Category: 1878-65-5

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Recommanded Product: 3-Chlorophenylacetic acid.

Li, Chenchen;Zhao, Pei;Li, Ruoling;Zhang, Bing;Zhao, Wanxiang research published 《 Oxidation of Alkynyl Boronates to Carboxylic Acids, Esters, and Amides》, the research content is summarized as follows. A general efficient protocol was developed for the synthesis of carboxylic acids, esters, and amides through oxidation of alkynyl boronates, generated directly from terminal alkynes. This protocol represents the first example of C(sp)-B bond oxidation This approach displays a broad substrate scope, including aryl and alkyl alkynes, and exhibits excellent functional group tolerance. Water, primary and secondary alcs., and amines are suitable nucleophiles for this transformation. Notably, amino acids and peptides can be used as nucleophiles, providing an efficient method for the synthesis and modification of peptides. The practicability of this methodol. was further highlighted by the preparation of pharmaceutical mols.

Recommanded Product: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. HPLC of Formula: 1878-65-5.

Li, He;Zhang, Yijun;Liu, Dinghua;Liu, Xiaoqin research published 《 An improved method for the synthesis of phenylacetic acid derivatives via carbonylation》, the research content is summarized as follows. A series of phenylacetic acid derivatives RCH₂CO₂H [R = 2-ClC₆H₄, 4-MeC₆H₄, 2,4-Cl₂C₆H₃, etc.] was synthesized via bistriphenylphosphine palladium dichloride catalyzed carbonylation reaction of benzyl chloride derivatives in presence of tetraethylammonium chloride and sodium hydroxide as reagents and xylene as solvent at 80°C under a CO atm. 2,4-Dichlorophenylacetic acid was obtained in a maximum yield of 95% from 2,4-dichlorobenzyl chloride using the same reaction system.

HPLC of Formula: 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. COA of Formula: C8H7ClO2.

Laha, Joydev K.;Gulati, Upma;Saima;Gupta, Anjali;Indurthi, Harish Kumar research published ã€?Improved, gram-scale synthesis of sildenafil in water using arylacetic acid as the acyl source in the pyrazolo[4,3-d]pyrimidin-7-one ring formationã€? the research content is summarized as follows. An improved, gram-scale synthesis of the blockbuster drug sildenafil, used for the treatment of male erectile dysfunction, has been developed. Unlike the previous literature, the current method demonstrates the use of arylacetic acid as an acyl source, a cheap oxidant K₂S₂O₈, and water as the reaction medium in the key step of pyrazolo[4,3-d]pyrimidin-7-one ring formation. As well as being a green and benign approach, the current method reduces the cost by half compared to our previous strategy. In addition, the general relevance of the method has been demonstrated in the synthesis of a variety of quinazolinone and benzothiazole derivatives with excellent functional group tolerance.

COA of Formula: C8H7ClO2, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Electric Literature of 1878-65-5.

Koenig, Gerhard;Sokkar, Pandian;Pryk, Niclas;Heinrich, Sascha;Moeller, David;Cimicata, Giuseppe;Matzov, Donna;Dietze, Pascal;Thiel, Walter;Bashan, Anat;Bandow, Julia Elisabeth;Zuegg, Johannes;Yonath, Ada;Schulz, Frank;Sanchez-Garcia, Elsa research published �Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance� the research content is summarized as follows. Antibiotic resistance is a major threat to global health; this problem can be addressed by the development of new antibacterial agents to keep pace with the evolutionary adaptation of pathogens. Computational approaches are essential tools to this end since their application enables fast and early strategical decisions in the drug development process. We present a rational design approach, in which acylide antibiotics were screened based on computational predictions of solubility, membrane permeability, and binding affinity toward the ribosome. To assess our design strategy, we tested all candidates for in vitro inhibitory activity and then evaluated them in vivo with several antibiotic-resistant strains to determine minimal inhibitory concentrations The predicted best candidate is synthetically more accessible, exhibits higher solubility and binding affinity to the ribosome, and is up to 56 times more active against resistant pathogens than telithromycin. Notably, the best compounds designed by us show activity, especially when combined with the membrane-weakening drug colistin, against Acinetobacter baumanii, Pseudomonas aeruginosa, and Escherichia coli, which are the three most critical targets from the priority list of pathogens of the World Health Organization.

Electric Literature of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Electric Literature of 1878-65-5.

Kim, Byungjun;Kim, Yongjae;Lee, Sarah Yunmi research published ã€?Stereodivergent Carbon-Carbon Bond Formation between Iminium and Enolate Intermediates by Synergistic Organocatalysisã€? the research content is summarized as follows. Herein a stereodivergent method for the Michael addition of aryl acetic acid esters to α,β-unsaturated aldehydes catalyzed by a combination of a chiral pyrrolidine and a chiral Lewis base has been reported. This reaction proceeds through a synergistic catalytic cycle which consists of one cycle leading to a chiral iminium electrophile and a second cycle generating a nucleophilic chiral enolate for the construction of a carbon-carbon bond. By varying the combinations of catalyst enantiomers, all four stereoisomers of the products with two vicinal stereocenters are accessible with high enantio- and diastereoselectivity. The products of the Michael addition, 1,5-aldehyde esters, can be readily transformed into a variety of other valuable enantioenriched structures, including those bearing three contiguous stereocenters in an acyclic system, thus providing an efficient route to an array of structural and stereochem. diversity.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Electric Literature of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Application In Synthesis of 1878-65-5.

Katopodi, Annita;Tsotsou, Evangelia;Iliou, Triantafylia;Deligiannidou, Georgia-Eirini;Pontiki, Eleni;Kontogiorgis, Christos;Tsopelas, Fotios;Detsi, Anastasia research published ã€?Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivativesã€? the research content is summarized as follows. A series of novel multi-substituted coumarin derivatives I [R₁ = H, F, Cl; R₂ = H, Cl, Br, etc.; R₃ = H, OH, Cl, etc.; R₄ = H, Br; R₅ = H, Br, Cl; R₆ = H, OH, acetoxy] were synthesized, spectroscopically characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) inhibitory ability, their influence on cell viability in immortalized human keratinocytes (HaCaT) and cytotoxicity in adenocarcinomic human alveolar basal epithelial cells (A549) and human melanoma (A375) cells, in-vitro. Coumarin analogs I, bearing a hydroxyl group at position 5 of the coumarin scaffold and halogen substituents at the 3-Ph ring, were the most promising ABTSâ€? scavengers. 6,8-Dibromo-3-(4-hydroxyphenyl)-4-methyl-chromen-2-one and 6-bromo-3-(4,5-diacetyloxyphenyl)-4-methyl-chromen-2-one exhibited significant lipid peroxidation inhibitory activity (IC₅₀ 36.9 and 37.1μM). In the DCF-DA assay, the 4′-fluoro-substituted compound I [R₁=R₂=R₄=R₅ = H, R₃ = F; R₆ = bacetoxy] (100%), and the 6-bromo substituted compounds I [R₁=R₂=R₄=R₆ = H; R₃ =acetoxy; R₅ =Br] (80.9%) and I [R₁=R₂=R₄=R₆ = H; R₃ = OH; R₅ = Br] (100%) presented the highest activity. The 3′-fluoro-substituted coumarins I [R₁=R₃=R₄=R₅ = H; R₂ = F, R₆ = acetoxy] and I [R₁=R₃=R₄=R₅ = H; R₂ = F; R₆ = OH], along with 3-(4-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2-one, were the most potent lipoxygenase (LOX) inhibitors (IC₅₀ 11.4, 4.1, and 8.7μM, resp.) while displaying remarkable hydroxyl radical scavenging ability, 85.2%, 100%, and 92.9%, resp. In silico docking studies of compounds I [R₁=R₃=R₄=R₅ = H; R₂ = F; R₆ = OH] and [R₁=R₂=R₆ = H; R₃ = acetoxy; R₄=R₅ = Br], revealed that they present allosteric interactions with the enzyme. The majority of the analogs (100μM) did not affect the cell viability of HaCaT cells, though several compounds presented over 60% cytotoxicity in A549 or A375 cells. Finally, the human oral absorption (%HOA) and plasma protein binding (%PPB) properties of the synthesized coumarins I were also estimated using biomimetic chromatog., and all compounds presented high %HOA (>99%) and %PPB (60-97%) values.

Application In Synthesis of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Related Products of 1878-65-5.

Kang, Jin Mi;Kwon, Sun Ok;Ann, Jihyae;Lee, Sunho;Kim, Changhoon;Do, Nayeon;Jeong, Jin Ju;Blumberg, Peter M.;Ha, Heejin;Vu, Thi Ngoc Lan;Yoon, Sanghee;Choi, Sun;Frank-Foltyn, Robert;Lesch, Bernhard;Bahrenberg, Gregor;Stockhausen, Hannelore;Christoph, Thomas;Lee, Jeewoo research published �2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists� the research content is summarized as follows. A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure-activity anal. targeting their three pharmacophoric regions indicated that halogenated Ph A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists I and II exhibited potent antagonism toward capsaicin for hTRPV1 with K_i[CAP] = 2.6 and 6.9 nM, resp. Further, antagonist II displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A mol. modeling study of II indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Related Products of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Reference of 1878-65-5.

Jose, Arathy;Guest, Daniel;LeGay, Remi;Tizzard, Graham J.;Coles, Simon J.;Derveni, Mariliza;Wright, Edward;Marrison, Lester;Lee, Alpha A.;Morris, Aaron;Robinson, Matt;von Delft, Frank;Fearon, Daren;Koekemoer, Lizbe;Matviuk, Tetiana;Aimon, Anthony;Schofield, Christopher J.;Malla, Tika R.;London, Nir;Greenland, Barnaby W.;Bagley, Mark C.;Spencer, John;The Covid Moonshot Consortium research published ã€?Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffoldsã€? the research content is summarized as follows. The pentafluorosulfanyl (-SF₅) functional group is of increasing interest as a bioisostere in medicinal chem. A library of SF₅-containing compounds, including amide, isoxazole, and oxindole derivatives, was synthesized using a range of solution-based and solventless methods, including microwave and ball-mill techniques. The library was tested against targets including human dihydroorotate dehydrogenase (HDHODH). A subsequent focused approach led to synthesis of analogs of the clin. used disease modifying anti-rheumatic drugs (DMARDs), Teriflunomide and Leflunomide, considered for potential COVID-19 use, where SF₅ bioisostere deployment led to improved inhibition of HDHODH compared with the parent drugs. The results demonstrate the utility of the SF₅ group in medicinal chem.

Reference of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Related Products of 1878-65-5.

Johnson, James A.;Kim, Soong-Hoon;Jiang, Ji;Phillips, Monique;Schumacher, William A.;Bostwick, Jeffrey S.;Gargalovic, Peter S.;Onorato, Joelle M.;Luk, Chiuwa E.;Generaux, Claudia;He, Yan;Chen, Xue-Qing;Xu, Carrie;Galella, Michael A.;Wang, Tao;Gordon, David A.;Wexler, Ruth R.;Finlay, Heather J. research published �Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate� the research content is summarized as follows. Apelin-13 is an endogenous peptidic agonist of the apelin receptor (APJ) receptor with the potential for improving cardiac function in heart failure patients. However, the low plasma stability of apelin-13 necessitates continuous i.v. infusion for therapeutic use. There are several approaches to increase the stability of apelin-13 including attachment of pharmacokinetic enhancing groups, stabilized peptides, and Fc-fusion approaches. We sought a small-mol. APJ receptor agonist approach to target a compound with a pharmacokinetic profile amenable for chronic oral administration. This manuscript describes sequential optimization of the pyrimidinone series, leading to pyridinone 14(I), with in vitro potency equivalent to the endogenous ligand apelin-13 and with an excellent oral bioavailability and PK profile in multiple preclin. species. Compound 14 exhibited robust pharmacodynamic effects similar to apelin-13 in an acute rat pressure-volume loop model and was advanced as a clin. candidate.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Related Products of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Synthetic Route of 1878-65-5.

Ji, Xiaoming;Wei, Feng;Wan, Bin;Cheng, Cang;Zhang, Yanghui research published �Palladium-catalyzed intermolecular C-H silylation initiated by aminopalladation� the research content is summarized as follows. A Pd(II)-catalyzed intermol. C-H silylation reaction initiated by aminopalladation was developed. The C-H bonds were activated by an alkyl Pd(II) species generated through aminopalladation and then disilylated with hexamethyldisilane to form disilylated indolines as the final products. The reaction provides a new method for the introduction of silyl groups into complex organic mols.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Synthetic Route of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics