Category: 19652-33-6

Jiang, Yuan published the artcileSynthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans, Category: chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2022), 128525, database is CAplus and MEDLINE.

In this work, it was focused on boron trifluoride etherate catalyzed condensation of indole and salicylaldehydes RCHO (R = 2-hydroxyphenyl, 4-(dimethylamino)-2-hydroxyphenyl, 3,5-dibromo-2-hydroxyphenyl, etc.) to form bis(indolyl)methanes (BIMs) I in high yields, and in vitro antifungal activity against Candida albicans were evaluated. The results showed that most phenol-derived BIMs I combined with fluconazole (FLC) exhibited good antifungal activity against sensitive and drug-resistant C. albicans. Further mechanism study demonstrated that I (R = 3-bromo-2-hydroxyphenyl) combined with FLC could inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability.

Bioorganic & Medicinal Chemistry Letters published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yue published the artcileStructure-activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin, Formula: C7H4BrClO2, the publication is Tetrahedron (2016), 72(25), 3554-3558, database is CAplus.

C-di-AMP, a bacterial second messenger, regulates various processes in Gram-pos. bacteria and mycobacteria. Small mol. inhibitors of c-di-AMP metabolic enzymes could affect bacterial growth and viability. A medium throughput screening identified bromophenol-thiohydantoin (BTH) as the first inhibitor of c-di-AMP synthase, DisA. Herein, the authors performed SAR studies of bromophenol-thiohydantoin to identify the salient features on BTH that are important for DisA inhibition. Seemingly minor substitution changes (e.g., aromatic bromo to chloro substitutions) resulted in dramatic changes in ligand potency. Bromophenol TH is specific for c-di-AMP synthase and did not inhibit RocR (c-di-GMP PDE), YybT (c-di-AMP PDE) or WspR (c-di-GMP synthase).

Tetrahedron published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C14H14, Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grunwald, Marco Andre published the artcileColumnar Propeller-Like 1,3,5-Triphenylbenzenes: Probing the Effect of Chlorine on the Suzuki Cross-Coupling and Liquid Crystalline Properties, Category: chlorides-buliding-blocks, the publication is European Journal of Organic Chemistry (2020), 2020(15), 2190-2198, database is CAplus.

Suzuki cross-couplings either between chlorinated N-methyliminodiacetic acid (MIDA)-protected aryl boronates and 1,3,5-tribromobenzene or between chlorinated aryl bromides and phenyltrisboronic species to star-shaped 1,3,5-triphenylbenzenes with different substitution patterns and chloro substituents at the outer Ph rings were studied. The chlorinated precursors required for the resp. reaction were synthesized and characterized. Depending on the used coupling reaction target triphenylbenzenes were isolated in yields between 42% and 88%. Their mesomorphic properties were influenced by the substitution pattern and number of peripheral chlorine atoms. Triphenylbenzene with 3,5-alkoxy substitution and H in para-position self-assembled into either columnar hexagonal (Col_h) mesophases or a soft crystal. While threefold chloro substitution in meta-position of the outer Ph rings led to stable room temperature Col_ho phases, triphenylbenzenes with threefold para-chloro or 3,5-dichloro substitution were non-mesomorphic. Based on x-ray diffraction data a helical packing model for the observed phases similar to that of related alkoxy-substituted triphenylbenzenes is proposed.

European Journal of Organic Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mukhtar, Asma published the artcileIndane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies, Computed Properties of 19652-33-6, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2021), 17(8), 887-902, database is CAplus and MEDLINE.

Diabetes mellitus is one of the most chronic metabolic disorders. Since past few years, our research group had synthesized and evaluated libraries of heterocyclic compounds against α and β-glucosidase enzymes and found encouraging results. The current study comprises of evaluation of indane-1,3-dione as antidiabetic agents based on our previously reported results obtained from closely related moiety isatin and its derivatives A library of twenty three indane-1,3-dione derivatives (1-23) was synthesized and evaluated for α and β-glucosidase inhibitions. Moreover, in silico docking studies were carried out to investigate the putative binding mode of selected compounds with the target enzyme. The indane-1,3-dione derivatives (1-23) were synthesized by Knoevenagel condensation of different substituted benzaldehydes with indane-1,3-dione under basic condition. The structures of synthetic mols. were deduced by using different spectroscopic techniques, including ¹H-, ¹³C-NMR, EI-MS, and CHN anal. Compounds (1-23) were evaluated for α and β-glucosidase inhibitions by adopting the literature protocols. Off twenty three, eleven compounds displayed good to moderate activity against α- glucosidase enzyme, nonetheless, all compounds exhibited less than 50% inhibition against β- glucosidase enzyme. Compounds 1, 14, and 23 displayed good activity against α-glucosidase enzyme with IC₅₀ values of 2.80 ± 0.11, 0.76 ± 0.01, and 2.17 ± 0.18 μM, resp. The results have shown that these compounds have selectively inhibited the α-glucosidase enzyme. The in silico docking studies also supported the above results and showed different types of interactions of synthetic mols. with the active site of enzyme. The compounds 1, 14, and 23 have shown good inhibition against α-glucosidase and may potentially serve as lead for the development of new therapeutic representatives.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Computed Properties of 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mukhtar, Asma published the artcileSynthesis of Chalcones as Potential α-Glucosidase Inhibitors, In-Vitro and In-Silico Studies, HPLC of Formula: 19652-33-6, the publication is ChemistrySelect (2021), 6(37), 9933-9940, database is CAplus.

Seventeen chalcones derivatives I [R = 2-HO-3-ClC₆H₃, 4-NMe₂C₆H₄, 2-Br-4,5-(OMe)₂C₆H₂, etc.; R¹ = 3-MeC₆H₄, 4-MeC₆H₄, 4-ClC₆H₄, etc.] were synthesized by reactions of diversely substituted aldehydes with various ketones. The structures of compounds were characterized by using NMR (NMR) spectroscopy, mass spectrometry (MS) and carbon, hydrogen, nitrogen (CHN) anal. These synthetic mols. were tested for α-glucosidase inhibitory activity. Acarbose was used as a standard drug and pos. control in this study. Compound I [R = 2-HO-3,5-Cl₂C₆H₂; R¹ = 4-MeC₆H₄] with hydroxy and chloro substitutions was found to be the most active compound and a novel compound of this library. Active mols. were subjected to in silico study to determine binding interactions with target site of α-glucosidase.

ChemistrySelect published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, HPLC of Formula: 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rehder, Dieter published the artcileWater and bromide in the active center of vanadate-dependent haloperoxidases, HPLC of Formula: 19652-33-6, the publication is Journal of Inorganic Biochemistry (2000), 80(1-2), 115-121, database is CAplus and MEDLINE.

Two aqua-oxovanadium complexes, viz. [A-VO(H₂O)(sal-L-Leu)] (I) and [VO(H₂O)₂(5-Br-sal-Gly)]·H₂O(II·H₂O ), containing the water ligands in cis- and trans-positions to the oxo group at V-OH₂ distances ranging from 2.008 to 2.228 Å, have been structurally characterized in order to model the apical electron d. feature found in the structures of fungal and algal vanadate-dependent peroxidases. Br K-edge XAS of bromide-treated bromoperoxidase from Ascophyllum nodosum and model compounds (including II·H₂O) has been used to show that the substrate bromide does not bind to active site vanadium but to a light atom, possibly carbon, in its vicinity.

Journal of Inorganic Biochemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, HPLC of Formula: 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoshida, Masahito published the artcileStructure-activity relationship study on Col-003, a protein-protein interaction inhibitor between collagen and Hsp47, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Chemical & Pharmaceutical Bulletin (2020), 68(3), 220-226, database is CAplus and MEDLINE.

This study demonstrates the structure-activity relationship of Col-003, a potent collagen-heat-shock protein 47 (Hsp47) interaction inhibitor. Col-003 analogs were successfully synthesized by Pd(0)-catalyzed cross-coupling reactions of 5-bromosalicylaldehyde derivatives with alkyl-metal species, and the inhibitory activities of the synthetic analogs were evaluated using surface plasmon resonance anal. (BIAcore). We succeeded in discovering two potent inhibitors that showed 85 and 81% inhibition at a concentration of 1.9μM against the collagen-Hsp47 interaction. This indicates that elongation of an alkyl linker between two aromatic rings could considerably improve inhibitory activity due to the adjustment of a pendant Ph moiety to an appropriate position, in addition to the hydrophobic interaction with an alkyl linker moiety.

Chemical & Pharmaceutical Bulletin published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C4H10O2, Recommanded Product: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Silvestri, Maximilian A. published the artcileDesign, Synthesis, Anti-HIV Activities, and Metabolic Stabilities of Alkenyldiarylmethane (ADAM) Non-nucleoside Reverse Transcriptase Inhibitors, Computed Properties of 19652-33-6, the publication is Journal of Medicinal Chemistry (2004), 47(12), 3149-3162, database is CAplus and MEDLINE.

The alkenyldiarylmethane (ADAM) HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are effective anti-HIV agents in cell culture. However, the potential clin. utility of the ADAMs is expected to be limited by the presence of Me ester moieties that are likely to be metabolized by nonspecific esterases in blood plasma to biol. inactive carboxylic acid derivatives The present investigation was therefore undertaken to investigate the anti-HIV activities of the ADAMs vs. HIV-1_IIIB and HIV-2_ROD in MT-4 cells and the stabilities of the biol. active ADAMs in rat plasma. Synthesis of most of the ADAMs I (R¹ = R⁴ = CO₂Me, R² = MeO, R³ = Br, Cl, Me, cyano; R¹ = CO₂Me, R² = MeO, R³ = Br, Cl, Me, R⁴ = CC, CH:CH, Ph, CO₂-n-Pr, CO₂CHMe₂; etc.) were reported previously. However, 13 of the 32 compounds, I (R¹ = CO₂Me, R² = MeO, R³ = Br, R⁴ = CH₂OMe; R¹ = R⁴ = CH₂OH, R² = MeO, R³ = Cl; R¹ = R⁴ = CH₂OMe, R² = MeO, R³ = Cl; etc.), tested were newly synthesized. For example, reacting Me 5-methoxypentanoate with benzophenone II gave I (R¹ = CO₂Me, R² = MeO, R³ = Br, R⁴ = CH₂OMe) in 24% yield. The ADAMs displayed a wide range of metabolic stabilities in rat plasma, with half-lives ranging from 0.9 to 76.6 min. A wide assortment of structural modifications was tolerated, with 18 of the 32 compounds tested displaying EC₅₀ values between 0.3 and 3.7 μM vs. HIV-1_IIIB in MT-4 cells, 3 compounds in the EC₅₀ = 13.2-35.4 μM range, and the remaining compounds inactive. Consistent with the mechanism of action of the ADAMs as NNRTIs, they were inactive or displayed comparatively low activity vs. HIV-2_ROD. The replacement of the two aromatic Me ester substituents in one of the most active ADAMs (EC₅₀ = 0.6 μM) with two Me thioester groups resulted in an increase in plasma half-life from 5.8 to 55.3 min, while maintaining the antiviral potency at the EC₅₀ = 1.8 μM level. At the same time, the bis(thioester) modification was less cytotoxic to uninfected MT-4 cells, with a CC₅₀ of >224 μM vs. 160 μM for the parent compound

Journal of Medicinal Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C10H16Br3N, Computed Properties of 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thekkeppat, Nipun P. published the artcileCombining Optical Properties with Flexibility in Halogen-Substituted Benzothiazole Crystals, Computed Properties of 19652-33-6, the publication is Crystal Growth & Design (2020), 20(6), 3937-3943, database is CAplus.

Combining optical properties with flexibility in organic crystals may find promising applications in optical waveguides, flexible optoelectronics, etc. We describe a family of halogen-substituted benzothiazole compounds which grow with an acicular needle morphol. based on a slip-stacked supramol. assembly sustained by a series of noncovalent interactions, including halogen bonds etc. Some of them comply with necessary packing features for elasticity; therefore, bending-relaxation cycles can be repeated several times. As these compounds are fluorescent in nature, the optical properties can be gainfully combined with flexibility toward achieving a new class of crystalline materials for optical waveguides and flexible optoelectronics. We describe a family of halogen-substituted benzothiazole compounds which grow with an acicular needle morphol., and some of them are elastically flexible and fluorescent as well. By combining elasticity and optical properties, they will find applications in optical waveguides, flexible optoelectronics, etc.

Crystal Growth & Design published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C9H10O3S, Computed Properties of 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prasad, Y. Rajendra published the artcileSynthesis and antimicrobial activity of some novel chalcones of 2-hydroxy-1-acetonaphthone and 3-acetylcoumarin, COA of Formula: C7H4BrClO2, the publication is E-Journal of Chemistry (2006), 3(13), 236-241, database is CAplus.

Five novel chalcones were synthesized by condensing 2-hydroxy-1-acetonaphthone with aldehydes and another five novel chalcones were prepared by refluxing 3-acetylcoumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were characterized by means of their IR, ¹H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

E-Journal of Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, COA of Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics