Category: 1711-11-1

Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening was written by Pibiri, Ivana;Lentini, Laura;Tutone, Marco;Melfi, Raffaella;Pace, Andrea;Di Leonardo, Aldo. And the article was included in European Journal of Medicinal Chemistry in 2016.Reference of 1711-11-1 This article mentions the following:

Ataluren, also known as PTC124, is a 5-(fluorophenyl)-1,2,4-oxadiazolyl-benzoic acid suggested to suppress nonsense mutations by readthrough of premature stop codons in the mRNA. Potential interaction of PTC124 with mRNA has been recently studied by mol. dynamics simulations highlighting the importance of H-bonding and stacking π-π interactions. A series of non-acidic analogs of PTC124 were selected from a large database via a ligand-based virtual screening approach. Eight of them were synthesized and tested for their readthrough activity using the Fluc reporter harboring the UGA premature stop codon. The most active compound was further tested for suppression of the UGA nonsense mutation in the bronchial epithelial IB3.1 cell line carrying the W1282X mutation in the CFTR gene. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Reference of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Syntheses and Structures of Ag(I)-Containing Coordination Polymers and Co(II)-Containing Supramolecular Complex Based on Novel Fulvene Ligands was written by Dong, Yu-Bin;Wang, Peng;Huang, Ru-Qi;Smith, Mark D.. And the article was included in Inorganic Chemistry in 2004.Computed Properties of C8H4ClNO This article mentions the following:

Three new rigid conjugated fulvene ligands L1-L3 were synthesized. L1 and L3 were prepared by an aroylation reaction of cyclohexyl-substituted cyclopentadienyl anions. L2 was prepared by the reaction of L1 with PhNHNH₂ in hot ethanol. Six new coordination polymers, [Ag(C₂₅H₂₀N₂O₂)(ClO₄)]·3.5C₆H₆ (1), [Ag₂(μ-C₃₁H₂₄N₄)(η²-C₆H₆)(H₂O)](ClO₄)₂·(C₆H₆)·(H₂O)_0.5 (3), [Ag(C₃₁H₂₄N₄)]SbF₆·solvate (4), [Ag(C₃₁H₂₄N₄)](SbF₆)·2C₆H₆·CH₂Cl₂ (5), [Ag(C₂₅H₂₀N₂O₂)₂]SbF₆ (6), and [Ag(C₂₅H₂₀N₂O₂)₂]SbF₆ (7), and one seven-membered cobaltacycle-containing complex, Co(C₂₅H₂₀N₂O₂)₂(EtOH)₂ (2), were obtained through self-assembly based on these three new fulvene ligands. L2-L3 and compounds 1-7 were fully characterized by IR spectroscopy, elemental anal., and single-crystal x-ray diffraction. The coordination chem. of new fulvene ligands is versatile. They can bind metal ions not only through the terminal N-donors and fulvene C atoms into organometallic coordination polymers but also through the two chelating carbonyl groups into unusual seven-membered metallo-ring supramol. complexes. In the solid state, ligands L1-L3 are luminescent. A blue-shift in the emission was observed between the free ligand L1 and the one incorporated into Co(II)-containing complex 2, and a red shift in the emission was observed between the free ligand L3 and the one incorporated into Ag(I)-containing polymeric compounds 6 and 7. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Computed Properties of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors was written by Patil, Shivaputra;Kamath, Shantaram;Sanchez, Tino;Neamati, Nouri;Schinazi, Raymond F.;Buolamwini, John K.. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Quality Control of 3-Cyanobenzoyl chloride This article mentions the following:

A new series of phenanthridinone derivatives, and diketo acid analogs, as well as related phenanthrene and anthracene diketo acids have been synthesized and evaluated as HIV integrase (IN) inhibitors. Several new β-diketo acid analogs with the phenanthridinone scaffold replaced by phenanthrene, anthracene or pyrene exhibited the highest IN inhibitory potency. There is a general selectivity against the integrase strand transfer step. The most potent IN was 2,4-dioxo-4-phenanthren-9-yl-butyric acid (27f) with an IC₅₀ of 0.38 μM against integrase strand transfer. The phenanthrene diketo acids 27d-f were more potent (IC₅₀ = 2.7-0.38 μM) than the corresponding phenanthridinone diketo acid 16 (IC₅₀ = 65 μM), suggesting that the polar amide bridge in the phenanthridinone system decreases inhibitory activity relative to the more lipophilic phenanthrene system. This might have to do with the possible binding of the aryl group of the compounds binding to a lipophilic pocket at the integrase active site as suggested by the docking simulations. Mol. modeling also suggested that effectiveness of chelation of the active site Mg²⁺ contributes to IN inhibitory potency. Finally, some of the potent compounds inhibited HIV-1 replication in human peripheral blood mononuclear cells (PBMC) with EC₅₀ down to 8 μM for phenanthrene-3-(2,4-dioxo)butyric acid (27d), with a selectivity index of 10 against PBMCs. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Quality Control of 3-Cyanobenzoyl chloride).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 3-Cyanobenzoyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors was written by Vergelli, Claudia;Schepetkin, Igor A.;Crocetti, Letizia;Iacovone, Antonella;Giovannoni, Maria Paola;Guerrini, Gabriella;Khlebnikov, Andrei I.;Ciattini, Samuele;Ciciani, Giovanna;Quinn, Mark T.. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2017.Formula: C8H4ClNO This article mentions the following:

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, the authors report the synthesis, structure-activity relationship anal., and biol. evaluation of a new series of HNE inhibitors with an isoxazol-5(2H)-one scaffold. The most potent compound (2o) (3-isopropyl-2-(4-methylbenzoyl)isoxazol-5(2H)-one) had a good balance between HNE inhibitory activity (IC₅₀ value =20 nM) and chem. stability in aqueous buffer (t_1/2=8.9 h). Anal. of reaction kinetics revealed that the most potent isoxazolone derivatives were reversible competitive inhibitors of HNE. Furthermore, since compounds (2o) and (2s) (3-isopropyl-2-(4-(trifluoromethyl)benzoyl)isoxazol-5(2H)-one) contain two carbonyl groups (2-N-CO and 5-CO) as possible points of attack for Ser 195, the amino acid of the active site responsible for the nucleophilic attack, docking studies allowed the authors to clarify the different roles played by these groups. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Small-molecule Ca_Vα₁·Ca_Vβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking was written by Chen, Xingjuan;Liu, Degang;Zhou, Donghui;Si, Yubing;Xu, David;Stamatkin, Christopher W.;Ghozayel, Mona K.;Ripsch, Matthew S.;Obukhov, Alexander G.;White, Fletcher A.;Meroueh, Samy O.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2018.Computed Properties of C8H4ClNO This article mentions the following:

Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the postsynaptic central nociceptive neurons. The CaV2.2 channel is composed of a pore-forming α1 subunit (CaVα1) that is engaged in protein-protein interactions with auxiliary α2/δ and β subunits. The high-affinity CaV2.2α1-CaVβ3 protein-protein interaction is essential for proper trafficking of CaV2.2 channels to the plasma membrane. Here, structure-based computational screening led to small mols. that disrupt the CaV2.2α1-CaVβ3 protein-protein interaction. The binding mode of these compounds reveals that three substituents closely mimic the side chains of hot-spot residues located on the α-helix of CaV2.2α1. Site-directed mutagenesis confirmed the critical nature of a salt-bridge interaction between the compounds and CaVβ3 Arg-307. In cells, compounds decreased trafficking of CaV2.2 channels to the plasma membrane and modulated the functions of the channel. In a rodent neuropathic pain model, the compounds suppressed pain responses. Small-mol. α-helical mimetics targeting ion channel protein-protein interactions may represent a strategy for developing nonopioid analgesia and for treatment of other neurol. disorders associated with calcium-channel trafficking. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Computed Properties of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors was written by Jin, Zhuang;Khan, Pasha;Shin, Youseung;Wang, Jingyi;Lin, Li;Cameron, Michael D.;Lindstrom, Jon M.;Kenny, Paul J.;Kamenecka, Theodore M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.COA of Formula: C8H4ClNO This article mentions the following:

The design and synthesis of a series of substituted heteroaromatic α4β2α5 pos. allosteric modulators is reported. The optimization and development of the heteroaromatic series was carried out from NS9283, and several potent analogs, such as 3-(5-(pyridin-3-yl)-2H-tetrazol-2-yl)benzonitrile and 3,3′-(2H-tetrazole-2,5-diyl)dipyridine with good in vitro efficacy were discovered. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1COA of Formula: C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists was written by Cole, Andrew G.;Stroke, Ilana L.;Brescia, Marc-Raleigh;Simhadri, Srilatha;Zhang, Joan J.;Hussain, Zahid;Snider, Michael;Haskell, Christopher;Ribeiro, Sofia;Appell, Kenneth C.;Henderson, Ian;Webb, Maria L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.HPLC of Formula: 1711-11-1 This article mentions the following:

The identification and evaluation of aryl-[1,4]diazepane ureas as functional antagonists of the chemokine receptor CXCR3 are described. Specific examples exhibit IC₅₀ values of ∼60 nM in a calcium mobilization functional assay, and dose-dependently inhibit CXCR3 functional response to CXCL11 (interferon-inducible T-cell α chemoattractant/I-TAC) as measured by T-cell chemotaxis, with a potency of approx. 100 nM. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1HPLC of Formula: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of imidamide analogs as selective anti-trypanosomal agents was written by Bobba, Viharika;Li, Yaxin;Afrin, Marjia;Dano, Raina;Zhang, Wenjing;Li, Bibo;Su, Bin. And the article was included in Bioorganic & Medicinal Chemistry in 2022.Recommanded Product: 1711-11-1 This article mentions the following:

Human African trypanosomiasis is caused by a protozoan parasite Trypanosoma brucei majorly infecting people living in sub-Saharan Africa. Current limited available treatments suffer from drug resistance, severe adverse effects, low efficacy, and costly administrative procedures in African countries with limited medical resources. Therefore, there is always a perpetual demand for advanced drug development and invention of new strategies to combat the disease. Previous work in our lab generated a library of sulfonamide analogs as selective tubulin inhibitors, based on the structural difference between mammalian and trypanosome tubulin proteins. Further lead derivatization was performed in the current study and generated 25 potential drug candidates to improve the drug efficacy and uptake by selectively targeting the parasite′s P2 membrane transporter protein with imidamide moiety. One of the newly synthesized analogs, compound 25 with a di-imidamide moiety, has shown greater potency with an IC50 of 1 nM to selectively inhibit the growth of trypanosome cells without affecting the viability of mammalian cells. Western blot analyses reveal that the compound suppressed tubulin polymerization in T. brucei cells. A detailed structure-activity relationship (SAR) was summarized that will be used to guide future lead optimization. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Recommanded Product: 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction was written by Kim, Seung-Hoi;Rieke, Reuben D.. And the article was included in Tetrahedron in 2010.Synthetic Route of C8H4ClNO This article mentions the following:

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides I (X = CH₂, N; Y = N, CH₂) has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, resp. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Synthetic Route of C8H4ClNO).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C8H4ClNO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzothiazoles exhibit broad-spectrum antitumor activity: Their potency, structure-activity and structure-metabolism relationships was written by Xie, Xilei;Yan, Yu;Zhu, Ning;Liu, Gang. And the article was included in European Journal of Medicinal Chemistry in 2014.Application of 1711-11-1 This article mentions the following:

An antitumor activity oriented benzothiazole sublibrary was constructed from a hit compound I via a five stepwise procedure. All target compounds were screened for their antitumor activity against 60 human cancer cell lines. Compounds II, III and IV, showing higher potency than hit I, were identified. Particularly, the compound II gave its average 50% growth inhibition (GIC₅₀) at 0.38 μM. Furthermore, incubation in human liver microsome primarily proved their metabolic stability in vitro. General structure-activity and structure-metabolism relationships were both summarized, which provides information on further strategically optimization. In the experiment, the researchers used many compounds, for example, 3-Cyanobenzoyl chloride (cas: 1711-11-1Application of 1711-11-1).

3-Cyanobenzoyl chloride (cas: 1711-11-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 1711-11-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics