1878-65-5 Archives - Page 3 of 10 - Chlorides-buliding-blocks

Vu, Vu V. team published research in Current Bioactive Compounds in 2021 | 1878-65-5

SDS of cas: 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. SDS of cas: 1878-65-5.

Vu, Vu V.;Vu, Tran K. research published 《 Synthesis of New Zerumbone Hydrazones and Their In-vitro Anticancer Activity》, the research content is summarized as follows. A series of new zerumbone hydrazones 5a-f and 9a-f have been synthesized in via an in situ procedure in high yields. The structure of synthesized compounds has been confirmed using ¹H ¹³C NMR and HR-MS. The bioassay result showed that several compounds exhibited cytotoxic effects against three human cancer cell lines, including HepG-2, SK-LU-1, and MCF-7. Compound 9a showed the best cytotoxic effect against HepG-2, SK-LU-1, and MCF-7 with IC₅₀ values of 8.20, 6.66, and 9.35 μM, resp. This study aims at developing new zerumbone hydrazones as anticancer agents based on zerumbone, a natural compound wildly growing in Vietnam. A series of new zerumbone hydrazones was designed, synthesized, and evaluated for cytotoxicity against three human cancer cell lines, including HepG-2, MCF-7, and SKLu-1, using the MTT method. Especially, compound 9a displayed the best cytotoxic effect against HepG-2, SK-LU-1, and MCF-7 with IC₅₀ values of 8.20, 6.66, and 9.35 μM, resp. The research results suggest that some compounds could be considered as leads for the future design of zerumbone hydrazones in which bio-isosteric replacements in theortho position of the Ph ring could be performed to improve the cytotoxic activity.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Gang team published research in Nature Communications in 2019 | 1878-65-5

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Name: 3-Chlorophenylacetic acid

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Name: 3-Chlorophenylacetic acid.

Wang, Gang;Xin, Xiaodong;Wang, Zehua;Lu, Gang;Ma, Yudao;Liu, Lei research published 《 Catalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives》, the research content is summarized as follows. A formal catalytic enantioselective cross-dehydrogenative coupling of saturated ethers with diverse carboxylic acid derivatives involving an initial oxidative acetal formation, followed by nickel(II)-catalyzed asym. alkylation. The one-pot, general and modular method exhibited wide compatibility of a broad range of saturated ethers not only including prevalent THF and tetrahydropyran but also including medium- and large-sized cyclic moieties and acyclic ones with excellent enantioselectivity and functional group tolerance. The application in the rapid preparation of biol. active mols. that are difficult to access with existing methods was also demonstrated.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Guangcheng team published research in Arabian Journal of Chemistry in 2020 | 1878-65-5

Wang, Guangcheng;Liu, Wenjing;Huang, Yong;Li, Yongjun;Peng, Zhiyun research published 《 Design, synthesis and biological evaluation of isoxazole-naphthalene derivatives as anti-tubulin agents》, the research content is summarized as follows. In this study, a novel series of isoxazole-naphthalene hybrids I [R = 2-ClC₆H₄, 4-EtOC₆H₄, 3,4,5-(MeO)₃C₆H₂, 2H-1,3-benzodioxol-5-yl, etc.] as tubulin polymerization inhibitors were designed, synthesized and evaluated for their anti-proliferative activities against human breast cancer cell line MCF-7. Most of the synthesized compounds I exhibited moderate to potent antiproliferative activity (IC₅₀ < 10.0μM), as compared to cisplatin (15.24 ± 1.27μM). Among them, compound I (R = 4-EtOC₆H₄) was found to be the most active compound with IC₅₀ value of 1.23 ± 0.16μM. Mechanistic studies revealed that this compound arrested cell cycle at G2/M phase and induced apoptosis. Furthermore, in vitro tubulin polymerization assay showed that the compound I (R = 4-EtOC₆H₄) displayed better inhibition activity on tubulin polymerization (IC₅₀ = 3.4μM) than colchicine (IC₅₀ = 7.5μM). Mol. docking study also revealed that this compound binds to the colchicine binding site of tubulin.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Hongyu team published research in ACS Catalysis in 2020 | 1878-65-5

Wang, Hongyu;Liu, Chen-Fei;Song, Zhihui;Yuan, Mingbin;Ho, Yee Ann;Gutierrez, Osvaldo;Koh, Ming Joo research published 《 Engaging α-Fluorocarboxylic Acids Directly in Decarboxylative C-C Bond Formation》, the research content is summarized as follows. The readily accessible α-monofluoro carboxylic acids, which are conventionally difficult substrates for cross-coupling, undergo direct decarboxylative cross-coupling with sp²– and sp³-hybridized organohalides afforded a wide assortment of fluorinated products. Reactions were typically promoted by a combination of 1 mol % of an Ir-based photocatalyst and 2-15 mol % of a bipyridine-Ni complex, delivering products in up to 86% yield under blue LED light irradiation Concise synthesis of key therapeutic candidates underscores utility, complementarity and distinct advantages compared with existing methods. DFT calculations were used to rationalize the distinct reactivity of α-fluoro carboxylic acid substrates (vs nonfluorinated parent acids) under decarboxylation conditions.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Hui team published research in Applied Organometallic Chemistry in 2020 | 1878-65-5

Wang, Hui;Dong, Wei;Hou, Zhipeng;Cheng, Lidan;Li, Xiufen;Huang, Longjiang research published 《 Direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp₂Cl₂》, the research content is summarized as follows. A mild and efficient direct amidation of non-activated carboxylic acid and amine derivatives catalyzed by TiCp₂Cl₂ was described. Arylacetic acid derivatives reacted with different amines to afford the corresponding amides in good to excellent yield except of aniline. Aryl formic acids failed to react with aniline but smoothly reacted with aliphatic amines and benzylamine in moderate to good yield, fatty acids reacting with benzyl and aliphatic amines give amides in good to excellent yield. Chiral amino acids derivatives were transformed into amides without racemization in moderate yield. The possible mechanism of direct amidation catalyzed by TiCp₂Cl₂ was discussed. This catalytic method was very suitable for the amidation of low sterically hindered arylacetic acid, fatty acids with different low sterically hindered amines except aniline, as well as the amidation of aryl formic acid with benzyl and aliphatic amines.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Kaikai team published research in Organic Letters in 2021 | 1878-65-5

Wang, Kaikai;Li, Yajun;Li, Xiaoyan;Li, Daliang;Bao, Hongli research published 《 Iron-Catalyzed Asymmetric Decarboxylative Azidation》, the research content is summarized as follows. The first iron-catalyzed asym. azidation of benzylic peresters has been reported with trimethylsilyl azide (TMSN₃) as the azido source. Hydrocarbon radicals that lack of strong interactions were capable to be enantioselectively azidated. The reaction features good functional group tolerance, high yields, and mild conditions. The chiral benzylic azides can further be used in click reaction, phosphoramidation, and reductive amination, which demonstrate the synthetic values of this reaction.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Kang team published research in Chemistry – A European Journal in 2022 | 1878-65-5

Electric Literature of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 1878-65-5.

Wang, Kang;Li, Shu-Sen;Wang, Jianbo research published 《 Cu(I)/Chiral Bisoxazoline-Catalyzed Enantioselective Doyle-Kirmse Reaction of Allenyl Sulfides with α-diazoesters》, the research content is summarized as follows. A Cu(I)-catalyzed enantioselective Doyle-Kirmse reaction of allenyl sulfides ArSCH=C=CH₂(Ar = 2,3,5,6-tetrafluorophenyl, 2-ethoxy-3,5,6-trifluoropyridin-4-yl, 2,3,5,6-tetrafluoro-4-methylphenyl, etc.)and α-diazoesters R¹C(=N₂)COOR (R = t-Bu, 1-adamantyl, 2-phenylpropan-2-yl, 2-methylbutan-2-yl; R¹ = Me, 4-fluorophenyl, naphthalen-2-yl, etc.) was reported, and provided an efficient synthetic route to enantio-enriched chiral tertiary homopropargylic sulfides R¹C(SAr)(COOR)CH₂CCH. This reaction features high enantioselectivities (up to 96% ee) and good functional group tolerance. The alkyl substituted α-diazoester has also been demonstrated as the efficient substrates in the asym. Doyle-Kirmse reaction. Mechanistic studies, including kinetic experiments, were conducted to gain insights into the details of the reaction pathway. The potential synthetic utility of this protocol has also been demonstrated.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tien, Chieh-Hung team published research in Angewandte Chemie, International Edition in 2021 | 1878-65-5

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Electric Literature of 1878-65-5.

Tien, Chieh-Hung;Trofimova, Alina;Holownia, Aleksandra;Kwak, Branden S.;Larson, Reed T.;Yudin, Andrei K. research published 《 Carboxyboronate as a Versatile In Situ CO Surrogate in Palladium-Catalyzed Carbonylative Transformations》, the research content is summarized as follows. The application of carboxy-MIDA-boronate (MIDA=N-methyliminodiacetic acid) as an in situ CO surrogate for various palladium-catalyzed transformations is described. Carboxy-MIDA-boronate was previously shown to be a bench-stable boron-containing building block for the synthesis of borylated heterocycles. The present study demonstrates that, in addition to its utility as a precursor to heterocycle synthesis, carboxy-MIDA-boronate is an excellent in situ CO surrogate that is tolerant of reactive functionalities such as amines, alcs., and carbon-based nucleophiles. Its wide functional-group compatibility is highlighted in the palladium-catalyzed aminocarbonylation, alkoxycarbonylation, carbonylative Sonogashira coupling, and carbonylative Suzuki-Miyaura coupling of aryl halides. A variety of amides, esters, (hetero)aromatic ynones, and bis(hetero)aryl ketones were synthesized in good-to-excellent yields in a one-pot fashion.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tian, Xun team published research in Advanced Synthesis & Catalysis in 2021 | 1878-65-5

Tian, Xun;Li, Xin;Duan, Shengzu;Du, Ya;Liu, Tongqi;Fang, Yongsheng;Chen, Wen;Zhang, Hongbin;Li, Minyan;Yang, Xiaodong research published 《 Room Temperature Benzofused Lactam Synthesis Enabled by Cobalt(III)-Catalyzed C(sp²)-H Amidation》, the research content is summarized as follows. A room temperature and robust synthesis of benzofused lactams, e.g., I through cobalt(III)-catalyzed C(sp₂)-H amidation has been described. In this protocol, in-situ formation of Cp*Co(III)(ligand) catalyst from Cp*Co(CO)I2 and ligand simplify the synthetic effort of cobalt complexes. Simple and readily synthesized 1,4,2-dioxazol-5-ones II [R = C₆H₅, 1-naphthyl, benzo[d][1,3]dioxol-5-yl, etc.] underwent room temperature intramol. C-H amidation and afforded a wide variety of functionalized benzofused lactams in up to 86% yield. The scalability of the reaction is also be demonstrated.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tahir, Mehwish team published research in Journal of the Iranian Chemical Society in 2021 | 1878-65-5

Category: chlorides-buliding-blocks, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Tahir, Mehwish;Sirajuddin, Muhammad;Zubair, Muhammad;Haider, Ali;Nadman, Akhtar;Ali, Saqib;Perveen, Fouzia;Tanveer, Haris bin;Tahir, Muhammad nawaz research published 《 Designing, spectroscopic and structural characterization and evaluation of biological potential as well as molecular docking studies of Zn(II)-based metallo-pharmaceuticals》, the research content is summarized as follows. Six new Zn(II) carboxylates derived from 2-(3-chlorophenyl) acetic acid, 2-(2-chlorophenyl) acetic acid and 2-(2-methoxy phenyl) acetic acid were synthesized and characterized by FTIR, multinuclear NMR (¹H and ¹³C NMR) and single-crystal XRD. The geometry around the Zn atom in complexes 1 and 2 is distorted tetrahedral and distorted trigonal bipyramidal, resp. The compounds were assessed for DNA interaction using UV-visible spectroscopy and viscosity measurements approving a partial intercalation mode of interaction. The interaction of compounds with CTAB was carried out by conductometric method showing a strong interaction with CTAB, which is noticeable from relatively higher CMC and neg. Gibbs free energy of micellization. The IC₅₀ values of the synthesized compounds were highly efficient in contrast to the standard Glucantime. The activity represents a higher multitude interaction that might be a cause of enhanced antileishmanial activity. The results of cytotoxicity revealed that the activity of the compounds is higher even at lower concentrations which make them biocompatible as potent drug applicants for further researches in this field. Mol. docking studies also confirm the partial intercalation for the screened compounds with DNA.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics