Category: 1878-65-5

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Safety of 3-Chlorophenylacetic acid.

Ji, Dong-Sheng;Liang, Hui;Yang, Kai-Xuan;Feng, Zhi-Tao;Luo, Yong-Chun;Xu, Guo-Qiang;Gu, Yucheng;Xu, Peng-Fei research published ã€?Solvent directed chemically divergent synthesis of β-lactams and α-amino acid derivatives with chiral isothioureaã€? the research content is summarized as follows. A protocol for the chem. divergent synthesis of β-lactams I (R¹ = Ph, 3-ClC₆H₄, 2-thienyl, etc.; R² = Ph, 1-naphthyl, 3-thienyl, 3-indolyl, etc.; R³ = Me, Et, PhCH₂) and α-amino esters II with isothiourea catalysis by switching solvents has been developed. The stereospecific Mannich reaction occurring between imines III and zwitterionic enolate intermediates, generated from the catalyst and perfluorophenyl esters IV, followed by intramol. lactamization afforded β-lactams I when dichloromethane and acetonitrile were used as solvents. However, when EtOH was used as the solvent, the intermediates underwent an intermol. esterification reaction, and α-amino acid derivatives II were produced. Detailed mechanistic experiments were conducted to prove that these two kinds of products came from the same intermediates. Furthermore, chem. diversified transformations of β-lactam and α-amino acid derivatives were achieved.

Safety of 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Electric Literature of 1878-65-5.

Hoejgaard Hansen, Anders;Christensen, Henriette B.;Pandey, Sunil K.;Sergeev, Eugenia;Valentini, Alice;Dunlop, Julia;Dedeo, Domonkos;Fratta, Simone;Hudson, Brian D.;Milligan, Graeme;Ulven, Trond;Rexen Ulven, Elisabeth research published �Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2� the research content is summarized as follows. Free fatty acid receptor 2 (FFA2) is a sensor for short-chain fatty acids that has been identified as an interesting potential drug target for treatment of metabolic and inflammatory diseases. Although several ligand series are known for the receptor, there is still a need for improved compounds One of the most potent and frequently used antagonists is the amide-substituted phenylbutanoic acid known as CATPB (1). We here report the structure-activity relationship exploration of this compound, leading to the identification of homologues with increased potency. The preferred compound 37 (TUG-1958) was found, besides improved potency, to have high solubility and favorable pharmacokinetic properties.

Electric Literature of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Related Products of 1878-65-5.

He, Meicui;Gu, Linghui;Tan, Yuqiang;Wang, Yang;Wang, Yuchi;Zhang, Chunran;Ma, Wenbo research published 《 Palladium-Catalyzed Distal C-H Selenylation of 2-Aryl Acetamides with Diselenides and Selenyl Chlorides》, the research content is summarized as follows. A convenient and effective method of palladium-catalyzed C-H selenylation of the 2-aryl acetamides assisted with removable 8-aminoquinoline with readily available diselenides and selenyl chlorides was developed to give (6-(arylselanyl)aryl)-N-(quinolin-8-yl)acetamides I [R = 2-Me, 5-OMe, 3-Cl, etc.; R¹ = H, 4-Me, 4-F, etc.; X = S, Se]. This selenylation reaction was scalable and tolerated a wide range of functional groups, provided a straightforward way of the compounds I and dibenzo[b,f]selenepin-10(11H)-one.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Related Products of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Related Products of 1878-65-5.

Hasegawa, Yoko;Cantin, Thomas;Decaens, Jonathan;Couve-Bonnaire, Samuel;Charette, Andre B.;Poisson, Thomas;Jubault, Philippe research published 《 Catalytic Asymmetric Syntheses of Alkylidenecyclopropanes from Allenoates with Donor-Acceptor and Diacceptor Diazo Reagents》, the research content is summarized as follows. The first diastereo- and enantioselective cyclopropanation reactions of electron-deficient allenes with donor-acceptor and diacceptor diazo reagents was described. The desired enantioenriched alkylidenecyclopropanes (ACPs) were obtained in high yields with high diastereo- and enantioselectivities in the presence of Rh₂((S)-TCPTAD)₄ or Rh₂((R)-BTPCP)₄ catalysts (up to 95 % yield, >95 : 5 d.r. and 99 : 1 e.r.). This methodol. gave a direct access to ACPs bearing multiple electron-deficient substituents and allows to further expand the availability of ACPs chem. Interestingly, during the examination of the scope of this reaction, the asym. intramol. C-H insertion reaction into tert-Bu group was observed as a side reaction with up to 94 : 6 e.r.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Related Products of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Reference of 1878-65-5.

Gholap, Aniket;Bag, Sukdev;Pradhan, Sukumar;Kapdi, Anant R.;Maiti, Debabrata research published 《 Diverse meta-C-H Functionalization of Amides》, the research content is summarized as follows. Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) was demonstrated for diverse remote meta-C-H functionalizations of arenes including allylation, cyanation, alkylation, alkynylation, and deuteration. This methodol. afforded diverse functionalized amides I [R = H, 2-Me, 3-Me, etc.; R¹ = 3-(oct-5-en-4-yl)phenyl, 3-(hex-4-en-3-yl)phenyl, 3-(4-methylpent-3-en-2-yl)phenyl, etc.; R² = 2-(pyrimidin-5-yl)phenyl, biphenyl-2-yl; R³ = H, Me, Ph, etc.]. The scope of palladium-catalyzed meta-C-H functionalizations was presented with various pharmaceutically relevant phenylacetic acid, hydrocinnamic acid, and naphthylacetic acid derivatives

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Reference of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Recommanded Product: 3-Chlorophenylacetic acid.

Gao, Min;Lv, QiaoLi;Zhang, HouPan;Tu, GuoGang research published 《 Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors》, the research content is summarized as follows. As a target for anticancer treatment, aminopeptidase N (APN) shows its overexpression on diverse malignant tumor cells and associates with cancer invasion, angiogenesis and metastasis. The objective of the study was the design, synthesis and biol. activity evaluation of alanine hydroxamic acid derivatives as APN inhibitors, and investigation of the binding mode of inhibitors in the APN active site. Alanine hydroxamic acid derivatives were synthesized and evaluated for their in vitro anti-cancer activity using CCK-8 assay. Mol. docking and 4D-QSAR studies were carried out to suggest the mechanism of biol. activity. Compared with Bestatin, compound 9b showed the best APN inhibition activity. The putative binding mode of 9b in the APN active site was also discussed. Moreover, the robust and reliable 4D-QSAR model exhibited the following statistics: R² = 0.9352, q²_LOO = 0.8484, q²_LNO =0.7920, R²_Pred = 0.8739. Newly synthesized compounds exerted acceptable anticancer activity and further investigation of the current scaffold would be beneficial.

Recommanded Product: 3-Chlorophenylacetic acid, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Product Details of C8H7ClO2.

Gan, Haifeng;Macfarlane, Douglas R. research published 《 Facile preparation of 2-arylbenzoselenazoles from three components reactions: 2-Chloronitrobenzenes, Se, and arylacetic acids》, the research content is summarized as follows. A selenium-mediated decarboxylative cyclization of 2-chloronitrobenzene and arylacetic acids to prepare 2-arylbenzoselenazoles has been established under metal-free condition. The reactions proceeded in moderate to good yields with good functional tolerance and gram-scale application.

Product Details of C8H7ClO2, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Related Products of 1878-65-5.

Dubart, Amaury;Evano, Gwilherm research published 《 Divergent Synthesis of α-Fluorinated Carbonyl and Carboxyl Derivatives by Double Electrophilic Activation of Amides》, the research content is summarized as follows. A straightforward and divergent entry to α-fluorinated carbonyl and carboxyl derivatives was reported. Upon activation of amides with triflic anhydride and a 2-halo-pyridine and subsequent trapping of the resulting keteniminium ions with nucleophiles followed by a second electrophilic activation with NFSI and final hydrolysis, a range of amides was transformed to α-fluorinated ketones, esters and amides under mild conditions. Moreover, this reaction was performed to yield enantioenriched products with a traceless chiral auxiliary.

Related Products of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 3-Chlorophenylacetic acid.

Cheng, Aolin;Zhang, Liangliang;Zhou, Qinghai;Liu, Tao;Cao, Jing;Zhao, Guoqing;Zhang, Kun;Song, Guanshui;Zhao, Baoguo research published 《 Efficient asymmetric biomimetic aldol reaction of glycinates and trifluoromethyl ketones by carbonyl catalysis》, the research content is summarized as follows. The direct asym. aldol reaction of glycinates represents an intriguing and straightforward strategy to make biol. significant chiral β-hydroxy-α-amino-acid derivatives But it is not easy to realize the transformation due to the disruption of the reactive NH₂ group of glycinates. Inspired by the enzymic aldol reaction of glycine, we successfully developed an asym. aldol reaction of glycinate, NH₂-CH₂ CO-O-tert-Bu, and trifluoromethyl ketones with 0.1-0.0033 mol % of chiral N-Me pyridoxal (I) as the catalyst, producing chiral β-trifluoromethyl-β-hydroxy-α-amino-acid esters 6 in 55-82% yields (for the syn-diastereomers) with up to >20:1 dr and 99% ee under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymic aldol reaction of glycine. Pyridoxal catalyst I activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo- and enantioselectivities.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Recommanded Product: 3-Chlorophenylacetic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Quality Control of 1878-65-5.

Chen, Mu-Yi;Pannecoucke, Xavier;Jubault, Philippe;Besset, Tatiana research published 《 Pd-Catalyzed Selective Chlorination of Acrylamides at Room Temperature》, the research content is summarized as follows. In this Letter, the transition-metal-catalyzed chlorination of alkenes is reported. In the presence of the com. available and inexpensive N-chlorosuccinimide and without additive, the Pd-catalyzed chlorination of acrylamides by C-H bond activation was developed at room temperature under air. Under these mild reaction conditions, the versatility of the methodol. was demonstrated as an array of acrylamides was functionalized to selectively provide the corresponding difficult-to-synthesize chlorinated olefins as a single Z stereoisomer. Mechanistic studies were conducted to get insights into the reaction mechanism, and post-functionalization reactions further demonstrated the synthetic utility of the approach toward the access to high value-added chlorinated compounds

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Quality Control of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics