Category: 18637-02-0

A Three-Component Approach to 3,5-Diaryl-1,2,4-thiadiazoles under Transition-Metal-Free Conditions was written by Xie, Hao;Cai, Jinhui;Wang, Zilong;Huang, Huawen;Deng, Guo-Jun. And the article was included in Organic Letters in 2016.Application In Synthesis of 2-Chloro-benzamidine hydrochloride This article mentions the following:

A novel route is disclosed for the synthesis of 1,2,4-thiadiazoles starting from amidines, elemental sulfur, and 2-methylquinolines or aldehydes under transition-metal-free conditions. This three-component approach affords efficient and rapid access to 3,5-diaryl substituted 1,2,4-thiadiazoles with good tolerance of a broad range of functional groups. Mechanistic studies reveal a radical-involved pathway. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Application In Synthesis of 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Multi-component cascade reaction of 3-formylchromones: highly selective synthesis of 4,5-dihydro-[4,5′-bipyrimidin]-6(1H)-one derivatives was written by Chen, Li;Huang, Rong;Yun, Xing-Han;Hao, Tian-Hui;Yan, Sheng-Jiao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Synthetic Route of C7H8Cl2N2 This article mentions the following:

A novel protocol for the construction of highly functionalized bipyrimidine derivatives from 3-formylchromones, Et 2-(pyridine-2-yl)acetate derivatives, and amidine hydrochlorides via an interesting and considerably complex multi-component cascade reaction was developed. The cascade reaction was manifested by refluxing a mixture of the three substrates in acetonitrile or DMF along with Cs₂CO₃. A series of 4,5-dihydro-[4,5′-bipyrimidin]-6(1H)-ones (DBPMOs) was constructed regioselectively in suitable to excellent yields. Moreover, DBPMOs then underwent a novel, metal and oxidant-free cascade reaction to produce a series of [4,5′-bipyrimidin]-6(1H)-ones (BPMOs). The formation of the bipyrimidine derivatives was enabled by the formation of five bonds and the cleavage of one bond in one pot. This protocol can be used in the synthesis of functionalized bipyrimidine derivatives via a multi-component one-pot cascade reaction rather than multi-step reactions, which were suitable for both combinatorial and parallel syntheses of bipyrimidine derivatives In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Synthetic Route of C7H8Cl2N2).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Synthetic Route of C7H8Cl2N2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Four-Component Reaction Strategy for Pyrimidine Carboxamide Synthesis was written by Guo, Wei;Liao, Jianhua;Liu, Dongqing;Li, Jiawei;Ji, Fanghua;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Angewandte Chemie, International Edition in 2017.Name: 2-Chloro-benzamidine hydrochloride This article mentions the following:

Demonstrated herein is a highly effective 3 starting materials and 4 component reaction (3SM-4CR) strategy for the synthesis of pyrimidinecarboxamides from amidines, styrenes, and N,N-dimethylformamide (DMF) by a palladium-catalyzed oxidative process. This transformation represents the first example of employing DMF as a dual synthon, a one-carbon-atom synthon and amide synthon, and was proven by isotope-labeling experiments Addnl., the combination of C-H bond functionalization and cross-dehydrogenative coupling processes affords four chem. bond formations. This sequential 3SM-4CR strategy features inexpensive, readily available starting materials, green oxidants, as well as atom and step economy. It leads to the preparation of pyrimidine carboxamides and has potential applications in the pharmaceutical industry. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Name: 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium-Catalyzed 3-Aryl-5-acyl-1,2,4-thiadiazole Formation from Ketones, Amidines, and Sulfur Powder was written by Wang, Zilong;Xie, Hao;Xiao, Fuhong;Guo, Yanjun;Huang, Huawen;Deng, Guo-Jun. And the article was included in European Journal of Organic Chemistry in 2017.Related Products of 18637-02-0 This article mentions the following:

An efficient strategy for the preparation of 3,5-disubstituted 1,2,4-thiadiazoles from ketones, amidines, and sulfur powder under palladium-catalyzed conditions was developed. In this transformation, aromatic ketones act as both the carbon and acyl sources. The reaction provided efficient access to 3-aryl-5-acyl-1,2,4-thiadiazoles from readily available starting materials. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Related Products of 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Promoted Metal-/Oxidant-Free Three-Component Tandem Annulation: A Strategy for the Construction of 2,4,5-Trisubstituted Thiazoles via C-N Bond Cleavage of Amidines was written by Guo, Wei;Zhao, Mingming;Tan, Wen;Zheng, Lvyin;Tao, Kailiang;Chen, Luyan;Wang, Mingfeng;Chen, Deliang;Fan, Xiaolin. And the article was included in Asian Journal of Organic Chemistry in 2018.HPLC of Formula: 18637-02-0 This article mentions the following:

A base-promoted and metal-/oxidant-free one-pot three-component tandem annulation of amidines, aryl/alkyl isothiocyanates, and α-bromoesters/ketones to 2,4,5-trisubstituted thiazoles I (R¹ = Ph, 4-FC₆H₄, 3-BrC₆H₄, etc.; R² = 4-FC₆H₄, 4-EtC₆H₄, 2-ClC₆H₄, etc.; R³ = OEt, 4-NCC₆H₄, 3-FC₆H₄, etc.) is described. This operationally simple protocol involves a base-promoted C-N bond cleavage of amidines and features readily available starting materials, excellent functional group tolerance, and high step-economy. It leads to the preparation of 2,4,5-trisubstituted thiazoles efficiently and has potential applications in the field of drug screening and modification. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0HPLC of Formula: 18637-02-0).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 18637-02-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Immobilization of copper(II) on mesoporous MCM-41: A highly efficient and recyclable catalyst for tandem oxidative annulation of amidines and methylarenes was written by Jiang, Minhua;Tuo, Yuxin;Cai, Mingzhong. And the article was included in Journal of Porous Materials in 2020.Formula: C7H8Cl2N2 This article mentions the following:

A new 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-Cu(OAc)₂] was easily prepared from com. available and inexpensive 3-(2-aminoethylamino)propyltrimethoxysilane via immobilization on MCM-41, followed by reaction with copper(II) acetate and characterized by various physico-chem. techniques. It was found that this heterogeneous copper complex is a highly efficient catalyst for the tandem oxidative annulation of amidine hydrochlorides RC(=NH)NH₂·HCl (R = Me, 4-fluorophenyl, cyclopropyl, 2-pyridinyl, etc.) and methylarenes ArCH₃ (Ar = 3,4-dichlorophenyl, 1-naphthyl, 3-thienyl, 4-pyridinyl, etc.) with tert-Bu hydroperoxide as oxidant to give 3,5-disubstituted 1,2,4-oxadiazoles I and can be reused at least eight consecutive trials with almost consistent activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Formula: C7H8Cl2N2).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Formula: C7H8Cl2N2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic sulfur compounds. XXII. 2,5-Diaryl-1,6,6aS(super IV)trithia-3,4-diazapentalenes was written by Derocque, Jean Luc;Perrier, Michel;Vialle, Jean. And the article was included in Bulletin de la Societe Chimique de France in 1968.Quality Control of 2-Chloro-benzamidine hydrochloride This article mentions the following:

Ureas RNHC(:NR1)SMe(Ia) → R1NHC(:NR)SMe(Ib) are treated with P2S5 to give II compounds; the II are treated with NH3 to give IIIa → IIIb which are oxidized to amides IVa → IVb. Thus, BzNHCONHBz, m. 219°, and the following I are prepared according to known methods (R, R1, and m.p. given): Bz, Bz, 148°; p-ClC6H4CO, p-ClC6H4CO, 182°; p-MeOC6H4CO, p-MeOC6H4CO, 164°; H, Bz, – (methosulfate m. 160°); Bz, o-ClC6H4CO, 173°; Bz, p-ClC6H4CO, 164°; Bz, p-MeOC6H4CO, 144°; Bz, tert-BuCO, 109°. A mixture of I (R = R1 = Bz) and P2S5, 2:1 P2S5-I weight ratio is refluxed 0.5 hr. in xylene to give 60% 2,5-diphenyl-1,6,-6aSIV-trithia-3,4-diazepentalene (V), m. 211°. Similarly prepared are the following II (R, R1, m.p., and % yield given): p-ClC6H4, p-ClC6H4, 215°, 55; p-MeOC6H4, p-MeOC6H4, 232°, 55; Ph, o-ClC6H4, 184°, 45; Ph, p-ClC6H4, 181°, 50; Ph, p-MeOC6H4, 179°, 60; Ph, tert-Bu, 109°, 40. A solution of V in a 50:50 C6H6-alc. mixture is boiled and NH3 introduced 4-5 hrs. to give N-(3-phenyl-1,2,4-thiadiazol-5-yl)thiobenzimidic acid (VI), m. 198°. Similarly prepared are (m.p. given): III (R = R1 = p-ClC6H4), 227°; IIIa (R = Ph, R1 = o-ClC6H4), 209°; IIIb (R = Ph, R1 = o-ClC6H4), 83°; IIIa (R = Ph, R1 = p-ClC6H4), 190°; IIIb (R = Ph, R1 = p-ClC6H4), 215°. A solution of VI in a 50:50 HOAc-Me2CO mixture containing water is treated with Hg(OAc)2, [1:1 Hg(OAc)2-VI weight ratio] and the mixture is agitated overnight to give 60% N-(4-phenyl-1,3,5-thiadiazol-2-yl)benzamide (VII), m. 172°. 3-Phenyl-5-amino-1,2,4-thiadiazole is treated with BzCl to give 55% VII. Similarly prepared are [m.p., % yield Hg(OAc)2 method, and % yield aroylation method given]: IVa (R = Ph, R1 = o-ClC6H4), 166°, 60, 50; IVb (R = Ph, R1 = o-ClC6H4), 180°, 60, 80; IVa (R = Ph, R1 = p-ClC6H4), 266°, 60, 65; IVb (R = Ph, R1 = p-ClC6H4), 244°, 60, 75. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Quality Control of 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct oxidative coupling of amidine hydrochlorides and methylarenes: TBHP-mediated synthesis of substituted 1,3,5-triazines under metal-free conditions was written by Guo, Wei. And the article was included in Organic & Biomolecular Chemistry in 2015.Name: 2-Chloro-benzamidine hydrochloride This article mentions the following:

Various 2,4,6-trisubstituted 1,3,5-triazines I (R = C₆H₅, 4-ClC₆H₄, cyclopropyl, etc.; Ar = 5-Br-2-H₃COC₆H₃, 1-naphthyl, thiophen-2-yl, etc.) were smoothly formed via TBHP-mediated direct oxidative coupling of amidine and methylarenes. This tandem oxidation-imination-cyclization transformation exhibits a straightforward protocol to prepare 1,3,5-triazines I from easily available starting materials and green oxidants under metal-free conditions. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Name: 2-Chloro-benzamidine hydrochloride).

2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 2-Chloro-benzamidine hydrochloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics