Category: 172222-30-9

Synthetic Route of C43H72Cl2P2RuIn 2020 ,《Stereoselective Synthesis of Tetrahydroisoquinolines from Chiral 4-Azaocta-1,7-diynes and 4-Azaocta-1,7-enynes》 was published in European Journal of Organic Chemistry. The article was written by Sirvent, Ana; Garcia-Munoz, M. Jesus; Yus, Miguel; Foubelo, Francisco. The article contains the following contents:

The N-propargylation of enantioenriched homopropargylic amine derivatives III (R1 = e.g., phenethyl) proceeds in high yields under basic conditions. The resulting 4-azaocta-1,7-dynes V were transformed into 1,2,3,4-tetrahydrosioquinolines VII (R2 = e.g., Et) bearing substituents at 3-, 6- and 7-positions, upon reaction with sym. alkynes, through a [2+2+2] cyclotrimerization promoted by Wilkinson catalyst. Ruthenium-catalyzed ring closing metathesis of azaocta-1,7-enynes (e.g., IX) gave 1,3-diene X in high yields. Tetrahydroisoquinoline XII with a substitution pattern in the aromatic ring different from VII was prepared by a [4+2] cycloaddition of di-Me acetylenedicarboxylate with diene X. Other substitution patters were also obtained. In the experiment, the researchers used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Synthetic Route of C43H72Cl2P2Ru)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Synthetic Route of C43H72Cl2P2Ru

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gramani, Subramanian G.; Sriramula, Ravi K.; Sekar, Karthik; Yang, Eugene G.; Battu, Praveena; Kopecky, Aicha; Lear, Martin J. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Cis Selective RCM Study to the 14-Membered Cyclic Subunit of Bielschowskysin》.HPLC of Formula: 172222-30-9 The article contains the following contents:

A concise, (Z)-selective ring-closing metathesis (RCM) route to the 14-membered carbocycle of bielschowskysin is detailed using naturally occurring chiral starting materials. Unproductive RCM substrates were attributed to alkyne chelation of the ruthenium catalyst and steric disadvantages within the cembranoid precursors, which was eventually circumvented by using cyclic diol benzylidene protection involving a C8-quaternary carbinol center. In the experiment, the researchers used many compounds, for example, Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9HPLC of Formula: 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.HPLC of Formula: 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Acikalin, Hande; Ziegler, Felix; Wang, Dongren; Buchmeiser, Michael R. published an article in 2021. The article was titled 《A Hard Templating Approach to Functional Mesoporous Poly(norborn-2-ene)-Based Monolithic Supports》, and you may find the article in Macromolecular Chemistry and Physics.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium The information in the text is summarized as follows:

A hard-templating method is presented for the synthesis of functional ring-opening metathesis polymerization (ROMP) derived, poly(norborn-2-ene)-based monolithic supports prepared under solvent-induced phase separation conditions using the first-generation Grubbs initiator RuCl2(PCy3)2(CHPh) (1, Cy = cyclohexyl). Norborn-2-ene (NBE), 1,4,4a,5,8,8a-hexahydro-1,4,5,8-exo,endo-dimethanonaphthalene (DMN-H6) and trimethylolpropane-tris-(5-norbornene-2-yl-carboxylate (TMPTNC) are used as monomers and crosslinkers, resp. 2-Propanol and toluene are used as macro- and microporogen. Silica (SiO2) nanowires (SNWs) surface-modified with NBE are used as hard templates. exo,endo-Norborn-5-ene-2-ylmethanol (NBE-CH2OH) is used as functional comonomer. The tailored porogenic system together with the surface-functionalized SNWs allows for a full dispersion of the SNWs in the polymerization mixture and their incorporation into the monolithic structure during the phase separation process. This way, ROMP-derived monoliths with pore dimensions of 10-15 nm, sp. surface areas up to 3.7 m2 g-1, and pore porosities up to 33% are obtained after removal of the SNWs by chem. etching at room temperature The experimental part of the paper was very detailed, including the reaction process of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Reference of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of C43H72Cl2P2RuIn 2021 ,《Ring-Opening Metathesis Polymerization of endo- and exo-Norbornene Lactones》 was published in Macromolecular Rapid Communications. The article was written by Miyasako, Narumi; Matsuoka, Shin-ichi; Suzuki, Masato. The article contains the following contents:

New ester-functionalized bicyclic aliphatic polymers are synthesized through the ring-opening metathesis polymerization (ROMP) of endo- and exo-norbornene lactones (endo-NBL and exo-NBL) and their oxa-norbornene analog (exo-oxa-NBL) followed by hydrogenation. The polymerizability between endo- and exo-NBLs, and the thermal properties between the six types of polymers before and after hydrogenation are compared and discussed. The ROMP of all three monomers proceeded in a living fashion under optimized conditions, which is confirmed by chain extension experiments Endo-NBL shows a much lower homo- and copolymerizability than exo-NBL probably owing to six-membered chelation to the Ru center and steric hindrance in the ruthenacyclobutane intermediate. Stereo-block and stereo-gradient copolymers of poly(endo-NBL) and poly(exo-NBL) are also synthesized. The hydrogenation catalyzed by RuHCl(CO)(PPh3)3 in the mixed solvents of o-xylene and N,N-di-Me acetamide (DMAc) results in more than 95% conversion. The obtained hydrogenated polymers, H-poly(endo-NBL) and H-poly(exo-NBL), are amorphous, soluble in chlorinated aliphatic solvents, and thermally stable until 400°C without a weight loss. Their glass transition temperatures are 163 and 131°C, resp.; the values are appropriate in terms of both thermal stability and processing deformation for the application of transparent resin materials. After reading the article, we found that the author used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Synthetic Route of C43H72Cl2P2Ru)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Synthetic Route of C43H72Cl2P2Ru

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Staiger, Anne; Paren, Benjamin A.; Zunker, Robin; Hoang, Son; Haeussler, Manuel; Winey, Karen I.; Mecking, Stefan published their research in Journal of the American Chemical Society in 2021. The article was titled 《Anhydrous Proton Transport within Phosphonic Acid Layers in Monodisperse Telechelic Polyethylenes》.Product Details of 172222-30-9 The article contains the following contents:

Polymers bearing phosphonic acid groups have been proposed as anhydrous proton-conducting membranes at elevated operating temperatures for applications in fuel cells. However, the synthesis of phosphonated polymers and the control over the nanostructure of such polymers is challenging. Here, we report the straightforward synthesis of phosphonic acid-terminated, long-chain aliphatic materials with precisely 26 and 48 carbon atoms (C26PA2 and C48PA2). These materials combine the structuring ability of monodisperse polyethylenes with the ability of phosphonic acid groups to form strong hydrogen-bonding networks. Anhydride formation is absent so that charge carrier loss by a condensation reaction is avoided even at elevated temperatures Below the melting temperature (Tm), both materials exhibit a crystalline polyethylene backbone and a layered morphol. with planar phosphonic acid aggregates separated by 29 and 55 Å for C26PA2 and C48PA2, resp. Above Tm, the amorphous polyethylene (PE) segments coexist with the layered aggregates. This phenomenon is especially pronounced for the C26PA2 and is identified as a thermotropic smectic liquid crystalline phase. Under these conditions, an extraordinarily high correlation length (940 Å) along the layer normal is observed, demonstrating the strength of the hydrogen bond network formed by the phosphonic acid groups. The proton conductivity in both materials in the absence of water reaches 10-4 S/cm at 150 °C. These new precise phosphonic acid-based materials illustrate the importance of controlling the chem. to form self-assembled nanoscale aggregates that facilitate rapid proton conductivity The experimental process involved the reaction of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Product Details of 172222-30-9)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Product Details of 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Name: Benzylidenebis(tricyclohexylphosphine)dichlororutheniumIn 2020 ,《Ru-Catalyzed, cis-Selective Living Ring-Opening Metathesis Polymerization of Various Monomers, Including a Dendronized Macromonomer, and Implications to Enhanced Shear Stability》 was published in Journal of the American Chemical Society. The article was written by Song, Jung-Ah; Peterson, Gregory I.; Bang, Ki-Taek; Ahmed, Tonia S.; Sung, Jong-Chan; Grubbs, Robert H.; Choi, Tae-Lim. The article contains the following contents:

An unsaturated polymer’s cis/trans-olefin content has a significant influence on its properties. For polymers obtained by ring-opening metathesis polymerization (ROMP), the cis/trans-olefin content can be tuned by using specific catalysts. However, cis-selective ROMP has suffered from narrow monomer scope and lack of control over the polymerization (giving polymers with broad mol. weight distributions and prohibiting the synthesis of block copolymers). Herein, we report the versatile cis-selective controlled living ROMP of various endo-tricyclo[4.2.2.02,5]deca-3,9-diene and various norbornene derivatives using a fast-initiating dithiolate-chelated Ru catalyst. Polymers with cis-olefin content as high as 99% could be obtained with high mol. weight (up to Mn of 105.1 kDa) and narrow dispersity (<1.4). The living nature of the polymerization was also exploited to prepare block copolymers with high cis-olefin content for the first time. Furthermore, owing to the successful control over the stereochem. and narrow dispersity, we could compare cis- and trans-rich polynorbornene and found the former to have enhanced resistance to shear degradation In the experiment, the researchers used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is the first metathesis catalyst to be widely used in organic synthesis. It is useful for acyclic diene metathesis polymerization (ADMET), Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, ring opening metathesis (ROM), and so on.Name: Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Enol Ethers Are Effective Monomers for Ring-Opening Metathesis Polymerization: Synthesis of Degradable and Depolymerizable Poly(2,3-dihydrofuran)》 was written by Feist, John D.; Xia, Yan. Safety of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Enol ethers are widely used as quenching reagents for Grubbs catalysts. However, we report the surprisingly effective ring-opening metathesis polymerization (ROMP) of cyclic enol ethers, because the resulting electron-rich ruthenium alkylidene complex remains active toward metathesis of electron-rich olefins, despite its deactivation toward hydrocarbon olefins. We demonstrate the first example of ROMP of cyclic enol ethers, using 2,3-dihydrofuran as the monomer, producing a new type of degradable and depolymerizable poly(enol ether). The polymers exhibited perfect regioregularity, and their mol. weights can be regulated by the loading of Grubbs initiators or by the use of a linear vinyl ether as the chain transfer agent. We also developed protocols to deactivate the catalyst following metathesis of enol ethers and cleave the catalyst off the resulting polymers using H2O2 oxidation The resulting poly(dihydrofuran) can be recycled to monomer via depolymerization with Grubbs catalyst or degraded to small mols. by hydrolysis under acidic conditions. This work opens exciting opportunities for a new class of ROMP monomers that lead to degradable polymers. The experimental part of the paper was very detailed, including the reaction process of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Safety of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Safety of Benzylidenebis(tricyclohexylphosphine)dichlororuthenium

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gupta, Saswata; Su, Siyuan; Zhang, Yu; Liu, Peng; Wink, Donald J.; Lee, Daesung published their research in Journal of the American Chemical Society in 2021. The article was titled 《Ruthenabenzene: A Robust Precatalyst》.Computed Properties of C43H72Cl2P2Ru The article contains the following contents:

Metallaaroms. constitute a unique class of aromatic compounds where one or more transition metal elements are incorporated into the aromatic system, the parent of which is metallabenzene. One of the main concerns about metallabenzenes generally deals with the structural characterization related to their relative aromaticity compared to the carbon archetype. Transition metal-containing metallabenzenes are also implicated in certain catalytic processes such as alkyne metathesis polymerization; however, these transition metal-based metallaarom. compounds have not been developed as a catalyst. Herein, we describe an effective strategy to generate diverse arrays of ruthenabenzenes and demonstrated them as an aromatic equivalent of the Grubbs-type ruthenium alkylidene catalysts. These ruthenabenzenes can be prepared via an enyne metathesis and metallotropic [1,3]-shift cascade process to form alkyne-chelated ruthenium alkylidene intermediates followed by spontaneous cycloaromatization. The aromatic nature of these complexes was confirmed by spectroscopic and X-ray crystallog. data, and the mechanistic pathways for the cycloaromatization process were studied by DFT calculations These ruthenabenzenes display robust catalytic activity for metathesis and other transformations, which illustrates that metallabenzenes are not only compounds of structural and theor. interests but also are a novel platform for new catalyst development. After reading the article, we found that the author used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Computed Properties of C43H72Cl2P2Ru)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Computed Properties of C43H72Cl2P2Ru

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Teng-Wei; Huang, Pin-Ruei; Chow, Jayme L.; Kaminsky, Werner; Golder, Matthew R. published their research in Journal of the American Chemical Society in 2021. The article was titled 《A Cyclic Ruthenium Benzylidene Initiator Platform Enhances Reactivity for Ring-Expansion Metathesis Polymerization》.SDS of cas: 172222-30-9 The article contains the following contents:

Ring-expansion metathesis polymerization (REMP) has shown potential as an efficient strategy to access cyclic macromols. Current approaches that utilize cyclic olefin feedstocks suffer from poor functional group tolerance, low initiator stability, and slow reaction kinetics. Improvements to current initiators will address these issues in order to develop more versatile and user-friendly technologies. Herein, we report a reinvigorated tethered ruthenium-benzylidene initiator, CB6, that utilizes design features from ubiquitous Grubbs-type initiators that are regularly applied in linear polymerizations We report the controlled synthesis of functionalized cyclic poly(norbornene)s and demonstrate that judicious ligand modifications not only greatly improve kinetics but also lead to enhanced initiator stability. Overall, CB6 is an adaptable platform for the study and application of cyclic macromols. via REMP. In addition to this study using Benzylidenebis(tricyclohexylphosphine)dichlororuthenium, there are many other studies that have used Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9SDS of cas: 172222-30-9) was used in this study.

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.SDS of cas: 172222-30-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Bendelac, Audrey; Benedetti, Francoise; Doublet-Decabras, Valerie; Lokovi, Rachel; Decalogne, Francois; Bigot, Antony published an article in Organic Process Research & Development. The title of the article was 《Fit-for-Purpose Synthesis of an Aza-Cryptophycin Analogue as the Payload for an Antibody-Drug Conjugate》.Computed Properties of C43H72Cl2P2Ru The author mentioned the following in the article:

The synthesis of an aza-cryptophycin analog (I) is described, featuring a highly trans-selective ring-closing metathesis reaction and an asym. Corey-Chaykovsky-type reaction to install the epoxide function. This latter reaction is an answer to the long-standing synthetic challenged posed by the efficient formation of the epoxide function of the cryptophycin family of compounds in a diastereoselective manner. It allows for a one-third reduction in the number of steps compared with the previously used synthesis (27 to 19 steps) and increases the overall yield of the longest linear sequence by a factor of 27 (0.6% to 16%). This fit-for-purpose synthesis allowed the production of a steady supply of the material for the early phase of a cryptophycin-based antibody-drug conjugate program. Safety: cryptophycin analogs are highly cytotoxic and should be prepared with appropriate precautions, and decomposition risk of chiral sulfonium. In the part of experimental materials, we found many familiar compounds, such as Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9Computed Properties of C43H72Cl2P2Ru)

Benzylidenebis(tricyclohexylphosphine)dichlororuthenium(cas: 172222-30-9) is a ruthenium-based olefin metathesis catalyst. It is useful for olefin cross metathesis (CM) and ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions, and so on.Computed Properties of C43H72Cl2P2Ru

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics