Yan, Luping’s team published research in Journal of Natural Products in 2021-03-26 | CAS: 19376-57-9

Journal of Natural Products published new progress about Antitumor agents. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Application of Methyl 4,4,4-trichlorobutanoate.

Yan, Luping published the artcileStructure-Activity Relationships for the Marine Natural Product Sintokamides: Androgen Receptor N-Terminus Antagonists of Interest for Treatment of Metastatic Castration-Resistant Prostate Cancer, Application of Methyl 4,4,4-trichlorobutanoate, the main research area is marine sintokamide androgen receptor antagonist prostate cancer antitumor preparation.

Synthetic analogs of the marine natural product sintokamides have been prepared in order to investigate the structure-activity relationships for the androgen receptor N-terminal domain (AR NTD) antagonist activity of the sintokamide scaffold. An in vitro LNCaP cell-based transcriptional activity assay with an androgen-driven luciferase (Luc) reporter was used to monitor the potency of analogs. The data have shown that the chlorine atoms on the leucine side chains are essential for potent activity. Analogs missing the nonchlorinated Me groups of the leucine side chains (C-1 and C-17) are just as active and in some cases more active than the natural products. Analogs with the natural R configuration at C-10 and the unnatural R configuration at C-4 are most potent. Replacing the natural propionamide N-terminus cap with the more sterically hindered pivaloylamide N-terminus cap leads to enhanced potency. The tetramic acid fragment and the Me ether on the tetramic acid fragment are essential for activity. The SAR optimized analog 76 is more selective, easier to synthesize, more potent, and presumed to be more resistant to proteolysis than the natural sintokamides.

Journal of Natural Products published new progress about Antitumor agents. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Application of Methyl 4,4,4-trichlorobutanoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shono, Tatsuya’s team published research in Tetrahedron Letters in 1990-11-26 | CAS: 19376-57-9

Tetrahedron Letters published new progress about Addition reaction. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Shono, Tatsuya published the artcileFormation of a reasonably stabilized trichloromethyl anion by the reaction of chloroform with electrogenerated base and its 1,4-addition to α,β-unsaturated carbonyl compounds, Recommanded Product: Methyl 4,4,4-trichlorobutanoate, the main research area is addition anion chloromethyl unsaturated carboxylate nitrile; ammonium tetraalkyl electrochem reduction pyrrolidinone; chloromethyl anion addition unsaturated carboxylate nitrile; carboxylate unsaturated addition chloromethyl anion; cyclopropanation chloroacetate anion; electrochem reduction pyrrolidinone tetraalkylammonium; nitrile unsaturated addition chloromethyl anion; pyrrolidinone reduction electrochem tetraalkylammonium; reduction electrochem pyrrolidinone tetraalkylammonium.

Electrochem. reduction of 2-pyrrolidinone in the presence of tetraalkylammonium salts gave the resp. tetraalkylammonium salts with pyrrolidinone. The latter reacted with CHCl3 to give Cl3C-, which underwent addition reactions with α,β-unsaturated carboxylates or nitriles. Thus, reaction of Cl2CHCO2Me in the presence of tetraalkylammonium salts with pyrrolidinone gave di-Me 1-chloro-1,2-cyclopropanedicarboxylates. Addition of CHCl3 to CH2:CHCO2Me in the presence of the tetraethylammonium-pyrrolidinone salt gave 87% Cl3CCH2CH2CO2Me.

Tetrahedron Letters published new progress about Addition reaction. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ram, Ram N.’s team published research in European Journal of Organic Chemistry in 2016 | CAS: 19376-57-9

European Journal of Organic Chemistry published new progress about Crystal structure. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Ram, Ram N. published the artcileCopper(I)-Promoted Synthesis of Highly Substituted and Functionalized Tetrahydrothiophenes, Recommanded Product: Methyl 4,4,4-trichlorobutanoate, the main research area is radical cyclization trihaloethyl allyl sulfide; tetrahydrothiophene stereoselective preparation; thiophene tetrahydro stereoselective preparation.

Copper(I)-promoted 5-exo halogen-atom-transfer radical cyclization of 2,2,2-trihaloethyl allyl sulfides gave highly functionalized tetrahydrothiophenes in good to high yields. Stereochem. aspects of the diastereomeric mixtures of products formed under different reaction conditions were evaluated, and single crystal diffraction anal. and 2D NMR spectroscopic anal. were carried out. The synthetic application of α-acetoxytetrahydrothiophenes in the preparation of a dihydrothiophene has also been demonstrated.

European Journal of Organic Chemistry published new progress about Crystal structure. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chance, Leon H.’s team published research in Journal of Chemical and Engineering Data in 1977 | CAS: 19376-57-9

Journal of Chemical and Engineering Data published new progress about Cyclocondensation reaction. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Category: chlorides-buliding-blocks.

Chance, Leon H. published the artcile2,4-Diaminotrihalopropyltriazines derived from γ-trihalobutyronitriles, Category: chlorides-buliding-blocks, the main research area is trichlorobutyronitrile; butyronitrile trihalo; triazinediamine trihalopropyl; butyrate trihalo cyclization biguanide; biguanidine cyclization trihalobutyrate.

Cl3CCH2CH2CN and Br3CCH2CH2CN were prepared in improved yields by modification of reported methods by reacting the appropriate haloform with H2C:CHCN. Cl3CCH2CH2CO2Me, Cl3CCH2CH2CO2Et, Br3CCH2CH2CO2Me and Br3CCH2CH2CO2Et were prepared from the corresponding nitriles. 2,4-Diamino-6-(3,3,3-trichloro-1-propyl)-1,3,5-triazine and 2,4-diamino-6-(3,3,3-tribromo-1-propyl)-1,3,5-triazine were prepared by the reaction of the corresponding methyl or ethyl trihalobutyrates with biguanide. The tetramethylol derivatives of the triazines, viz., 2,4-bis[di(hydroxymethyl)amino]-6-(3,3,3-trichloro-1-propyl)-1,3,5-triazine and 2,4-bis[di(hydroxymethyl)amino]-6-(3,3,3-tribromo-1-propyl)-1,3,5-triazine, were prepared by the reaction of the triazines with alk. aqueous formaldehyde.

Journal of Chemical and Engineering Data published new progress about Cyclocondensation reaction. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ghosh, Arun K.’s team published research in European Journal of Organic Chemistry in 2003-03-31 | CAS: 19376-57-9

European Journal of Organic Chemistry published new progress about Aldol condensation, stereoselective. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Ghosh, Arun K. published the artcileAsymmetric total synthesis of the gastroprotective microbial agent AI-77-B, Recommanded Product: Methyl 4,4,4-trichlorobutanoate, the main research area is gastroprotective pseudopeptide microbial agent AI77B asym total synthesis dihydroisocoumarin; coumarin dihydroiso condensation hydroxy amino acid; leucinal stereoselective alkylation alkynyl ester methoxycyclohexadiene regioselective Diels Alder; aldol reaction Curtius rearrangement homologation; AI-77-B; Asymmetric synthesis; Natural products; Total synthesis.

An enantioselective total synthesis of the pseudopeptide microbial agent AI-77-B, which has shown potent antiulcerogenic properties, is described. The synthesis is convergent and involves the assembly of a dihydroisocoumarin fragment and a hydroxy amino acid. The dihydroisocoumarin derivative was synthesized by means of a Diels-Alder reaction between 1-methoxy-1,3-cyclohexadiene and an alkynyl ester derivative as the dienophile. The alkynyl ester was obtained stereo-selectively by two different synthetic routes: (1) A stereoselective alkylation of leucinal, and (2) a titanium enolate-mediated anti-aldol reaction with trichlorobutyraldehyde, a novel homopropargylaldehyde equivalent The stereocenters of the hydroxy amino acid moiety were generated through a titanium enolate-mediated syn-aldol reaction, Curtius rearrangement, and application of Dondoni’s aldehyde homologation. Condensation of the dihydroisocoumarin and hydroxy amino acid moieties and subsequent removal of the protecting groups furnished optically active AI-77-B.

European Journal of Organic Chemistry published new progress about Aldol condensation, stereoselective. 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kashimura, S.’s team published research in Electrochimica Acta in 1997-04-21 | CAS: 19376-57-9

Electrochimica Acta published new progress about Aldehydes Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Kashimura, S. published the artcileFormation of electrogenerated base by the electroreduction of polyacrylamides, Recommanded Product: Methyl 4,4,4-trichlorobutanoate, the main research area is electrogenerated base electroreduction polyacrylamide; trichloromethylation unsaturated ester electrogenerated base polyacrylamide.

The electroreduction of polyacrylamide derivatives in DMF using tetralkylammonium salts (R4NX) as supporting electrolytes yields the corresponding anionic species possessing interesting reactivities as electrogenerated bases (EGBs). The homopolymer of N-methylacrylamide (MAAm) and its copolymers with N,N-dimethylacrylamide (DMAAm) and styrene (St) were used as polymeric probases and the reactivity of the resulting polymer EGBs was studied. The polymer EGB prepared from the copolymer of MAAm with DMAAm [copoly(MAAm-DMAAm)] containing 65% of MAAm unit gave the best result in the trichloromethylation of α,β-unsaturated esters (89%). Also polymeric probases were easily recovered by reprecipitation and they were repeatedly usable as probases.

Electrochimica Acta published new progress about Aldehydes Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 19376-57-9 belongs to class chlorides-buliding-blocks, name is Methyl 4,4,4-trichlorobutanoate, and the molecular formula is C5H7Cl3O2, Recommanded Product: Methyl 4,4,4-trichlorobutanoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics