provided compounds of potential use in in vivo models. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Product Details of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives was written by Li, Yu;Shi, Qiuyan;Shao, Jiajia;Yuan, Yaping;Yang, Zhigang;Chen, Shizhen;Zhou, Xin;Wen, Shijun;Jiang, Zhong-Xing. And the article was included in European Journal of Medicinal Chemistry in 2018.HPLC of Formula: 1711-11-1 This article mentions the following:

To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool mol. Using a K-ras cellular model, salinomycin and its derivatives showed different mol. mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial evaluation of nitazoxanide-based analogs: Identification of selective and broad spectrum activity was written by Ballard, T. Eric;Wang, Xia;Olekhnovich, Igor;Koerner, Taylor;Seymour, Craig;Salamoun, Joseph;Warthan, Michelle;Hoffman, Paul S.;MacDonald, Timothy L.. And the article was included in ChemMedChem in 2011.Name: 3-Cyanobenzoyl chloride This article mentions the following:

A library composed of nitazoxanide-based analogs was synthesized and assayed for increased antibacterial efficacy against the pyruvate-ferredoxin oxidoreductase (PFOR) using microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitulate and improve activity against these organism,s and select analogs were tested for their ability to disrupt the PFOR enzyme directly. The library was also screened for activity against staphylococci and resulted in the identification of analogs capable of inhibiting both staphylococci and all PFOR organisms at low micromolar min. inhibitory concentrations with low toxicity to human foreskin cells. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Name: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity evaluation of new uracil-based non-nucleoside inhibitors of HIV reverse transcriptase was written by Matyugina, Elena S.;Valuev-Elliston, Vladimir T.;Geisman, Alexander N.;Novikov, Mikhail S.;Chizhov, Alexander O.;Kochetkov, Sergey N.;Seley-Radtke, Katherine L.;Khandazhinskaya, Anastasia L.. And the article was included in MedChemComm in 2013.Reference of 1711-11-1 This article mentions the following:

A new series of potential nonnucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) based on the carbocyclic 5′-nor-uracil scaffold were designed and synthesized. Three different aspects of the scaffold were investigated: the effects of adding a linker between the carbocyclic and Ph fragments, introduction of different substituents on the benzoyl residue and replacing the central carbocyclic ring with a benzyl group. Analogs of 2′,3′-dideoxy-2′,3′-didehydro-5′-nor-uridine, bearing 3,5-dichloro- or 3,5-dimethylbenzoyl groups, showed inhibitory activity against HIV-RT wild-type (IC₅₀ 5-10 渭M) and mutants L100I (IC₅₀ 1.2-2.1 渭M) and K103N (IC₅₀ 8-17 渭M). In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzimidazole-based compounds kill Mycobacterium tuberculosis was written by Gong, Yaling;Somersan Karakaya, Selin;Guo, Xiaoyong;Zheng, Purong;Gold, Ben;Ma, Yao;Little, David;Roberts, Julia;Warrier, Thulasi;Jiang, Xiuju;Pingle, Maneesh;Nathan, Carl F.;Liu, Gang. And the article was included in European Journal of Medicinal Chemistry in 2014.Safety of 3-Cyanobenzoyl chloride This article mentions the following:

Tuberculosis remains one of the deadliest infectious diseases, killing 1.4 million people annually and showing a rapid increase in cases resistant to multiple drugs. New antibiotics against tuberculosis are urgently needed. Here the authors describe the design, synthesis and structure-activity relationships of a series of benzimidazole-based compounds, e.g. I [R¹ = Me, cyclobutyl, t-Bu, etc.; R² = morpholin-4-yl, thiomorpholin-4-yl; R³ = H, Me] with activity against Mycobacterium tuberculosis in a replicating state, a physiol.-induced nonreplicating state, or both. Several compounds, which shared a 5-nitrofuranyl moiety, exhibited high potency and acceptable selectivity indexes (SI). As illustrated by compound I [R¹ = isopentyl, R² = morpholin-4-yl, R³ = Me] (MIC₉₀ < 0.049 渭g/mL, SI > 512), the 5-nitrofuranyl group was compatible with minimal cytotoxicity and good intramacrophage killing, although it lacked nonreplicating activity when assessed by CFU assays. Compound I [R¹ = isopentyl, R² = morpholin-4-yl, R³ = Me] had low mutagenic potential by SOS Chromotest assay, making this class of compounds good candidates for further evaluation and target identification. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Safety of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of 4-chlorocolchicine derivatives as potent anticancer agents with broad effective dosage ranges was written by Nishiyama, Hiroyuki;Ono, Masahiro;Sugimoto, Takuya;Sasai, Toshio;Asakawa, Naoyuki;Yaegashi, Takashi;Nagaoka, Masato;Matsuzaki, Takeshi;Kogure, Noriyuki;Kitajima, Mariko;Takayama, Hiromitsu. And the article was included in MedChemComm in 2012.Synthetic Route of C8H4ClNO This article mentions the following:

4-Chlorocolchicine derivatives were synthesized with a view of developing new anticancer agents. The derivatives were examined for their potent activity and effective dosage range in mice, as well as favorable metabolic stability. As a result, several compounds bearing an 伪-hydroxyalkanoyl group on the C-7 amino function, were revealed to exhibit potent activities with broad effective dosage ranges. The title compounds thus formed included a colchicine amide derivative (I) and related substances. The title compounds were evaluated against N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide (colchicine). The synthesis of the target compounds was achieved using (7S)-7-amino-4-chloro-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one (4-chlorodeacetylcolchicine) as a starting material. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Synthetic Route of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solid-phase synthesis of 2,3-diphenylpropionic acid library as VLA-4 antagonists was written by Hoshina, Yoichiro;Ikegami, Satoru;Fujimoto, Kyoko;Okuyama, Akihiko;Harada, Tatsuhiro;James, Susan;Griffiths, Peter G.;Wu, Zemin;Lilly, Michael;Bray, Andrew M.. And the article was included in Tetrahedron Letters in 2005.Recommanded Product: 3-Cyanobenzoyl chloride This article mentions the following:

A 2,3-diphenylpropionic acid library was synthesized on solid-phase. There are two practical synthetic routes via an orthogonal generation of two aromatic amino functional groups. Several compounds were identified as potent VLA-4 antagonists. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Recommanded Product: 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy was written by Amato, George;Roeloffs, Rosemarie;Rigdon, Greg C.;Antonio, Brett;Mersch, Theresa;McNaughton-Smith, Grant;Wickenden, Alan D.;Fritch, Paul;Suto, Mark J.. And the article was included in ACS Medicinal Chemistry Letters in 2011.HPLC of Formula: 1711-11-1 This article mentions the following:

A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC₅₀ of 0.38 渭M and is selective for KCNQ2/Q3 channels. This compound was active in several rodent models of epilepsy and pain but upon repeated dosing had a number of unacceptable toxicities that prevented further development. On the basis of the structure-activity relationships developed around 12, a second compound, 51, [N-(2-chloro-pyrimidin-5-yl)-3,4-difluoro-benzamide, ICA-069673], was prepared and advanced into a phase 1 clin. study. Herein, we describe the structure-activity relationships that led to the identification of compound 12 and to the corresponding pyrimidine 51. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A meta-selective C-H borylation directed by a secondary interaction between ligand and substrate was written by Kuninobu, Yoichiro;Ida, Haruka;Nishi, Mitsumi;Kanai, Motomu. And the article was included in Nature Chemistry in 2015.Safety of 3-Cyanobenzoyl chloride This article mentions the following:

Regioselective C-H bond transformations are potentially the most efficient method for the synthesis of organic mols. However, the presence of many C-H bonds in organic mols. and the high activation barrier for these reactions make these transformations difficult. Directing groups in the reaction substrate are often used to control regioselectivity, which has been especially successful for the ortho-selective functionalization of aromatic substrates. Here, authors describe an iridium-catalyzed meta-selective C-H borylation of aromatic compounds using a newly designed catalytic system. The bipyridine-derived ligand that binds iridium contains a pendant urea moiety. A secondary interaction between this urea and a hydrogen-bond acceptor in the substrate places the iridium in close proximity to the meta-C-H bond and thus controls the regioselectivity. ¹H NMR studies and control experiments support the participation of hydrogen bonds in inducing regioselectivity. Reversible direction of the catalyst through hydrogen bonds is a versatile concept for regioselective C-H transformations. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Safety of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics