Category: 17601-75-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17601-75-1, name is 2,4-Dichloro-5-methylaniline, A new synthetic method of this compound is introduced below., Quality Control of 2,4-Dichloro-5-methylaniline

Comparative Example 2-11-(2′,2′,2′-Trichloroethyl)-2,4-dichloro-5-methylbenzene; At room temperature, 7.04 g [0.04 mol] of 2,4-dichloro-5-methylaniline are introduced into 28 ml of conc. hydrochloric acid, the mixture is cooled to -5 to 0 C. and a solution, cooled to 0 C., of 3.31 g [0.048 mol] of NaNO2 in 80 ml of water is added dropwise within 60 minutes. Subsequently, the mixture is stirred at -5 to 0 C. for 15 minutes. Subsequently, 3.23 g [0.024 mol] of copper(II) chloride are added. To this mixture is added dropwise, at 0 C. within 30 minutes, a solution of 38.8 g [0.4 mol=10 molar equivalents] of vinylidene chloride in 130 ml of acetone. The mixture is allowed to come to room temperature with good stirring and left to react for another 3 hours. The reaction mixture is diluted with 100 ml of water and extracted twice with 70 ml each time of MTBE. The combined organic phases are washed with 30 ml of water, dried over sodium sulphate and concentrated under reduced pressure. This gives 12.3 g of oil which, according to GC-MS, contains 64.05 area % of 1-(2′,2′,2′-trichloroethyl)-2,4-dichloro-5-methylbenzene. This corresponds to a yield of 67.4% of theory.The GC-MS shows, as by-products, 5.7 area % of Sandmeyer product and 23.8 area % of 1,5-dichloro-2-methyl-4-(2′,2′,4′,4′,4′-pentachlorobutyl)benzene.

The synthetic route of 17601-75-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer CropScience AG; US2010/234651; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17601-75-1, name is 2,4-Dichloro-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H7Cl2N

Example 21-(2′-Bromo-2′,2′-dichloroethyl)-2,4-dichloro-5-methylbenzene; At room temperature, 7.04 g [0.04 mol] of 2,4-dichloro-5-methylaniline are introduced into 30 ml of 36% aqueous HBr, the mixture is cooled to -10 to -5 C. and a solution, cooled to 0 C., of 3.31 g [0.048 mol] of NaNO2 in 80 ml of water is added dropwise within 60 minutes. Subsequently, the mixture is stirred at -10 to -5 C. for 15 minutes. Subsequently, 1.79 g [0.008 mol] of copper(II) bromide and 6.95 g [0.08 mol] of LiBr are added. To this mixture is added dropwise, at -10 to -5 C. within 30 minutes, a solution of 38.8 g [0.4 mol=10 molar equivalents] of vinylidene chloride in 130 ml of acetone. The mixture is allowed to come to room temperature with good stirring and left to react for another 3 hours. The reaction mixture is diluted with 100 ml of water and extracted twice with 70 ml each time of MTBE. The combined organic phases are washed with 30 ml of water, dried over sodium sulphate and concentrated under reduced pressure. This gives 12.8 g of oil which, according to GC-MS, contains 92 area % of 1-(2′-bromo-2′,2′-dichloroethyl)-2,4-dichloro-5-methylbenzene. This corresponds to a yield of 87.4% of theory.The GC-MS shows, as by-products, 3.3 area % of Sandmeyer product and 1.2 area % of 1-(4-bromo-2′,2′,4′,4′-tetrachlorobutyl)-2,4-dichloro-5-methylbenzene.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17601-75-1.

Reference:
Patent; Bayer CropScience AG; US2010/234651; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics